Protein

MIA_05169_1

Length
338 amino acids

Browser: contig07:909161-910178+

Protein function

EGGNOG:0PI3ZPGUG_00020Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity)
SGD closest match:S000002303YDL144CUncharacterized protein YDL144C
CGD closest match:CAL0000195493orf19.2446Uncharacterized protein

Protein alignments

%idAln lengthE-value
MCA_03784_152.439%3289.31e-118MCA_03784_1
A0A0J9X5C9_GEOCN42.587%3172.96e-852-dehydropantoate 2-reductase OS=Geotrichum candidum GN=BN980_GECA03s04278g PE=3 SV=1
UniRef50_A0A0J9X5C942.587%3176.05e-822-dehydropantoate 2-reductase n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9X5C9_GEOCN
A0A060TD36_BLAAD38.973%3312.97e-712-dehydropantoate 2-reductase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D04070g PE=3 SV=1
A0A1E3PDX5_9ASCO36.522%3454.26e-616-phosphogluconate dehydrogenase C-terminal domain-like protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_44328 PE=4 SV=1
A0A167C5M4_9ASCO27.859%3411.38e-35Uncharacterized protein OS=Sugiyamaella lignohabitans GN=AWJ20_4049 PE=4 SV=1
Q5AA38_CANAL28.363%3422.78e-31Uncharacterized protein OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.2446 PE=4 SV=1
Q6C092_YARLI28.909%3395.86e-312-dehydropantoate 2-reductase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F26719g PE=3 SV=1
YD144_YEAST24.217%3513.38e-23Uncharacterized protein YDL144C OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YDL144C PE=1 SV=2

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0313

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 50 100 150 200 250 300 338

Detailed signature matches

  1. Family IPR003710
    Ketopantoate reductase ApbA/PanE
    1. TIGR00745
  2. Domain IPR016040
    NAD(P)-binding domain
    1. SSF51735 (NAD(P)-bi...)
  3. Domain IPR013332
    Ketopantoate reductase, N-terminal domain
    1. PF02558 (ApbA)
  4. Domain IPR013752
    Ketopantoate reductase, C-terminal domain
    1. PF08546 (ApbA_C)
  5. Domain IPR008927
    6-phosphogluconate dehydrogenase C-terminal domain-like
    1. SSF48179 (6-phospho...)
  6. Domain IPR013328
    6-phosphogluconate dehydrogenase, domain 2
    1. G3DSA:1.10.10...
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.40.50...
  2. NON_CYTOPLASM... (N...)
  3. SIGNAL_PEPTIDE (Sig...)
  4. SIGNAL_PEPTID... (S...)
  5. SIGNAL_PEPTID... (S...)
  6. SIGNAL_PEPTID... (S...)

Protein sequence

>MIA_05169_1
MSSESPIRVLLVGAGAVGLIYASYLDCHSNVEVTVLARSNFSAIKSQGAEIKVLSDPPVITTYKPYNVIEWNENTLQSFD
NKNAFDYVIIATKSLGKEALQGLQNFMSPEKTLLILFQNGVEIERPYLDAYPGIPLGSAVVRVAASADGLRKAEMYPGGM
RVIAGLVNEYAGQPILEEKLKQLMDLSLDGGIEKFVLSPNIDASRWEKMLWNGTFNMLASIMDLNTGELLDAGLEGTIRQ
MMTEIWQIAHAILGPDSKDWPPVSKVDELMAWTRTAVPATFVPSTLQDVRKGNQIEIEAIMGNTIRAAEREGVNVPTLSI
IYQLLNAVNYRLKLKASS

GO term prediction

Biological Process

GO:0015940 pantothenate biosynthetic process
GO:0055114 oxidation-reduction process

Molecular Function

GO:0008677 2-dehydropantoate 2-reductase activity
GO:0016491 oxidoreductase activity
GO:0050661 NADP binding

Cellular Component

GO:0005737 cytoplasm