Protein

MCA_03662_1

Length
767 amino acids

Gene name: MET6

Description: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

Browser: contigC:715757-718061-

RNA-seq: read pairs 40234, FPKM 647.3, percentile rank 95.3% (100% = highest expression)

Protein function

Annotation:MET65-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase
KEGG:K00549metE 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase [EC:2.1.1.14]
EGGNOG:0PHASMET65-methyltetrahydropteroyltriglutamate-homocysteine methyltransferase
SGD closest match:S000000893MET65-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase
CGD closest match:CAL0000186137MET65-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

Protein alignments

%idAln lengthE-value
A0A0J9XHW0_GEOCN86.42%7660.0Similar to Saccharomyces cerevisiae YER091C MET6 Cobalamin-independent methionine synthase OS=Geotrichum candidum GN=BN980_GECA18s00835g PE=3 SV=1
MIA_05258_186.27%7650.0MIA_05258_1
A0A167DWB8_9ASCO83.98%7680.05-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase OS=Sugiyamaella lignohabitans GN=MET6 PE=3 SV=1
A0A060T5U9_BLAAD79.90%7660.0ARAD1C08184p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C08184g PE=3 SV=1
METE_CANAL75.68%7690.05-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=MET6 PE=1 SV=2
METE_YEAST73.08%7690.05-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MET6 PE=1 SV=4
A0A1E3PHL9_9ASCO77.27%7700.05-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_25071 PE=3 SV=1
A0A1E4TE11_9ASCO73.34%7690.0Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_98963 PE=3 SV=1
Q6C638_YARLI74.21%7640.0YALI0E12683p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E12683g PE=3 SV=1
UniRef50_A0A0F4XCC165.55%7750.05-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase n=8 Tax=Dikarya TaxID=451864 RepID=A0A0F4XCC1_HANUV

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.4755
Predicted cleavage: 13

Protein family membership

Domains and repeats

  1. Domain
1 100 200 300 400 500 600 700 767

Detailed signature matches

  1. Family IPR006276
    Cobalamin-independent methionine synthase
    1. MF_00172 (Meth_synth)
    2. TIGR01371
    3. PIRSF000382 (Met_sy...)
  2. Domain IPR013215
    Cobalamin-independent methionine synthase MetE, N-terminal
    1. PF08267 (Meth_synt_1)
  3. Domain IPR002629
    Cobalamin-independent methionine synthase MetE, C-terminal/archaeal
    1. PF01717 (Meth_synt_2)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.20.20...
  2. SSF51726 (UROD/MetE...)
  3. cd03311 (CIMS_C_ter...)
  4. cd03312 (CIMS_N_ter...)

Residue annotation

  1. THF binding site c...
  2. substrate binding ...
  3. THF binding site c...
  4. zinc-binding site ...

Protein sequence

>MCA_03662_1
MVLSSVLGFPRIGAQRELKKATEAYWAGKVSVEDLFKVGKEIRAHNWKLQKDAGVDIIASNDFSYYDQVLDLSLLFNVIP
ERYSKYNLPAIDTLFAMGRGLQRPATDSTPAVDVPALEMVKWFDSNYHYVRPTFSHSTQFKLNGQKPVDEYLEAKELGVE
TRPVLVGPISYLFLGKADKDSLDLDLLSLLPKLLPVYAEILEKLAAAGAKSVQIDEPVLVLDLPEAYQAAYKTAYEFLAS
KSVPEIIIASYFGDVRPNLDAVKGLPVAGFHYDFVRAPEQLDAVAEALTPKQVLSVGIVDGRNIWKTDLNKAIKFVESAK
AKVGAERVIVATSSSLLHTPVDLDNEKKLDPVIKDWFSFATQKLSEVVIIAKAVTNGPESVADALEANAKSIAARASSNI
TVDTTVRERLSSVTDADSNRKAPFSVRLEAQKVLNLPLFPTTTIGSFPQTKEIRVQRNKFTKGEITAEEYEKFIEKEIQD
VVKFQEEIGLDVLVHGEPERNDMVQYFGEKLKGFAFTTNGWVQSYGSRYVRPPIIVGDVSRPAAMTVKESKYAQSITKKP
MKGMLTGPVTILRWSFPRNDISLKDQSLQLSLALRDEVNDLEAAGVKVIQVDEPAIREGLPLRKGAERDAYLKWAPLSFR
LATSGVENDTQIHSHFCYSDLDPAQIKALDADVVSIEFSKKDDPNYIREFSDYPNHIGLGLFDIHSPRVPPKEEFVSRIA
EILKVYPKENLWVNPDCGLKTRKWDETKKQLTNMVEAAKEFRAQYSN

GO term prediction

Biological Process

GO:0008652 cellular amino acid biosynthetic process
GO:0009086 methionine biosynthetic process

Molecular Function

GO:0003871 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity
GO:0008270 zinc ion binding

Cellular Component

None predicted.