Protein

MIA_05458_1

Length
1,441 amino acids

Browser: contig08:524829-529254+

Protein function

EGGNOG:0PI6PVPS15protein kinase (VPS15)
SGD closest match:S000000301VPS15Serine/threonine-protein kinase VPS15
CGD closest match:CAL0000193001VPS15Ubiquitin-binding serine/threonine protein kinase

Protein alignments

%idAln lengthE-value
MCA_00741_159.045%14870.0MCA_00741_1
A0A0J9X9Y0_GEOCN51.944%14920.0Similar to Saccharomyces cerevisiae YBR097W VPS15 Myristoylated serine/threonine protein kinase involved in vacuolar protein sorting OS=Geotrichum candidum GN=BN980_GECA06s03354g PE=4 SV=1
UniRef50_A0A0J9X9Y051.944%14920.0Similar to Saccharomyces cerevisiae YBR097W VPS15 Myristoylated serine/threonine protein kinase involved in vacuolar protein sorting n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9X9Y0_GEOCN
A0A060T6G4_BLAAD43.133%15000.0ARAD1B11946p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B11946g PE=4 SV=1
A0A167CVY0_9ASCO37.664%13700.0Ubiquitin-binding serine/threonine protein kinase VPS15 OS=Sugiyamaella lignohabitans GN=VPS15 PE=4 SV=1
A0A1E4TGZ5_9ASCO34.898%15130.0Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_2665 PE=4 SV=1
Q6C3L7_YARLI44.966%8740.0YALI0E33774p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E33774g PE=4 SV=1
VPS15_YEAST33.062%13520.0Serine/threonine-protein kinase VPS15 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=VPS15 PE=1 SV=4
A0A1D8PPK3_CANAL30.822%15930.0Ubiquitin-binding serine/threonine protein kinase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=VPS15 PE=4 SV=1
A0A1E3PNT5_9ASCO32.609%9209.99e-154WD40 repeat-like protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_81694 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.1350

Protein family membership

None predicted.

Domains and repeats

  1. Domain
  2. Domain
  3. Repeat
1 200 400 600 800 1000 1200 1441

Detailed signature matches

  1. Domain IPR011009
    Protein kinase-like domain
    1. SSF56112 (Protein k...)
  2. Domain IPR000719
    Protein kinase domain
    1. PS50011 (PROTEIN_KI...)
    2. PF00069 (Pkinase)
    3. SM00220 (serkin_6)
  3. Domain IPR016024
    Armadillo-type fold
    1. SSF48371 (ARM repeat)
  4. Domain IPR011989
    Armadillo-like helical
    1. G3DSA:1.25.10.10
  5. Domain IPR015943
    WD40/YVTN repeat-like-containing domain
    1. G3DSA:2.130.1...
  6. Domain IPR017986
    WD40-repeat-containing domain
    1. SSF50978 (WD40 repe...)
    2. PS50294 (WD_REPEATS...)
  7. Repeat IPR001680
    WD40 repeat
    1. PF00400 (WD40)
    2. PS50082 (WD_REPEATS_2)
    3. SM00320 (WD40_4)
  8. SITE IPR008271
    Serine/threonine-protein kinase, active site
    1. PS00108 (PROTEIN_KI...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. CYTOPLASMIC_D... (C...)
  2. Coil
  3. G3DSA:1.10.51...
  4. G3DSA:3.30.20...
  5. NON_CYTOPLASM... (N...)
  6. TRANSMEMBRANE (Tran...)
  7. cd13980 (STKc_Vps15)
  8. mobidb-lite (disord...)

Residue annotation

  1. ATP binding site c...
  2. active site cd13980
  3. polypeptide substr...
  4. activation loop (A...

Protein sequence

>MIA_05458_1
MGNQLSLTTHTAATVAIDAYISELNNVQYDRNLGNARFLKTVKGISDNSLVVAKVFIKPSQDIDLSSFSDELIRQRDSLL
KIENALPYSRFLETDRAGYLVRQYIKTNLYDRISTRPFLEPIEKLWIVFQLLVCLEKCHEKNVYHGDIKSENILVTSWNW
AYLSDFAPFKPAYIPENDPSQFSFFFDTSQRRSCYVAPERFTSSGESIQGGLTAQMDIFSLGCVIAELFLEGSHIFSLAQ
LFKYRRGEYTPSFTGIENENIKKMVSSMISLNPDDRLTASEYLKKWRHSIFPDYFYTFLHEFMTTVSSTTMQKTEIQSIL
DNRMSFIYQHFKEISLAFGFQPLVEKIQWDSSQSIIPGVLELPGTRHLVKQNTNMLDLSKDDGALIVLAVVLSTVRNVSN
SSLKLKGCDLILALGEMINDEAKLDRCLPYLLSFLDDDSDIVQATAIRNMTELLGMVTVITPLNGEIFFEYIFSKLDSIF
RSNPAKSTFVRAIYASCFPTLSTIASRFLEMSQILKTSGMLDSYDPETENGARFDIIPYDVNRQSIVEKFEEHTIALLSD
NDSAVRKALLKEIIPLCLFFGKQKTNDIILSHILTYLNDQDSSLKIQFFDCIIGLSPFIGPVGLEMYILPLMLQALSDSE
EFVTSKTFEAYKAFSDLGLIKKQHIWDLLRVAVRYTVHPNKWIRYAAFAFISSSTKWMSQAEIYCLLYPILEPFLENDIT
DFSQASLVSNAKPPLSRATFNAAISWATKAQKSHFWKIAAKSSGVFTSDSISTLPKSIDDIKQSAEDKKWITVLKEISVT
DEDFWKMAVLREHLYRLAEALTLTQMPLNKDINVANFGTSLVEKLKVPINSYEVSNNDFDWNNSKSSDSLSNFEDIKTSL
SEAISKPSSSDGRRPADITVSSDGATVEQSPATIGTVTTDVYGTVEQPFSSILPKNDPNAEPRYLTKTKIQLKKEHEFDP
YVAKFLDSVNVKHARAEPSDFGPQVIPVTHSEQFHKIGTSNSLPKWEPSGVLASQFSEHQSAVNKIEVSPDHSFFLSCSD
DGTIKIWDCLRLEKNVINRSIHTYKCGPTKVKFICFMENSYTFAASCTNGTVEFIRIDVTLIKGASQVRFKRFVPIRKFS
LQPDEYAIFMKHIKTTDASMLVIATTKSRIIGLDVGTLEENFVLNCPVSHGIPMCFAVDSKKNWLLLGTSLGVLNLFDLR
FLILVKSWTFENPAPIRSLQITSKSQGASFFMLGGTSKLEASAWSLEKLTCLEVFSIAPVIEQRKSYRLISLEDSLTGRN
KIKFPRMEDPSVKSEALLCMAVESESFKSIDSADKKLLRNAYILATGTDHKIRFWDTESVDFCSIMSGLTSDSGTPSFFT
TYNNSAIKIVGERFTHKSSSSGDNKTPSAYTPRPPRPSVIGTEQQELAKNHQASIVDIAILYRPYQMIVTADRTGVIKVF
I

GO term prediction

Biological Process

GO:0006468 protein phosphorylation

Molecular Function

GO:0004672 protein kinase activity
GO:0005488 binding
GO:0005515 protein binding
GO:0005524 ATP binding

Cellular Component

None predicted.