Protein

MIA_05167_1

Length
762 amino acids

Browser: contig07:905251-907540+

Protein function

EGGNOG:0PHNUTOP1Topoisomerase I
SGD closest match:S000005366TOP1DNA topoisomerase 1
CGD closest match:CAL0000177495TOP1DNA topoisomerase 1

Protein alignments

%idAln lengthE-value
MCA_05802_175.463%6480.0MCA_05802_1
A0A0J9XHU2_GEOCN70.525%6480.0Similar to Saccharomyces cerevisiae YOL006C TOP1 Topoisomerase I OS=Geotrichum candidum GN=BN980_GECA17s01759g PE=4 SV=1
A0A1E3PTY7_9ASCO64.670%6510.0Putative DNA topoisomerase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_48946 PE=4 SV=1
A0A167C2J8_9ASCO63.889%6480.0DNA topoisomerase 1 OS=Sugiyamaella lignohabitans GN=TOP1 PE=4 SV=1
Q6C7R2_YARLI63.580%6480.0YALI0D26103p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D26103g PE=4 SV=1
UniRef50_Q6C7R263.580%6480.0YALI0D26103p n=36 Tax=Eukaryota TaxID=2759 RepID=Q6C7R2_YARLI
TOP1_YEAST60.094%6390.0DNA topoisomerase 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TOP1 PE=1 SV=2
A0A060T5Z3_BLAAD59.133%6460.0ARAD1B06952p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B06952g PE=4 SV=1
A0A1D8PPI2_CANAL60.000%6500.0DNA topoisomerase 1 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=TOP1 PE=4 SV=1
A0A1E4TDV2_9ASCO38.346%6652.71e-155Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_31028 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0679

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
  3. Domain
  4. Domain
1 100 200 300 400 500 600 700 762

Detailed signature matches

  1. Family IPR001631
    DNA topoisomerase I
    1. PR00416 (EUTPISMRASEI)
  2. Domain IPR008336
    DNA topoisomerase I, DNA binding, eukaryotic-type
    1. SSF56741 (Eukaryoti...)
    2. PF02919 (Topoisom_I_N)
  3. Domain IPR013034
    DNA topoisomerase I, domain 1
    1. G3DSA:1.10.10.41
  4. Domain IPR013030
    DNA topoisomerase I, DNA binding, mixed alpha/beta motif, eukaryotic-type
    1. G3DSA:2.170.1...
  5. Domain IPR013499
    DNA topoisomerase I, eukaryotic-type
    1. SM00435 (topeu)
  6. Domain IPR014711
    DNA topoisomerase I, catalytic core, alpha-helical subdomain, eukaryotic-type
    1. G3DSA:3.90.15.10
  7. Domain IPR011010
    DNA breaking-rejoining enzyme, catalytic core
    1. SSF56349 (DNA break...)
  8. Domain IPR013500
    DNA topoisomerase I, catalytic core, eukaryotic-type
    1. cd00659 (Topo_IB_C)
    2. PF01028 (Topoisom_I)
  9. Domain IPR014727
    DNA topoisomerase I, catalytic core, alpha/beta subdomain
    1. G3DSA:1.10.13...
  10. Domain IPR025834
    Topoisomerase I C-terminal domain
    1. PF14370 (Topo_C_assoc)
  11. SITE IPR018521
    DNA topoisomerase I, active site
    1. PS00176 (TOPOISOMER...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. Coil
  2. cd03488 (Topoisomer...)
  3. mobidb-lite (disord...)

Residue annotation

  1. DNA binding cd03488
  2. topo1 poison bindi...
  3. DNA binding site c...
  4. active site cd00659

Protein sequence

>MIA_05167_1
MSVTVKSEPQMALIDVKGASAPPTETKKRKSTPATNGKSKKVKTENGDEKSVSAKKKTTPKPKKEATNGKAKTAVSVKKN
TPKKKASPKAASTLKKEQSEDLDDDREEEEEEEEYKWWEQSEGTDNSIKWTTLSHNGVLFPPEYIPLPKNIHLIYDGKPV
SLPVEAEEVAGFFGAMVETDHAKNPVFQKNFFNDFITVLKETKQPALEKQNKTPVDIKSFEKCDFSVMHNYFSAEREKKR
NLPSSEKKRIKAERDELEAPYKFAYLDGRKEALGNFRIEPPGLFRGRGAHPKTGKLKRRVRPEDITINIGKEAKIPEPPS
GHKWAEVKHDNTVAWLATWRENINGATKYVMLAATSSLKGMSDFKKFEKARELKNHIDRIRKDYLKELKDPTMLARQRAT
ATYLIDVLALRAGGEKGEDEADTVGCCSLRYEHVSLKPPNIVVFDFLGKDSVPYHNEMEVTPQVFKNLKIFKKTPKTTGD
QIFDRLDPSILNKHLQNYMPGLTAKVFRTFNATHTMQQQLDLIPNQGTVAEKIVAYNSANRQVAILCNHQKAVGKTHETT
IEKIEDKIKEYKWKRTILKKTMVAIDPNIKKKRKAYFEDMTEFTKPELVEIVKKFYDREKERWTKKFERMFERQKIEKVP
AEDKVYQKDLKEKISGIKEQEKAALADVRCQKIEPKASQTIEKLEAQVAKLDEQIKNTQLNLQDKEDNSQVALGTSKLNY
IDPRLTVMFSKKYDVPIERLFGKSMREKFKWAIESADENWRF

GO term prediction

Biological Process

GO:0006265 DNA topological change

Molecular Function

GO:0003677 DNA binding
GO:0003917 DNA topoisomerase type I activity

Cellular Component

GO:0005694 chromosome