MIA_05434_1

Protein

Length

1,929 amino acids

Protein function

EGGNOG:	0PG56	RRP5	rRNA biogenesis protein RRP5
SGD closest match:	S000004842	RRP5	rRNA biogenesis protein RRP5
CGD closest match:	CAL0000188474	orf19.1578	Uncharacterized protein

Protein alignments

	%id	Aln length	E-value
MCA_05032_1	61.107%	1445	0.0	MCA_05032_1
A0A0J9X4Q2_GEOCN	43.547%	1387	0.0	Similar to Saccharomyces cerevisiae YMR229C RRP5 RNA binding protein with preference for single stranded tracts of U's involved in synthesis of both 18S and 5.8S rRNAs OS=Geotrichum candidum GN=BN980_GECA01s11439g PE=4 SV=1
UniRef50_A0A0J9X4Q2	43.547%	1387	0.0	Similar to Saccharomyces cerevisiae YMR229C RRP5 RNA binding protein with preference for single stranded tracts of U's involved in synthesis of both 18S and 5.8S rRNAs n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9X4Q2_GEOCN
A0A1E3PIA8_9ASCO	40.790%	1417	0.0	Nucleic acid-binding protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_51740 PE=4 SV=1
A0A060TDE1_BLAAD	39.589%	1412	0.0	ARAD1D43010p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D43010g PE=4 SV=1
A0A1E4TJ38_9ASCO	35.209%	1386	0.0	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_30106 PE=4 SV=1
A0A1D8PGR5_CANAL	33.381%	1405	0.0	Uncharacterized protein OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.1578 PE=4 SV=1
RRP5_YEAST	31.601%	1462	0.0	rRNA biogenesis protein RRP5 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RRP5 PE=1 SV=1
A0A167C4U7_9ASCO	37.800%	791	8.67e-152	Rrp5p OS=Sugiyamaella lignohabitans GN=RRP5 PE=4 SV=1
Q6C430_YARLI	28.411%	1422	1.29e-120	YALI0E30217p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E30217g PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0367
Predicted cleavage: 11

Protein family membership

None predicted.

Domains and repeats

Domain
124 - 325
Nucleic acid-binding, OB-fold (IPR012340)
RNA-binding domain, S1 (IPR022967)
S1 domain (IPR003029)
332 - 423
Nucleic acid-binding, OB-fold (IPR012340)
RNA-binding domain, S1 (IPR022967)
S1 domain (IPR003029)
447 - 525
RNA-binding domain, S1 (IPR022967)
S1 domain (IPR003029)
528 - 616
Nucleic acid-binding, OB-fold (IPR012340)
RNA-binding domain, S1 (IPR022967)
S1 domain (IPR003029)
623 - 707
Nucleic acid-binding, OB-fold (IPR012340)
RNA-binding domain, S1 (IPR022967)
S1 domain (IPR003029)
713 - 811
Nucleic acid-binding, OB-fold (IPR012340)
RNA-binding domain, S1 (IPR022967)
S1 domain (IPR003029)
818 - 905
Nucleic acid-binding, OB-fold (IPR012340)
RNA-binding domain, S1 (IPR022967)
S1 domain (IPR003029)
931 - 1,016
Nucleic acid-binding, OB-fold (IPR012340)
RNA-binding domain, S1 (IPR022967)
S1 domain (IPR003029)
1,042 - 1,142
Nucleic acid-binding, OB-fold (IPR012340)
RNA-binding domain, S1 (IPR022967)
S1 domain (IPR003029)
1,150 - 1,241
Nucleic acid-binding, OB-fold (IPR012340)
RNA-binding domain, S1 (IPR022967)
S1 domain (IPR003029)
1,236 - 1,327
Nucleic acid-binding, OB-fold (IPR012340)
RNA-binding domain, S1 (IPR022967)
S1 domain (IPR003029)
1,337 - 1,424
Nucleic acid-binding, OB-fold (IPR012340)
RNA-binding domain, S1 (IPR022967)
S1 domain (IPR003029)
1,556 - 1,888
Tetratricopeptide-like helical domain (IPR011990)
Repeat
1,556 - 1,587
HAT (Half-A-TPR) repeat (IPR003107)
1,589 - 1,626
HAT (Half-A-TPR) repeat (IPR003107)
1,661 - 1,694
HAT (Half-A-TPR) repeat (IPR003107)
1,754 - 1,786
HAT (Half-A-TPR) repeat (IPR003107)

1 200 400 600 800 1000 1200 1400 1600 1800 1929

Detailed signature matches

IPR012340

Nucleic acid-binding, OB-fold
1. SSF50249 (Nucleic a...)
  
  332 - 411
  
  SUPERFAMILY
  SSF50249 (Nucleic acid-binding proteins)
  
  1,236 - 1,327
  
  SUPERFAMILY
  SSF50249 (Nucleic acid-binding proteins)
  
  818 - 905
  
  SUPERFAMILY
  SSF50249 (Nucleic acid-binding proteins)
  
  196 - 243
  
  SUPERFAMILY
  SSF50249 (Nucleic acid-binding proteins)
  
  124 - 166
  
  SUPERFAMILY
  SSF50249 (Nucleic acid-binding proteins)
  
  1,337 - 1,424
  
  SUPERFAMILY
  SSF50249 (Nucleic acid-binding proteins)
  
  1,042 - 1,118
  
  SUPERFAMILY
  SSF50249 (Nucleic acid-binding proteins)
  
  528 - 616
  
  SUPERFAMILY
  SSF50249 (Nucleic acid-binding proteins)
  
  713 - 811
  
  SUPERFAMILY
  SSF50249 (Nucleic acid-binding proteins)
  
  232 - 325
  
  SUPERFAMILY
  SSF50249 (Nucleic acid-binding proteins)
  
  1,150 - 1,241
  
  SUPERFAMILY
  SSF50249 (Nucleic acid-binding proteins)
  
  931 - 1,011
  
  SUPERFAMILY
  SSF50249 (Nucleic acid-binding proteins)
  
  623 - 707
  
  SUPERFAMILY
  SSF50249 (Nucleic acid-binding proteins)
IPR022967

RNA-binding domain, S1
1. SM00316 (S1_6)
  
  540 - 612
  
  SMART
  SM00316 (S1_6)
  
  1,344 - 1,417
  
  SMART
  SM00316 (S1_6)
  
  1,155 - 1,228
  
  SMART
  SM00316 (S1_6)
  
  1,250 - 1,321
  
  SMART
  SM00316 (S1_6)
  
  343 - 423
  
  SMART
  SM00316 (S1_6)
  
  825 - 899
  
  SMART
  SM00316 (S1_6)
  
  938 - 1,016
  
  SMART
  SM00316 (S1_6)
  
  630 - 701
  
  SMART
  SM00316 (S1_6)
  
  447 - 525
  
  SMART
  SM00316 (S1_6)
  
  1,057 - 1,142
  
  SMART
  SM00316 (S1_6)
  
  251 - 322
  
  SMART
  SM00316 (S1_6)
  
  720 - 797
  
  SMART
  SM00316 (S1_6)
  
  131 - 237
  
  SMART
  SM00316 (S1_6)
IPR003029

S1 domain
1. PS50126 (S1)
  
  133 - 237
  
  PROSITE profiles
  PS50126 (S1)
  
  1,157 - 1,228
  
  PROSITE profiles
  PS50126 (S1)
  
  253 - 324
  
  PROSITE profiles
  PS50126 (S1)
  
  1,059 - 1,142
  
  PROSITE profiles
  PS50126 (S1)
  
  940 - 1,014
  
  PROSITE profiles
  PS50126 (S1)
  
  721 - 797
  
  PROSITE profiles
  PS50126 (S1)
  
  827 - 899
  
  PROSITE profiles
  PS50126 (S1)
  
  449 - 525
  
  PROSITE profiles
  PS50126 (S1)
  
  1,252 - 1,321
  
  PROSITE profiles
  PS50126 (S1)
  
  632 - 701
  
  PROSITE profiles
  PS50126 (S1)
  
  542 - 612
  
  PROSITE profiles
  PS50126 (S1)
  
  345 - 423
  
  PROSITE profiles
  PS50126 (S1)
  
  1,346 - 1,417
  
  PROSITE profiles
  PS50126 (S1)
2. PF00575 (S1)
  
  344 - 407
  
  Pfam
  PF00575 (S1)
  
  1,343 - 1,417
  
  Pfam
  PF00575 (S1)
  
  1,250 - 1,321
  
  Pfam
  PF00575 (S1)
  
  637 - 696
  
  Pfam
  PF00575 (S1)
  
  253 - 313
  
  Pfam
  PF00575 (S1)
IPR011990

Tetratricopeptide-like helical domain
1. G3DSA:1.25.40.10
  
  1,617 - 1,709
  
  GENE3D
  G3DSA:1.25.40.10 (G3DSA:1.25.40.10)
  
  1,556 - 1,616
  
  GENE3D
  G3DSA:1.25.40.10 (G3DSA:1.25.40.10)
  
  1,710 - 1,881
  
  GENE3D
  G3DSA:1.25.40.10 (G3DSA:1.25.40.10)
2. SSF48452 (TPR-like)
  
  1,556 - 1,643
  
  SUPERFAMILY
  SSF48452 (TPR-like)
  
  1,644 - 1,888
  
  SUPERFAMILY
  SSF48452 (TPR-like)
IPR003107

HAT (Half-A-TPR) repeat
1. SM00386 (hat_new_1)
  
  1,754 - 1,786
  
  SMART
  SM00386 (hat_new_1)
  
  1,556 - 1,587
  
  SMART
  SM00386 (hat_new_1)
  
  1,589 - 1,626
  
  SMART
  SM00386 (hat_new_1)
  
  1,661 - 1,694
  
  SMART
  SM00386 (hat_new_1)

no IPR

Unintegrated signatures

Coil

1,918 - 1,929

COILS
Coil (Coil)

1,581 - 1,601

COILS
Coil (Coil)

1,703 - 1,730

COILS
Coil (Coil)
G3DSA:2.40.50...

1,050 - 1,146

GENE3D
G3DSA:2.40.50.140 (G3DSA:2.40.50.140)

622 - 705

GENE3D
G3DSA:2.40.50.140 (G3DSA:2.40.50.140)

1,336 - 1,421

GENE3D
G3DSA:2.40.50.140 (G3DSA:2.40.50.140)

532 - 616

GENE3D
G3DSA:2.40.50.140 (G3DSA:2.40.50.140)

243 - 328

GENE3D
G3DSA:2.40.50.140 (G3DSA:2.40.50.140)

1,159 - 1,239

GENE3D
G3DSA:2.40.50.140 (G3DSA:2.40.50.140)

706 - 802

GENE3D
G3DSA:2.40.50.140 (G3DSA:2.40.50.140)

436 - 530

GENE3D
G3DSA:2.40.50.140 (G3DSA:2.40.50.140)

109 - 242

GENE3D
G3DSA:2.40.50.140 (G3DSA:2.40.50.140)

805 - 904

GENE3D
G3DSA:2.40.50.140 (G3DSA:2.40.50.140)

1,240 - 1,326

GENE3D
G3DSA:2.40.50.140 (G3DSA:2.40.50.140)

329 - 428

GENE3D
G3DSA:2.40.50.140 (G3DSA:2.40.50.140)

927 - 1,031

GENE3D
G3DSA:2.40.50.140 (G3DSA:2.40.50.140)
cd05693 (S1_Rrp5_re...)

130 - 242

CDD
cd05693 (S1_Rrp5_repeat_hs1_sc1)
cd05708 (S1_Rrp5_re...)

1,345 - 1,421

CDD
cd05708 (S1_Rrp5_repeat_sc12)
mobidb-lite (disord...)

1,507 - 1,560

MobiDB Lite
mobidb-lite (disorder_prediction)

176 - 199

MobiDB Lite
mobidb-lite (disorder_prediction)

1,420 - 1,495

MobiDB Lite
mobidb-lite (disorder_prediction)

1,886 - 1,929

MobiDB Lite
mobidb-lite (disorder_prediction)

1 - 59

MobiDB Lite
mobidb-lite (disorder_prediction)

71 - 94

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

RNA binding site c...

141A

RNA binding site
141A, 149V, 159Y, 161P
CDD
cd05693 (S1_Rrp5_repeat_hs1_sc1)

149V

RNA binding site
141A, 149V, 159Y, 161P
CDD
cd05693 (S1_Rrp5_repeat_hs1_sc1)

159Y

RNA binding site
141A, 149V, 159Y, 161P
CDD
cd05693 (S1_Rrp5_repeat_hs1_sc1)

161P

RNA binding site
141A, 149V, 159Y, 161P
CDD
cd05693 (S1_Rrp5_repeat_hs1_sc1)
RNA binding site c...

1,354K

RNA binding site
1,354K, 1,362F, 1,374L, 1,376H
CDD
cd05708 (S1_Rrp5_repeat_sc12)

1,362F

RNA binding site
1,354K, 1,362F, 1,374L, 1,376H
CDD
cd05708 (S1_Rrp5_repeat_sc12)

1,374L

RNA binding site
1,354K, 1,362F, 1,374L, 1,376H
CDD
cd05708 (S1_Rrp5_repeat_sc12)

1,376H

RNA binding site
1,354K, 1,362F, 1,374L, 1,376H
CDD
cd05708 (S1_Rrp5_repeat_sc12)

Protein sequence

>MIA_05434_1
MAVPVKRKRSASTNSNVKSEDTKPAKKPETAPREKKQSVLGDDSAFPRGGGSVLTPLEMKQAANEAVKDVLFSNNKSTAP
APNAEGPKKKRKSNLLAAKKAKVFSNGKKSSSATQDEEIAKIDYLNYAGLIQGTHILGQIAKIKPLELVVSLPNSLVGYV
PITNISAQLSKILEQQDQDVDMSSDDEDESKPELNSSEPPALDTLFKIGQFVKTTVVSTTSPYGGTAEKRHIELSIDPAQ
VNADLPKEDYLPGMAIQGAVSSIEDHGLILDIGSKDGVSGFISNKDLKSVFGFSIPQTPVVGQVLLLTIVSVSGNGRTLT
LTSNPLAQKVPLLTSVESIKSVTAGVLVDATITDVRPNGIFVSLYDHATGTIPLSHIPGHSTSNSKDEEAKREKFVIGDR
IKARVINTLPHLDKGYNVSLSLLPHILELKSLFSGADSVSDPLEALPAGQIIENAKVVEVELNRGIFLDVHYQGLQGYAH
ITKLSDTSKPNALGPTLGPYRIGTVHRARILNYSYMDNLYKLSLQESVLKREFLNIAEIPVGVVTQVTVSNILPTGDMVV
SLSDGIKGFVPSLYVSDVKLAFPEKKYKTGSKVKARVISIDLVKNRLKLTLKKTYVSYTEPIITSYTESSVGVKTIATVI
SIKAGGIIVEFFNNTRAFIHRSEISEAFVSNPKDHFRLGQTVNVRILEVDVENERMLATCRTFNSADNAEIVAELEKIQP
GKTICSGSVVEKAGDSVILDIQPQNIRGILNFKHLSDDSSDEKKRALLKKVQVGQTLSELLVLDKDAKKQLVILTSKPSL
VKTAKEILEATNKSRGLPASLDDVQVGQRLYGFISNVTEAAGVFVTFANKLTALAPKSELFNSNTFVKDPTQYFNPFSTV
ACTVLSVDTAAKRFIVSLKDSSVETGNAEDDEEAVNIAKQRGALNPVDPTIKKLLDYKVGRLTKARILGVTNTHVNLEFA
DNQLGRIDISEIYDNFDEIENPKKPLDKFLEGNEIEVRIIGTFNAKSAKSLAVTRPDAISIVLESSCKPSLTSGNPSKFI
KLDASEEDGVSALKKIEVGSVHTAFVHHLEDDLVFVNITPKLTGNIAAVDMSSDVEKIKNLRQEFPEGCALQVSVLKKLE
PKTDESGKNKNAARNTLILSTRTTAPLFDKIDESLSGLVTPAEIIKKSRLKLTVRISGVLVATLHYTDIVDDYSGLEAKV
QSLEVGSFLNVKIVDVDVPNQKIFVSSRPSQFDKKKKSMNKYIGSFDDIKAGETVEGFISNVANSGIFVELGHSVVARVQ
IKNVSDAFLADWKRGFVVKQKVKGVVLSVDPKAGKADLSLKQSHLDGEGLEESATGSKSFDELQVGDVFDGRIKRILEYG
VFVKLTGTKNVDGLCHISEIADVPVTDIEKLFSVGDKVKAKILAIDEKKKRLSLGLKASYFDDDEEDEDDEDDDEEDDED
EEMLDVDNDEDEDEDDDEDDDEDDDEDDDEDDEDDEDEDKPLDPASLEGLAEGSGLSASFDWSASLFDDDEAGENDDSDA
ANSDEEEDEKESRRARRNRKRTNVNVEDKTAELSTRAPQSAKDYERLLVSKPNSSVVWISYMAFQLQLNEVEKAREIAER
ALKTISFRDEQEKLNVWIALLNMEANFGTPGTVKAAFARALQFMDSKTVYLKMANIYQASGSIDEAGQMMKECCKKLAKE
DSSLWSKYGELYYKEAAVPSKTASEREELLEKARGVLEKAQQMLRHMIQEKYVNATRALAEVVSQYAKYEYQYGEVERGR
SLFEGLLALYKKRVDLWVVYIDFEIKYNVGPAVASATAGKKSQSKEVRADLLERRKSVESLFERLVGSGTEVKSEDKSGE
VKLSLKQARFFFKKWLGFESDFGDSKAVEYVKAKAADYVSKYMAAKEASKVHESRLNNIEGSDEEEEDSEEDSEEDSEED
SEEESEDEE

GO term prediction

Biological Process

GO:0006396 RNA processing

Molecular Function

GO:0003676 nucleic acid binding
GO:0005515 protein binding

Cellular Component