Protein
MCA_05261_1
Length
894 amino acids
Gene name: OCT1
Description: Mitochondrial intermediate peptidase
Browser: contigD:789949-792634-
RNA-seq: read pairs 2080, FPKM 28.7, percentile rank 51.5% (100% = highest expression)
Protein function
| Annotation: | OCT1 | Mitochondrial intermediate peptidase | |
|---|---|---|---|
| KEGG: | K01410 | MIPEP | mitochondrial intermediate peptidase [EC:3.4.24.59] |
| EGGNOG: | 0PGPG | OCT1 | Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane |
| SGD closest match: | S000001617 | OCT1 | Mitochondrial intermediate peptidase |
| CGD closest match: | CAL0000183469 | OCT1 | Mitochondrial intermediate peptidase |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| MIA_05390_1 | 57.88% | 793 | 0.0 | MIA_05390_1 |
| A0A0J9X551_GEOCN | 52.20% | 772 | 0.0 | Similar to Saccharomyces cerevisiae YKL134C OCT1 Mitochondrial intermediate peptidase OS=Geotrichum candidum GN=BN980_GECA02s07963g PE=3 SV=1 |
| A0A060T261_BLAAD | 47.63% | 781 | 0.0 | ARAD1C26422p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C26422g PE=3 SV=1 |
| A0A167CTG1_9ASCO | 45.92% | 773 | 0.0 | Oct1p OS=Sugiyamaella lignohabitans GN=OCT1 PE=3 SV=1 |
| UniRef50_A0A167CTG1 | 45.92% | 773 | 0.0 | Oct1p n=2 Tax=Saccharomycetales TaxID=4892 RepID=A0A167CTG1_9ASCO |
| A0A1E3PQI0_9ASCO | 43.46% | 810 | 0.0 | Zincin OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_21876 PE=3 SV=1 |
| PMIP_YARLI | 42.10% | 810 | 0.0 | Mitochondrial intermediate peptidase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=OCT1 PE=3 SV=1 |
| PMIP_YEAST | 41.32% | 789 | 0.0 | Mitochondrial intermediate peptidase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=OCT1 PE=1 SV=2 |
| A0A1E4TBQ2_9ASCO | 40.71% | 737 | 2e-173 | Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_32504 PE=3 SV=1 |
| PMIP_CANAL | 36.60% | 806 | 5e-152 | Mitochondrial intermediate peptidase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=OCT1 PE=3 SV=2 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.9253
Predicted cleavage: 45
Protein family membership
- Mitochondrial intermediate peptidase (IPR033851)
Domains and repeats
-
Domain
1
100
200
300
400
500
600
700
800
894
Detailed signature matches
no IPR
Unintegrated signatures
-
-
SSF55486 (Metallopr...)
Residue annotation
-
Zn binding site cd...
-
active site cd06457
Protein sequence
>MCA_05261_1 MISVLNGSKCYTRLSPSGLKSLTSSTIVRHPGLVRSLTHTNQNSSSFVLHKIGAKLHQKLQQFDVTNGKIPSSINLKVNS QTSRDALEEKNHDKTLRLIFDSDAFWQDFNRNSPNSKKVTGLFDNPYLTSPQGLLNFTQVSLAQAQALAQKILQENESDV SDPGRLIRLLDRLSDTLCQVIDLMGCLQASHANSKYQAAARQSHETMFEFMNILNTSVELYQRLESVFSSPERVAKLTRE EKSVGRLLLSDFVKSGIQLNPEAREKFVKLSSLISTNGHEFMTSATAPPTDPKDSFLSVPKSRLEGIDPYLESVLPNASS FNLFKTSSNKNLLLPTTGGEAATALRTVKDEEIRHDIWLQGRKSPDPKQIPRLESILKARQQLAELMGQNSFSGYELQDK MVKTPQNVMKFLNKLASDIYPKAQLEISALAKLKNQAQDIPYKTDSIQPWDRDYFGSLFLHQQHLKTDHRDDTPTKAQVS LLPQYFSLGTVMQGLSRLFSSIYGIKFVPVESKPGETWRNDIRRLNVVADDGSLIGVMYCDLFQAPGKSPNPAHFTVRCS RKIFAEEDDEVRKMDPLAAVRYTNNGINKDEQQLPIIVLTCNFSPGYSSESNSSQLNDDRSSRNIPSLLSFTEVETLFHE MGHAMHSMLGQTDLHNVSGTRCATDFVELPSVLMERFASAPQVLSLYSHHYLTGEPLPFRLLQEYQRTTQQLLQYSETYS QIKLAMLDQLFHSGKEQVLSDLAGSYQELEAQNSLFPLTKEYEESLKSDLWFTQFGHLVGYGASYYCYLFDRAIADRVWD HVFKQDPTNRASGEKWKNQVLKWGGSRNPWELVADVLDIPELVNGDEKAIAQLAYSSTEDEVHLPFNEKSNEKDENRIFL GSSKIDDTVSHTAK
GO term prediction
Biological Process
GO:0006508 proteolysis
GO:0006627 protein processing involved in protein targeting to mitochondrion
Molecular Function
GO:0004222 metalloendopeptidase activity
Cellular Component
GO:0005759 mitochondrial matrix