Protein

MIA_04276_1

Length
344 amino acids

Browser: contig05:1291816-1292851-

Protein function

EGGNOG:0PJT2GRE2NADPH-dependent methylglyoxal reductase GRE2
SGD closest match:S000003125ARI1NADPH-dependent aldehyde reductase ARI1
CGD closest match:CAL0000189861GRP2Putative NADPH-dependent methylglyoxal reductase GRP2

Protein alignments

%idAln lengthE-value
MCA_06352_161.449%3456.57e-155MCA_06352_1
A0A0J9XCC0_GEOCN61.357%3391.38e-148Similar to Saccharomyces cerevisiae YGL157W ARI1 NADPH-dependent aldehyde reductase OS=Geotrichum candidum GN=BN980_GECA07s05433g PE=4 SV=1
UniRef50_A0A0J9XB2258.407%3394.52e-133Similar to Saccharomyces cerevisiae YGL157W ARI1 NADPH-dependent aldehyde reductase n=2 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XB22_GEOCN
A0A060T4V0_BLAAD47.059%3401.83e-98ARAD1B02860p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B02860g PE=4 SV=1
A0A167C177_9ASCO45.748%3417.78e-92Carbonyl reductase (NADPH-dependent) OS=Sugiyamaella lignohabitans GN=AWJ20_3889 PE=4 SV=1
Q6C9S0_YARLI43.620%3373.21e-92YALI0D08844p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D08844g PE=4 SV=1
A0A1E3PSR4_9ASCO45.954%3467.62e-88Putative NADPH-dependent methylglyoxal reductase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_45022 PE=4 SV=1
ARI1_YEAST39.828%3491.19e-85NADPH-dependent aldehyde reductase ARI1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ARI1 PE=1 SV=1
GRP2_CANAL39.474%3421.56e-80Putative NADPH-dependent methylglyoxal reductase GRP2 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=GRP2 PE=1 SV=2
A0A1E4T9D1_9ASCO38.000%3506.05e-62Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_4495 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.3692

Protein family membership

None predicted.

Domains and repeats

  1. Domain
1 50 100 150 200 250 300 344

Detailed signature matches

  1. Domain IPR016040
    NAD(P)-binding domain
    1. SSF51735 (NAD(P)-bi...)
  2. Domain IPR001509
    NAD-dependent epimerase/dehydratase
    1. PF01370 (Epimerase)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.40.50...
  2. G3DSA:3.90.25.10
  3. NON_CYTOPLASM... (N...)
  4. SIGNAL_PEPTIDE (Sig...)
  5. SIGNAL_PEPTID... (S...)
  6. SIGNAL_PEPTID... (S...)
  7. SIGNAL_PEPTID... (S...)
  8. cd05227 (AR_SDR_e)

Residue annotation

  1. NADP binding site ...
  2. putative substrate...
  3. active site cd05227

Protein sequence

>MIA_04276_1
MTHSKVLLTGASGFLAIYVLKTLFERGYSVKATVRSKEKGDYLHKTFPNKPLEIVIVEDIQAPNAFDEALKDSAITAVIH
TASPFFPAKSDPVKELLDPAIKGTKNVLQAIKTHAPQITTVVITSSNASINNVSKYHDHSFVQSEETWADVTWDQAVSDL
SLTYRASKKYAERAFWDFIAQEKPNFTGTTVNPPLIFGPLLHQVASPEVINTSNAFVWKNVIHSTPNDTADTYSNNPGLW
VDVRDVALAHVLPLEKPELAGKRLLVTPGFYSVQTLLDIVNEKVPALKGKIAIGQPGTGSKNVDKVFQYDNHVTNELLGI
KYHSLEESIVETVESLLELKDKSA

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0003824 catalytic activity
GO:0050662 coenzyme binding

Cellular Component

None predicted.