Protein
MIA_05258_1
Length
764 amino acids
Browser: contig07:1147127-1149422-
Protein function
EGGNOG: | 0PHAS | MET6 | 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferase |
---|---|---|---|
SGD closest match: | S000000893 | MET6 | 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase |
CGD closest match: | CAL0000186137 | MET6 | 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase |
Protein alignments
%id | Aln length | E-value | ||
---|---|---|---|---|
MCA_03662_1 | 86.275% | 765 | 0.0 | MCA_03662_1 |
A0A0J9XHW0_GEOCN | 84.334% | 766 | 0.0 | Similar to Saccharomyces cerevisiae YER091C MET6 Cobalamin-independent methionine synthase OS=Geotrichum candidum GN=BN980_GECA18s00835g PE=3 SV=1 |
A0A167DWB8_9ASCO | 83.943% | 766 | 0.0 | 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase OS=Sugiyamaella lignohabitans GN=MET6 PE=3 SV=1 |
A0A060T5U9_BLAAD | 81.046% | 765 | 0.0 | ARAD1C08184p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C08184g PE=3 SV=1 |
METE_CANAL | 74.772% | 769 | 0.0 | 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=MET6 PE=1 SV=2 |
A0A1E4TE11_9ASCO | 73.238% | 766 | 0.0 | Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_98963 PE=3 SV=1 |
A0A1E3PHL9_9ASCO | 76.172% | 768 | 0.0 | 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_25071 PE=3 SV=1 |
METE_YEAST | 72.490% | 767 | 0.0 | 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MET6 PE=1 SV=4 |
Q6C638_YARLI | 72.775% | 764 | 0.0 | YALI0E12683p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E12683g PE=3 SV=1 |
UniRef50_A0A0F4XCC1 | 64.942% | 773 | 0.0 | 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase n=8 Tax=Dikarya TaxID=451864 RepID=A0A0F4XCC1_HANUV |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.2535
Predicted cleavage: 13
Protein family membership
- Cobalamin-independent methionine synthase (IPR006276)
Domains and repeats
-
Domain
1
100
200
300
400
500
600
700
764
Detailed signature matches
-
-
MF_00172 (Meth_synth)
-
-
PIRSF000382 (Met_sy...)
-
-
-
PF08267 (Meth_synt_1)
-
-
-
PF01717 (Meth_synt_2)
-
no IPR
Unintegrated signatures
Residue annotation
-
THF binding site c...
-
substrate binding ...
-
THF binding site c...
-
zinc-binding site ...
Protein sequence
>MIA_05258_1 MVLSSVLGFPRIGAHRELKKVTEAYWSGKATVEELFKVGKEIRAHNWKLQKESGVDIIASNDFSFYDQVLDLSLLFNVIP ERYSKYNLPAIDTLFAMGRGLQRPATDASPAVDVPALEMVKWFDSNYHYVRPTFSNSTEFKLNGQKPVDEYLEAKELGVE TRPVLLGPLSYLFLGKADKDSLDLDLLSLLPKLVPVYAEILKKLADAGAKNVQIDEPILVLDLPESYKAAYKSTYETLSK SGLEIILATYFGDVRPNLDAIKGLPVAGFHYDFVRVPEQFGEVSDALTAEQVLSAGVVDGRNIWKTDLNKAVDFIEAAKQ KLGEDRVIVATSSSLLHTPVDLENETKLNPEIKDWFSFATQKLSEVVVIAKAVTSGRESVSAELETNAKSISARAHSKIT NDPAVRSRLSAVTEADSKRKAPFAERLEAQKSLNLPLFPTTTIGSFPQTKEIRVYRNKFTKGEITPEEYEKFIEKEIEEV VKFQEEVGLDVLVHGEPERNDMVQYFGEQLKGFAFTQNGWVQSYGSRYVRPPIIVGDVSRPHAMTVKESKYAQSLTKKPM KGMLTGPVTILRWSFPRDDISLKDQSLQLALALRDEVNDLEAAGVKVIQVDEPAIREGLPLRAGPEREAYAQWAPLSFRL ATSGVDNDTQIHSHFCYSDLDPVHIKALDADVVSIEFSKKDDNKYIQEFSDYPNHIGLGLFDIHSPRVPPQEEFEARINE ILKVYPKENLWINPDCGLKTRKWDETKKQLTNMVNAAKVYRAKF
GO term prediction
Biological Process
GO:0008652 cellular amino acid biosynthetic process
GO:0009086 methionine biosynthetic process
Molecular Function
GO:0003871 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity
GO:0008270 zinc ion binding
Cellular Component
None predicted.