Protein

MIA_05356_1

Length
597 amino acids

Browser: contig08:245198-246992-

Protein function

EGGNOG:0PG9BATG15Lipase which is essential for lysis of subvacuolar cytoplasm to vacuole targeted bodies and intravacuolar autophagic bodies. Involved in the lysis of intravacuolar multivesicular body (MVB) vesicles. The intravacuolar membrane disintegration by ATG15 is critical to life span extension (By similarity)
SGD closest match:S000000664ATG15Putative lipase ATG15
CGD closest match:CAL0000191921ATG15Putative lipase ATG15

Protein alignments

%idAln lengthE-value
MCA_02568_167.347%4900.0MCA_02568_1
A0A0J9YHF8_GEOCN55.600%5000.0Similar to Saccharomyces cerevisiae YCR068W ATG15 Lipase required for intravacuolar lysis of autophagic bodies and Cvt bodies OS=Geotrichum candidum GN=BN980_GECA01s03882g PE=4 SV=1
A0A167FES2_9ASCO51.737%5180.0Triglyceride lipase ATG15 OS=Sugiyamaella lignohabitans GN=ATG15 PE=4 SV=1
UniRef50_A0A167FES251.737%5181.71e-179Triglyceride lipase ATG15 n=4 Tax=Saccharomycetales TaxID=4892 RepID=A0A167FES2_9ASCO
ATG15_YARLI53.908%4995.89e-178Putative lipase ATG15 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=ATG15 PE=3 SV=2
A0A060T3S6_BLAAD58.034%4171.34e-171ARAD1C42372p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C42372g PE=4 SV=1
ATG15_CANAL46.084%5499.86e-150Putative lipase ATG15 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=ATG15 PE=3 SV=1
ATG15_YEAST50.790%4439.70e-149Putative lipase ATG15 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ATG15 PE=1 SV=2
A0A1E4TG06_9ASCO42.147%5032.39e-130Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_31554 PE=4 SV=1
A0A1E3PCM9_9ASCO58.255%3211.22e-128Alpha/beta-hydrolase (Fragment) OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_6034 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0010

Protein family membership

None predicted.

Domains and repeats

  1. Domain
1 100 200 300 400 500 597

Detailed signature matches

  1. Domain IPR029058
    Alpha/Beta hydrolase fold
    1. SSF53474 (alpha/bet...)
    2. G3DSA:3.40.50...
  2. Domain IPR002921
    Fungal lipase-like domain
    1. PF01764 (Lipase_3)
Unintegrated signatures no IPR
Unintegrated signatures
  1. NON_CYTOPLASM... (N...)
  2. SIGNAL_PEPTIDE (Sig...)
  3. SIGNAL_PEPTID... (S...)
  4. SIGNAL_PEPTID... (S...)
  5. SIGNAL_PEPTID... (S...)
  6. cd00519 (Lipase_3)
  7. mobidb-lite (disord...)

Residue annotation

  1. active site flap/l...
  2. nucleophilic elbow...
  3. catalytic triad cd...

Protein sequence

>MIA_05356_1
MPQEKTPLLNQNQPSDRKKRRKSYSTLPSAQSRAPATSSSPRTTTIRLLALLLVLSTSLVLFSPKQCHALKALFFLPPEQ
ADFPQPPPPNAVDLSDIYTPGDLRFSIKHIFHHNTDKPNDSAAHGRLDITPGNLAQLRQTTPLLTFGRNTASPRKVSPWE
ARLALRPRPNFRVRRLADRHPDSVEALVHYANTHAERGLPQIAAEALDWRDEHISVPDVQDRNTVVALAVMSSDAYVDIP
NTGDWQNVTGPWHNETSDFGWAGEGVRGHVFVSEADEAMGVPAAGTVVIAIKGTSAAVFDDGGDTAPNDKINDNLLFSCC
CARVSYLWNTVCDCYTGKSYTCNQDCLERELYKKDRYYKAAMDIYRNVSAIYPSSNIWITGHSLGGSLASLVGRTYGLPT
VAYEAPGELLPSRRLHLPMPPGVPRWGEHIWHFGHTADPIFVGSCNGAGSSCWVAGYAMETVCHSGLECTYDVVSDKGWH
VSLMNHRIHVVIDDVLLAYNDTATCAVPPICSDCFDWTFVSDHDDDSREPIKSSSTTGHSTKSLSTRLSTPAASTTPTSP
VSAPGDDDDTSPKPTEPPQVCKRRTWYGWCMEWGPEK

GO term prediction

Biological Process

GO:0006629 lipid metabolic process

Molecular Function

None predicted.

Cellular Component

None predicted.