MIA_05345_1

Protein

Length

562 amino acids

Protein function

EGGNOG:	0PFTW	FG04370.1	transporter
SGD closest match:	S000003951	TPO1	Polyamine transporter 1
CGD closest match:	CAL0000199735	FLU1	Flu1p

Protein alignments

	%id	Aln length	E-value
A0A0J9X353_GEOCN	58.513%	511	0.0	Similar to Saccharomyces cerevisiae YLL028W TPO1 Polyamine transporter that recognizes spermine, putrescine,and spermidine OS=Geotrichum candidum GN=BN980_GECA01s01011g PE=4 SV=1
MCA_02420_1	55.962%	520	0.0	MCA_02420_1
A0A1E3PPH0_9ASCO	52.381%	546	4.18e-178	MFS general substrate transporter OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_81829 PE=4 SV=1
Q6C2K7_YARLI	51.099%	546	8.07e-172	YALI0F07062p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F07062g PE=4 SV=1
A0A167CKS0_9ASCO	52.222%	540	3.81e-163	Tpo1p OS=Sugiyamaella lignohabitans GN=TPO1 PE=4 SV=1
UniRef50_A0A167CKS0	52.222%	540	1.05e-159	Tpo1p n=22 Tax=Saccharomycetales TaxID=4892 RepID=A0A167CKS0_9ASCO
A0A060T8V0_BLAAD	51.481%	540	3.20e-158	ARAD1C32472p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C32472g PE=4 SV=1
A0A1E4TAB0_9ASCO	47.852%	512	3.15e-141	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_127309 PE=4 SV=1
TPO1_YEAST	49.427%	524	7.43e-134	Polyamine transporter 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TPO1 PE=1 SV=1
G1UB37_CANAL	45.387%	542	4.33e-133	Flu1p OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=FLU1 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.1628

Protein family membership

Major facilitator superfamily (IPR011701)

Domains and repeats

Domain
94 - 553
Major facilitator superfamily domain (IPR020846)

1 100 200 300 400 500 562

Detailed signature matches

IPR011701

Major facilitator superfamily
1. PF07690 (MFS_1)
  
  123 - 511
  
  Pfam
  PF07690 (MFS_1)
IPR020846

Major facilitator superfamily domain
1. PS50850 (MFS)
  
  117 - 552
  
  PROSITE profiles
  PS50850 (MFS)
2. SSF103473 (MFS gene...)
  
  94 - 553
  
  SUPERFAMILY
  SSF103473 (MFS general substrate transporter)
3. cd06174 (MFS)
  
  119 - 546
  
  CDD
  cd06174 (MFS)

no IPR

Unintegrated signatures

CYTOPLASMIC_D... (C...)

234 - 244

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

171 - 181

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

549 - 562

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

1 - 114

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

478 - 488

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

411 - 430

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

296 - 350

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)
G3DSA:1.20.12...

101 - 314

GENE3D
G3DSA:1.20.1250.20 (G3DSA:1.20.1250.20)

340 - 555

GENE3D
G3DSA:1.20.1250.20 (G3DSA:1.20.1250.20)
NON_CYTOPLASM... (N...)

378 - 388

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

453 - 457

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

136 - 146

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

267 - 277

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

515 - 525

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

201 - 211

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)
TMhelix

216 - 238

TMHMM
TMhelix (TMhelix)

431 - 450

TMHMM
TMhelix (TMhelix)

245 - 267

TMHMM
TMhelix (TMhelix)

184 - 201

TMHMM
TMhelix (TMhelix)

149 - 171

TMHMM
TMhelix (TMhelix)

282 - 304

TMHMM
TMhelix (TMhelix)

346 - 368

TMHMM
TMhelix (TMhelix)

526 - 548

TMHMM
TMhelix (TMhelix)

115 - 134

TMHMM
TMhelix (TMhelix)

460 - 482

TMHMM
TMhelix (TMhelix)

388 - 410

TMHMM
TMhelix (TMhelix)

489 - 511

TMHMM
TMhelix (TMhelix)
TRANSMEMBRANE (Tran...)

389 - 410

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

489 - 514

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

245 - 266

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

351 - 377

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

431 - 452

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

526 - 548

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

115 - 135

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

182 - 200

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

147 - 170

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

278 - 295

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

212 - 233

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

458 - 477

PHOBIUS
TRANSMEMBRANE (Transmembrane region)
mobidb-lite (disord...)

1 - 55

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

putative substrate...

132S

putative substrate translocation pore
132S, 135F, 136S, 137P, 139L, 140G, 157I, 160F, 161V, 164F, 168P, 169V, 171W, 172S, 218A, 219S, 222L, 223T, 226A, 227A, 230A, 245I, 246N, 249A, 250A, 256P, 363Y, 366L, 367Y, 370L, 371S, 374P, 388S, 392Y, 396L, 399M, 403A, 471G, 474L, 475M, 478M, 482M, 483N, 486V, 496A, 497L, 500L, 501T, 504R, 505S, 508G
CDD
cd06174 (MFS)

135F

putative substrate translocation pore
132S, 135F, 136S, 137P, 139L, 140G, 157I, 160F, 161V, 164F, 168P, 169V, 171W, 172S, 218A, 219S, 222L, 223T, 226A, 227A, 230A, 245I, 246N, 249A, 250A, 256P, 363Y, 366L, 367Y, 370L, 371S, 374P, 388S, 392Y, 396L, 399M, 403A, 471G, 474L, 475M, 478M, 482M, 483N, 486V, 496A, 497L, 500L, 501T, 504R, 505S, 508G
CDD
cd06174 (MFS)

136S

putative substrate translocation pore
132S, 135F, 136S, 137P, 139L, 140G, 157I, 160F, 161V, 164F, 168P, 169V, 171W, 172S, 218A, 219S, 222L, 223T, 226A, 227A, 230A, 245I, 246N, 249A, 250A, 256P, 363Y, 366L, 367Y, 370L, 371S, 374P, 388S, 392Y, 396L, 399M, 403A, 471G, 474L, 475M, 478M, 482M, 483N, 486V, 496A, 497L, 500L, 501T, 504R, 505S, 508G
CDD
cd06174 (MFS)

137P

putative substrate translocation pore
132S, 135F, 136S, 137P, 139L, 140G, 157I, 160F, 161V, 164F, 168P, 169V, 171W, 172S, 218A, 219S, 222L, 223T, 226A, 227A, 230A, 245I, 246N, 249A, 250A, 256P, 363Y, 366L, 367Y, 370L, 371S, 374P, 388S, 392Y, 396L, 399M, 403A, 471G, 474L, 475M, 478M, 482M, 483N, 486V, 496A, 497L, 500L, 501T, 504R, 505S, 508G
CDD
cd06174 (MFS)

139L

putative substrate translocation pore
132S, 135F, 136S, 137P, 139L, 140G, 157I, 160F, 161V, 164F, 168P, 169V, 171W, 172S, 218A, 219S, 222L, 223T, 226A, 227A, 230A, 245I, 246N, 249A, 250A, 256P, 363Y, 366L, 367Y, 370L, 371S, 374P, 388S, 392Y, 396L, 399M, 403A, 471G, 474L, 475M, 478M, 482M, 483N, 486V, 496A, 497L, 500L, 501T, 504R, 505S, 508G
CDD
cd06174 (MFS)

140G

putative substrate translocation pore
132S, 135F, 136S, 137P, 139L, 140G, 157I, 160F, 161V, 164F, 168P, 169V, 171W, 172S, 218A, 219S, 222L, 223T, 226A, 227A, 230A, 245I, 246N, 249A, 250A, 256P, 363Y, 366L, 367Y, 370L, 371S, 374P, 388S, 392Y, 396L, 399M, 403A, 471G, 474L, 475M, 478M, 482M, 483N, 486V, 496A, 497L, 500L, 501T, 504R, 505S, 508G
CDD
cd06174 (MFS)

157I

putative substrate translocation pore
132S, 135F, 136S, 137P, 139L, 140G, 157I, 160F, 161V, 164F, 168P, 169V, 171W, 172S, 218A, 219S, 222L, 223T, 226A, 227A, 230A, 245I, 246N, 249A, 250A, 256P, 363Y, 366L, 367Y, 370L, 371S, 374P, 388S, 392Y, 396L, 399M, 403A, 471G, 474L, 475M, 478M, 482M, 483N, 486V, 496A, 497L, 500L, 501T, 504R, 505S, 508G
CDD
cd06174 (MFS)

160F

putative substrate translocation pore
132S, 135F, 136S, 137P, 139L, 140G, 157I, 160F, 161V, 164F, 168P, 169V, 171W, 172S, 218A, 219S, 222L, 223T, 226A, 227A, 230A, 245I, 246N, 249A, 250A, 256P, 363Y, 366L, 367Y, 370L, 371S, 374P, 388S, 392Y, 396L, 399M, 403A, 471G, 474L, 475M, 478M, 482M, 483N, 486V, 496A, 497L, 500L, 501T, 504R, 505S, 508G
CDD
cd06174 (MFS)

161V

putative substrate translocation pore
132S, 135F, 136S, 137P, 139L, 140G, 157I, 160F, 161V, 164F, 168P, 169V, 171W, 172S, 218A, 219S, 222L, 223T, 226A, 227A, 230A, 245I, 246N, 249A, 250A, 256P, 363Y, 366L, 367Y, 370L, 371S, 374P, 388S, 392Y, 396L, 399M, 403A, 471G, 474L, 475M, 478M, 482M, 483N, 486V, 496A, 497L, 500L, 501T, 504R, 505S, 508G
CDD
cd06174 (MFS)

164F

putative substrate translocation pore
132S, 135F, 136S, 137P, 139L, 140G, 157I, 160F, 161V, 164F, 168P, 169V, 171W, 172S, 218A, 219S, 222L, 223T, 226A, 227A, 230A, 245I, 246N, 249A, 250A, 256P, 363Y, 366L, 367Y, 370L, 371S, 374P, 388S, 392Y, 396L, 399M, 403A, 471G, 474L, 475M, 478M, 482M, 483N, 486V, 496A, 497L, 500L, 501T, 504R, 505S, 508G
CDD
cd06174 (MFS)

168P

putative substrate translocation pore
132S, 135F, 136S, 137P, 139L, 140G, 157I, 160F, 161V, 164F, 168P, 169V, 171W, 172S, 218A, 219S, 222L, 223T, 226A, 227A, 230A, 245I, 246N, 249A, 250A, 256P, 363Y, 366L, 367Y, 370L, 371S, 374P, 388S, 392Y, 396L, 399M, 403A, 471G, 474L, 475M, 478M, 482M, 483N, 486V, 496A, 497L, 500L, 501T, 504R, 505S, 508G
CDD
cd06174 (MFS)

169V

putative substrate translocation pore
132S, 135F, 136S, 137P, 139L, 140G, 157I, 160F, 161V, 164F, 168P, 169V, 171W, 172S, 218A, 219S, 222L, 223T, 226A, 227A, 230A, 245I, 246N, 249A, 250A, 256P, 363Y, 366L, 367Y, 370L, 371S, 374P, 388S, 392Y, 396L, 399M, 403A, 471G, 474L, 475M, 478M, 482M, 483N, 486V, 496A, 497L, 500L, 501T, 504R, 505S, 508G
CDD
cd06174 (MFS)

171W

putative substrate translocation pore
132S, 135F, 136S, 137P, 139L, 140G, 157I, 160F, 161V, 164F, 168P, 169V, 171W, 172S, 218A, 219S, 222L, 223T, 226A, 227A, 230A, 245I, 246N, 249A, 250A, 256P, 363Y, 366L, 367Y, 370L, 371S, 374P, 388S, 392Y, 396L, 399M, 403A, 471G, 474L, 475M, 478M, 482M, 483N, 486V, 496A, 497L, 500L, 501T, 504R, 505S, 508G
CDD
cd06174 (MFS)

172S

putative substrate translocation pore
132S, 135F, 136S, 137P, 139L, 140G, 157I, 160F, 161V, 164F, 168P, 169V, 171W, 172S, 218A, 219S, 222L, 223T, 226A, 227A, 230A, 245I, 246N, 249A, 250A, 256P, 363Y, 366L, 367Y, 370L, 371S, 374P, 388S, 392Y, 396L, 399M, 403A, 471G, 474L, 475M, 478M, 482M, 483N, 486V, 496A, 497L, 500L, 501T, 504R, 505S, 508G
CDD
cd06174 (MFS)

218A

putative substrate translocation pore
132S, 135F, 136S, 137P, 139L, 140G, 157I, 160F, 161V, 164F, 168P, 169V, 171W, 172S, 218A, 219S, 222L, 223T, 226A, 227A, 230A, 245I, 246N, 249A, 250A, 256P, 363Y, 366L, 367Y, 370L, 371S, 374P, 388S, 392Y, 396L, 399M, 403A, 471G, 474L, 475M, 478M, 482M, 483N, 486V, 496A, 497L, 500L, 501T, 504R, 505S, 508G
CDD
cd06174 (MFS)

219S

putative substrate translocation pore
132S, 135F, 136S, 137P, 139L, 140G, 157I, 160F, 161V, 164F, 168P, 169V, 171W, 172S, 218A, 219S, 222L, 223T, 226A, 227A, 230A, 245I, 246N, 249A, 250A, 256P, 363Y, 366L, 367Y, 370L, 371S, 374P, 388S, 392Y, 396L, 399M, 403A, 471G, 474L, 475M, 478M, 482M, 483N, 486V, 496A, 497L, 500L, 501T, 504R, 505S, 508G
CDD
cd06174 (MFS)

222L

putative substrate translocation pore
132S, 135F, 136S, 137P, 139L, 140G, 157I, 160F, 161V, 164F, 168P, 169V, 171W, 172S, 218A, 219S, 222L, 223T, 226A, 227A, 230A, 245I, 246N, 249A, 250A, 256P, 363Y, 366L, 367Y, 370L, 371S, 374P, 388S, 392Y, 396L, 399M, 403A, 471G, 474L, 475M, 478M, 482M, 483N, 486V, 496A, 497L, 500L, 501T, 504R, 505S, 508G
CDD
cd06174 (MFS)

223T

putative substrate translocation pore
132S, 135F, 136S, 137P, 139L, 140G, 157I, 160F, 161V, 164F, 168P, 169V, 171W, 172S, 218A, 219S, 222L, 223T, 226A, 227A, 230A, 245I, 246N, 249A, 250A, 256P, 363Y, 366L, 367Y, 370L, 371S, 374P, 388S, 392Y, 396L, 399M, 403A, 471G, 474L, 475M, 478M, 482M, 483N, 486V, 496A, 497L, 500L, 501T, 504R, 505S, 508G
CDD
cd06174 (MFS)

226A

putative substrate translocation pore
132S, 135F, 136S, 137P, 139L, 140G, 157I, 160F, 161V, 164F, 168P, 169V, 171W, 172S, 218A, 219S, 222L, 223T, 226A, 227A, 230A, 245I, 246N, 249A, 250A, 256P, 363Y, 366L, 367Y, 370L, 371S, 374P, 388S, 392Y, 396L, 399M, 403A, 471G, 474L, 475M, 478M, 482M, 483N, 486V, 496A, 497L, 500L, 501T, 504R, 505S, 508G
CDD
cd06174 (MFS)

227A

putative substrate translocation pore
132S, 135F, 136S, 137P, 139L, 140G, 157I, 160F, 161V, 164F, 168P, 169V, 171W, 172S, 218A, 219S, 222L, 223T, 226A, 227A, 230A, 245I, 246N, 249A, 250A, 256P, 363Y, 366L, 367Y, 370L, 371S, 374P, 388S, 392Y, 396L, 399M, 403A, 471G, 474L, 475M, 478M, 482M, 483N, 486V, 496A, 497L, 500L, 501T, 504R, 505S, 508G
CDD
cd06174 (MFS)

230A

putative substrate translocation pore
132S, 135F, 136S, 137P, 139L, 140G, 157I, 160F, 161V, 164F, 168P, 169V, 171W, 172S, 218A, 219S, 222L, 223T, 226A, 227A, 230A, 245I, 246N, 249A, 250A, 256P, 363Y, 366L, 367Y, 370L, 371S, 374P, 388S, 392Y, 396L, 399M, 403A, 471G, 474L, 475M, 478M, 482M, 483N, 486V, 496A, 497L, 500L, 501T, 504R, 505S, 508G
CDD
cd06174 (MFS)

245I

putative substrate translocation pore
132S, 135F, 136S, 137P, 139L, 140G, 157I, 160F, 161V, 164F, 168P, 169V, 171W, 172S, 218A, 219S, 222L, 223T, 226A, 227A, 230A, 245I, 246N, 249A, 250A, 256P, 363Y, 366L, 367Y, 370L, 371S, 374P, 388S, 392Y, 396L, 399M, 403A, 471G, 474L, 475M, 478M, 482M, 483N, 486V, 496A, 497L, 500L, 501T, 504R, 505S, 508G
CDD
cd06174 (MFS)

246N

putative substrate translocation pore
132S, 135F, 136S, 137P, 139L, 140G, 157I, 160F, 161V, 164F, 168P, 169V, 171W, 172S, 218A, 219S, 222L, 223T, 226A, 227A, 230A, 245I, 246N, 249A, 250A, 256P, 363Y, 366L, 367Y, 370L, 371S, 374P, 388S, 392Y, 396L, 399M, 403A, 471G, 474L, 475M, 478M, 482M, 483N, 486V, 496A, 497L, 500L, 501T, 504R, 505S, 508G
CDD
cd06174 (MFS)

249A

putative substrate translocation pore
132S, 135F, 136S, 137P, 139L, 140G, 157I, 160F, 161V, 164F, 168P, 169V, 171W, 172S, 218A, 219S, 222L, 223T, 226A, 227A, 230A, 245I, 246N, 249A, 250A, 256P, 363Y, 366L, 367Y, 370L, 371S, 374P, 388S, 392Y, 396L, 399M, 403A, 471G, 474L, 475M, 478M, 482M, 483N, 486V, 496A, 497L, 500L, 501T, 504R, 505S, 508G
CDD
cd06174 (MFS)

250A

putative substrate translocation pore
132S, 135F, 136S, 137P, 139L, 140G, 157I, 160F, 161V, 164F, 168P, 169V, 171W, 172S, 218A, 219S, 222L, 223T, 226A, 227A, 230A, 245I, 246N, 249A, 250A, 256P, 363Y, 366L, 367Y, 370L, 371S, 374P, 388S, 392Y, 396L, 399M, 403A, 471G, 474L, 475M, 478M, 482M, 483N, 486V, 496A, 497L, 500L, 501T, 504R, 505S, 508G
CDD
cd06174 (MFS)

256P

putative substrate translocation pore
132S, 135F, 136S, 137P, 139L, 140G, 157I, 160F, 161V, 164F, 168P, 169V, 171W, 172S, 218A, 219S, 222L, 223T, 226A, 227A, 230A, 245I, 246N, 249A, 250A, 256P, 363Y, 366L, 367Y, 370L, 371S, 374P, 388S, 392Y, 396L, 399M, 403A, 471G, 474L, 475M, 478M, 482M, 483N, 486V, 496A, 497L, 500L, 501T, 504R, 505S, 508G
CDD
cd06174 (MFS)

363Y

putative substrate translocation pore
132S, 135F, 136S, 137P, 139L, 140G, 157I, 160F, 161V, 164F, 168P, 169V, 171W, 172S, 218A, 219S, 222L, 223T, 226A, 227A, 230A, 245I, 246N, 249A, 250A, 256P, 363Y, 366L, 367Y, 370L, 371S, 374P, 388S, 392Y, 396L, 399M, 403A, 471G, 474L, 475M, 478M, 482M, 483N, 486V, 496A, 497L, 500L, 501T, 504R, 505S, 508G
CDD
cd06174 (MFS)

366L

putative substrate translocation pore
132S, 135F, 136S, 137P, 139L, 140G, 157I, 160F, 161V, 164F, 168P, 169V, 171W, 172S, 218A, 219S, 222L, 223T, 226A, 227A, 230A, 245I, 246N, 249A, 250A, 256P, 363Y, 366L, 367Y, 370L, 371S, 374P, 388S, 392Y, 396L, 399M, 403A, 471G, 474L, 475M, 478M, 482M, 483N, 486V, 496A, 497L, 500L, 501T, 504R, 505S, 508G
CDD
cd06174 (MFS)

367Y

putative substrate translocation pore
132S, 135F, 136S, 137P, 139L, 140G, 157I, 160F, 161V, 164F, 168P, 169V, 171W, 172S, 218A, 219S, 222L, 223T, 226A, 227A, 230A, 245I, 246N, 249A, 250A, 256P, 363Y, 366L, 367Y, 370L, 371S, 374P, 388S, 392Y, 396L, 399M, 403A, 471G, 474L, 475M, 478M, 482M, 483N, 486V, 496A, 497L, 500L, 501T, 504R, 505S, 508G
CDD
cd06174 (MFS)

370L

putative substrate translocation pore
132S, 135F, 136S, 137P, 139L, 140G, 157I, 160F, 161V, 164F, 168P, 169V, 171W, 172S, 218A, 219S, 222L, 223T, 226A, 227A, 230A, 245I, 246N, 249A, 250A, 256P, 363Y, 366L, 367Y, 370L, 371S, 374P, 388S, 392Y, 396L, 399M, 403A, 471G, 474L, 475M, 478M, 482M, 483N, 486V, 496A, 497L, 500L, 501T, 504R, 505S, 508G
CDD
cd06174 (MFS)

371S

putative substrate translocation pore
132S, 135F, 136S, 137P, 139L, 140G, 157I, 160F, 161V, 164F, 168P, 169V, 171W, 172S, 218A, 219S, 222L, 223T, 226A, 227A, 230A, 245I, 246N, 249A, 250A, 256P, 363Y, 366L, 367Y, 370L, 371S, 374P, 388S, 392Y, 396L, 399M, 403A, 471G, 474L, 475M, 478M, 482M, 483N, 486V, 496A, 497L, 500L, 501T, 504R, 505S, 508G
CDD
cd06174 (MFS)

374P

putative substrate translocation pore
132S, 135F, 136S, 137P, 139L, 140G, 157I, 160F, 161V, 164F, 168P, 169V, 171W, 172S, 218A, 219S, 222L, 223T, 226A, 227A, 230A, 245I, 246N, 249A, 250A, 256P, 363Y, 366L, 367Y, 370L, 371S, 374P, 388S, 392Y, 396L, 399M, 403A, 471G, 474L, 475M, 478M, 482M, 483N, 486V, 496A, 497L, 500L, 501T, 504R, 505S, 508G
CDD
cd06174 (MFS)

388S

putative substrate translocation pore
132S, 135F, 136S, 137P, 139L, 140G, 157I, 160F, 161V, 164F, 168P, 169V, 171W, 172S, 218A, 219S, 222L, 223T, 226A, 227A, 230A, 245I, 246N, 249A, 250A, 256P, 363Y, 366L, 367Y, 370L, 371S, 374P, 388S, 392Y, 396L, 399M, 403A, 471G, 474L, 475M, 478M, 482M, 483N, 486V, 496A, 497L, 500L, 501T, 504R, 505S, 508G
CDD
cd06174 (MFS)

392Y

putative substrate translocation pore
132S, 135F, 136S, 137P, 139L, 140G, 157I, 160F, 161V, 164F, 168P, 169V, 171W, 172S, 218A, 219S, 222L, 223T, 226A, 227A, 230A, 245I, 246N, 249A, 250A, 256P, 363Y, 366L, 367Y, 370L, 371S, 374P, 388S, 392Y, 396L, 399M, 403A, 471G, 474L, 475M, 478M, 482M, 483N, 486V, 496A, 497L, 500L, 501T, 504R, 505S, 508G
CDD
cd06174 (MFS)

396L

putative substrate translocation pore
132S, 135F, 136S, 137P, 139L, 140G, 157I, 160F, 161V, 164F, 168P, 169V, 171W, 172S, 218A, 219S, 222L, 223T, 226A, 227A, 230A, 245I, 246N, 249A, 250A, 256P, 363Y, 366L, 367Y, 370L, 371S, 374P, 388S, 392Y, 396L, 399M, 403A, 471G, 474L, 475M, 478M, 482M, 483N, 486V, 496A, 497L, 500L, 501T, 504R, 505S, 508G
CDD
cd06174 (MFS)

399M

putative substrate translocation pore
132S, 135F, 136S, 137P, 139L, 140G, 157I, 160F, 161V, 164F, 168P, 169V, 171W, 172S, 218A, 219S, 222L, 223T, 226A, 227A, 230A, 245I, 246N, 249A, 250A, 256P, 363Y, 366L, 367Y, 370L, 371S, 374P, 388S, 392Y, 396L, 399M, 403A, 471G, 474L, 475M, 478M, 482M, 483N, 486V, 496A, 497L, 500L, 501T, 504R, 505S, 508G
CDD
cd06174 (MFS)

403A

putative substrate translocation pore
132S, 135F, 136S, 137P, 139L, 140G, 157I, 160F, 161V, 164F, 168P, 169V, 171W, 172S, 218A, 219S, 222L, 223T, 226A, 227A, 230A, 245I, 246N, 249A, 250A, 256P, 363Y, 366L, 367Y, 370L, 371S, 374P, 388S, 392Y, 396L, 399M, 403A, 471G, 474L, 475M, 478M, 482M, 483N, 486V, 496A, 497L, 500L, 501T, 504R, 505S, 508G
CDD
cd06174 (MFS)

471G

putative substrate translocation pore
132S, 135F, 136S, 137P, 139L, 140G, 157I, 160F, 161V, 164F, 168P, 169V, 171W, 172S, 218A, 219S, 222L, 223T, 226A, 227A, 230A, 245I, 246N, 249A, 250A, 256P, 363Y, 366L, 367Y, 370L, 371S, 374P, 388S, 392Y, 396L, 399M, 403A, 471G, 474L, 475M, 478M, 482M, 483N, 486V, 496A, 497L, 500L, 501T, 504R, 505S, 508G
CDD
cd06174 (MFS)

474L

putative substrate translocation pore
132S, 135F, 136S, 137P, 139L, 140G, 157I, 160F, 161V, 164F, 168P, 169V, 171W, 172S, 218A, 219S, 222L, 223T, 226A, 227A, 230A, 245I, 246N, 249A, 250A, 256P, 363Y, 366L, 367Y, 370L, 371S, 374P, 388S, 392Y, 396L, 399M, 403A, 471G, 474L, 475M, 478M, 482M, 483N, 486V, 496A, 497L, 500L, 501T, 504R, 505S, 508G
CDD
cd06174 (MFS)

475M

putative substrate translocation pore
132S, 135F, 136S, 137P, 139L, 140G, 157I, 160F, 161V, 164F, 168P, 169V, 171W, 172S, 218A, 219S, 222L, 223T, 226A, 227A, 230A, 245I, 246N, 249A, 250A, 256P, 363Y, 366L, 367Y, 370L, 371S, 374P, 388S, 392Y, 396L, 399M, 403A, 471G, 474L, 475M, 478M, 482M, 483N, 486V, 496A, 497L, 500L, 501T, 504R, 505S, 508G
CDD
cd06174 (MFS)

478M

putative substrate translocation pore
132S, 135F, 136S, 137P, 139L, 140G, 157I, 160F, 161V, 164F, 168P, 169V, 171W, 172S, 218A, 219S, 222L, 223T, 226A, 227A, 230A, 245I, 246N, 249A, 250A, 256P, 363Y, 366L, 367Y, 370L, 371S, 374P, 388S, 392Y, 396L, 399M, 403A, 471G, 474L, 475M, 478M, 482M, 483N, 486V, 496A, 497L, 500L, 501T, 504R, 505S, 508G
CDD
cd06174 (MFS)

482M

putative substrate translocation pore
132S, 135F, 136S, 137P, 139L, 140G, 157I, 160F, 161V, 164F, 168P, 169V, 171W, 172S, 218A, 219S, 222L, 223T, 226A, 227A, 230A, 245I, 246N, 249A, 250A, 256P, 363Y, 366L, 367Y, 370L, 371S, 374P, 388S, 392Y, 396L, 399M, 403A, 471G, 474L, 475M, 478M, 482M, 483N, 486V, 496A, 497L, 500L, 501T, 504R, 505S, 508G
CDD
cd06174 (MFS)

483N

putative substrate translocation pore
132S, 135F, 136S, 137P, 139L, 140G, 157I, 160F, 161V, 164F, 168P, 169V, 171W, 172S, 218A, 219S, 222L, 223T, 226A, 227A, 230A, 245I, 246N, 249A, 250A, 256P, 363Y, 366L, 367Y, 370L, 371S, 374P, 388S, 392Y, 396L, 399M, 403A, 471G, 474L, 475M, 478M, 482M, 483N, 486V, 496A, 497L, 500L, 501T, 504R, 505S, 508G
CDD
cd06174 (MFS)

486V

putative substrate translocation pore
132S, 135F, 136S, 137P, 139L, 140G, 157I, 160F, 161V, 164F, 168P, 169V, 171W, 172S, 218A, 219S, 222L, 223T, 226A, 227A, 230A, 245I, 246N, 249A, 250A, 256P, 363Y, 366L, 367Y, 370L, 371S, 374P, 388S, 392Y, 396L, 399M, 403A, 471G, 474L, 475M, 478M, 482M, 483N, 486V, 496A, 497L, 500L, 501T, 504R, 505S, 508G
CDD
cd06174 (MFS)

496A

putative substrate translocation pore
132S, 135F, 136S, 137P, 139L, 140G, 157I, 160F, 161V, 164F, 168P, 169V, 171W, 172S, 218A, 219S, 222L, 223T, 226A, 227A, 230A, 245I, 246N, 249A, 250A, 256P, 363Y, 366L, 367Y, 370L, 371S, 374P, 388S, 392Y, 396L, 399M, 403A, 471G, 474L, 475M, 478M, 482M, 483N, 486V, 496A, 497L, 500L, 501T, 504R, 505S, 508G
CDD
cd06174 (MFS)

497L

putative substrate translocation pore
132S, 135F, 136S, 137P, 139L, 140G, 157I, 160F, 161V, 164F, 168P, 169V, 171W, 172S, 218A, 219S, 222L, 223T, 226A, 227A, 230A, 245I, 246N, 249A, 250A, 256P, 363Y, 366L, 367Y, 370L, 371S, 374P, 388S, 392Y, 396L, 399M, 403A, 471G, 474L, 475M, 478M, 482M, 483N, 486V, 496A, 497L, 500L, 501T, 504R, 505S, 508G
CDD
cd06174 (MFS)

500L

putative substrate translocation pore
132S, 135F, 136S, 137P, 139L, 140G, 157I, 160F, 161V, 164F, 168P, 169V, 171W, 172S, 218A, 219S, 222L, 223T, 226A, 227A, 230A, 245I, 246N, 249A, 250A, 256P, 363Y, 366L, 367Y, 370L, 371S, 374P, 388S, 392Y, 396L, 399M, 403A, 471G, 474L, 475M, 478M, 482M, 483N, 486V, 496A, 497L, 500L, 501T, 504R, 505S, 508G
CDD
cd06174 (MFS)

501T

putative substrate translocation pore
132S, 135F, 136S, 137P, 139L, 140G, 157I, 160F, 161V, 164F, 168P, 169V, 171W, 172S, 218A, 219S, 222L, 223T, 226A, 227A, 230A, 245I, 246N, 249A, 250A, 256P, 363Y, 366L, 367Y, 370L, 371S, 374P, 388S, 392Y, 396L, 399M, 403A, 471G, 474L, 475M, 478M, 482M, 483N, 486V, 496A, 497L, 500L, 501T, 504R, 505S, 508G
CDD
cd06174 (MFS)

504R

putative substrate translocation pore
132S, 135F, 136S, 137P, 139L, 140G, 157I, 160F, 161V, 164F, 168P, 169V, 171W, 172S, 218A, 219S, 222L, 223T, 226A, 227A, 230A, 245I, 246N, 249A, 250A, 256P, 363Y, 366L, 367Y, 370L, 371S, 374P, 388S, 392Y, 396L, 399M, 403A, 471G, 474L, 475M, 478M, 482M, 483N, 486V, 496A, 497L, 500L, 501T, 504R, 505S, 508G
CDD
cd06174 (MFS)

505S

putative substrate translocation pore
132S, 135F, 136S, 137P, 139L, 140G, 157I, 160F, 161V, 164F, 168P, 169V, 171W, 172S, 218A, 219S, 222L, 223T, 226A, 227A, 230A, 245I, 246N, 249A, 250A, 256P, 363Y, 366L, 367Y, 370L, 371S, 374P, 388S, 392Y, 396L, 399M, 403A, 471G, 474L, 475M, 478M, 482M, 483N, 486V, 496A, 497L, 500L, 501T, 504R, 505S, 508G
CDD
cd06174 (MFS)

508G

putative substrate translocation pore
132S, 135F, 136S, 137P, 139L, 140G, 157I, 160F, 161V, 164F, 168P, 169V, 171W, 172S, 218A, 219S, 222L, 223T, 226A, 227A, 230A, 245I, 246N, 249A, 250A, 256P, 363Y, 366L, 367Y, 370L, 371S, 374P, 388S, 392Y, 396L, 399M, 403A, 471G, 474L, 475M, 478M, 482M, 483N, 486V, 496A, 497L, 500L, 501T, 504R, 505S, 508G
CDD
cd06174 (MFS)

Protein sequence

>MIA_05345_1
MQNQISTQNSNQSSSASSSAPYTNDPEKFFMKPASNPPSRRNSIASEMPSLDEQEAISRVLSCRQPQDYPQDSCPPMGAD
RQYPPLLPEQEAYRVDFTGPDDPLHPFNWPLSKKLVIALCLGATTFTSVWGSSVFSPALGVISEKFHVASVVSSLTISLF
VLGFASGPVLWSPLSELYGRKVPIVIALFLFTCFTFATATAKDLQTIIICRFFSGIAASAPLTIVAAVFADIFPNTGVVS
RGTAINLFAAIVFSGPMVAPIVGGFIVQSYLGWRWTEYLTGIMAGATLIAVVLFMEETYTPIILVRKAQIIREHTGNWGI
HAVHESVKLDFSEILTKTITRPLRMLFSEPIILLLAIYNGFCYLILYLCLSSYPYAFRGMYHFALNLSMLPYLGILIGMI
LCALGMIFFFEPRYERKLAAAGVKSNPELRLEPVLLSALIFPIGLFWFFWTANYADHVHWIVPSISGIFTGFGLMGIMVP
SMNYIVDAYLWFAASALAALTFLRSMFGASAPLFADFMFDRIHLNWSGLLLGLLAVAMAPVPYLFFAYGKKIRGVSKYAF
DG

GO term prediction

Biological Process

GO:0055085 transmembrane transport

Molecular Function

None predicted.

Cellular Component

GO:0016021 integral component of membrane

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Entry type

Status

Per-residue features