Protein
MCA_06403_1
Length
491 amino acids
Gene name: SSN3
Description: Serine/threonine protein kinase Ssn3; cyclin-dependent protein kinase
Browser: contigD:4106567-4108043-
RNA-seq: read pairs 995, FPKM 25.0, percentile rank 47.6% (100% = highest expression)
Protein function
| Annotation: | SSN3 | Serine/threonine protein kinase Ssn3; cyclin-dependent protein kinase | |
|---|---|---|---|
| KEGG: | K02208 | CDK8_11 | cyclin-dependent kinase 8/11 [EC:2.7.11.22 2.7.11.23] |
| EGGNOG: | 0PGXB | SSN3 | Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II- dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II |
| SGD closest match: | S000005963 | SSN3 | Meiotic mRNA stability protein kinase SSN3 |
| CGD closest match: | CAL0000183529 | SSN3 | Serine/threonine-protein kinase SSN3 |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| MIA_05462_1 | 73.15% | 406 | 0.0 | MIA_05462_1 |
| A0A060TIS6_BLAAD | 72.26% | 393 | 0.0 | ARAD1D48994p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D48994g PE=4 SV=1 |
| A0A0J9X5B1_GEOCN | 71.43% | 399 | 0.0 | Similar to Saccharomyces cerevisiae YPL042C SSN3 Cyclin-dependent protein kinase, component of RNA polymerase II holoenzyme OS=Geotrichum candidum GN=BN980_GECA03s01165g PE=4 SV=1 |
| A0A161HX00_9ASCO | 70.63% | 395 | 0.0 | Cyclin-dependent serine/threonine protein kinase SSN3 OS=Sugiyamaella lignohabitans GN=SSN3 PE=4 SV=1 |
| UniRef50_A0A161HX00 | 70.63% | 395 | 0.0 | Cyclin-dependent serine/threonine protein kinase SSN3 n=1 Tax=Sugiyamaella lignohabitans TaxID=796027 RepID=A0A161HX00_9ASCO |
| SSN3_YARLI | 68.21% | 390 | 0.0 | Serine/threonine-protein kinase SSN3 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=SSN3 PE=3 SV=1 |
| A0A1E4TLJ8_9ASCO | 59.28% | 388 | 1e-161 | Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_147630 PE=4 SV=1 |
| SSN3_CANAL | 53.81% | 420 | 2e-145 | Serine/threonine-protein kinase SSN3 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=SSN3 PE=3 SV=2 |
| SSN3_YEAST | 60.37% | 328 | 1e-142 | Meiotic mRNA stability protein kinase SSN3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SSN3 PE=1 SV=3 |
| A0A1E3PQA7_9ASCO | 59.08% | 347 | 3e-144 | Kinase-like protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_82050 PE=4 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.0555
Protein family membership
None predicted.
Domains and repeats
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Domain
1
50
100
150
200
250
300
350
400
450
491
Detailed signature matches
no IPR
Unintegrated signatures
-
-
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cd07842 (STKc_CDK8_...)
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mobidb-lite (disord...)
Residue annotation
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ATP binding site c...
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active site cd07842
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CDK/cyclin interfa...
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polypeptide substr...
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activation loop (A...
Protein sequence
>MCA_06403_1 MFNNTNSNSSNSNSGNINYNITSDDRINSSSQRYNSNNNHGPVYTKARFYPPPQVIPHLNSSSHQLIHQPASQNRNSNLQ QGQQHISSHQRQSQGFHKKPLPSMVSNPLANFKSRKDRSRRRLLDSYEILGYIAAGTYGKVYKAKSKHQENGDKLYAIKK FKADKEGEVSHYTGISQSACREMALCKELSHQNVVNLAEIILEDKSIYMVFDYAEHDLLQLIHYHTHPDRKAIPESTVKS ILWQILNGVSYLHQNWVLHRDLKPANIMLSVDGVVKIGDLGLARLFSDPLQSFFTGDKVIVTIWYRAPELLLGGRHYTPA IDLWAVGCIFAELLALKPIFKGEEAKMDNKKNVPFQRNQFQKVVDILGMPSTENWPTLSKYPEASQLNLIRRCRPSLESW YQSQIFGASSQNAFDLLNRLLTYDPAKRITAHDALVDPYFLDNPKVQKNVFQGQCYEYPNRRISNDDNDIKCQTKRPAAN DDNLHPRKKQK
GO term prediction
Biological Process
GO:0006468 protein phosphorylation
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Cellular Component
None predicted.