Protein

MCA_06352_1

Length
349 amino acids

Browser: contigD:3965085-3966135+

RNA-seq: read pairs 1084, FPKM 38.3, percentile rank 59.4% (100% = highest expression)

Protein function

EGGNOG:0PJT2GRE2NADPH-dependent methylglyoxal reductase GRE2
SGD closest match:S000002949YDR541CPutative uncharacterized oxidoreductase YDR541C
CGD closest match:CAL0000189861GRP2Putative NADPH-dependent methylglyoxal reductase GRP2

Protein alignments

%idAln lengthE-value
MIA_04276_161.45%3454e-153MIA_04276_1
A0A0J9XCC0_GEOCN58.55%3453e-147Similar to Saccharomyces cerevisiae YGL157W ARI1 NADPH-dependent aldehyde reductase OS=Geotrichum candidum GN=BN980_GECA07s05433g PE=4 SV=1
UniRef50_A0A0J9XB2255.65%3453e-133Similar to Saccharomyces cerevisiae YGL157W ARI1 NADPH-dependent aldehyde reductase n=2 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XB22_GEOCN
A0A1E3PJ87_9ASCO43.14%3501e-93NAD(P)-binding protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_83062 PE=4 SV=1
A0A060T4V0_BLAAD43.31%3441e-92ARAD1B02860p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B02860g PE=4 SV=1
Q6C9S0_YARLI43.36%3399e-89YALI0D08844p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D08844g PE=4 SV=1
A0A167C177_9ASCO40.87%3451e-87Carbonyl reductase (NADPH-dependent) OS=Sugiyamaella lignohabitans GN=AWJ20_3889 PE=4 SV=1
GRP2_CANAL39.65%3431e-85Putative NADPH-dependent methylglyoxal reductase GRP2 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=GRP2 PE=1 SV=2
YD541_YEAST41.45%3454e-77Putative uncharacterized oxidoreductase YDR541C OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YDR541C PE=3 SV=2
A0A1E4T9D1_9ASCO40.23%3532e-69Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_4495 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.6045

Protein family membership

None predicted.

Domains and repeats

  1. Domain
1 50 100 150 200 250 300 349

Detailed signature matches

  1. Domain IPR016040
    NAD(P)-binding domain
    1. SSF51735 (NAD(P)-bi...)
  2. Domain IPR002225
    3-beta hydroxysteroid dehydrogenase/isomerase
    1. PF01073 (3Beta_HSD)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.40.50...
  2. cd05227 (AR_SDR_e)

Residue annotation

  1. NADP binding site ...
  2. putative substrate...
  3. active site cd05227

Protein sequence

>MCA_06352_1
MSTLSHSKVLVTGGSGFVATHILDLLLKRGYNVKTTIRSQEKADYLATKFGSEKLEFSIVKDMQTEGAFDKTLEDDKEIT
AVIHTASPFFFASSDPLNNLINPAINGTKNILKAIKAHAPQVNTVVITSSYAAIANVEKRYDPSFVHTEETWADMSMEDA
INDLSKSYRGSKKYAEKAFWEFIETNKPNFTGTTVNPPMIYGPLLQQVKSIDELNTSSKLLLDMVFNTDPSEDPTDKYAK
DPNIWADVRDVAFAHVAPLENKKLAGKRLFVTPGFYSNQTVLDIVNKNFPSLQGKIAKGIPGTGDKYINTVSQYDNHVTN
ELLGIKYHTLEETIVDSFKSLIELKEKSN

GO term prediction

Biological Process

GO:0006694 steroid biosynthetic process
GO:0055114 oxidation-reduction process

Molecular Function

GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

Cellular Component

None predicted.