Protein

MCA_02045_1

Length
411 amino acids

Gene name: URA9

Description: Dihydroorotate dehydrogenase (quinone), mitochondrial

Browser: contigB:91157-92393+

RNA-seq: read pairs 2842, FPKM 85.2, percentile rank 76.3% (100% = highest expression)

Protein function

Annotation:URA9Dihydroorotate dehydrogenase (quinone), mitochondrial
KEGG:K00254DHODH dihydroorotate dehydrogenase [EC:1.3.5.2]
EGGNOG:0PFTFURA9Dihydroorotate dehydrogenase
CGD closest match:CAL0000178448URA9Dihydroorotate dehydrogenase (quinone), mitochondrial

Protein alignments

%idAln lengthE-value
MIA_05563_176.04%4090.0MIA_05563_1
M1X873_GEOCN70.90%4090.0Dihydroorotate dehydrogenase (quinone), mitochondrial OS=Geotrichum candidum GN=URA1 PE=3 SV=1
UniRef50_M1X87370.90%4090.0Dihydroorotate dehydrogenase (quinone), mitochondrial n=3 Tax=Saccharomycetales TaxID=4892 RepID=M1X873_GEOCN
A0A167FW03_9ASCO57.93%4161e-154Uncharacterized protein OS=Sugiyamaella lignohabitans GN=AWJ20_3415 PE=4 SV=1
A0A060SYX1_BLAAD58.52%3937e-144Dihydroorotate dehydrogenase (quinone), mitochondrial OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C00682g PE=3 SV=1
Q6C8K4_YARLI51.97%4062e-128Dihydroorotate dehydrogenase (quinone), mitochondrial OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D18920g PE=3 SV=1
PYRD_CANAL52.39%4181e-126Dihydroorotate dehydrogenase (quinone), mitochondrial OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=URA9 PE=1 SV=1
A0A1E3PSP9_9ASCO54.03%4092e-124Dihydroorotate dehydrogenase (quinone), mitochondrial OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_81411 PE=3 SV=1
A0A1E4THX2_9ASCO52.83%4071e-124Dihydroorotate dehydrogenase (quinone), mitochondrial OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_57589 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.8777
Predicted cleavage: 33

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 50 100 150 200 250 300 350 411

Detailed signature matches

  1. Family IPR005719
    Dihydroorotate dehydrogenase, class 2
    1. cd04738 (DHOD_2_like)
    2. TIGR01036
  2. Domain IPR013785
    Aldolase-type TIM barrel
    1. G3DSA:3.20.20.70
  3. Domain IPR005720
    Dihydroorotate dehydrogenase domain
    1. PF01180 (DHO_dh)
  4. SITE IPR001295
    Dihydroorotate dehydrogenase, conserved site
    1. PS00911 (DHODEHASE_1)
    2. PS00912 (DHODEHASE_2)
Unintegrated signatures no IPR
Unintegrated signatures
  1. CYTOPLASMIC_D... (C...)
  2. NON_CYTOPLASM... (N...)
  3. SSF51395 (FMN-linke...)
  4. TRANSMEMBRANE (Tran...)

Residue annotation

  1. quinone interactio...
  2. active site cd04738
  3. catalytic residues...
  4. FMN binding site c...
  5. substrate binding ...

Protein sequence

>MCA_02045_1
MFKYGRKAVTYSTVLGAGAIGLYYIHGRDCRTSAQKYLFTPAVRSVMDGEQAHNFAIQVFKNPSLAPKAPEDWKTTHDPN
NTLDVTLFKSPANPKVHSISLDSPLGIAAGFDKNGDAIDSLFNLGFSYVEIGSITPLPQPGNPKPRVFRLERDRAVINRY
GFNSEGHLAVLAKLKMREVKLNNSTSDNFAGKPKHALAINLGKNKTGDEVEDYIKGVDTFGPHADLLVVNVSSPNTPGLR
DLQSEEKLTNLLKTLVNRRDALPMESLPPIVVKIAPDLTKPEIESIASAVKESKIDGVIVSNTTVARPETLKSAPELTKQ
AGGLSGVPLKPYSLAALKTLRKELGKDITIIGCGGISSGADAIEFAKAGADFVQLYTSMTYKGPGVACEVKEEILDQLQG
KKWTEIVGSSS

GO term prediction

Biological Process

GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process
GO:0055114 oxidation-reduction process

Molecular Function

GO:0003824 catalytic activity
GO:0004152 dihydroorotate dehydrogenase activity
GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors

Cellular Component

GO:0005737 cytoplasm
GO:0016020 membrane