Protein

MIA_05496_1

Length
660 amino acids

Browser: contig08:644910-646893+

Protein function

EGGNOG:0PFRGPGUG_05588ubiquitin carboxyl-terminal hydrolase
SGD closest match:S000005993UBP16Ubiquitin carboxyl-terminal hydrolase 16
CGD closest match:CAL0000181496orf19.3661Putative ubiquitin-specific protease

Protein alignments

%idAln lengthE-value
A0A060SYE5_BLAAD47.733%4191.68e-113ARAD1A15510p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A15510g PE=3 SV=1
UniRef50_A0A060SYE547.733%4194.15e-110ARAD1A15510p n=1 Tax=Blastobotrys adeninivorans TaxID=409370 RepID=A0A060SYE5_BLAAD
A0A0J9X414_GEOCN47.598%4581.94e-110Similar to Saccharomyces cerevisiae YPL072W UBP16 Deubiquitinating enzyme anchored to the outer mitochondrial membrane OS=Geotrichum candidum GN=BN980_GECA02s06269g PE=3 SV=1
MCA_02106_149.727%3665.34e-104MCA_02106_1
Q6CC80_YARLI39.539%5214.99e-94YALI0C11649p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_C11649g PE=3 SV=1
A0A1E3PDY1_9ASCO42.424%4295.56e-94Cysteine proteinase (Fragment) OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_4705 PE=4 SV=1
A0A167EYM4_9ASCO51.447%3112.53e-86Ubp16p OS=Sugiyamaella lignohabitans GN=UBP16 PE=3 SV=1
A0A1E4TI54_9ASCO38.421%3803.81e-65Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_25988 PE=3 SV=1
A0A1D8PCM4_CANAL31.768%3621.65e-37Putative ubiquitin-specific protease OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.3661 PE=3 SV=1
UBP16_YEAST28.070%3991.60e-38Ubiquitin carboxyl-terminal hydrolase 16 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=UBP16 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0083

Protein family membership

None predicted.

Domains and repeats

  1. Domain
1 100 200 300 400 500 600 660

Detailed signature matches

  1. Domain IPR028889
    Ubiquitin specific protease domain
    1. PS50235 (USP_3)
  2. Domain IPR001394
    Peptidase C19, ubiquitin carboxyl-terminal hydrolase
    1. PF00443 (UCH)
  3. SITE IPR018200
    Ubiquitin specific protease, conserved site
    1. PS00972 (USP_1)
    2. PS00973 (USP_2)
Unintegrated signatures no IPR
Unintegrated signatures
  1. CYTOPLASMIC_D... (C...)
  2. G3DSA:3.90.70.10
  3. NON_CYTOPLASM... (N...)
  4. SSF54001 (Cysteine ...)
  5. TMhelix
  6. TRANSMEMBRANE (Tran...)
  7. cd02662 (Peptidase_...)
  8. mobidb-lite (disord...)

Residue annotation

  1. Active Site cd02662

Protein sequence

>MIA_05496_1
MPGNDDTILTSTTAYLQTQLTQLLAQLFPSSSTSPIIRRTSSNTLVYTTAAAACLIYIFGPATLRLFTSVTSFIFSPFSS
SQTMRWPRAKKREGKHTVGLVNRANDCFANSNLQALGALPSLYTYLVALLAVPRPPPEAYRLLVSRTLTDATETAARRSA
GANMTGPVEITGALRSMVAALNEPVLEHKELDPWDFLHAVERFYNSLISRAQHDAHELLLLVLETLETEQLRLTRYYAAL
RAQTTDEKEQESLDKVINSIPKFPFKGATRDQITCSRCGYVPPTTPSPFAVLSLMVPQRARATLPDLLVDFAAPEYIQDY
GCARCRVGTLMQRAQVAGDGALVSALKPYAEDPSQLPAELEERLPRDVTSAIAKSTQFHRLPQVLAIHLSRSIYGGFGAS
RNSCKVSVPERLELYENYAPEEDKLRAMMGAQRRVEYELAAMIRHKGTHYAGHYECFRRKNLTWWRSHLESEQEAAAAQE
GGRAGTANGGSQEGANRTQESVEINDLDRLPYPQQRSAQVSPAVVTTKTHTHDATPSSAPAGEAPDSGRSPASSSSSWLF
SFLGGPSPASGPSPSPSPPLSGSAASSPGEGAAGAAGEDGEYEVLPASPQHGWWQVSDDKVWERNVREVLKEESGAYLLF
YERVEGGGGSTNGGGKRRKK

GO term prediction

Biological Process

GO:0006511 ubiquitin-dependent protein catabolic process
GO:0016579 protein deubiquitination

Molecular Function

GO:0036459 thiol-dependent ubiquitinyl hydrolase activity

Cellular Component

None predicted.