Protein

MCA_00741_1

Length
1,473 amino acids

Gene name: VPS15

Description: Serine/threonine-protein kinase Vps15; S. cerevisiae homologue is involved in vacuolar protein sorting

Browser: contigA:2311543-2316112-

RNA-seq: read pairs 940, FPKM 7.9, percentile rank 22.1% (100% = highest expression)

Protein function

Annotation:VPS15Serine/threonine-protein kinase Vps15; S. cerevisiae homologue is involved in vacuolar protein sorting
KEGG:K08333PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4 [EC:2.7.11.1]
EGGNOG:0PI6PVPS15protein kinase (VPS15)
SGD closest match:S000000301VPS15Serine/threonine-protein kinase VPS15
CGD closest match:CAL0000193001VPS15Ubiquitin-binding serine/threonine protein kinase

Protein alignments

%idAln lengthE-value
MIA_05458_159.05%14870.0MIA_05458_1
A0A0J9X9Y0_GEOCN51.17%14930.0Similar to Saccharomyces cerevisiae YBR097W VPS15 Myristoylated serine/threonine protein kinase involved in vacuolar protein sorting OS=Geotrichum candidum GN=BN980_GECA06s03354g PE=4 SV=1
UniRef50_A0A0J9X9Y051.17%14930.0Similar to Saccharomyces cerevisiae YBR097W VPS15 Myristoylated serine/threonine protein kinase involved in vacuolar protein sorting n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9X9Y0_GEOCN
A0A060T6G4_BLAAD39.95%15170.0ARAD1B11946p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B11946g PE=4 SV=1
A0A1E4TGZ5_9ASCO34.79%15290.0Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_2665 PE=4 SV=1
A0A167CVY0_9ASCO36.05%13730.0Ubiquitin-binding serine/threonine protein kinase VPS15 OS=Sugiyamaella lignohabitans GN=VPS15 PE=4 SV=1
Q6C3L7_YARLI42.00%8690.0YALI0E33774p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E33774g PE=4 SV=1
VPS15_YEAST31.81%13770.0Serine/threonine-protein kinase VPS15 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=VPS15 PE=1 SV=4
A0A1D8PPK3_CANAL36.41%9099e-173Ubiquitin-binding serine/threonine protein kinase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=VPS15 PE=4 SV=1
A0A1E3PNT5_9ASCO31.67%9442e-146WD40 repeat-like protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_81694 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.1897

Protein family membership

None predicted.

Domains and repeats

  1. Domain
  2. Domain
  3. Repeat
1 200 400 600 800 1000 1200 1473

Detailed signature matches

  1. Domain IPR011009
    Protein kinase-like domain
    1. SSF56112 (Protein k...)
  2. Domain IPR000719
    Protein kinase domain
    1. PS50011 (PROTEIN_KI...)
    2. PF00069 (Pkinase)
    3. SM00220 (serkin_6)
  3. Domain IPR016024
    Armadillo-type fold
    1. SSF48371 (ARM repeat)
  4. Domain IPR011989
    Armadillo-like helical
    1. G3DSA:1.25.10.10
  5. Domain IPR015943
    WD40/YVTN repeat-like-containing domain
    1. G3DSA:2.130.1...
  6. Domain IPR017986
    WD40-repeat-containing domain
    1. SSF50978 (WD40 repe...)
    2. PS50294 (WD_REPEATS...)
  7. Repeat IPR001680
    WD40 repeat
    1. PF00400 (WD40)
    2. PS50082 (WD_REPEATS_2)
    3. SM00320 (WD40_4)
  8. SITE IPR008271
    Serine/threonine-protein kinase, active site
    1. PS00108 (PROTEIN_KI...)
  9. SITE IPR019775
    WD40 repeat, conserved site
    1. PS00678 (WD_REPEATS_1)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:1.10.51...
  2. G3DSA:3.30.20...
  3. cd13980 (STKc_Vps15)
  4. mobidb-lite (disord...)

Residue annotation

  1. ATP binding site c...
  2. active site cd13980
  3. polypeptide substr...
  4. activation loop (A...

Protein sequence

>MCA_00741_1
MGNQLSATTPTSTTVAIDAYISELQTVQYDRNLGNARFLKTVKGVSEGSLVVVKVFIKPGHDVFLSDIDREMFRQRNILL
NIDNSLPYSRFLETDRAGYLVRQYIKTNLYDRISTRPFLEPIEKLWIVFQLLTCLNKCHQASVYHGDIKSENILVTSWNW
VYLTDFASFKPAFIPETDPSQFYFFFDSSQRRSCYLAPERFHSAEEIIHGGITPAMDIFSLGCVIAELFLEGTHIFNLAQ
LFKYRKGDYIPSLEGIENEYVKQMITQMISLDPKDRKTASHYLTEWKHKLFPDYFYDFLYDFVANVSMTNQYDNSGKPFK
PNLFLDNRMSYIYNNFTDITTHLGFRVTLEDTTAAILDNNRHMLPNFLELPGTRKVIEKQDLAMDITRDDGALIVLSIVL
STIRNVSNSSLKIKGCDLIIALGEMINDDAKLDRCLPYFLTLLDDPSELVQASAIRNMIKLLGMVTTITPLNGEIFLEYI
FPKLDTILRSNPKKSIFVRVMYASCFPSLAQIALRFLEMSQILKTSGMFDSYDPETENGSRFGIIPFDLNRQGLIEKFEE
HTIALLSDEDTSVKKAILREVVPLCLFFGKQKTNDIVLSHILTYLNDPDYSLKTQFFDSIIGLGPFIGPVALEEYIQPLT
LQALNDTEEFVIAKTFEAYKAFAEFGLIREKSIWSLLEISVRYTVHPNLWIRNAAVSFVSASTTWMSASEIYCMLYPILR
PYLENDITEFSQANITLHIKQPLSRSFFNWAVTWASKAQKSIFWKSAAKKAETDKYSSDQTTTIYLNSTDKILLSSEDQI
WVGRLKKKGGKEEDLWKIKALEDHIYKLAAAIVSTQKPLLNDNTLIKGDRGKSQDLINNFTTVESLGIKPDRYKFTTGDY
DWDNEDDPSRPISKESSSDALLNLDGMKSALKETVVHVNQASKNDSIASNLLGDHFGDQNGATAEPSVAVIGTSTTQAYG
TVEQPFSTIQKPPSAPSPDFSSNLQEQQINVYVSKFLSAQNVIHGKTEPAEFGPQVIPVLYAENFHSLSVYGPTSNWRPS
GVLASRFVEHTAAVNKIVPSPDHSFFLSCSDDGSIKIWDCARLEKNVINRSIQTISYGSETKVKFICFMVNSYTIAASLS
TGKIAFIRVDVSLLKNASRVRFKKFVPLKTFELQKGEYATWMKHVKTNRSSVLIITTTKSRIIGINVSTLKEDFSFSCPL
NHGVPTCFIVDYRKCWMLVGTQQGVLDLYDLRFNVLAKSWTFENAAPIYSLDFLPRSKERKFCMLGGTSKNEVTIWDVTN
MTCHGVYTNSASIDQSKNYSAINFEELTTEKHKSLVSKQFDIAPKSSDIFCMAVGIDSKANKDDEPHIHILSGGADRKVR
FWDLNSVNMSTIVSGLTTNAKPPTFFQAYNNFSIKVVAEKSTVGEPQDSSDISSNTGTKITRPLKPTRTAVIAAEQQDLA
RNHSASITDIAILHRPYQMVISADITGVIRVYI

GO term prediction

Biological Process

GO:0006468 protein phosphorylation

Molecular Function

GO:0004672 protein kinase activity
GO:0005488 binding
GO:0005515 protein binding
GO:0005524 ATP binding

Cellular Component

None predicted.