MCA_04797_1

Protein

Length

1,523 amino acids

RNA-seq: read pairs 2949, FPKM 23.9, percentile rank 46.3% (100% = highest expression)

Protein function

EGGNOG:	0PFJT	VPS10	Functions as a sorting receptor in the Golgi compartment required for the intracellular sorting and delivery of soluble vacuolar proteins, like carboxypeptidase Y (CPY) and proteinase A. Executes multiple rounds of sorting by cycling between the late Golgi and a prevacuolar endosome-like compartment
SGD closest match:	S000000113	PEP1	Vacuolar protein sorting/targeting protein VPS10
CGD closest match:	CAL0000201763	PEP1	Sortilin

Protein alignments

	%id	Aln length
MIA_05240_1	67.16%	1489	MIA_05240_1
A0A0J9X8L5_GEOCN	59.24%	1499	Sortilin OS=Geotrichum candidum GN=BN980_GECA05s02716g PE=4 SV=1
UniRef50_A0A0J9X8L5	59.24%	1499	Sortilin n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9X8L5_GEOCN
A0A1E3PEG5_9ASCO	47.73%	1473	Sortilin OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_84442 PE=4 SV=1
A0A060TCB1_BLAAD	46.27%	1461	Sortilin OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B22352g PE=4 SV=1
A0A1E4TGV0_9ASCO	40.85%	1481	Sortilin OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_113925 PE=4 SV=1
Q6C6Y6_YARLI	51.94%	720	Sortilin OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E05247g PE=4 SV=1
A0A1D8PFH5_CANAL	37.40%	1214	Sortilin OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=PEP1 PE=4 SV=1
VPS10_YEAST	32.84%	1489	Vacuolar protein sorting/targeting protein VPS10 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PEP1 PE=1 SV=1
A0A167DIS0_9ASCO	63.16%	513	Sortilin OS=Sugiyamaella lignohabitans GN=PEP1 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.1640
Predicted cleavage: 12

Protein family membership

None predicted.

Domains and repeats

Domain
27 - 574
WD40/YVTN repeat-like-containing domain (IPR015943)
736 - 1,107
WD40/YVTN repeat-like-containing domain (IPR015943)
1,108 - 1,244
WD40/YVTN repeat-like-containing domain (IPR015943)
Domain
52 - 688
VPS10 (IPR006581)
741 - 1,376
VPS10 (IPR006581)
Domain
63 - 511
Sortilin, N-terminal (IPR031778)
515 - 683
Sortilin, C-terminal (IPR031777)
751 - 1,199
Sortilin, N-terminal (IPR031778)
1,201 - 1,371
Sortilin, C-terminal (IPR031777)

1 200 400 600 800 1000 1200 1400 1523

Detailed signature matches

IPR015943

WD40/YVTN repeat-like-containing domain
1. G3DSA:2.130.1...
  
  27 - 574
  
  GENE3D
  G3DSA:2.130.10.10 (G3DSA:2.130.10.10)
  
  736 - 1,107
  
  GENE3D
  G3DSA:2.130.10.10 (G3DSA:2.130.10.10)
  
  1,108 - 1,244
  
  GENE3D
  G3DSA:2.130.10.10 (G3DSA:2.130.10.10)
IPR006581

VPS10
1. SM00602 (vps10)
  
  52 - 688
  
  SMART
  SM00602 (vps10)
  
  741 - 1,376
  
  SMART
  SM00602 (vps10)
IPR031778

Sortilin, N-terminal
1. PF15902 (Sortilin-V...)
  
  63 - 511
  
  Pfam
  PF15902 (Sortilin-Vps10)
  
  751 - 1,199
  
  Pfam
  PF15902 (Sortilin-Vps10)
IPR031777

Sortilin, C-terminal
1. PF15901 (Sortilin_C)
  
  1,201 - 1,371
  
  Pfam
  PF15901 (Sortilin_C)
  
  515 - 683
  
  Pfam
  PF15901 (Sortilin_C)

no IPR

Unintegrated signatures

CYTOPLASMIC_D... (C...)

1,410 - 1,429

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)
NON_CYTOPLASM... (N...)

29 - 1,387

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

1,454 - 1,523

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)
SIGNAL_PEPTIDE (Sig...)

1 - 28

PHOBIUS
SIGNAL_PEPTIDE (Signal Peptide)
SIGNAL_PEPTID... (S...)

21 - 28

PHOBIUS
SIGNAL_PEPTIDE_C_REGION (Signal peptide C-region)
SIGNAL_PEPTID... (S...)

9 - 20

PHOBIUS
SIGNAL_PEPTIDE_H_REGION (Signal peptide H-region)
SIGNAL_PEPTID... (S...)

1 - 8

PHOBIUS
SIGNAL_PEPTIDE_N_REGION (Signal peptide N-region)
SSF110296 (Oligoxyl...)

360 - 509

SUPERFAMILY
SSF110296 (Oligoxyloglucan reducing end-specific cellobiohydrolase)

54 - 191

SUPERFAMILY
SSF110296 (Oligoxyloglucan reducing end-specific cellobiohydrolase)

1,047 - 1,216

SUPERFAMILY
SSF110296 (Oligoxyloglucan reducing end-specific cellobiohydrolase)

739 - 932

SUPERFAMILY
SSF110296 (Oligoxyloglucan reducing end-specific cellobiohydrolase)
SignalP-noTM

1 - 28

SignalP euk
SignalP-noTM (SignalP-noTM)
TMhelix

1,387 - 1,409

TMHMM
TMhelix (TMhelix)

1,430 - 1,452

TMHMM
TMhelix (TMhelix)
TRANSMEMBRANE (Tran...)

1,430 - 1,453

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

1,388 - 1,409

PHOBIUS
TRANSMEMBRANE (Transmembrane region)
cd15482 (Sialidase_...)

355 - 499

CDD
cd15482 (Sialidase_non-viral)

1,134 - 1,194

CDD
cd15482 (Sialidase_non-viral)
mobidb-lite (disord...)

689 - 711

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

catalytic site cd1...

481Q

catalytic site
481Q
CDD
cd15482 (Sialidase_non-viral)
catalytic site cd1...

1,158Q

catalytic site
1,158Q
CDD
cd15482 (Sialidase_non-viral)

Protein sequence

>MCA_04797_1
MRWLSFSSGASLFTAALTVLSSIPSTHAFAPAIEKSNFDSSPKNFIYFEDSNILIYIEEDGKTVSRSTDDGRSWKKIDVK
LDSPVEHIIAHPTDFQRAYLLTTGKTHYYTKDRGIHWNKISVDLPPVPLASAFVLHAHNPDYVLYAGLDCPSSDYIDGSC
VPRYYYTTDSFKTAPKPLISSHQCIFAQSTKEFTEGDERAIVCSVNSEAEPKDNRPVNRRLLYSTDFFTNKEFLMLDGMN
IRGIVGLGVTSKFMVASARHRNDDHVSFLVSLDGRTWDEAEFSERGDAPMTEYSVTVLESSKHSLHVDVLKEKDDLAGDF
YVSNSNGTYFRKSLEHTHRNKMGFVDIEKLENVEGILIANVISNYDEYSRTAGEKNVRTVISYDDGRHWKYLSVDDSKCK
GDESCGLNLHSVLDKSNVGRIFSSPAPGVIAGIGNLGTKLKDYEDGDMFVSHDSGLTWVKSKSDAHKYEFGDSGNVMVAI
QDEGVVNKMSYSVDRGLTWNDFDLGVDIRAKYLFTTQDSTSMNFVLIGKPSSSKDKTMVIAIDFDGLYKQQCKLKEDGSG
DYEKWYARWEDRSNPSCIMGHKQYFWRKKLDAKCFVGNVFNEQKALEEICECSEDDFECDYNYFRTSEGFCVPSPALVED
KSACDSNPEGTYEGVSGFRLIPGNNCKKVPNGVDLEKKVMKSCVDGSIVKSAQPPKSDKPKNTEDDKKPASKEVANKLTE
FNGKIIDYFYLKAEKPEEADETIILRTDSNQVFISHDHGGKWERIFEDKEIIAIYANPYFPNACYLITTKEEVVFTLDRG
HNWKSFRTPAKRNNAGIPYITFSKKFVNWFIWTGEIGCENPFSATCHTVAYYTKSHGERWNKLQENVKRCVYVNELEEAK
SERIIYCERVYTDSQGKVKNMLVSSYDFFNTQKVLFDDIIGFALEHEFAVVATLAENAESLTAYVSVDAENFSQVRFPLN
YQIGKQQAYTILESITHSIFLHLTTSARPGSEYGTILKSNSNGTDYISSLDYVNRNQQGYVDFEKVIGLEGVAIVNTVEN
PNEAFEGSKKKLKSRITHNDGGEWSYIFPPLKDSEGNKYKCPGASLNKCSLNLHGYTERLDYRDTFSSQSAVGMMLAVGN
VGQYLTPLHDGNTFFTKDGGITWKEVKKGFYMWEFGDQGSIIVIVNGKDNTNVVHYSLDEGDTWTEYKFSEELVRIEDIA
TVPSDSSRKFLLIGRPRLSRGEKSITIQLDFSGMFERQCELSLTDPDHDDFELWTPSHPFQQDNCLFGHETQYYRKIKGR
DCYIGRSLLKPYEIIRNCSCTRRDYECDFNYERGSDGACRLVPGYSPPDHSSICKEMPGTIEYWEPTGYRKIPLSTCEGG
QTLDKIEAKPCPGKEKEFNQKHRGLHGFGLFMVIVLPIGMAGVIGYIMWDHFSKRYGQIRLGEDDEDQNVIVRSLVISVA
AVIAVLSVIPDFFQSAYRTIKSKFKRSRRFTTRGSLSRGRNDYSIVAAAEDELLGPDDEDIGLDEDDEISASMSDAEEIE
INP

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0005515 protein binding

Cellular Component

GO:0016021 integral component of membrane

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Entry type

Status

Per-residue features