Protein

MCA_02106_1

Length
791 amino acids

Gene name: UBP16

Description: Ubiquitin carboxyl-terminal hydrolase 16

Browser: contigB:257152-259528-

RNA-seq: read pairs 2533, FPKM 39.5, percentile rank 60.0% (100% = highest expression)

Protein function

Annotation:UBP16Ubiquitin carboxyl-terminal hydrolase 16
KEGG:K11874UBP16 ubiquitin carboxyl-terminal hydrolase 16 [EC:3.4.19.12]
EGGNOG:0PFRGPGUG_05588ubiquitin carboxyl-terminal hydrolase
SGD closest match:S000005993UBP16Ubiquitin carboxyl-terminal hydrolase 16
CGD closest match:CAL0000181496orf19.3661Putative ubiquitin-specific protease

Protein alignments

%idAln lengthE-value
MIA_05496_144.25%5224e-118MIA_05496_1
A0A167EYM4_9ASCO41.81%5195e-90Ubp16p OS=Sugiyamaella lignohabitans GN=UBP16 PE=3 SV=1
UniRef50_A0A167EYM441.81%5191e-86Ubp16p n=1 Tax=Sugiyamaella lignohabitans TaxID=796027 RepID=A0A167EYM4_9ASCO
A0A0J9X414_GEOCN48.30%3522e-83Similar to Saccharomyces cerevisiae YPL072W UBP16 Deubiquitinating enzyme anchored to the outer mitochondrial membrane OS=Geotrichum candidum GN=BN980_GECA02s06269g PE=3 SV=1
A0A060SYE5_BLAAD47.40%3465e-80ARAD1A15510p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A15510g PE=3 SV=1
Q6CC80_YARLI43.90%3693e-76YALI0C11649p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_C11649g PE=3 SV=1
A0A1E3PDY1_9ASCO42.27%3622e-65Cysteine proteinase (Fragment) OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_4705 PE=4 SV=1
A0A1E4TI54_9ASCO38.22%3482e-44Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_25988 PE=3 SV=1
A0A1D8PCM4_CANAL28.85%4167e-26Putative ubiquitin-specific protease OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.3661 PE=3 SV=1
UBP16_YEAST26.86%4843e-25Ubiquitin carboxyl-terminal hydrolase 16 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=UBP16 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.5782
Predicted cleavage: 98

Protein family membership

None predicted.

Domains and repeats

  1. Domain
1 100 200 300 400 500 600 700 791

Detailed signature matches

  1. Domain IPR028889
    Ubiquitin specific protease domain
    1. PS50235 (USP_3)
  2. Domain IPR001394
    Peptidase C19, ubiquitin carboxyl-terminal hydrolase
    1. PF00443 (UCH)
  3. SITE IPR018200
    Ubiquitin specific protease, conserved site
    1. PS00972 (USP_1)
    2. PS00973 (USP_2)
Unintegrated signatures no IPR
Unintegrated signatures
  1. CYTOPLASMIC_D... (C...)
  2. Coil
  3. G3DSA:3.90.70.10
  4. NON_CYTOPLASM... (N...)
  5. SSF54001 (Cysteine ...)
  6. TMhelix
  7. TRANSMEMBRANE (Tran...)
  8. cd02662 (Peptidase_...)
  9. mobidb-lite (disord...)

Residue annotation

  1. Active Site cd02662

Protein sequence

>MCA_02106_1
MNVLSSLFDTHSQQPPISSPPVSHSPVVPPQAIIYRLVSIISSSISKASSTVAGINSDQKSASTISKITSKLLFWWTGSI
YWIKRNPRIFSVYLITASTFLYIFAPTLFPSSFRFYITDSEEEEEEDDDDNGEYNGEKKSAKKLRKKSKKQRMQWLRRKK
KEGKYTVGLINDANDCFANSNLQALSALRSLYGYICHLALLLPVEEADIAKYRQVLIDYERNKNESKKKPSSSSSSSFVS
SSSNNLNGDNASTSATTTPTENNDDNDDDNDDYSVNRRGASITRAMPLEISMALGRMIVQLNEPILTPKALSPWSFLRVL
ENFYTSKISRSQHDAHELLHLILETLEIEYSRIKRYYIALQEEERGQSSASLNTSASQSNNNRIELPPFPFKGSTRDKIT
CSKCGYVSNTTPSSFIVLSLMVPQKHSVTLNELLLDFNSPEYIQDYGCTRCRLIALIGRLQTEYNKLSSIKKGSNNNNKS
ADNIKYTIKELSQYVDDPDKLPEKYSNSLPREINSPISKSTQFYKLPQILTIHLSRSIYEGYGASRNSCKVSVPEYLELI
QDTSGQKQSESSEGQQSSSNSSSSSNSRSNGFAKAQSILGKKRRVQYTLVAMIRHKGTHYAGHYECFRRKNLTWWKTQLA
AQNGINKKKQRKSTDTFSSVATDSNNNNNNNHEVVDSASASSSSSSSAAAAAATTNNNNNNNTNTNGSSSNLESIQNMFS
QFTSSSSSLSSSFLGGQSEQQQQQLLNDVLPASINDDWWQISDDKVWEKSIKEVMKEESGAYLLFYERITK

GO term prediction

Biological Process

GO:0006511 ubiquitin-dependent protein catabolic process
GO:0016579 protein deubiquitination

Molecular Function

GO:0036459 thiol-dependent ubiquitinyl hydrolase activity

Cellular Component

None predicted.