Protein

MIA_05390_1

Length
821 amino acids


Browser: contig08:322346-324812+

Protein function

EGGNOG:0PGPGOCT1Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane
SGD closest match:S000001617OCT1Mitochondrial intermediate peptidase
CGD closest match:CAL0000183469OCT1Mitochondrial intermediate peptidase

Protein alignments

%idAln lengthE-value
MCA_05261_157.881%7930.0MCA_05261_1
A0A0J9X551_GEOCN50.000%7580.0Similar to Saccharomyces cerevisiae YKL134C OCT1 Mitochondrial intermediate peptidase OS=Geotrichum candidum GN=BN980_GECA02s07963g PE=3 SV=1
A0A060T261_BLAAD47.321%7840.0ARAD1C26422p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C26422g PE=3 SV=1
A0A167CTG1_9ASCO46.772%7590.0Oct1p OS=Sugiyamaella lignohabitans GN=OCT1 PE=3 SV=1
UniRef50_A0A167CTG146.772%7590.0Oct1p n=2 Tax=Saccharomycetales TaxID=4892 RepID=A0A167CTG1_9ASCO
A0A1E3PQI0_9ASCO44.837%7650.0Zincin OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_21876 PE=3 SV=1
PMIP_YARLI43.210%8100.0Mitochondrial intermediate peptidase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=OCT1 PE=3 SV=1
PMIP_YEAST40.845%7810.0Mitochondrial intermediate peptidase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=OCT1 PE=1 SV=2
A0A1E4TBQ2_9ASCO40.241%7481.67e-166Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_32504 PE=3 SV=1
PMIP_CANAL37.483%7394.28e-140Mitochondrial intermediate peptidase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=OCT1 PE=3 SV=2

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.9921
Predicted cleavage: 63

Protein family membership

Domains and repeats

  1. Domain
1 100 200 300 400 500 600 700 821

Detailed signature matches

Unintegrated signatures no IPR
Unintegrated signatures
  1. SSF55486 (Metallopr...)

Residue annotation

  1. Zn binding site cd...
  2. active site cd06457

Protein sequence

>MIA_05390_1
MLRLTATARRAPAMAVPRILCRHISLFTPINDKPGMSAAAAAVNTQNSSAKAPTIKLQTPRDEADARHGDASLRLMFDDA
GFWKSMSPAHNPGKKTGLFDNPYLTTPRGMLQFTQVSLAQAQALAQRILSGTVRDGGDLVRTLDRLSDTLCQVIDLMGCV
RAAHPAPGFQAAAQQAHETMFEYMNVLNTSVELYDRLAAVFESPEQVAKLSAEEDATGRLLLADFEKSGIRLDPNSRNKF
VQLMNVISVVGQEFMEAAAEPPKDPSVAFVKATTSELQGLDRGLARYLAQNQQSRLSKIFGDKDPGSLLVPTTGWEAAVA
LRTVRDEKVRREIWTRGHLASADLEQDGRLQTILRARGELANLMGSPSYAAYELHGKMLKTPALANSFLKAIEAAVAPKA
HGEIAALARIKAQATDVPHKTDTMEAWDRDFFGARFLHQQHLLRDHRDDTPSQEAVARIPEYFSVGTVIQGLSRLFTSIY
GIRFEPVAPKEGETWRDDVRRVNIVSDTDGLVGVMYCDLFQAPGKSPNPAHFTVRCSRRIYADENDSVRALDPLANERFA
HVVAGRDAHQLPVIVLMCDFAPGPAGGPALLTFNNVQTLFHEMGHAMHSMLGRTDLHNVSGTRCATDFVELPSVLMEKFA
ASPQVLGLFAYHYATGAPLPLNLLQEHERTAQQLLHHSETHAQIVLALLDQLFHSGDPALLASPEGLHHAYYALESHYGL
FPAQRESRWYTQFGHLVGYGASYYCYLLGRAIADRVWAHVFQQDPTARAAGEKWRGEVLQWGGSKDPWEMVASVLDDPTL
APGDTAAITSLTRGFDSIEEQ

GO term prediction

Biological Process

GO:0006508 proteolysis
GO:0006627 protein processing involved in protein targeting to mitochondrion

Molecular Function

GO:0004222 metalloendopeptidase activity

Cellular Component

GO:0005759 mitochondrial matrix