Protein

MIA_05412_1

Length
1,014 amino acids

Browser: contig08:379840-382936+

Protein function

EGGNOG:0PIETPGUG_05881Telomerase reverse transcriptase
SGD closest match:S000004310EST2Telomerase reverse transcriptase
CGD closest match:CAL0000184329TERTTertp

Protein alignments

%idAln lengthE-value
MCA_06076_134.26%11216e-169MCA_06076_1
A0A0J9X2K1_GEOCN31.13%10127e-117Similar to Saccharomyces cerevisiae YLR318W EST2 Reverse transcriptase subunit of the telomerase holoenzyme OS=Geotrichum candidum GN=BN980_GECA01s02870g PE=4 SV=1
UniRef50_A0A0J9X2K131.13%10121e-113Similar to Saccharomyces cerevisiae YLR318W EST2 Reverse transcriptase subunit of the telomerase holoenzyme n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9X2K1_GEOCN
Q6C9D0_YARLI26.56%7538e-51YALI0D12188p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D12188g PE=4 SV=1
A0A060T762_BLAAD28.75%5539e-48ARAD1D00880p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D00880g PE=4 SV=1
A0A167CQ75_9ASCO26.00%5272e-43Est2p OS=Sugiyamaella lignohabitans GN=EST2 PE=4 SV=1
TERT_YEAST20.61%4905e-16Telomerase reverse transcriptase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=EST2 PE=1 SV=2
A0A1D8PEA0_CANAL20.78%5392e-13Tertp OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=TERT PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.6461
Predicted cleavage: 20

Protein family membership

Domains and repeats

  1. Domain
1 100 200 300 400 500 600 700 800 900 1014

Detailed signature matches

  1. Family IPR003545
    Telomerase reverse transcriptase
    1. PR01365 (TELOMERASERT)
  2. Domain IPR021891
    Telomerase ribonucleoprotein complex - RNA-binding domain
    1. PF12009 (Telomerase...)
    2. SM00975 (Telomerase...)
  3. Domain IPR000477
    Reverse transcriptase domain
    1. PF00078 (RVT_1)
    2. PS50878 (RT_POL)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.30.70...
  2. SSF56672 (DNA/RNA p...)
  3. cd01648 (TERT)

Residue annotation

  1. putative NTP bindi...
  2. putative active si...
  3. putative nucleic a...

Protein sequence

>MIA_05412_1
MAPPQPALVRLLVEALVARHAYLPAALCASHVLAAGFKPDTDGGVGATYTAAHINTTAAHVAAHPSWLALRAAAAPSTVF
FLLAHCSVFCAPPGSASSHTLLQVAGPSFHAVVEGSPLLLPKPPPDKERNLADANSARILFKKTKILYKNPYVVNKKIIF
GFNPHFILKKYSRDSPASLHLVLRSIFPVQFRIPCPLSTPLNFPLAPRAPDPPPSKARLPKRLHGQILPLIGQLALNVNK
CPYYQLLNHYCPNAYEEASSKIINQFGCKNAWTLTPAGKRAYWGLMKSQNLSTPDYQVFLFCKSVFRKTFPVDLIGKSNW
GPLLNALDQFIKLRRLEQIQLQSIVQGMSTNNLSWTWPGSTDTPPPGRQDHNKRRELLLELVFWIFDTFLPTLLRGHFYA
TQVLQSAPGNRVLYFRHDVWAQVSTLAFTEFSKLSFLSPLSSPQQITSPLGAAPIRIIPKEQILSPSTVAIAGYRPIVCM
SRVRRTYTPTGPLETPSINTLLKDVFSALSFEHSQKIKARGFHNVATTSSVPELFQRILHFKQQIGTPSPKLFVVKVDIK
SCFDTIPQSLALDMASRLLRNDSFKEYFFHAFKVFKVPLPAPSKRKNKPQPAVMVKYLRNAEYTTSTSTSMDVVEQLAKD
EATALQQSAVHGPGTLANKTANIVVDLVYGARQSGQQLASLLRAHLTENLVYLEGGRNKQLYKQQVGIPQGSVLSTLLCN
LVYEELETEILAEVFDTPSQSSPHMLARFTDDFLFISTNQAHAEAFLNKMIAGVPKYGATVRPEKTIINFVPSVMTTDTA
RCKVLAPGEILPYIGIGLNLQNLNIFRDSDHVPSFTDASHGVESTPGALPRARSSVYLGVPDRVTLPHRGIRSSPVLLKR
MLLRFISMRLLRAFVDLRVNSRGTVSQNVSTVVTEVARRLVFALDMQWGFPRSAQQTRNAATMMNILAEVLDKVCSIITH
VNGPQVFDNRDKPLDLLKSAADDIAVVLRKANKGKRCGASKEVLRLGVEYLNSL

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0003677 DNA binding
GO:0003721 telomerase RNA reverse transcriptase activity
GO:0003964 RNA-directed DNA polymerase activity

Cellular Component

None predicted.