Protein

MIA_05503_1

Length
578 amino acids

Browser: contig08:661775-663512-

Protein function

EGGNOG:0PHYRHSP60Heat shock protein
SGD closest match:S000004249HSP60Heat shock protein 60, mitochondrial
CGD closest match:CAL0000174464HSP60Heat shock protein 60, mitochondrial

Protein alignments

%idAln lengthE-value
MCA_02103_192.727%5500.0MCA_02103_1
A0A0J9XFG1_GEOCN88.000%5500.0Similar to Saccharomyces cerevisiae YLR259C HSP60 Tetradecameric mitochondrial chaperonin required for ATP-dependent folding of polypeptides and complex assembly OS=Geotrichum candidum GN=BN980_GECA14s01594g PE=3 SV=1
A0A167DU91_9ASCO87.890%5450.0Chaperone ATPase HSP60 OS=Sugiyamaella lignohabitans GN=HSP60 PE=3 SV=1
A0A060TF66_BLAAD88.117%5470.0ARAD1D20570p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D20570g PE=3 SV=1
Q6C342_YARLI85.844%5510.0YALI0F02805p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F02805g PE=3 SV=1
A0A1E3PQ00_9ASCO84.335%5490.0Chaperonin GroL OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_81832 PE=3 SV=1
HSP60_CANAL80.769%5460.0Heat shock protein 60, mitochondrial OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=HSP60 PE=3 SV=1
A0A1E4TAM1_9ASCO79.856%5560.0Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_128919 PE=3 SV=1
UniRef50_F0XTG880.340%5290.0Heat shock protein mitochondrial n=12 Tax=Sordariomycetes TaxID=147550 RepID=F0XTG8_GROCL
HSP60_YEAST77.148%5470.0Heat shock protein 60, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HSP60 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.9476
Predicted cleavage: 25

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 100 200 300 400 500 578

Detailed signature matches

  1. Family IPR002423
    Chaperonin Cpn60/TCP-1 family
    1. PF00118 (Cpn60_TCP1)
  2. Family IPR001844
    Chaperonin Cpn60
    1. PR00298 (CHAPERONIN60)
    2. MF_00600 (CH60)
    3. TIGR02348
    4. cd03344 (GroEL)
  3. Domain IPR027413
    GroEL-like equatorial domain
    1. G3DSA:1.10.56...
  4. Domain IPR027409
    GroEL-like apical domain
    1. SSF52029 (GroEL api...)
    2. G3DSA:3.50.7.10
  5. SITE IPR018370
    Chaperonin Cpn60, conserved site
    1. PS00296 (CHAPERONIN...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. SSF48592 (GroEL equ...)
  2. SSF54849 (GroEL-int...)
  3. mobidb-lite (disord...)

Residue annotation

  1. ring oligomerisati...
  2. ATP/Mg binding sit...
  3. stacking interacti...
  4. hinge regions cd03...

Protein sequence

>MIA_05503_1
MSAMKSAIRPSAVRSLSAKSVRTYALSSHKELKFGVEGRAALLKGVDTLAKAVSVTLGPKGRNVLIEQSFGAPKITKDGV
TVARSITLQDKFENMGARLLQEVASKTNESAGDGTTSATVLGRSIFTESVKNVAAGCNPMDLRRGTQAAVEAVVEFLQKN
KREITTSEEIAQVATISANGDVHIGRLIASAMEKVGKEGVITVKEGKTIEDELEVTEGMRFDRGYISPYFVTDAKSGKVE
FENPLILLSEKKISTLADVLPSLELSNKTRRPLVIIAEDIDGEALAACILNKLRGQVQVAAVKAPGFGDNRKNILGDIAI
LTGGTVFTEELDIKPENATQELLGTSGAITITKEDTIVLNGDGDKQNIVQRCEQIRGYINDASTSEYEKEKLQERLAKLS
GGVAVIRVGGSSEVEVGEKKDRFVDALNATRAAVEEGILPGGGTALLKASRILDDLKTDNFDQKLGVNIIKTACSKPVRT
IVENAGGEGSVVAGKLIDDFGEDFDKGYNAAAGEFTDMIAAGIIDPFKVVRTGLVDASGVASLLATTECAIVDAPVESSP
AAPGGAPGMGGMGGMPGF

GO term prediction

Biological Process

GO:0006457 protein folding
GO:0042026 protein refolding

Molecular Function

GO:0005524 ATP binding

Cellular Component

GO:0005737 cytoplasm