Protein
MCA_02568_1
Length
581 amino acids
Gene name: ATG15
Description: Putative lipase ATG15
Browser: contigB:1675213-1676959+
RNA-seq: read pairs 1247, FPKM 26.5, percentile rank 49.2% (100% = highest expression)
Protein function
Annotation: | ATG15 | Putative lipase ATG15 | |
---|---|---|---|
KEGG: | K17900 | ATG15 | lipase ATG15 [EC:3.1.1.3] |
EGGNOG: | 0PG9B | ATG15 | Lipase which is essential for lysis of subvacuolar cytoplasm to vacuole targeted bodies and intravacuolar autophagic bodies. Involved in the lysis of intravacuolar multivesicular body (MVB) vesicles. The intravacuolar membrane disintegration by ATG15 is critical to life span extension (By similarity) |
SGD closest match: | S000000664 | ATG15 | Putative lipase ATG15 |
CGD closest match: | CAL0000191921 | ATG15 | Putative lipase ATG15 |
Protein alignments
%id | Aln length | E-value | ||
---|---|---|---|---|
MIA_05356_1 | 67.76% | 490 | 0.0 | MIA_05356_1 |
A0A0J9YHF8_GEOCN | 58.75% | 480 | 0.0 | Similar to Saccharomyces cerevisiae YCR068W ATG15 Lipase required for intravacuolar lysis of autophagic bodies and Cvt bodies OS=Geotrichum candidum GN=BN980_GECA01s03882g PE=4 SV=1 |
ATG15_YARLI | 53.89% | 488 | 6e-169 | Putative lipase ATG15 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=ATG15 PE=3 SV=2 |
UniRef50_Q6C2N7 | 53.89% | 488 | 1e-165 | Putative lipase ATG15 n=16 Tax=Saccharomycetales TaxID=4892 RepID=ATG15_YARLI |
A0A167FES2_9ASCO | 52.76% | 508 | 7e-168 | Triglyceride lipase ATG15 OS=Sugiyamaella lignohabitans GN=ATG15 PE=4 SV=1 |
A0A060T3S6_BLAAD | 60.10% | 416 | 2e-159 | ARAD1C42372p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C42372g PE=4 SV=1 |
ATG15_CANAL | 52.83% | 460 | 4e-142 | Putative lipase ATG15 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=ATG15 PE=3 SV=1 |
ATG15_YEAST | 49.34% | 458 | 5e-141 | Putative lipase ATG15 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ATG15 PE=1 SV=2 |
A0A1E4TG06_9ASCO | 51.87% | 401 | 1e-128 | Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_31554 PE=4 SV=1 |
A0A1E3PCM9_9ASCO | 60.50% | 319 | 6e-130 | Alpha/beta-hydrolase (Fragment) OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_6034 PE=4 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.0190
Protein family membership
None predicted.
Domains and repeats
-
Domain
1
100
200
300
400
500
581
Detailed signature matches
no IPR
Unintegrated signatures
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CYTOPLASMIC_D... (C...)
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NON_CYTOPLASM... (N...)
-
-
TRANSMEMBRANE (Tran...)
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cd00519 (Lipase_3)
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mobidb-lite (disord...)
Residue annotation
-
active site flap/l...
-
nucleophilic elbow...
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catalytic triad cd...
Protein sequence
>MCA_02568_1 MAEKKSKSIHDITSIASNQPKQERFINNNNNKKNYKTRRKAVHLLLFLIVSSLFIFRLYTSSCFYINSPNYDTLQNNLGL SPNILHPLDPTPPQEPNPPSTQKFLIKHIFHHNTDKPHGLSTHARLDIKGETLKTLEALTPSISFAGGSRKLSPWTSPLH LRNKPNYPIRRLKENSPDFVESYIHYANTRQERGLPEIKSEDLIWIDQEIPVPNVTDKDTIVSLAIMSSNAYVDVPFTGD WQNVTSSWNNSLDFGWDSDGVRGHIFVSQDDEFGGKENDTVVIAIKGTSAAVFDDGGDTAPNDKINDNLLFSCCCARVSY LWTPVCDCYTGKTYTCNQDCLERELYKKDRYYKAVLDIYRNVTNIYPNSKIWLTGHSLGGSLASLLGRTYGVPTVTFEAP GELLPSHRLHLPMPPGVPRWREHIWHIGHTADPIYMGICNGAGSSCWVAGYAMETVCHSGLECVYDVVTDKGWHVSLMNH RIHTVIDDILLVYNETAECKVPKICKDCFDWSFVTDHDDDSREPVASSSTFVPTAPATTATSVLPPGSTGDKDNDGDEDI PKTPPIQCKRRTWYGRCIDWY
GO term prediction
Biological Process
GO:0006629 lipid metabolic process
Molecular Function
None predicted.
Cellular Component
None predicted.