MIA_05307_1

Protein

Length

1,655 amino acids

Protein function

EGGNOG:	0PKA3		reverse transcriptase
CGD closest match:	CAL0000176110	orf19.7274	Uncharacterized protein

Protein alignments

	%id	Aln length	E-value
MCA_03180_1	38.600%	1057	0.0	MCA_03180_1
A0A167E5I2_9ASCO	35.047%	1070	0.0	Polyprotein of L1-like non-LTR retrotransposon Zorro 3 OS=Sugiyamaella lignohabitans GN=POL92 PE=4 SV=1
UniRef50_A0A167E5I2	35.047%	1070	0.0	Polyprotein of L1-like non-LTR retrotransposon Zorro 3 n=7 Tax=Sugiyamaella lignohabitans TaxID=796027 RepID=A0A167E5I2_9ASCO
A0A0J9XC44_GEOCN	28.968%	252	6.90e-22	Uncharacterized protein (Fragment) OS=Geotrichum candidum GN=BN980_GECA08s04349g PE=4 SV=1
A0A1D8PFY7_CANAL	25.279%	269	2.37e-11	Uncharacterized protein OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.7274 PE=4 SV=1
A0A060T0U2_BLAAD	52.000%	50	6.69e-09	ARAD1C18194p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C18194g PE=4 SV=1
Q6C7P5_YARLI	21.304%	230	2.19e-07	YALI0D26444p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D26444g PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0199

Protein family membership

None predicted.

Domains and repeats

Domain
584 - 820
Endonuclease/exonuclease/phosphatase (IPR005135)
1,065 - 1,333
Reverse transcriptase domain (IPR000477)

1 200 400 600 800 1000 1200 1400 1655

Detailed signature matches

IPR005135

Endonuclease/exonuclease/phosphatase
1. SSF56219 (DNase I-like)
  
  602 - 817
  
  SUPERFAMILY
  SSF56219 (DNase I-like)
2. G3DSA:3.60.10.10
  
  584 - 820
  
  GENE3D
  G3DSA:3.60.10.10 (G3DSA:3.60.10.10)
3. PF14529 (Exo_endo_p...)
  
  697 - 812
  
  Pfam
  PF14529 (Exo_endo_phos_2)
IPR000477

Reverse transcriptase domain
1. PF00078 (RVT_1)
  
  1,084 - 1,332
  
  Pfam
  PF00078 (RVT_1)
2. PS50878 (RT_POL)
  
  1,065 - 1,333
  
  PROSITE profiles
  PS50878 (RT_POL)

no IPR

Unintegrated signatures

Coil

177 - 218

COILS
Coil (Coil)

297 - 317

COILS
Coil (Coil)

865 - 885

COILS
Coil (Coil)

901 - 921

COILS
Coil (Coil)
G3DSA:1.20.5.170

153 - 283

GENE3D
G3DSA:1.20.5.170 (G3DSA:1.20.5.170)
G3DSA:3.30.70...

1,080 - 1,333

GENE3D
G3DSA:3.30.70.270 (G3DSA:3.30.70.270)
SSF56672 (DNA/RNA p...)

1,094 - 1,277

SUPERFAMILY
SSF56672 (DNA/RNA polymerases)
cd01650 (RT_nLTR_like)

1,084 - 1,333

CDD
cd01650 (RT_nLTR_like)

Residue annotation

putative NTP bindi...

1,162D

putative NTP binding site
1,162D, 1,163I, 1,164Q, 1,165G, 1,166A, 1,167F, 1,221Q, 1,253D
CDD
cd01650 (RT_nLTR_like)

1,163I

putative NTP binding site
1,162D, 1,163I, 1,164Q, 1,165G, 1,166A, 1,167F, 1,221Q, 1,253D
CDD
cd01650 (RT_nLTR_like)

1,164Q

putative NTP binding site
1,162D, 1,163I, 1,164Q, 1,165G, 1,166A, 1,167F, 1,221Q, 1,253D
CDD
cd01650 (RT_nLTR_like)

1,165G

putative NTP binding site
1,162D, 1,163I, 1,164Q, 1,165G, 1,166A, 1,167F, 1,221Q, 1,253D
CDD
cd01650 (RT_nLTR_like)

1,166A

putative NTP binding site
1,162D, 1,163I, 1,164Q, 1,165G, 1,166A, 1,167F, 1,221Q, 1,253D
CDD
cd01650 (RT_nLTR_like)

1,167F

putative NTP binding site
1,162D, 1,163I, 1,164Q, 1,165G, 1,166A, 1,167F, 1,221Q, 1,253D
CDD
cd01650 (RT_nLTR_like)

1,221Q

putative NTP binding site
1,162D, 1,163I, 1,164Q, 1,165G, 1,166A, 1,167F, 1,221Q, 1,253D
CDD
cd01650 (RT_nLTR_like)

1,253D

putative NTP binding site
1,162D, 1,163I, 1,164Q, 1,165G, 1,166A, 1,167F, 1,221Q, 1,253D
CDD
cd01650 (RT_nLTR_like)
putative active si...

1,162D

putative active site
1,162D, 1,163I, 1,164Q, 1,165G, 1,166A, 1,167F, 1,221Q, 1,222G, 1,251F, 1,253D, 1,254D, 1,329L, 1,330G
CDD
cd01650 (RT_nLTR_like)

1,163I

putative active site
1,162D, 1,163I, 1,164Q, 1,165G, 1,166A, 1,167F, 1,221Q, 1,222G, 1,251F, 1,253D, 1,254D, 1,329L, 1,330G
CDD
cd01650 (RT_nLTR_like)

1,164Q

putative active site
1,162D, 1,163I, 1,164Q, 1,165G, 1,166A, 1,167F, 1,221Q, 1,222G, 1,251F, 1,253D, 1,254D, 1,329L, 1,330G
CDD
cd01650 (RT_nLTR_like)

1,165G

putative active site
1,162D, 1,163I, 1,164Q, 1,165G, 1,166A, 1,167F, 1,221Q, 1,222G, 1,251F, 1,253D, 1,254D, 1,329L, 1,330G
CDD
cd01650 (RT_nLTR_like)

1,166A

putative active site
1,162D, 1,163I, 1,164Q, 1,165G, 1,166A, 1,167F, 1,221Q, 1,222G, 1,251F, 1,253D, 1,254D, 1,329L, 1,330G
CDD
cd01650 (RT_nLTR_like)

1,167F

putative active site
1,162D, 1,163I, 1,164Q, 1,165G, 1,166A, 1,167F, 1,221Q, 1,222G, 1,251F, 1,253D, 1,254D, 1,329L, 1,330G
CDD
cd01650 (RT_nLTR_like)

1,221Q

putative active site
1,162D, 1,163I, 1,164Q, 1,165G, 1,166A, 1,167F, 1,221Q, 1,222G, 1,251F, 1,253D, 1,254D, 1,329L, 1,330G
CDD
cd01650 (RT_nLTR_like)

1,222G

putative active site
1,162D, 1,163I, 1,164Q, 1,165G, 1,166A, 1,167F, 1,221Q, 1,222G, 1,251F, 1,253D, 1,254D, 1,329L, 1,330G
CDD
cd01650 (RT_nLTR_like)

1,251F

putative active site
1,162D, 1,163I, 1,164Q, 1,165G, 1,166A, 1,167F, 1,221Q, 1,222G, 1,251F, 1,253D, 1,254D, 1,329L, 1,330G
CDD
cd01650 (RT_nLTR_like)

1,253D

putative active site
1,162D, 1,163I, 1,164Q, 1,165G, 1,166A, 1,167F, 1,221Q, 1,222G, 1,251F, 1,253D, 1,254D, 1,329L, 1,330G
CDD
cd01650 (RT_nLTR_like)

1,254D

putative active site
1,162D, 1,163I, 1,164Q, 1,165G, 1,166A, 1,167F, 1,221Q, 1,222G, 1,251F, 1,253D, 1,254D, 1,329L, 1,330G
CDD
cd01650 (RT_nLTR_like)

1,329L

putative active site
1,162D, 1,163I, 1,164Q, 1,165G, 1,166A, 1,167F, 1,221Q, 1,222G, 1,251F, 1,253D, 1,254D, 1,329L, 1,330G
CDD
cd01650 (RT_nLTR_like)

1,330G

putative active site
1,162D, 1,163I, 1,164Q, 1,165G, 1,166A, 1,167F, 1,221Q, 1,222G, 1,251F, 1,253D, 1,254D, 1,329L, 1,330G
CDD
cd01650 (RT_nLTR_like)
putative nucleic a...

1,222G

putative nucleic acid binding site
1,222G
CDD
cd01650 (RT_nLTR_like)

Protein sequence

>MIA_05307_1
MPDPPDKNNPTTPSGNDPRADINNLDNHVEQTKINDIEKTIAVGLKQKGVSHLKGHHSHDVHHVKASPKIHKDDDKIDKI
ANLDKLQKKLDHLNKHPDHEHQENDPDSQMLDTTSDPDSPTENFSSGGDTEIDANNSRDIDINMADNITITPTHEIESVN
CISETLVAKVNSLAEILVEVNNKYDNMGKNCQSLKKENELLKKESEILTAENAVLRNKFAEFSLKFDQFEGSWNTLRSEV
DNLKSKEVHSEVKKITIEQIKKDVKANHDHCVRNSQKAEELANLAITDWTQRAAENKQTVKKEINHVKEITQNLEKRIDG
IEYQVGTISTKTDLASKEITYAKQEIKSAVRKVDTLPYKLTTRPSNSNPIKLKDIMKAQKQQREEQVANAKPIYRVCIRI
PATANNIRRETIGAKIDSIAQKNVAEMVEFTTKGNLYVNINDKEFADRAAEWIPQIDPTFSLLDTEPWYKAKLLGVPEEA
TIQEVKDALYTFGEYHIVLNNEPKVIYKNHDSQTILVCFRNVSDFAKCADKLVIRYTKIKVTPYVNRPKTPEQLRRIQMK
NKKTKRLQMRNPQKNLWMTQKLKNSWNLLQKKPQLLRIPLMIYKVFQLNCHKSKSITETILDEKEPDILLLQEPYFSKYG
PINHKEWIPIYAIAQNGNTPCRAITYIRSNSDLRAVTTKIEKLTNTDMVTIMVKDFTLVNVYNQPKPSKKFPEPPALEIL
KKEVQGQYDRLIIAGDYNLHHREWETESNPDADTNEIVDWLHENDMMLITPPNRKTYRNKTTIDLVYCSVNLLHRIIFRK
IDENSLSDHAIVEWDLSFFQHQHEEEKLTSIERLNIQQANWDKFEQELSNAIKTLNVHDKALKSLDQIDSQAEILENVIK
KAMASSMEKIKLVRKSKRYWNAELRKKLEFALKAKREARLRQPTFALKKQKIQEAKEATRDFDRSLREASSEQWNKFLSG
LEENDIWRVLRYINPKGNDTIIPQIRKEDGTLTTTVEEKRHEIWKALLPEIDHGPDKHFEIDDDSRWPKLDIKEVEIALA
NTPNDKAAGDDGITGLVLKKAWKNKDYQIRFLNYYKLVSTLDIIQKSGDMALLXAYRPISLLKIPSKVLEKIMQTRMTKL
TVKLLPPEQYGGRKGYCATDAVLELVQRIETSREKISAILIDIQGAFDNVNRNILAETMENMGLPNALISWTYQFISQRE
ASMLMDRRKGPVQKISTGIPQGSPISPLLFLIYSTPMYKAIQQRGGKAFGFIDDVTITVEGTIDKNTELLSNILAKCCEW
AKSRMTKIDLGDKLGFIHFAKNIKANDQKAQLTLPNGEHLKPQKEVKLLGIILDNTLDFKSHIMSKITKARKAIGAIWRL
GGTFRGMRGSSVRSLYIACVRPIIEYGMEIWFHKILKGEIHKLEVAQNMALRRVVGAYRTTPIAVLQKEAGVMPYSIRLN
FMIARKAIRLHLNISNTNPIKEHLLTLIENSPIAKLTSVYLEAEEDRKVVIKNLMKTRKKPVFGPVTRELLQSQLIAILK
KQAIEKWRDAYWHSKKDQWYHDITAETPCSDNLSKMTTGVVMKKDSRRTLSFITQFRTGHGNFGAWFKKFGIQKDSYDCE
CGELETVRHILVECPLLEEKRKGLRRISPEMDMSTLLNSLIGLQEIARFISVWRE

GO term prediction

Biological Process

None predicted.

Molecular Function

None predicted.

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features

MIA_05307_1

Protein function

Protein alignments

Mitochondrial localization by mitoprotII

Protein family membership

Domains and repeats

Detailed signature matches

Residue annotation

Protein sequence

GO term prediction

Biological Process

Molecular Function

Cellular Component