Protein
MIA_05247_1
Length
364 amino acids
Browser: contig07:1124423-1125518-
Protein function
| EGGNOG: | 0PFHG | LEU2 | Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate |
|---|---|---|---|
| SGD closest match: | S000000523 | LEU2 | 3-isopropylmalate dehydrogenase |
| CGD closest match: | CAL0000185901 | LEU2 | 3-isopropylmalate dehydrogenase |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| MCA_04741_1 | 91.389% | 360 | 0.0 | MCA_04741_1 |
| A0A0J9XAW1_GEOCN | 88.736% | 364 | 0.0 | 3-isopropylmalate dehydrogenase OS=Geotrichum candidum GN=BN980_GECA07s02881g PE=3 SV=1 |
| LEU3_BLAAD | 81.667% | 360 | 0.0 | 3-isopropylmalate dehydrogenase OS=Blastobotrys adeninivorans GN=LEU2 PE=3 SV=1 |
| A0A167FCG6_9ASCO | 80.663% | 362 | 0.0 | 3-isopropylmalate dehydrogenase OS=Sugiyamaella lignohabitans GN=LEU2 PE=3 SV=1 |
| LEU3_YEAST | 78.729% | 362 | 0.0 | 3-isopropylmalate dehydrogenase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=LEU2 PE=1 SV=4 |
| UniRef50_Q96WT9 | 78.846% | 364 | 0.0 | 3-isopropylmalate dehydrogenase n=31 Tax=saccharomyceta TaxID=716545 RepID=LEU3_SACEX |
| A0A1D8PQK5_CANAL | 72.900% | 369 | 0.0 | 3-isopropylmalate dehydrogenase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=LEU2 PE=3 SV=1 |
| A0A1E3PPA0_9ASCO | 75.138% | 362 | 0.0 | 3-isopropylmalate dehydrogenase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_81723 PE=3 SV=1 |
| A0A1E4TM50_9ASCO | 68.871% | 363 | 1.56e-170 | 3-isopropylmalate dehydrogenase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_93497 PE=3 SV=1 |
| LEU3_YARLI | 68.927% | 354 | 2.38e-160 | 3-isopropylmalate dehydrogenase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=LEU2 PE=3 SV=2 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.0113
Protein family membership
- Isopropylmalate dehydrogenase (IPR004429)
Domains and repeats
-
Domain
1
50
100
150
200
250
300
364
Detailed signature matches
-
-
PS00470 (IDH_IMDH)
-
no IPR
Unintegrated signatures
-
-
SSF53659 (Isocitrat...)
Protein sequence
>MIA_05247_1 MSSDTKTVVVLGGDHVGPECTNEAVKVLKAIAEIRPNIKFDFQEHLIGGAAIDATGNPLPDETLEAAKKADAVLLGAVGG PKWGTGAVRPEQGLLKIRKELNLYANLRPCNFISESLYDLSPLKSEIVKGTDFVIVRELVGGIYFGEREEDNGSGKAWDT EAYSVEEVKRLTRMAAFLALQSNPPLPVWSLDKANVLASSRLWRKTVTETIEKEFPQLTLKHQLIDSAAMIMVKSPSSLN GVLLTTNMFGDILSDEASVIPGSLGLLPSASLASLPDKNTAFGLYEPCHGTAPDLPKNKVNPIATILSAAMMLKLSLNLK EEGEAVEKAARIVLDNGIRTGDLGGKNSTNEVGDAIVAELKKLL
GO term prediction
Biological Process
GO:0009098 leucine biosynthetic process
GO:0055114 oxidation-reduction process
Molecular Function
GO:0000287 magnesium ion binding
GO:0003862 3-isopropylmalate dehydrogenase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0051287 NAD binding
Cellular Component
GO:0005737 cytoplasm