Protein

MIA_05298_1

Length
347 amino acids

Browser: contig08:70450-71494+

Protein function

EGGNOG:0PJT2FG01476.1NADPH-dependent methylglyoxal reductase GRE2
SGD closest match:S000003125ARI1NADPH-dependent aldehyde reductase ARI1
CGD closest match:CAL0000189861GRP2Putative NADPH-dependent methylglyoxal reductase GRP2

Protein alignments

%idAln lengthE-value
MCA_06352_157.061%3474.28e-142MCA_06352_1
A0A0J9XCC0_GEOCN56.845%3366.41e-131Similar to Saccharomyces cerevisiae YGL157W ARI1 NADPH-dependent aldehyde reductase OS=Geotrichum candidum GN=BN980_GECA07s05433g PE=4 SV=1
UniRef50_A0A0J9XB2254.762%3365.78e-123Similar to Saccharomyces cerevisiae YGL157W ARI1 NADPH-dependent aldehyde reductase n=2 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XB22_GEOCN
A0A060T4V0_BLAAD46.471%3402.26e-96ARAD1B02860p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B02860g PE=4 SV=1
A0A1E3PSR4_9ASCO48.034%3565.64e-92Putative NADPH-dependent methylglyoxal reductase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_45022 PE=4 SV=1
Q6C9S0_YARLI44.510%3371.49e-83YALI0D08844p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D08844g PE=4 SV=1
ARI1_YEAST41.520%3421.60e-82NADPH-dependent aldehyde reductase ARI1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ARI1 PE=1 SV=1
GRP2_CANAL40.413%3392.96e-80Putative NADPH-dependent methylglyoxal reductase GRP2 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=GRP2 PE=1 SV=2
A0A167C177_9ASCO42.388%3359.82e-78Carbonyl reductase (NADPH-dependent) OS=Sugiyamaella lignohabitans GN=AWJ20_3889 PE=4 SV=1
A0A1E4T9D1_9ASCO38.728%3463.32e-64Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_4495 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.1127

Protein family membership

None predicted.

Domains and repeats

  1. Domain
1 50 100 150 200 250 300 347

Detailed signature matches

  1. Domain IPR016040
    NAD(P)-binding domain
    1. SSF51735 (NAD(P)-bi...)
  2. Domain IPR001509
    NAD-dependent epimerase/dehydratase
    1. PF01370 (Epimerase)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.40.50...
  2. G3DSA:3.90.25.10
  3. cd05227 (AR_SDR_e)

Residue annotation

  1. NADP binding site ...
  2. putative substrate...
  3. active site cd05227

Protein sequence

>MIA_05298_1
MTTNNHTNVLLTGASGFVAIHTLDILLKKGYSVTATLRSQEKADYILETFKGKSLKTVIVKNIAAPGAFDDVFKNDTSIT
AVIHTASPFFSAKADPVKELLDPAIKGTRNVLESIKKYAPQVTTLVVTSSYAAILHVSKKNDHSFIQNEETWSDVTWDDA
VNNLEVSYLGSKKFAEQEVWKFIKEEKPNFSATTVNPPLIFGPLLQNINSPEELNTSNSILWNIIINSPANDTSDNYVDN
TSPWVDVRDVALAHVLPLENEKLAGKRLLISGGYFTAQSILDIVNKNFPTLKGKIAVGQPGTGLKNLEKVSQLENHVTNE
LLNLKYHTLEESIVDTFKTFEKLPTKD

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0003824 catalytic activity
GO:0050662 coenzyme binding

Cellular Component

None predicted.