Protein
MIA_05462_1
Length
609 amino acids
Browser: contig08:549957-551898-
Protein function
| EGGNOG: | 0PGXB | SSN3 | Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II- dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II |
|---|---|---|---|
| SGD closest match: | S000005963 | SSN3 | Meiotic mRNA stability protein kinase SSN3 |
| CGD closest match: | CAL0000183529 | SSN3 | Serine/threonine-protein kinase SSN3 |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| MCA_06403_1 | 73.15% | 406 | 0.0 | MCA_06403_1 |
| A0A060TIS6_BLAAD | 69.46% | 406 | 0.0 | ARAD1D48994p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D48994g PE=4 SV=1 |
| A0A161HX00_9ASCO | 72.63% | 369 | 0.0 | Cyclin-dependent serine/threonine protein kinase SSN3 OS=Sugiyamaella lignohabitans GN=SSN3 PE=4 SV=1 |
| UniRef50_A0A161HX00 | 72.63% | 369 | 0.0 | Cyclin-dependent serine/threonine protein kinase SSN3 n=1 Tax=Sugiyamaella lignohabitans TaxID=796027 RepID=A0A161HX00_9ASCO |
| A0A0J9X5B1_GEOCN | 70.94% | 406 | 0.0 | Similar to Saccharomyces cerevisiae YPL042C SSN3 Cyclin-dependent protein kinase, component of RNA polymerase II holoenzyme OS=Geotrichum candidum GN=BN980_GECA03s01165g PE=4 SV=1 |
| SSN3_YARLI | 65.10% | 404 | 0.0 | Serine/threonine-protein kinase SSN3 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=SSN3 PE=3 SV=1 |
| A0A1E4TLJ8_9ASCO | 62.37% | 372 | 4e-175 | Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_147630 PE=4 SV=1 |
| SSN3_CANAL | 53.32% | 437 | 4e-156 | Serine/threonine-protein kinase SSN3 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=SSN3 PE=3 SV=2 |
| SSN3_YEAST | 62.58% | 318 | 2e-143 | Meiotic mRNA stability protein kinase SSN3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SSN3 PE=1 SV=3 |
| A0A1E3PQA7_9ASCO | 58.81% | 335 | 8e-143 | Kinase-like protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_82050 PE=4 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.9125
Predicted cleavage: 145
Protein family membership
None predicted.
Domains and repeats
-
Domain
1
100
200
300
400
500
609
Detailed signature matches
no IPR
Unintegrated signatures
-
-
-
cd07842 (STKc_CDK8_...)
-
mobidb-lite (disord...)
Residue annotation
-
ATP binding site c...
-
active site cd07842
-
CDK/cyclin interfa...
-
polypeptide substr...
-
activation loop (A...
Protein sequence
>MIA_05462_1 MFNNTNNITTNSSSSKNIINNNNSQSFANNNNNNSSNSGRSSSNNSNSRQTSSSSSSQFQQFQQFSHISQLASTSASSSS NDRIASSHFVAPHPQQVSKPKYYPPPQIINPHNHPPQSFSLPLQTQAARSSINTSSSASRSARIPSVGIQPNNSIITGSA RVVQHQHPISQEIAQALSQTRQQQHHHHHHHHTSSSSSSSRSPMVTNPLASFKSRKDRTRKRLLDSYEILGYIAAGTYGK VYKAKSRNPEIKSRLFAIKKFKADKEGEIVHYTGISQSACREMALCRELRHKNVINLVEIVLEDKSIFMVFDFAEHDLLQ IIHYHTHPEHKPIPESTMKSVLWQILNGVSYLHQNWVLHRDLKPANIMLSSDGIVKIGDLGLARLFSDPIQSFFTGDKVV VTIWYRAPELLLGAKHYTPAIDLWAVGCIFAELLALKPIFKGEEAKMDSKKNIPFQRNQFQKVVDILGTPTTDKWPSLPK YPEFTQFQQLKKCPYHLNAWYQRHSLSVLNQQAFHLLASLFEYDPARRITAHAALSHAYFSEAPRVTENVFQGQRYEYPS RRISNDDNDIKSNVNYTSSTAHKRPVPNNAAAAAAMADQDLLHARKRQK
GO term prediction
Biological Process
GO:0006468 protein phosphorylation
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Cellular Component
None predicted.