Protein
MCA_05802_1
Length
754 amino acids
Gene name: TOP1
Description: DNA topoisomerase 1
Browser: contigD:2377198-2379668+
RNA-seq: read pairs 1423, FPKM 23.3, percentile rank 45.5% (100% = highest expression)
Protein function
| Annotation: | TOP1 | DNA topoisomerase 1 | |
|---|---|---|---|
| KEGG: | K03163 | TOP1 | DNA topoisomerase I [EC:5.99.1.2] |
| EGGNOG: | 0PHNU | TOP1 | Topoisomerase I |
| SGD closest match: | S000005366 | TOP1 | DNA topoisomerase 1 |
| CGD closest match: | CAL0000177495 | TOP1 | DNA topoisomerase 1 |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| MIA_05167_1 | 71.69% | 703 | 0.0 | MIA_05167_1 |
| A0A0J9XHU2_GEOCN | 67.79% | 680 | 0.0 | Similar to Saccharomyces cerevisiae YOL006C TOP1 Topoisomerase I OS=Geotrichum candidum GN=BN980_GECA17s01759g PE=4 SV=1 |
| Q6C7R2_YARLI | 62.48% | 669 | 0.0 | YALI0D26103p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D26103g PE=4 SV=1 |
| UniRef50_Q6C7R2 | 62.48% | 669 | 0.0 | YALI0D26103p n=36 Tax=Eukaryota TaxID=2759 RepID=Q6C7R2_YARLI |
| A0A1E3PTY7_9ASCO | 60.39% | 712 | 0.0 | Putative DNA topoisomerase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_48946 PE=4 SV=1 |
| A0A167C2J8_9ASCO | 59.35% | 706 | 0.0 | DNA topoisomerase 1 OS=Sugiyamaella lignohabitans GN=TOP1 PE=4 SV=1 |
| TOP1_YEAST | 58.91% | 645 | 0.0 | DNA topoisomerase 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TOP1 PE=1 SV=2 |
| A0A1D8PPI2_CANAL | 57.97% | 690 | 0.0 | DNA topoisomerase 1 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=TOP1 PE=4 SV=1 |
| A0A060T5Z3_BLAAD | 57.81% | 647 | 0.0 | ARAD1B06952p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B06952g PE=4 SV=1 |
| A0A1E4TDV2_9ASCO | 45.88% | 425 | 5e-123 | Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_31028 PE=4 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.2917
Protein family membership
- DNA topoisomerase I (IPR001631)
Domains and repeats
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Domain
-
Domain
-
Domain
-
Domain
1
100
200
300
400
500
600
700
754
Detailed signature matches
no IPR
Unintegrated signatures
-
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cd03488 (Topoisomer...)
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mobidb-lite (disord...)
Residue annotation
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DNA binding cd03488
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topo1 poison bindi...
-
DNA binding site c...
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active site cd00659
Protein sequence
>MCA_05802_1 MTEQITVSEKTVSALPKTRKTKTTPQKRKSSTASSTPAKKKAKTETPKSTKSTNGKKNGVAIKKDPDSKATPTKKPANSA EANGTTVAVKTEVKKEESEGPYDDEEDYKWWEQINEDDSIKWNTLEHNGVLFPPDYEPLPKNVHLIYDKKPIKLPLEAEE VAGFFGAMIETDHAKNPVFQKNFFNDFLAVLKETGEPAIDKNTNQPVEIKEFEKCDFSVMYKHFQALREQRRNLPTSEKK RLKAERDQIEAPYKEAILNGRKEMVGNFRIEPPGLFRGRGAHPKTGKLKRRVRPEDITINIGKEAKVPEPPAGHKWAKVQ HDNTVAWLATWRENINGNTKYVMLAANSSLKGKSDFTKFEKARKLKDYIEKIREDYRKELKDKVMLNRQRATATYLIDKL ALRAGGEKGEDEADTVGCCSLRYEHVSLKPPNIVVFDFLGKDSVPYHNEQEVDEQVFKNLKIFKKPPKGPGDQIFDRLDP TILNRHLQNYMPGLTAKVFRTYNATYTMQQQIDKIPNTGTIAEKVVKYNAANREVAILCNHQKAVGRTHESTIEKIEDRI KTLKWKRIIAQRKLVSLDSSLKKKRKDLFVGMTEFNQKDLVAIVNQHFASEIERTTKRFERLLEMQKIEKVEPEKKVTKK DMNEKIQLLKQQRKDAIEEAKKKVYEGNVGTTAEKLIVQIEKLTEQIGNTILNKQDKEANSNVALGTSKLNYIDPRLTVM FSKKYGVPLDKLFGKSMREKFKWAIESADENWRF
GO term prediction
Biological Process
GO:0006265 DNA topological change
Molecular Function
GO:0003677 DNA binding
GO:0003917 DNA topoisomerase type I activity
Cellular Component
GO:0005694 chromosome