Protein

MCA_06076_1

Length
1,266 amino acids

Gene name: EST2

Description: reverse transcriptase, catalytic subunit of the telomerase holoenzyme TERT

Browser: contigD:3178337-3182138-

RNA-seq: read pairs 352, FPKM 3.4, percentile rank 14.6% (100% = highest expression)

Protein function

Annotation:EST2reverse transcriptase, catalytic subunit of the telomerase holoenzyme TERT
KEGG:K11126TERT telomerase reverse transcriptase [EC:2.7.7.49]
EGGNOG:0PIETPGUG_05881Telomerase reverse transcriptase

Protein alignments

%idAln lengthE-value
MIA_05412_133.99%11219e-164MIA_05412_1
A0A0J9X2K1_GEOCN29.37%11512e-93Similar to Saccharomyces cerevisiae YLR318W EST2 Reverse transcriptase subunit of the telomerase holoenzyme OS=Geotrichum candidum GN=BN980_GECA01s02870g PE=4 SV=1
UniRef50_A0A0J9X2K129.37%11515e-90Similar to Saccharomyces cerevisiae YLR318W EST2 Reverse transcriptase subunit of the telomerase holoenzyme n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9X2K1_GEOCN
Q6C9D0_YARLI35.26%1731e-19YALI0D12188p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D12188g PE=4 SV=1
A0A060T762_BLAAD28.28%2442e-18ARAD1D00880p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D00880g PE=4 SV=1
A0A167CQ75_9ASCO33.71%1783e-17Est2p OS=Sugiyamaella lignohabitans GN=EST2 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.9850
Predicted cleavage: 54

Protein family membership

None predicted.

Domains and repeats

  1. Domain
1 200 400 600 800 1000 1266

Detailed signature matches

  1. Domain IPR021891
    Telomerase ribonucleoprotein complex - RNA-binding domain
    1. PF12009 (Telomerase...)
    2. SM00975 (Telomerase...)
  2. Domain IPR000477
    Reverse transcriptase domain
    1. PF00078 (RVT_1)
    2. PS50878 (RT_POL)
Unintegrated signatures no IPR
Unintegrated signatures
  1. CYTOPLASMIC_D... (C...)
  2. G3DSA:3.30.70...
  3. NON_CYTOPLASM... (N...)
  4. SSF56672 (DNA/RNA p...)
  5. TRANSMEMBRANE (Tran...)
  6. cd01648 (TERT)
  7. mobidb-lite (disord...)

Residue annotation

  1. putative NTP bindi...
  2. putative active si...
  3. putative nucleic a...

Protein sequence

>MCA_06076_1
MGSCSKSKRKKNRTKQRLNKKIGKNSANQTVIHEKQQYVQALNIVQTALKRVYSKSLTLFDFLESIYDRDETIFSKAWTT
KQKSFESFLKTTIIAFPYSFKKISPEDLTVSFSISGYGKSIDATDIPLDMFYKRLVRDLLLGHSAKLLSERINVVLSTPT
LSSQLVSSQSSSLSPIQRAIILDTIKKVQKGHILTYGFGVDSESAFEHRIVTKHINTTLNSLITDENWITLYNCLEKKSV
LYFLMLYFVIFQVSSDNLTTMLQVSGPVLEINSGEKKKQQDSQKQQTKESFQVSTAVKNASRIAIKKKDVLYARPYLHSN
RVRFGLAPNYILNLYNNYDDLTHIKSILRFIFPMQHGIETPLAYNTPITTEKKTVKENSTPIFAKKLKPSPGDEVDSPSQ
TKPVRLDESRVVRIPRFSQKSDRIPKRLHGKILGYVKMLIKNHTKCKYHLLLDHQCPNTLIVQANKLVNTLLDSNNLENK
PYAVLLKKLKTDEQKRNFVDALKNTNLTTPCYQVYLFCKQVFRQVLPAGLIGPAANWKRLFECLDVYLRLGRNEDLRLSY
IAEEMQTNSLDWAVSPSCQRREEASKTKPSSSSPTSCQEFNKRRELLLELLYWIFSSFLPSLISSNFYVTEILADTPTSK
LVYYRHDVWTQISQWTFADFKELSSLQPVSRSDVEPFAQELSGCPLAATPIRFIPKMKNEENVEVMSGYRPIVCMARSRK
PVLLTENVSPEDRVPSISTLLKDVFSALSFEHRQKVQKLVTKDSQRLENHFVEGTGSIALIPDLYHRIARFKQRILASHK
CTPETMPQLYFVKVDITRCFDTIPQAAALKVAKKLLQTSQHGPFKNYLFHAYKQVNIPALRSSTKHETAQKSSSSQQTAK
GVITRYIRDVEYVASSKTVTSQDMLHSVSKFRENMLKESAVHTADSLAFRTASVLIDLVYGTTALGKDLYNLLKAHISCN
LVYLDGSNQASEGGRIYRQTVGIPQGSILSTLLCNLVYDELELEVIKKLTSFSVANTKTSTTEQDSAKNHNSMLVRVCDD
FLFISTSKPLATTFLQTLVSGLPEFGASVNPDKTTTNLVDGDNVNLIPFIGCAIDTRTLDLLRDREPQDLVEPITQVAKK
LTVPGRGSGLRMSTAAMEHAVLRYPASRLTRPFVDATHNSWSTVLSNVARVARDTASRLLVILQTRWGLKRLETTVVVVK
IINKVLANVVEKIVDICIHVNKRGVPTKEVVKTVAQAMKQVFEKSASQGNKVKQKYGKVVEFLDSL

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0003964 RNA-directed DNA polymerase activity

Cellular Component

None predicted.