MIA_05240_1

Protein

Length

1,500 amino acids

Protein function

EGGNOG:	0PFJT	VPS10	Functions as a sorting receptor in the Golgi compartment required for the intracellular sorting and delivery of soluble vacuolar proteins, like carboxypeptidase Y (CPY) and proteinase A. Executes multiple rounds of sorting by cycling between the late Golgi and a prevacuolar endosome-like compartment
SGD closest match:	S000000113	PEP1	Vacuolar protein sorting/targeting protein VPS10
CGD closest match:	CAL0000201763	PEP1	Sortilin

Protein alignments

	%id	Aln length
MCA_04797_1	67.159%	1489	MCA_04797_1
A0A0J9X8L5_GEOCN	58.530%	1483	Sortilin OS=Geotrichum candidum GN=BN980_GECA05s02716g PE=4 SV=1
UniRef50_A0A0J9X8L5	58.530%	1483	Sortilin n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9X8L5_GEOCN
A0A1E3PEG5_9ASCO	48.909%	1421	Sortilin OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_84442 PE=4 SV=1
A0A060TCB1_BLAAD	46.528%	1440	Sortilin OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B22352g PE=4 SV=1
A0A1E4TGV0_9ASCO	42.666%	1418	Sortilin OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_113925 PE=4 SV=1
Q6C6Y6_YARLI	51.743%	717	Sortilin OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E05247g PE=4 SV=1
A0A1D8PFH5_CANAL	36.825%	1222	Sortilin OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=PEP1 PE=4 SV=1
A0A167DIS0_9ASCO	65.265%	452	Sortilin OS=Sugiyamaella lignohabitans GN=PEP1 PE=4 SV=1
VPS10_YEAST	31.419%	1480	Vacuolar protein sorting/targeting protein VPS10 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PEP1 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0906
Predicted cleavage: 12

Protein family membership

None predicted.

Domains and repeats

Domain
38 - 408
WD40/YVTN repeat-like-containing domain (IPR015943)
409 - 671
WD40/YVTN repeat-like-containing domain (IPR015943)
723 - 1,091
WD40/YVTN repeat-like-containing domain (IPR015943)
1,092 - 1,234
WD40/YVTN repeat-like-containing domain (IPR015943)
Domain
47 - 681
VPS10 (IPR006581)
730 - 1,365
VPS10 (IPR006581)
Domain
59 - 502
Sortilin, N-terminal (IPR031778)
508 - 676
Sortilin, C-terminal (IPR031777)
739 - 1,188
Sortilin, N-terminal (IPR031778)
1,190 - 1,360
Sortilin, C-terminal (IPR031777)

1 200 400 600 800 1000 1200 1400 1500

Detailed signature matches

IPR015943

WD40/YVTN repeat-like-containing domain
1. G3DSA:2.130.1...
  
  723 - 1,091
  
  GENE3D
  G3DSA:2.130.10.10 (G3DSA:2.130.10.10)
  
  409 - 671
  
  GENE3D
  G3DSA:2.130.10.10 (G3DSA:2.130.10.10)
  
  38 - 408
  
  GENE3D
  G3DSA:2.130.10.10 (G3DSA:2.130.10.10)
  
  1,092 - 1,234
  
  GENE3D
  G3DSA:2.130.10.10 (G3DSA:2.130.10.10)
IPR006581

VPS10
1. SM00602 (vps10)
  
  47 - 681
  
  SMART
  SM00602 (vps10)
  
  730 - 1,365
  
  SMART
  SM00602 (vps10)
IPR031778

Sortilin, N-terminal
1. PF15902 (Sortilin-V...)
  
  739 - 1,188
  
  Pfam
  PF15902 (Sortilin-Vps10)
  
  59 - 502
  
  Pfam
  PF15902 (Sortilin-Vps10)
IPR031777

Sortilin, C-terminal
1. PF15901 (Sortilin_C)
  
  1,190 - 1,360
  
  Pfam
  PF15901 (Sortilin_C)
  
  508 - 676
  
  Pfam
  PF15901 (Sortilin_C)

no IPR

Unintegrated signatures

CYTOPLASMIC_D... (C...)

1,399 - 1,418

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)
NON_CYTOPLASM... (N...)

1,443 - 1,500

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

25 - 1,376

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)
SIGNAL_PEPTIDE (Sig...)

1 - 24

PHOBIUS
SIGNAL_PEPTIDE (Signal Peptide)
SIGNAL_PEPTID... (S...)

20 - 24

PHOBIUS
SIGNAL_PEPTIDE_C_REGION (Signal peptide C-region)
SIGNAL_PEPTID... (S...)

8 - 19

PHOBIUS
SIGNAL_PEPTIDE_H_REGION (Signal peptide H-region)
SIGNAL_PEPTID... (S...)

1 - 7

PHOBIUS
SIGNAL_PEPTIDE_N_REGION (Signal peptide N-region)
SSF110296 (Oligoxyl...)

365 - 499

SUPERFAMILY
SSF110296 (Oligoxyloglucan reducing end-specific cellobiohydrolase)

38 - 201

SUPERFAMILY
SSF110296 (Oligoxyloglucan reducing end-specific cellobiohydrolase)

1,036 - 1,206

SUPERFAMILY
SSF110296 (Oligoxyloglucan reducing end-specific cellobiohydrolase)

730 - 884

SUPERFAMILY
SSF110296 (Oligoxyloglucan reducing end-specific cellobiohydrolase)
SignalP-noTM

1 - 24

SignalP euk
SignalP-noTM (SignalP-noTM)
TMhelix

1,376 - 1,398

TMHMM
TMhelix (TMhelix)

1,419 - 1,438

TMHMM
TMhelix (TMhelix)
TRANSMEMBRANE (Tran...)

1,419 - 1,442

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

1,377 - 1,398

PHOBIUS
TRANSMEMBRANE (Transmembrane region)
cd15482 (Sialidase_...)

1,123 - 1,232

CDD
cd15482 (Sialidase_non-viral)
mobidb-lite (disord...)

679 - 700

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

catalytic site cd1...

1,147Q

catalytic site
1,147Q, 1,157R, 1,211E
CDD
cd15482 (Sialidase_non-viral)

1,157R

catalytic site
1,147Q, 1,157R, 1,211E
CDD
cd15482 (Sialidase_non-viral)

1,211E

catalytic site
1,147Q, 1,157R, 1,211E
CDD
cd15482 (Sialidase_non-viral)

Protein sequence

>MIA_05240_1
MRFLPSPLLVGVLAAFSLGSKVLALPEITKSLFDSAPSTFVYFEDSPNLLYLDEEGSQLRKSRDDGKSWTNVDLGNSDPI
TSIVTHPSDKNRAYVVTSGKTHYGTKDRGDSWFTIEAPLRPSPQGYTFLFHGSKPDFVLYAGIDCSDDSFYEGKCLTKYS
YTTDNFANPPKSLTAAHQCLFLQANKYFTAGNENTIVCSVNSELEPNNNLPSNRRVVLSSDWFKTREYARLDGENIRGVV
GLGVASKFLVASAKHKSNKYVSLLVSLDGKIWDEAEFLDHDSSFTEFSITILESSTHSLHVDVLKDGSDISGDFYISNSN
GTYFTKSLEHTYRNSRGFVDFEKLENVDGILIANVVSNYDEAKNTGKVSLRTKISYDDGRTWSYLSVDDSQCKGDESCGL
NLHSISDKTNVGRIFSSPAPGVIAGIGNTGTSLADYEDGDMYVSHDSGLTWIRSRSDAHMYEFGDSGNVMVAINDEGSSN
TMSYSLDRGISWKDFSLGTDFKPKYLFTTQDSTSLQFVLMGRPSDNKQKFAVYSIDFEGIFTRQCELKEDGTADFEKWYA
RWEDRVNPSCIMGHKQYFWRKKTEAQCYVGNKYNEQTALEETCVCTRADFECDYNFIRRSDGACVPTDAFTEDKGLCPDG
KSKTYTGKSGYVLIPGNNCVRTDGGITIDKPVLKNCDGTLADPNANNGNDDDSEHSDPNFRGVRSKLTDFSGKILDYVYL
KADESFLSDETVLLRTDENKVFVSHNHGFKWEQVSTDKEIISIYTNPYFPNQCYLITTAEEVIYSTDRGHTWKSFRTPAQ
RNNMGTPYLTFSEKNANWIIWTGEIGCENPFSPTCHTAAYYSRSGGERWNLLQENVRRCLFANGLEASESDRRIFCERLY
TSQDGHIKNKLLTTTDFFETYETPFTDIIGFALEHEFLVVATVKEDGESLNAFVSVDGKNYAEVRFPSNFKIGKQQAYTI
LESITHSIFLHVTTSSRAGSEFGTILKSNSNGTDYISSLDLVNRNEEGFVDFEKMIGLEGVAIVNVVENPEEAFQGSRKK
LKTKITHNDGGEWAYIRPPIYDSEGNRYKCPGSSLNRCSLNVHGYTERVDYRDTFSSGSAVGMMLAVGNVGEYLTPLHDG
NTFFTKDGGITWKEIKKGAYMWEFGDQGSVIVIVNGRDNTNVIYYTLDEGTTWQEYKFSEDLVRVEDIVTVPSDSSLKFL
LIGRPPLSRGERSLTIQLDFSKIFSRNCVLDENNPNNDDFDLWTPSHPFQADNCLFGHETQYYRKVTGRDCYIGRSLLKP
FQDVRNCTCGRQDYECDFNYDRGVDGACHLVSGYTPPDHSLICTEMPGTIEYWIPTGYRRIPLSTCEGGREFDKVEAKPC
PGREKEFEKKHRGLHGFGLFLVIVLPIGMTAVIGYIMWDHFSKRYGQIRLGEEEDHQNVFINAFVVSVAAVIAVVSVVPE
FFRSLVRTVQNKFKRSRRFTSRRSLARGNDYSVVAAAEDELLGDDESDIGLDDDEQHHNP

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0005515 protein binding

Cellular Component

GO:0016021 integral component of membrane

Filter view on

Entry type

Status

Per-residue features