MIA_05161_1

Protein

Length

466 amino acids

Protein function

EGGNOG:	0PHD8	ARG4	argininosuccinate lyase
SGD closest match:	S000001060	ARG4	Argininosuccinate lyase
CGD closest match:	CAL0000190527	ARG4	Argininosuccinate lyase

Protein alignments

	%id	Aln length
MCA_05797_1	89.224%	464	MCA_05797_1
A0A0J9XHU7_GEOCN	85.683%	461	Similar to Saccharomyces cerevisiae YHR018C ARG4 Argininosuccinate lyase, catalyzes the final step in the arginine biosynthesis pathway OS=Geotrichum candidum GN=BN980_GECA17s01814g PE=3 SV=1
A0A167C5K1_9ASCO	81.481%	459	Argininosuccinate lyase ARG4 OS=Sugiyamaella lignohabitans GN=ARG4 PE=3 SV=1
Q6C7P9_YARLI	78.186%	463	YALI0D26367p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D26367g PE=3 SV=1
A0A060T606_BLAAD	78.492%	451	ARAD1B07062p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B07062g PE=3 SV=1
A0A1E3PJG0_9ASCO	75.435%	460	Argininosuccinate lyase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_42754 PE=3 SV=1
Q59R31_CANAL	73.261%	460	Argininosuccinate lyase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=ARG4 PE=3 SV=1
A0A1E4TID6_9ASCO	71.739%	460	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_71770 PE=3 SV=1
ARLY_YEAST	72.149%	456	Argininosuccinate lyase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ARG4 PE=1 SV=2
UniRef50_S8ALK6	65.870%	460	Uncharacterized protein n=1 Tax=Dactylellina haptotyla (strain CBS 200.50) TaxID=1284197 RepID=S8ALK6_DACHA

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.1555

Protein family membership

Fumarate lyase family (IPR000362)
- Argininosuccinate lyase (IPR009049)

Domains and repeats

Domain
11 - 310
Fumarase/histidase, N-terminal (IPR024083)
Fumarate lyase, N-terminal (IPR022761)
373 - 441
Argininosuccinate lyase, C-terminal (IPR029419)
Domain
15 - 465
L-Aspartase-like (IPR008948)

1 50 100 150 200 250 300 350 400 466

Detailed signature matches

IPR000362

Fumarate lyase family
1. PR00149 (FUMRATELYASE)
  
  241 - 268
  
  PRINTS
  PR00149 (FUMRATELYASE)
  
  112 - 130
  
  PRINTS
  PR00149 (FUMRATELYASE)
  
  157 - 175
  
  PRINTS
  PR00149 (FUMRATELYASE)
  
  285 - 301
  
  PRINTS
  PR00149 (FUMRATELYASE)
IPR009049

Argininosuccinate lyase
1. cd01359 (Argininosu...)
  
  31 - 465
  
  CDD
  cd01359 (Argininosuccinate_lyase)
2. TIGR00838
  
  12 - 463
  
  TIGRFAMs
  TIGR00838 (TIGR00838)
3. MF_00006 (Arg_succ_...)
  
  11 - 463
  
  HAMAP
  MF_00006 (Arg_succ_lyase)
IPR024083

Fumarase/histidase, N-terminal
1. G3DSA:1.10.27...
  
  11 - 116
  
  GENE3D
  G3DSA:1.10.275.10 (G3DSA:1.10.275.10)
IPR022761

Fumarate lyase, N-terminal
1. PF00206 (Lyase_1)
  
  15 - 310
  
  Pfam
  PF00206 (Lyase_1)
IPR008948

L-Aspartase-like
1. SSF48557 (L-asparta...)
  
  15 - 465
  
  SUPERFAMILY
  SSF48557 (L-aspartase-like)
IPR029419

Argininosuccinate lyase, C-terminal
1. PF14698 (ASL_C2)
  
  373 - 441
  
  Pfam
  PF14698 (ASL_C2)
IPR020557

Fumarate lyase, conserved site
1. PS00163 (FUMARATE_L...)
  
  285 - 294
  
  PROSITE patterns
  PS00163 (FUMARATE_LYASES)

no IPR

Unintegrated signatures

G3DSA:1.10.40.30

383 - 442

GENE3D
G3DSA:1.10.40.30 (G3DSA:1.10.40.30)
G3DSA:1.20.20...

117 - 382

GENE3D
G3DSA:1.20.200.10 (G3DSA:1.20.200.10)
PR00145 (ARGSUCLYASE)

111 - 133

PRINTS
PR00145 (ARGSUCLYASE)

320 - 339

PRINTS
PR00145 (ARGSUCLYASE)

152 - 172

PRINTS
PR00145 (ARGSUCLYASE)

285 - 301

PRINTS
PR00145 (ARGSUCLYASE)

241 - 265

PRINTS
PR00145 (ARGSUCLYASE)

203 - 219

PRINTS
PR00145 (ARGSUCLYASE)

Residue annotation

active sites cd01359

31S

active sites
31S, 35D, 91D, 93H, 117S, 118R, 119N, 122V, 164T, 165H, 241R, 284T, 286S, 294N, 296D, 299E, 326Y, 328K, 331Q, 333D, 334K
CDD
cd01359 (Argininosuccinate_lyase)

35D

active sites
31S, 35D, 91D, 93H, 117S, 118R, 119N, 122V, 164T, 165H, 241R, 284T, 286S, 294N, 296D, 299E, 326Y, 328K, 331Q, 333D, 334K
CDD
cd01359 (Argininosuccinate_lyase)

91D

active sites
31S, 35D, 91D, 93H, 117S, 118R, 119N, 122V, 164T, 165H, 241R, 284T, 286S, 294N, 296D, 299E, 326Y, 328K, 331Q, 333D, 334K
CDD
cd01359 (Argininosuccinate_lyase)

93H

active sites
31S, 35D, 91D, 93H, 117S, 118R, 119N, 122V, 164T, 165H, 241R, 284T, 286S, 294N, 296D, 299E, 326Y, 328K, 331Q, 333D, 334K
CDD
cd01359 (Argininosuccinate_lyase)

117S

active sites
31S, 35D, 91D, 93H, 117S, 118R, 119N, 122V, 164T, 165H, 241R, 284T, 286S, 294N, 296D, 299E, 326Y, 328K, 331Q, 333D, 334K
CDD
cd01359 (Argininosuccinate_lyase)

118R

active sites
31S, 35D, 91D, 93H, 117S, 118R, 119N, 122V, 164T, 165H, 241R, 284T, 286S, 294N, 296D, 299E, 326Y, 328K, 331Q, 333D, 334K
CDD
cd01359 (Argininosuccinate_lyase)

119N

active sites
31S, 35D, 91D, 93H, 117S, 118R, 119N, 122V, 164T, 165H, 241R, 284T, 286S, 294N, 296D, 299E, 326Y, 328K, 331Q, 333D, 334K
CDD
cd01359 (Argininosuccinate_lyase)

122V

active sites
31S, 35D, 91D, 93H, 117S, 118R, 119N, 122V, 164T, 165H, 241R, 284T, 286S, 294N, 296D, 299E, 326Y, 328K, 331Q, 333D, 334K
CDD
cd01359 (Argininosuccinate_lyase)

164T

active sites
31S, 35D, 91D, 93H, 117S, 118R, 119N, 122V, 164T, 165H, 241R, 284T, 286S, 294N, 296D, 299E, 326Y, 328K, 331Q, 333D, 334K
CDD
cd01359 (Argininosuccinate_lyase)

165H

active sites
31S, 35D, 91D, 93H, 117S, 118R, 119N, 122V, 164T, 165H, 241R, 284T, 286S, 294N, 296D, 299E, 326Y, 328K, 331Q, 333D, 334K
CDD
cd01359 (Argininosuccinate_lyase)

241R

active sites
31S, 35D, 91D, 93H, 117S, 118R, 119N, 122V, 164T, 165H, 241R, 284T, 286S, 294N, 296D, 299E, 326Y, 328K, 331Q, 333D, 334K
CDD
cd01359 (Argininosuccinate_lyase)

284T

active sites
31S, 35D, 91D, 93H, 117S, 118R, 119N, 122V, 164T, 165H, 241R, 284T, 286S, 294N, 296D, 299E, 326Y, 328K, 331Q, 333D, 334K
CDD
cd01359 (Argininosuccinate_lyase)

286S

active sites
31S, 35D, 91D, 93H, 117S, 118R, 119N, 122V, 164T, 165H, 241R, 284T, 286S, 294N, 296D, 299E, 326Y, 328K, 331Q, 333D, 334K
CDD
cd01359 (Argininosuccinate_lyase)

294N

active sites
31S, 35D, 91D, 93H, 117S, 118R, 119N, 122V, 164T, 165H, 241R, 284T, 286S, 294N, 296D, 299E, 326Y, 328K, 331Q, 333D, 334K
CDD
cd01359 (Argininosuccinate_lyase)

296D

active sites
31S, 35D, 91D, 93H, 117S, 118R, 119N, 122V, 164T, 165H, 241R, 284T, 286S, 294N, 296D, 299E, 326Y, 328K, 331Q, 333D, 334K
CDD
cd01359 (Argininosuccinate_lyase)

299E

active sites
31S, 35D, 91D, 93H, 117S, 118R, 119N, 122V, 164T, 165H, 241R, 284T, 286S, 294N, 296D, 299E, 326Y, 328K, 331Q, 333D, 334K
CDD
cd01359 (Argininosuccinate_lyase)

326Y

active sites
31S, 35D, 91D, 93H, 117S, 118R, 119N, 122V, 164T, 165H, 241R, 284T, 286S, 294N, 296D, 299E, 326Y, 328K, 331Q, 333D, 334K
CDD
cd01359 (Argininosuccinate_lyase)

328K

active sites
31S, 35D, 91D, 93H, 117S, 118R, 119N, 122V, 164T, 165H, 241R, 284T, 286S, 294N, 296D, 299E, 326Y, 328K, 331Q, 333D, 334K
CDD
cd01359 (Argininosuccinate_lyase)

331Q

active sites
31S, 35D, 91D, 93H, 117S, 118R, 119N, 122V, 164T, 165H, 241R, 284T, 286S, 294N, 296D, 299E, 326Y, 328K, 331Q, 333D, 334K
CDD
cd01359 (Argininosuccinate_lyase)

333D

active sites
31S, 35D, 91D, 93H, 117S, 118R, 119N, 122V, 164T, 165H, 241R, 284T, 286S, 294N, 296D, 299E, 326Y, 328K, 331Q, 333D, 334K
CDD
cd01359 (Argininosuccinate_lyase)

334K

active sites
31S, 35D, 91D, 93H, 117S, 118R, 119N, 122V, 164T, 165H, 241R, 284T, 286S, 294N, 296D, 299E, 326Y, 328K, 331Q, 333D, 334K
CDD
cd01359 (Argininosuccinate_lyase)
tetramer interface...

106K

tetramer interface
106K, 110G, 113H, 114T, 163Y, 164T, 165H, 166L, 167Q, 168R, 169A, 170Q, 176H, 180L, 181H, 187N, 190K, 191R, 194Q, 198R, 209L, 210A, 211G, 212H, 213P, 215G, 218R, 232G, 233N, 234S, 235L, 236A, 239S, 240D, 242D, 246E, 249F, 253L, 256N, 257H, 259A, 260K, 263E, 264D, 269S, 270T, 273F, 281A, 287S, 288L, 289M, 290P, 292K, 293K, 294N, 296D, 299E, 300L, 302R, 303G, 304K, 305S, 306G, 307R, 309F, 310G, 311Q, 314G, 316M, 317M, 318S, 326Y, 327N, 328K, 329D, 332E, 335E, 346H, 349Q, 375A, 380D, 384R, 389F, 390R, 393H, 396S, 443R, 445A, 446I, 447G, 448G, 449T, 457Q
CDD
cd01359 (Argininosuccinate_lyase)

110G

tetramer interface
106K, 110G, 113H, 114T, 163Y, 164T, 165H, 166L, 167Q, 168R, 169A, 170Q, 176H, 180L, 181H, 187N, 190K, 191R, 194Q, 198R, 209L, 210A, 211G, 212H, 213P, 215G, 218R, 232G, 233N, 234S, 235L, 236A, 239S, 240D, 242D, 246E, 249F, 253L, 256N, 257H, 259A, 260K, 263E, 264D, 269S, 270T, 273F, 281A, 287S, 288L, 289M, 290P, 292K, 293K, 294N, 296D, 299E, 300L, 302R, 303G, 304K, 305S, 306G, 307R, 309F, 310G, 311Q, 314G, 316M, 317M, 318S, 326Y, 327N, 328K, 329D, 332E, 335E, 346H, 349Q, 375A, 380D, 384R, 389F, 390R, 393H, 396S, 443R, 445A, 446I, 447G, 448G, 449T, 457Q
CDD
cd01359 (Argininosuccinate_lyase)

113H

tetramer interface
106K, 110G, 113H, 114T, 163Y, 164T, 165H, 166L, 167Q, 168R, 169A, 170Q, 176H, 180L, 181H, 187N, 190K, 191R, 194Q, 198R, 209L, 210A, 211G, 212H, 213P, 215G, 218R, 232G, 233N, 234S, 235L, 236A, 239S, 240D, 242D, 246E, 249F, 253L, 256N, 257H, 259A, 260K, 263E, 264D, 269S, 270T, 273F, 281A, 287S, 288L, 289M, 290P, 292K, 293K, 294N, 296D, 299E, 300L, 302R, 303G, 304K, 305S, 306G, 307R, 309F, 310G, 311Q, 314G, 316M, 317M, 318S, 326Y, 327N, 328K, 329D, 332E, 335E, 346H, 349Q, 375A, 380D, 384R, 389F, 390R, 393H, 396S, 443R, 445A, 446I, 447G, 448G, 449T, 457Q
CDD
cd01359 (Argininosuccinate_lyase)

114T

tetramer interface
106K, 110G, 113H, 114T, 163Y, 164T, 165H, 166L, 167Q, 168R, 169A, 170Q, 176H, 180L, 181H, 187N, 190K, 191R, 194Q, 198R, 209L, 210A, 211G, 212H, 213P, 215G, 218R, 232G, 233N, 234S, 235L, 236A, 239S, 240D, 242D, 246E, 249F, 253L, 256N, 257H, 259A, 260K, 263E, 264D, 269S, 270T, 273F, 281A, 287S, 288L, 289M, 290P, 292K, 293K, 294N, 296D, 299E, 300L, 302R, 303G, 304K, 305S, 306G, 307R, 309F, 310G, 311Q, 314G, 316M, 317M, 318S, 326Y, 327N, 328K, 329D, 332E, 335E, 346H, 349Q, 375A, 380D, 384R, 389F, 390R, 393H, 396S, 443R, 445A, 446I, 447G, 448G, 449T, 457Q
CDD
cd01359 (Argininosuccinate_lyase)

163Y

tetramer interface
106K, 110G, 113H, 114T, 163Y, 164T, 165H, 166L, 167Q, 168R, 169A, 170Q, 176H, 180L, 181H, 187N, 190K, 191R, 194Q, 198R, 209L, 210A, 211G, 212H, 213P, 215G, 218R, 232G, 233N, 234S, 235L, 236A, 239S, 240D, 242D, 246E, 249F, 253L, 256N, 257H, 259A, 260K, 263E, 264D, 269S, 270T, 273F, 281A, 287S, 288L, 289M, 290P, 292K, 293K, 294N, 296D, 299E, 300L, 302R, 303G, 304K, 305S, 306G, 307R, 309F, 310G, 311Q, 314G, 316M, 317M, 318S, 326Y, 327N, 328K, 329D, 332E, 335E, 346H, 349Q, 375A, 380D, 384R, 389F, 390R, 393H, 396S, 443R, 445A, 446I, 447G, 448G, 449T, 457Q
CDD
cd01359 (Argininosuccinate_lyase)

164T

tetramer interface
106K, 110G, 113H, 114T, 163Y, 164T, 165H, 166L, 167Q, 168R, 169A, 170Q, 176H, 180L, 181H, 187N, 190K, 191R, 194Q, 198R, 209L, 210A, 211G, 212H, 213P, 215G, 218R, 232G, 233N, 234S, 235L, 236A, 239S, 240D, 242D, 246E, 249F, 253L, 256N, 257H, 259A, 260K, 263E, 264D, 269S, 270T, 273F, 281A, 287S, 288L, 289M, 290P, 292K, 293K, 294N, 296D, 299E, 300L, 302R, 303G, 304K, 305S, 306G, 307R, 309F, 310G, 311Q, 314G, 316M, 317M, 318S, 326Y, 327N, 328K, 329D, 332E, 335E, 346H, 349Q, 375A, 380D, 384R, 389F, 390R, 393H, 396S, 443R, 445A, 446I, 447G, 448G, 449T, 457Q
CDD
cd01359 (Argininosuccinate_lyase)

165H

tetramer interface
106K, 110G, 113H, 114T, 163Y, 164T, 165H, 166L, 167Q, 168R, 169A, 170Q, 176H, 180L, 181H, 187N, 190K, 191R, 194Q, 198R, 209L, 210A, 211G, 212H, 213P, 215G, 218R, 232G, 233N, 234S, 235L, 236A, 239S, 240D, 242D, 246E, 249F, 253L, 256N, 257H, 259A, 260K, 263E, 264D, 269S, 270T, 273F, 281A, 287S, 288L, 289M, 290P, 292K, 293K, 294N, 296D, 299E, 300L, 302R, 303G, 304K, 305S, 306G, 307R, 309F, 310G, 311Q, 314G, 316M, 317M, 318S, 326Y, 327N, 328K, 329D, 332E, 335E, 346H, 349Q, 375A, 380D, 384R, 389F, 390R, 393H, 396S, 443R, 445A, 446I, 447G, 448G, 449T, 457Q
CDD
cd01359 (Argininosuccinate_lyase)

166L

tetramer interface
106K, 110G, 113H, 114T, 163Y, 164T, 165H, 166L, 167Q, 168R, 169A, 170Q, 176H, 180L, 181H, 187N, 190K, 191R, 194Q, 198R, 209L, 210A, 211G, 212H, 213P, 215G, 218R, 232G, 233N, 234S, 235L, 236A, 239S, 240D, 242D, 246E, 249F, 253L, 256N, 257H, 259A, 260K, 263E, 264D, 269S, 270T, 273F, 281A, 287S, 288L, 289M, 290P, 292K, 293K, 294N, 296D, 299E, 300L, 302R, 303G, 304K, 305S, 306G, 307R, 309F, 310G, 311Q, 314G, 316M, 317M, 318S, 326Y, 327N, 328K, 329D, 332E, 335E, 346H, 349Q, 375A, 380D, 384R, 389F, 390R, 393H, 396S, 443R, 445A, 446I, 447G, 448G, 449T, 457Q
CDD
cd01359 (Argininosuccinate_lyase)

167Q

tetramer interface
106K, 110G, 113H, 114T, 163Y, 164T, 165H, 166L, 167Q, 168R, 169A, 170Q, 176H, 180L, 181H, 187N, 190K, 191R, 194Q, 198R, 209L, 210A, 211G, 212H, 213P, 215G, 218R, 232G, 233N, 234S, 235L, 236A, 239S, 240D, 242D, 246E, 249F, 253L, 256N, 257H, 259A, 260K, 263E, 264D, 269S, 270T, 273F, 281A, 287S, 288L, 289M, 290P, 292K, 293K, 294N, 296D, 299E, 300L, 302R, 303G, 304K, 305S, 306G, 307R, 309F, 310G, 311Q, 314G, 316M, 317M, 318S, 326Y, 327N, 328K, 329D, 332E, 335E, 346H, 349Q, 375A, 380D, 384R, 389F, 390R, 393H, 396S, 443R, 445A, 446I, 447G, 448G, 449T, 457Q
CDD
cd01359 (Argininosuccinate_lyase)

168R

tetramer interface
106K, 110G, 113H, 114T, 163Y, 164T, 165H, 166L, 167Q, 168R, 169A, 170Q, 176H, 180L, 181H, 187N, 190K, 191R, 194Q, 198R, 209L, 210A, 211G, 212H, 213P, 215G, 218R, 232G, 233N, 234S, 235L, 236A, 239S, 240D, 242D, 246E, 249F, 253L, 256N, 257H, 259A, 260K, 263E, 264D, 269S, 270T, 273F, 281A, 287S, 288L, 289M, 290P, 292K, 293K, 294N, 296D, 299E, 300L, 302R, 303G, 304K, 305S, 306G, 307R, 309F, 310G, 311Q, 314G, 316M, 317M, 318S, 326Y, 327N, 328K, 329D, 332E, 335E, 346H, 349Q, 375A, 380D, 384R, 389F, 390R, 393H, 396S, 443R, 445A, 446I, 447G, 448G, 449T, 457Q
CDD
cd01359 (Argininosuccinate_lyase)

169A

tetramer interface
106K, 110G, 113H, 114T, 163Y, 164T, 165H, 166L, 167Q, 168R, 169A, 170Q, 176H, 180L, 181H, 187N, 190K, 191R, 194Q, 198R, 209L, 210A, 211G, 212H, 213P, 215G, 218R, 232G, 233N, 234S, 235L, 236A, 239S, 240D, 242D, 246E, 249F, 253L, 256N, 257H, 259A, 260K, 263E, 264D, 269S, 270T, 273F, 281A, 287S, 288L, 289M, 290P, 292K, 293K, 294N, 296D, 299E, 300L, 302R, 303G, 304K, 305S, 306G, 307R, 309F, 310G, 311Q, 314G, 316M, 317M, 318S, 326Y, 327N, 328K, 329D, 332E, 335E, 346H, 349Q, 375A, 380D, 384R, 389F, 390R, 393H, 396S, 443R, 445A, 446I, 447G, 448G, 449T, 457Q
CDD
cd01359 (Argininosuccinate_lyase)

170Q

tetramer interface
106K, 110G, 113H, 114T, 163Y, 164T, 165H, 166L, 167Q, 168R, 169A, 170Q, 176H, 180L, 181H, 187N, 190K, 191R, 194Q, 198R, 209L, 210A, 211G, 212H, 213P, 215G, 218R, 232G, 233N, 234S, 235L, 236A, 239S, 240D, 242D, 246E, 249F, 253L, 256N, 257H, 259A, 260K, 263E, 264D, 269S, 270T, 273F, 281A, 287S, 288L, 289M, 290P, 292K, 293K, 294N, 296D, 299E, 300L, 302R, 303G, 304K, 305S, 306G, 307R, 309F, 310G, 311Q, 314G, 316M, 317M, 318S, 326Y, 327N, 328K, 329D, 332E, 335E, 346H, 349Q, 375A, 380D, 384R, 389F, 390R, 393H, 396S, 443R, 445A, 446I, 447G, 448G, 449T, 457Q
CDD
cd01359 (Argininosuccinate_lyase)

176H

tetramer interface
106K, 110G, 113H, 114T, 163Y, 164T, 165H, 166L, 167Q, 168R, 169A, 170Q, 176H, 180L, 181H, 187N, 190K, 191R, 194Q, 198R, 209L, 210A, 211G, 212H, 213P, 215G, 218R, 232G, 233N, 234S, 235L, 236A, 239S, 240D, 242D, 246E, 249F, 253L, 256N, 257H, 259A, 260K, 263E, 264D, 269S, 270T, 273F, 281A, 287S, 288L, 289M, 290P, 292K, 293K, 294N, 296D, 299E, 300L, 302R, 303G, 304K, 305S, 306G, 307R, 309F, 310G, 311Q, 314G, 316M, 317M, 318S, 326Y, 327N, 328K, 329D, 332E, 335E, 346H, 349Q, 375A, 380D, 384R, 389F, 390R, 393H, 396S, 443R, 445A, 446I, 447G, 448G, 449T, 457Q
CDD
cd01359 (Argininosuccinate_lyase)

180L

tetramer interface
106K, 110G, 113H, 114T, 163Y, 164T, 165H, 166L, 167Q, 168R, 169A, 170Q, 176H, 180L, 181H, 187N, 190K, 191R, 194Q, 198R, 209L, 210A, 211G, 212H, 213P, 215G, 218R, 232G, 233N, 234S, 235L, 236A, 239S, 240D, 242D, 246E, 249F, 253L, 256N, 257H, 259A, 260K, 263E, 264D, 269S, 270T, 273F, 281A, 287S, 288L, 289M, 290P, 292K, 293K, 294N, 296D, 299E, 300L, 302R, 303G, 304K, 305S, 306G, 307R, 309F, 310G, 311Q, 314G, 316M, 317M, 318S, 326Y, 327N, 328K, 329D, 332E, 335E, 346H, 349Q, 375A, 380D, 384R, 389F, 390R, 393H, 396S, 443R, 445A, 446I, 447G, 448G, 449T, 457Q
CDD
cd01359 (Argininosuccinate_lyase)

181H

tetramer interface
106K, 110G, 113H, 114T, 163Y, 164T, 165H, 166L, 167Q, 168R, 169A, 170Q, 176H, 180L, 181H, 187N, 190K, 191R, 194Q, 198R, 209L, 210A, 211G, 212H, 213P, 215G, 218R, 232G, 233N, 234S, 235L, 236A, 239S, 240D, 242D, 246E, 249F, 253L, 256N, 257H, 259A, 260K, 263E, 264D, 269S, 270T, 273F, 281A, 287S, 288L, 289M, 290P, 292K, 293K, 294N, 296D, 299E, 300L, 302R, 303G, 304K, 305S, 306G, 307R, 309F, 310G, 311Q, 314G, 316M, 317M, 318S, 326Y, 327N, 328K, 329D, 332E, 335E, 346H, 349Q, 375A, 380D, 384R, 389F, 390R, 393H, 396S, 443R, 445A, 446I, 447G, 448G, 449T, 457Q
CDD
cd01359 (Argininosuccinate_lyase)

187N

tetramer interface
106K, 110G, 113H, 114T, 163Y, 164T, 165H, 166L, 167Q, 168R, 169A, 170Q, 176H, 180L, 181H, 187N, 190K, 191R, 194Q, 198R, 209L, 210A, 211G, 212H, 213P, 215G, 218R, 232G, 233N, 234S, 235L, 236A, 239S, 240D, 242D, 246E, 249F, 253L, 256N, 257H, 259A, 260K, 263E, 264D, 269S, 270T, 273F, 281A, 287S, 288L, 289M, 290P, 292K, 293K, 294N, 296D, 299E, 300L, 302R, 303G, 304K, 305S, 306G, 307R, 309F, 310G, 311Q, 314G, 316M, 317M, 318S, 326Y, 327N, 328K, 329D, 332E, 335E, 346H, 349Q, 375A, 380D, 384R, 389F, 390R, 393H, 396S, 443R, 445A, 446I, 447G, 448G, 449T, 457Q
CDD
cd01359 (Argininosuccinate_lyase)

190K

tetramer interface
106K, 110G, 113H, 114T, 163Y, 164T, 165H, 166L, 167Q, 168R, 169A, 170Q, 176H, 180L, 181H, 187N, 190K, 191R, 194Q, 198R, 209L, 210A, 211G, 212H, 213P, 215G, 218R, 232G, 233N, 234S, 235L, 236A, 239S, 240D, 242D, 246E, 249F, 253L, 256N, 257H, 259A, 260K, 263E, 264D, 269S, 270T, 273F, 281A, 287S, 288L, 289M, 290P, 292K, 293K, 294N, 296D, 299E, 300L, 302R, 303G, 304K, 305S, 306G, 307R, 309F, 310G, 311Q, 314G, 316M, 317M, 318S, 326Y, 327N, 328K, 329D, 332E, 335E, 346H, 349Q, 375A, 380D, 384R, 389F, 390R, 393H, 396S, 443R, 445A, 446I, 447G, 448G, 449T, 457Q
CDD
cd01359 (Argininosuccinate_lyase)

191R

tetramer interface
106K, 110G, 113H, 114T, 163Y, 164T, 165H, 166L, 167Q, 168R, 169A, 170Q, 176H, 180L, 181H, 187N, 190K, 191R, 194Q, 198R, 209L, 210A, 211G, 212H, 213P, 215G, 218R, 232G, 233N, 234S, 235L, 236A, 239S, 240D, 242D, 246E, 249F, 253L, 256N, 257H, 259A, 260K, 263E, 264D, 269S, 270T, 273F, 281A, 287S, 288L, 289M, 290P, 292K, 293K, 294N, 296D, 299E, 300L, 302R, 303G, 304K, 305S, 306G, 307R, 309F, 310G, 311Q, 314G, 316M, 317M, 318S, 326Y, 327N, 328K, 329D, 332E, 335E, 346H, 349Q, 375A, 380D, 384R, 389F, 390R, 393H, 396S, 443R, 445A, 446I, 447G, 448G, 449T, 457Q
CDD
cd01359 (Argininosuccinate_lyase)

194Q

tetramer interface
106K, 110G, 113H, 114T, 163Y, 164T, 165H, 166L, 167Q, 168R, 169A, 170Q, 176H, 180L, 181H, 187N, 190K, 191R, 194Q, 198R, 209L, 210A, 211G, 212H, 213P, 215G, 218R, 232G, 233N, 234S, 235L, 236A, 239S, 240D, 242D, 246E, 249F, 253L, 256N, 257H, 259A, 260K, 263E, 264D, 269S, 270T, 273F, 281A, 287S, 288L, 289M, 290P, 292K, 293K, 294N, 296D, 299E, 300L, 302R, 303G, 304K, 305S, 306G, 307R, 309F, 310G, 311Q, 314G, 316M, 317M, 318S, 326Y, 327N, 328K, 329D, 332E, 335E, 346H, 349Q, 375A, 380D, 384R, 389F, 390R, 393H, 396S, 443R, 445A, 446I, 447G, 448G, 449T, 457Q
CDD
cd01359 (Argininosuccinate_lyase)

198R

tetramer interface
106K, 110G, 113H, 114T, 163Y, 164T, 165H, 166L, 167Q, 168R, 169A, 170Q, 176H, 180L, 181H, 187N, 190K, 191R, 194Q, 198R, 209L, 210A, 211G, 212H, 213P, 215G, 218R, 232G, 233N, 234S, 235L, 236A, 239S, 240D, 242D, 246E, 249F, 253L, 256N, 257H, 259A, 260K, 263E, 264D, 269S, 270T, 273F, 281A, 287S, 288L, 289M, 290P, 292K, 293K, 294N, 296D, 299E, 300L, 302R, 303G, 304K, 305S, 306G, 307R, 309F, 310G, 311Q, 314G, 316M, 317M, 318S, 326Y, 327N, 328K, 329D, 332E, 335E, 346H, 349Q, 375A, 380D, 384R, 389F, 390R, 393H, 396S, 443R, 445A, 446I, 447G, 448G, 449T, 457Q
CDD
cd01359 (Argininosuccinate_lyase)

209L

tetramer interface
106K, 110G, 113H, 114T, 163Y, 164T, 165H, 166L, 167Q, 168R, 169A, 170Q, 176H, 180L, 181H, 187N, 190K, 191R, 194Q, 198R, 209L, 210A, 211G, 212H, 213P, 215G, 218R, 232G, 233N, 234S, 235L, 236A, 239S, 240D, 242D, 246E, 249F, 253L, 256N, 257H, 259A, 260K, 263E, 264D, 269S, 270T, 273F, 281A, 287S, 288L, 289M, 290P, 292K, 293K, 294N, 296D, 299E, 300L, 302R, 303G, 304K, 305S, 306G, 307R, 309F, 310G, 311Q, 314G, 316M, 317M, 318S, 326Y, 327N, 328K, 329D, 332E, 335E, 346H, 349Q, 375A, 380D, 384R, 389F, 390R, 393H, 396S, 443R, 445A, 446I, 447G, 448G, 449T, 457Q
CDD
cd01359 (Argininosuccinate_lyase)

210A

tetramer interface
106K, 110G, 113H, 114T, 163Y, 164T, 165H, 166L, 167Q, 168R, 169A, 170Q, 176H, 180L, 181H, 187N, 190K, 191R, 194Q, 198R, 209L, 210A, 211G, 212H, 213P, 215G, 218R, 232G, 233N, 234S, 235L, 236A, 239S, 240D, 242D, 246E, 249F, 253L, 256N, 257H, 259A, 260K, 263E, 264D, 269S, 270T, 273F, 281A, 287S, 288L, 289M, 290P, 292K, 293K, 294N, 296D, 299E, 300L, 302R, 303G, 304K, 305S, 306G, 307R, 309F, 310G, 311Q, 314G, 316M, 317M, 318S, 326Y, 327N, 328K, 329D, 332E, 335E, 346H, 349Q, 375A, 380D, 384R, 389F, 390R, 393H, 396S, 443R, 445A, 446I, 447G, 448G, 449T, 457Q
CDD
cd01359 (Argininosuccinate_lyase)

211G

tetramer interface
106K, 110G, 113H, 114T, 163Y, 164T, 165H, 166L, 167Q, 168R, 169A, 170Q, 176H, 180L, 181H, 187N, 190K, 191R, 194Q, 198R, 209L, 210A, 211G, 212H, 213P, 215G, 218R, 232G, 233N, 234S, 235L, 236A, 239S, 240D, 242D, 246E, 249F, 253L, 256N, 257H, 259A, 260K, 263E, 264D, 269S, 270T, 273F, 281A, 287S, 288L, 289M, 290P, 292K, 293K, 294N, 296D, 299E, 300L, 302R, 303G, 304K, 305S, 306G, 307R, 309F, 310G, 311Q, 314G, 316M, 317M, 318S, 326Y, 327N, 328K, 329D, 332E, 335E, 346H, 349Q, 375A, 380D, 384R, 389F, 390R, 393H, 396S, 443R, 445A, 446I, 447G, 448G, 449T, 457Q
CDD
cd01359 (Argininosuccinate_lyase)

212H

tetramer interface
106K, 110G, 113H, 114T, 163Y, 164T, 165H, 166L, 167Q, 168R, 169A, 170Q, 176H, 180L, 181H, 187N, 190K, 191R, 194Q, 198R, 209L, 210A, 211G, 212H, 213P, 215G, 218R, 232G, 233N, 234S, 235L, 236A, 239S, 240D, 242D, 246E, 249F, 253L, 256N, 257H, 259A, 260K, 263E, 264D, 269S, 270T, 273F, 281A, 287S, 288L, 289M, 290P, 292K, 293K, 294N, 296D, 299E, 300L, 302R, 303G, 304K, 305S, 306G, 307R, 309F, 310G, 311Q, 314G, 316M, 317M, 318S, 326Y, 327N, 328K, 329D, 332E, 335E, 346H, 349Q, 375A, 380D, 384R, 389F, 390R, 393H, 396S, 443R, 445A, 446I, 447G, 448G, 449T, 457Q
CDD
cd01359 (Argininosuccinate_lyase)

213P

tetramer interface
106K, 110G, 113H, 114T, 163Y, 164T, 165H, 166L, 167Q, 168R, 169A, 170Q, 176H, 180L, 181H, 187N, 190K, 191R, 194Q, 198R, 209L, 210A, 211G, 212H, 213P, 215G, 218R, 232G, 233N, 234S, 235L, 236A, 239S, 240D, 242D, 246E, 249F, 253L, 256N, 257H, 259A, 260K, 263E, 264D, 269S, 270T, 273F, 281A, 287S, 288L, 289M, 290P, 292K, 293K, 294N, 296D, 299E, 300L, 302R, 303G, 304K, 305S, 306G, 307R, 309F, 310G, 311Q, 314G, 316M, 317M, 318S, 326Y, 327N, 328K, 329D, 332E, 335E, 346H, 349Q, 375A, 380D, 384R, 389F, 390R, 393H, 396S, 443R, 445A, 446I, 447G, 448G, 449T, 457Q
CDD
cd01359 (Argininosuccinate_lyase)

215G

tetramer interface
106K, 110G, 113H, 114T, 163Y, 164T, 165H, 166L, 167Q, 168R, 169A, 170Q, 176H, 180L, 181H, 187N, 190K, 191R, 194Q, 198R, 209L, 210A, 211G, 212H, 213P, 215G, 218R, 232G, 233N, 234S, 235L, 236A, 239S, 240D, 242D, 246E, 249F, 253L, 256N, 257H, 259A, 260K, 263E, 264D, 269S, 270T, 273F, 281A, 287S, 288L, 289M, 290P, 292K, 293K, 294N, 296D, 299E, 300L, 302R, 303G, 304K, 305S, 306G, 307R, 309F, 310G, 311Q, 314G, 316M, 317M, 318S, 326Y, 327N, 328K, 329D, 332E, 335E, 346H, 349Q, 375A, 380D, 384R, 389F, 390R, 393H, 396S, 443R, 445A, 446I, 447G, 448G, 449T, 457Q
CDD
cd01359 (Argininosuccinate_lyase)

218R

tetramer interface
106K, 110G, 113H, 114T, 163Y, 164T, 165H, 166L, 167Q, 168R, 169A, 170Q, 176H, 180L, 181H, 187N, 190K, 191R, 194Q, 198R, 209L, 210A, 211G, 212H, 213P, 215G, 218R, 232G, 233N, 234S, 235L, 236A, 239S, 240D, 242D, 246E, 249F, 253L, 256N, 257H, 259A, 260K, 263E, 264D, 269S, 270T, 273F, 281A, 287S, 288L, 289M, 290P, 292K, 293K, 294N, 296D, 299E, 300L, 302R, 303G, 304K, 305S, 306G, 307R, 309F, 310G, 311Q, 314G, 316M, 317M, 318S, 326Y, 327N, 328K, 329D, 332E, 335E, 346H, 349Q, 375A, 380D, 384R, 389F, 390R, 393H, 396S, 443R, 445A, 446I, 447G, 448G, 449T, 457Q
CDD
cd01359 (Argininosuccinate_lyase)

232G

tetramer interface
106K, 110G, 113H, 114T, 163Y, 164T, 165H, 166L, 167Q, 168R, 169A, 170Q, 176H, 180L, 181H, 187N, 190K, 191R, 194Q, 198R, 209L, 210A, 211G, 212H, 213P, 215G, 218R, 232G, 233N, 234S, 235L, 236A, 239S, 240D, 242D, 246E, 249F, 253L, 256N, 257H, 259A, 260K, 263E, 264D, 269S, 270T, 273F, 281A, 287S, 288L, 289M, 290P, 292K, 293K, 294N, 296D, 299E, 300L, 302R, 303G, 304K, 305S, 306G, 307R, 309F, 310G, 311Q, 314G, 316M, 317M, 318S, 326Y, 327N, 328K, 329D, 332E, 335E, 346H, 349Q, 375A, 380D, 384R, 389F, 390R, 393H, 396S, 443R, 445A, 446I, 447G, 448G, 449T, 457Q
CDD
cd01359 (Argininosuccinate_lyase)

233N

tetramer interface
106K, 110G, 113H, 114T, 163Y, 164T, 165H, 166L, 167Q, 168R, 169A, 170Q, 176H, 180L, 181H, 187N, 190K, 191R, 194Q, 198R, 209L, 210A, 211G, 212H, 213P, 215G, 218R, 232G, 233N, 234S, 235L, 236A, 239S, 240D, 242D, 246E, 249F, 253L, 256N, 257H, 259A, 260K, 263E, 264D, 269S, 270T, 273F, 281A, 287S, 288L, 289M, 290P, 292K, 293K, 294N, 296D, 299E, 300L, 302R, 303G, 304K, 305S, 306G, 307R, 309F, 310G, 311Q, 314G, 316M, 317M, 318S, 326Y, 327N, 328K, 329D, 332E, 335E, 346H, 349Q, 375A, 380D, 384R, 389F, 390R, 393H, 396S, 443R, 445A, 446I, 447G, 448G, 449T, 457Q
CDD
cd01359 (Argininosuccinate_lyase)

234S

tetramer interface
106K, 110G, 113H, 114T, 163Y, 164T, 165H, 166L, 167Q, 168R, 169A, 170Q, 176H, 180L, 181H, 187N, 190K, 191R, 194Q, 198R, 209L, 210A, 211G, 212H, 213P, 215G, 218R, 232G, 233N, 234S, 235L, 236A, 239S, 240D, 242D, 246E, 249F, 253L, 256N, 257H, 259A, 260K, 263E, 264D, 269S, 270T, 273F, 281A, 287S, 288L, 289M, 290P, 292K, 293K, 294N, 296D, 299E, 300L, 302R, 303G, 304K, 305S, 306G, 307R, 309F, 310G, 311Q, 314G, 316M, 317M, 318S, 326Y, 327N, 328K, 329D, 332E, 335E, 346H, 349Q, 375A, 380D, 384R, 389F, 390R, 393H, 396S, 443R, 445A, 446I, 447G, 448G, 449T, 457Q
CDD
cd01359 (Argininosuccinate_lyase)

235L

tetramer interface
106K, 110G, 113H, 114T, 163Y, 164T, 165H, 166L, 167Q, 168R, 169A, 170Q, 176H, 180L, 181H, 187N, 190K, 191R, 194Q, 198R, 209L, 210A, 211G, 212H, 213P, 215G, 218R, 232G, 233N, 234S, 235L, 236A, 239S, 240D, 242D, 246E, 249F, 253L, 256N, 257H, 259A, 260K, 263E, 264D, 269S, 270T, 273F, 281A, 287S, 288L, 289M, 290P, 292K, 293K, 294N, 296D, 299E, 300L, 302R, 303G, 304K, 305S, 306G, 307R, 309F, 310G, 311Q, 314G, 316M, 317M, 318S, 326Y, 327N, 328K, 329D, 332E, 335E, 346H, 349Q, 375A, 380D, 384R, 389F, 390R, 393H, 396S, 443R, 445A, 446I, 447G, 448G, 449T, 457Q
CDD
cd01359 (Argininosuccinate_lyase)

236A

tetramer interface
106K, 110G, 113H, 114T, 163Y, 164T, 165H, 166L, 167Q, 168R, 169A, 170Q, 176H, 180L, 181H, 187N, 190K, 191R, 194Q, 198R, 209L, 210A, 211G, 212H, 213P, 215G, 218R, 232G, 233N, 234S, 235L, 236A, 239S, 240D, 242D, 246E, 249F, 253L, 256N, 257H, 259A, 260K, 263E, 264D, 269S, 270T, 273F, 281A, 287S, 288L, 289M, 290P, 292K, 293K, 294N, 296D, 299E, 300L, 302R, 303G, 304K, 305S, 306G, 307R, 309F, 310G, 311Q, 314G, 316M, 317M, 318S, 326Y, 327N, 328K, 329D, 332E, 335E, 346H, 349Q, 375A, 380D, 384R, 389F, 390R, 393H, 396S, 443R, 445A, 446I, 447G, 448G, 449T, 457Q
CDD
cd01359 (Argininosuccinate_lyase)

239S

tetramer interface
106K, 110G, 113H, 114T, 163Y, 164T, 165H, 166L, 167Q, 168R, 169A, 170Q, 176H, 180L, 181H, 187N, 190K, 191R, 194Q, 198R, 209L, 210A, 211G, 212H, 213P, 215G, 218R, 232G, 233N, 234S, 235L, 236A, 239S, 240D, 242D, 246E, 249F, 253L, 256N, 257H, 259A, 260K, 263E, 264D, 269S, 270T, 273F, 281A, 287S, 288L, 289M, 290P, 292K, 293K, 294N, 296D, 299E, 300L, 302R, 303G, 304K, 305S, 306G, 307R, 309F, 310G, 311Q, 314G, 316M, 317M, 318S, 326Y, 327N, 328K, 329D, 332E, 335E, 346H, 349Q, 375A, 380D, 384R, 389F, 390R, 393H, 396S, 443R, 445A, 446I, 447G, 448G, 449T, 457Q
CDD
cd01359 (Argininosuccinate_lyase)

240D

tetramer interface
106K, 110G, 113H, 114T, 163Y, 164T, 165H, 166L, 167Q, 168R, 169A, 170Q, 176H, 180L, 181H, 187N, 190K, 191R, 194Q, 198R, 209L, 210A, 211G, 212H, 213P, 215G, 218R, 232G, 233N, 234S, 235L, 236A, 239S, 240D, 242D, 246E, 249F, 253L, 256N, 257H, 259A, 260K, 263E, 264D, 269S, 270T, 273F, 281A, 287S, 288L, 289M, 290P, 292K, 293K, 294N, 296D, 299E, 300L, 302R, 303G, 304K, 305S, 306G, 307R, 309F, 310G, 311Q, 314G, 316M, 317M, 318S, 326Y, 327N, 328K, 329D, 332E, 335E, 346H, 349Q, 375A, 380D, 384R, 389F, 390R, 393H, 396S, 443R, 445A, 446I, 447G, 448G, 449T, 457Q
CDD
cd01359 (Argininosuccinate_lyase)

242D

tetramer interface
106K, 110G, 113H, 114T, 163Y, 164T, 165H, 166L, 167Q, 168R, 169A, 170Q, 176H, 180L, 181H, 187N, 190K, 191R, 194Q, 198R, 209L, 210A, 211G, 212H, 213P, 215G, 218R, 232G, 233N, 234S, 235L, 236A, 239S, 240D, 242D, 246E, 249F, 253L, 256N, 257H, 259A, 260K, 263E, 264D, 269S, 270T, 273F, 281A, 287S, 288L, 289M, 290P, 292K, 293K, 294N, 296D, 299E, 300L, 302R, 303G, 304K, 305S, 306G, 307R, 309F, 310G, 311Q, 314G, 316M, 317M, 318S, 326Y, 327N, 328K, 329D, 332E, 335E, 346H, 349Q, 375A, 380D, 384R, 389F, 390R, 393H, 396S, 443R, 445A, 446I, 447G, 448G, 449T, 457Q
CDD
cd01359 (Argininosuccinate_lyase)

246E

tetramer interface
106K, 110G, 113H, 114T, 163Y, 164T, 165H, 166L, 167Q, 168R, 169A, 170Q, 176H, 180L, 181H, 187N, 190K, 191R, 194Q, 198R, 209L, 210A, 211G, 212H, 213P, 215G, 218R, 232G, 233N, 234S, 235L, 236A, 239S, 240D, 242D, 246E, 249F, 253L, 256N, 257H, 259A, 260K, 263E, 264D, 269S, 270T, 273F, 281A, 287S, 288L, 289M, 290P, 292K, 293K, 294N, 296D, 299E, 300L, 302R, 303G, 304K, 305S, 306G, 307R, 309F, 310G, 311Q, 314G, 316M, 317M, 318S, 326Y, 327N, 328K, 329D, 332E, 335E, 346H, 349Q, 375A, 380D, 384R, 389F, 390R, 393H, 396S, 443R, 445A, 446I, 447G, 448G, 449T, 457Q
CDD
cd01359 (Argininosuccinate_lyase)

249F

tetramer interface
106K, 110G, 113H, 114T, 163Y, 164T, 165H, 166L, 167Q, 168R, 169A, 170Q, 176H, 180L, 181H, 187N, 190K, 191R, 194Q, 198R, 209L, 210A, 211G, 212H, 213P, 215G, 218R, 232G, 233N, 234S, 235L, 236A, 239S, 240D, 242D, 246E, 249F, 253L, 256N, 257H, 259A, 260K, 263E, 264D, 269S, 270T, 273F, 281A, 287S, 288L, 289M, 290P, 292K, 293K, 294N, 296D, 299E, 300L, 302R, 303G, 304K, 305S, 306G, 307R, 309F, 310G, 311Q, 314G, 316M, 317M, 318S, 326Y, 327N, 328K, 329D, 332E, 335E, 346H, 349Q, 375A, 380D, 384R, 389F, 390R, 393H, 396S, 443R, 445A, 446I, 447G, 448G, 449T, 457Q
CDD
cd01359 (Argininosuccinate_lyase)

253L

tetramer interface
106K, 110G, 113H, 114T, 163Y, 164T, 165H, 166L, 167Q, 168R, 169A, 170Q, 176H, 180L, 181H, 187N, 190K, 191R, 194Q, 198R, 209L, 210A, 211G, 212H, 213P, 215G, 218R, 232G, 233N, 234S, 235L, 236A, 239S, 240D, 242D, 246E, 249F, 253L, 256N, 257H, 259A, 260K, 263E, 264D, 269S, 270T, 273F, 281A, 287S, 288L, 289M, 290P, 292K, 293K, 294N, 296D, 299E, 300L, 302R, 303G, 304K, 305S, 306G, 307R, 309F, 310G, 311Q, 314G, 316M, 317M, 318S, 326Y, 327N, 328K, 329D, 332E, 335E, 346H, 349Q, 375A, 380D, 384R, 389F, 390R, 393H, 396S, 443R, 445A, 446I, 447G, 448G, 449T, 457Q
CDD
cd01359 (Argininosuccinate_lyase)

256N

tetramer interface
106K, 110G, 113H, 114T, 163Y, 164T, 165H, 166L, 167Q, 168R, 169A, 170Q, 176H, 180L, 181H, 187N, 190K, 191R, 194Q, 198R, 209L, 210A, 211G, 212H, 213P, 215G, 218R, 232G, 233N, 234S, 235L, 236A, 239S, 240D, 242D, 246E, 249F, 253L, 256N, 257H, 259A, 260K, 263E, 264D, 269S, 270T, 273F, 281A, 287S, 288L, 289M, 290P, 292K, 293K, 294N, 296D, 299E, 300L, 302R, 303G, 304K, 305S, 306G, 307R, 309F, 310G, 311Q, 314G, 316M, 317M, 318S, 326Y, 327N, 328K, 329D, 332E, 335E, 346H, 349Q, 375A, 380D, 384R, 389F, 390R, 393H, 396S, 443R, 445A, 446I, 447G, 448G, 449T, 457Q
CDD
cd01359 (Argininosuccinate_lyase)

257H

tetramer interface
106K, 110G, 113H, 114T, 163Y, 164T, 165H, 166L, 167Q, 168R, 169A, 170Q, 176H, 180L, 181H, 187N, 190K, 191R, 194Q, 198R, 209L, 210A, 211G, 212H, 213P, 215G, 218R, 232G, 233N, 234S, 235L, 236A, 239S, 240D, 242D, 246E, 249F, 253L, 256N, 257H, 259A, 260K, 263E, 264D, 269S, 270T, 273F, 281A, 287S, 288L, 289M, 290P, 292K, 293K, 294N, 296D, 299E, 300L, 302R, 303G, 304K, 305S, 306G, 307R, 309F, 310G, 311Q, 314G, 316M, 317M, 318S, 326Y, 327N, 328K, 329D, 332E, 335E, 346H, 349Q, 375A, 380D, 384R, 389F, 390R, 393H, 396S, 443R, 445A, 446I, 447G, 448G, 449T, 457Q
CDD
cd01359 (Argininosuccinate_lyase)

259A

tetramer interface
106K, 110G, 113H, 114T, 163Y, 164T, 165H, 166L, 167Q, 168R, 169A, 170Q, 176H, 180L, 181H, 187N, 190K, 191R, 194Q, 198R, 209L, 210A, 211G, 212H, 213P, 215G, 218R, 232G, 233N, 234S, 235L, 236A, 239S, 240D, 242D, 246E, 249F, 253L, 256N, 257H, 259A, 260K, 263E, 264D, 269S, 270T, 273F, 281A, 287S, 288L, 289M, 290P, 292K, 293K, 294N, 296D, 299E, 300L, 302R, 303G, 304K, 305S, 306G, 307R, 309F, 310G, 311Q, 314G, 316M, 317M, 318S, 326Y, 327N, 328K, 329D, 332E, 335E, 346H, 349Q, 375A, 380D, 384R, 389F, 390R, 393H, 396S, 443R, 445A, 446I, 447G, 448G, 449T, 457Q
CDD
cd01359 (Argininosuccinate_lyase)

260K

tetramer interface
106K, 110G, 113H, 114T, 163Y, 164T, 165H, 166L, 167Q, 168R, 169A, 170Q, 176H, 180L, 181H, 187N, 190K, 191R, 194Q, 198R, 209L, 210A, 211G, 212H, 213P, 215G, 218R, 232G, 233N, 234S, 235L, 236A, 239S, 240D, 242D, 246E, 249F, 253L, 256N, 257H, 259A, 260K, 263E, 264D, 269S, 270T, 273F, 281A, 287S, 288L, 289M, 290P, 292K, 293K, 294N, 296D, 299E, 300L, 302R, 303G, 304K, 305S, 306G, 307R, 309F, 310G, 311Q, 314G, 316M, 317M, 318S, 326Y, 327N, 328K, 329D, 332E, 335E, 346H, 349Q, 375A, 380D, 384R, 389F, 390R, 393H, 396S, 443R, 445A, 446I, 447G, 448G, 449T, 457Q
CDD
cd01359 (Argininosuccinate_lyase)

263E

tetramer interface
106K, 110G, 113H, 114T, 163Y, 164T, 165H, 166L, 167Q, 168R, 169A, 170Q, 176H, 180L, 181H, 187N, 190K, 191R, 194Q, 198R, 209L, 210A, 211G, 212H, 213P, 215G, 218R, 232G, 233N, 234S, 235L, 236A, 239S, 240D, 242D, 246E, 249F, 253L, 256N, 257H, 259A, 260K, 263E, 264D, 269S, 270T, 273F, 281A, 287S, 288L, 289M, 290P, 292K, 293K, 294N, 296D, 299E, 300L, 302R, 303G, 304K, 305S, 306G, 307R, 309F, 310G, 311Q, 314G, 316M, 317M, 318S, 326Y, 327N, 328K, 329D, 332E, 335E, 346H, 349Q, 375A, 380D, 384R, 389F, 390R, 393H, 396S, 443R, 445A, 446I, 447G, 448G, 449T, 457Q
CDD
cd01359 (Argininosuccinate_lyase)

264D

tetramer interface
106K, 110G, 113H, 114T, 163Y, 164T, 165H, 166L, 167Q, 168R, 169A, 170Q, 176H, 180L, 181H, 187N, 190K, 191R, 194Q, 198R, 209L, 210A, 211G, 212H, 213P, 215G, 218R, 232G, 233N, 234S, 235L, 236A, 239S, 240D, 242D, 246E, 249F, 253L, 256N, 257H, 259A, 260K, 263E, 264D, 269S, 270T, 273F, 281A, 287S, 288L, 289M, 290P, 292K, 293K, 294N, 296D, 299E, 300L, 302R, 303G, 304K, 305S, 306G, 307R, 309F, 310G, 311Q, 314G, 316M, 317M, 318S, 326Y, 327N, 328K, 329D, 332E, 335E, 346H, 349Q, 375A, 380D, 384R, 389F, 390R, 393H, 396S, 443R, 445A, 446I, 447G, 448G, 449T, 457Q
CDD
cd01359 (Argininosuccinate_lyase)

269S

tetramer interface
106K, 110G, 113H, 114T, 163Y, 164T, 165H, 166L, 167Q, 168R, 169A, 170Q, 176H, 180L, 181H, 187N, 190K, 191R, 194Q, 198R, 209L, 210A, 211G, 212H, 213P, 215G, 218R, 232G, 233N, 234S, 235L, 236A, 239S, 240D, 242D, 246E, 249F, 253L, 256N, 257H, 259A, 260K, 263E, 264D, 269S, 270T, 273F, 281A, 287S, 288L, 289M, 290P, 292K, 293K, 294N, 296D, 299E, 300L, 302R, 303G, 304K, 305S, 306G, 307R, 309F, 310G, 311Q, 314G, 316M, 317M, 318S, 326Y, 327N, 328K, 329D, 332E, 335E, 346H, 349Q, 375A, 380D, 384R, 389F, 390R, 393H, 396S, 443R, 445A, 446I, 447G, 448G, 449T, 457Q
CDD
cd01359 (Argininosuccinate_lyase)

270T

tetramer interface
106K, 110G, 113H, 114T, 163Y, 164T, 165H, 166L, 167Q, 168R, 169A, 170Q, 176H, 180L, 181H, 187N, 190K, 191R, 194Q, 198R, 209L, 210A, 211G, 212H, 213P, 215G, 218R, 232G, 233N, 234S, 235L, 236A, 239S, 240D, 242D, 246E, 249F, 253L, 256N, 257H, 259A, 260K, 263E, 264D, 269S, 270T, 273F, 281A, 287S, 288L, 289M, 290P, 292K, 293K, 294N, 296D, 299E, 300L, 302R, 303G, 304K, 305S, 306G, 307R, 309F, 310G, 311Q, 314G, 316M, 317M, 318S, 326Y, 327N, 328K, 329D, 332E, 335E, 346H, 349Q, 375A, 380D, 384R, 389F, 390R, 393H, 396S, 443R, 445A, 446I, 447G, 448G, 449T, 457Q
CDD
cd01359 (Argininosuccinate_lyase)

273F

tetramer interface
106K, 110G, 113H, 114T, 163Y, 164T, 165H, 166L, 167Q, 168R, 169A, 170Q, 176H, 180L, 181H, 187N, 190K, 191R, 194Q, 198R, 209L, 210A, 211G, 212H, 213P, 215G, 218R, 232G, 233N, 234S, 235L, 236A, 239S, 240D, 242D, 246E, 249F, 253L, 256N, 257H, 259A, 260K, 263E, 264D, 269S, 270T, 273F, 281A, 287S, 288L, 289M, 290P, 292K, 293K, 294N, 296D, 299E, 300L, 302R, 303G, 304K, 305S, 306G, 307R, 309F, 310G, 311Q, 314G, 316M, 317M, 318S, 326Y, 327N, 328K, 329D, 332E, 335E, 346H, 349Q, 375A, 380D, 384R, 389F, 390R, 393H, 396S, 443R, 445A, 446I, 447G, 448G, 449T, 457Q
CDD
cd01359 (Argininosuccinate_lyase)

281A

tetramer interface
106K, 110G, 113H, 114T, 163Y, 164T, 165H, 166L, 167Q, 168R, 169A, 170Q, 176H, 180L, 181H, 187N, 190K, 191R, 194Q, 198R, 209L, 210A, 211G, 212H, 213P, 215G, 218R, 232G, 233N, 234S, 235L, 236A, 239S, 240D, 242D, 246E, 249F, 253L, 256N, 257H, 259A, 260K, 263E, 264D, 269S, 270T, 273F, 281A, 287S, 288L, 289M, 290P, 292K, 293K, 294N, 296D, 299E, 300L, 302R, 303G, 304K, 305S, 306G, 307R, 309F, 310G, 311Q, 314G, 316M, 317M, 318S, 326Y, 327N, 328K, 329D, 332E, 335E, 346H, 349Q, 375A, 380D, 384R, 389F, 390R, 393H, 396S, 443R, 445A, 446I, 447G, 448G, 449T, 457Q
CDD
cd01359 (Argininosuccinate_lyase)

287S

tetramer interface
106K, 110G, 113H, 114T, 163Y, 164T, 165H, 166L, 167Q, 168R, 169A, 170Q, 176H, 180L, 181H, 187N, 190K, 191R, 194Q, 198R, 209L, 210A, 211G, 212H, 213P, 215G, 218R, 232G, 233N, 234S, 235L, 236A, 239S, 240D, 242D, 246E, 249F, 253L, 256N, 257H, 259A, 260K, 263E, 264D, 269S, 270T, 273F, 281A, 287S, 288L, 289M, 290P, 292K, 293K, 294N, 296D, 299E, 300L, 302R, 303G, 304K, 305S, 306G, 307R, 309F, 310G, 311Q, 314G, 316M, 317M, 318S, 326Y, 327N, 328K, 329D, 332E, 335E, 346H, 349Q, 375A, 380D, 384R, 389F, 390R, 393H, 396S, 443R, 445A, 446I, 447G, 448G, 449T, 457Q
CDD
cd01359 (Argininosuccinate_lyase)

288L

tetramer interface
106K, 110G, 113H, 114T, 163Y, 164T, 165H, 166L, 167Q, 168R, 169A, 170Q, 176H, 180L, 181H, 187N, 190K, 191R, 194Q, 198R, 209L, 210A, 211G, 212H, 213P, 215G, 218R, 232G, 233N, 234S, 235L, 236A, 239S, 240D, 242D, 246E, 249F, 253L, 256N, 257H, 259A, 260K, 263E, 264D, 269S, 270T, 273F, 281A, 287S, 288L, 289M, 290P, 292K, 293K, 294N, 296D, 299E, 300L, 302R, 303G, 304K, 305S, 306G, 307R, 309F, 310G, 311Q, 314G, 316M, 317M, 318S, 326Y, 327N, 328K, 329D, 332E, 335E, 346H, 349Q, 375A, 380D, 384R, 389F, 390R, 393H, 396S, 443R, 445A, 446I, 447G, 448G, 449T, 457Q
CDD
cd01359 (Argininosuccinate_lyase)

289M

tetramer interface
106K, 110G, 113H, 114T, 163Y, 164T, 165H, 166L, 167Q, 168R, 169A, 170Q, 176H, 180L, 181H, 187N, 190K, 191R, 194Q, 198R, 209L, 210A, 211G, 212H, 213P, 215G, 218R, 232G, 233N, 234S, 235L, 236A, 239S, 240D, 242D, 246E, 249F, 253L, 256N, 257H, 259A, 260K, 263E, 264D, 269S, 270T, 273F, 281A, 287S, 288L, 289M, 290P, 292K, 293K, 294N, 296D, 299E, 300L, 302R, 303G, 304K, 305S, 306G, 307R, 309F, 310G, 311Q, 314G, 316M, 317M, 318S, 326Y, 327N, 328K, 329D, 332E, 335E, 346H, 349Q, 375A, 380D, 384R, 389F, 390R, 393H, 396S, 443R, 445A, 446I, 447G, 448G, 449T, 457Q
CDD
cd01359 (Argininosuccinate_lyase)

290P

tetramer interface
106K, 110G, 113H, 114T, 163Y, 164T, 165H, 166L, 167Q, 168R, 169A, 170Q, 176H, 180L, 181H, 187N, 190K, 191R, 194Q, 198R, 209L, 210A, 211G, 212H, 213P, 215G, 218R, 232G, 233N, 234S, 235L, 236A, 239S, 240D, 242D, 246E, 249F, 253L, 256N, 257H, 259A, 260K, 263E, 264D, 269S, 270T, 273F, 281A, 287S, 288L, 289M, 290P, 292K, 293K, 294N, 296D, 299E, 300L, 302R, 303G, 304K, 305S, 306G, 307R, 309F, 310G, 311Q, 314G, 316M, 317M, 318S, 326Y, 327N, 328K, 329D, 332E, 335E, 346H, 349Q, 375A, 380D, 384R, 389F, 390R, 393H, 396S, 443R, 445A, 446I, 447G, 448G, 449T, 457Q
CDD
cd01359 (Argininosuccinate_lyase)

292K

tetramer interface
106K, 110G, 113H, 114T, 163Y, 164T, 165H, 166L, 167Q, 168R, 169A, 170Q, 176H, 180L, 181H, 187N, 190K, 191R, 194Q, 198R, 209L, 210A, 211G, 212H, 213P, 215G, 218R, 232G, 233N, 234S, 235L, 236A, 239S, 240D, 242D, 246E, 249F, 253L, 256N, 257H, 259A, 260K, 263E, 264D, 269S, 270T, 273F, 281A, 287S, 288L, 289M, 290P, 292K, 293K, 294N, 296D, 299E, 300L, 302R, 303G, 304K, 305S, 306G, 307R, 309F, 310G, 311Q, 314G, 316M, 317M, 318S, 326Y, 327N, 328K, 329D, 332E, 335E, 346H, 349Q, 375A, 380D, 384R, 389F, 390R, 393H, 396S, 443R, 445A, 446I, 447G, 448G, 449T, 457Q
CDD
cd01359 (Argininosuccinate_lyase)

293K

tetramer interface
106K, 110G, 113H, 114T, 163Y, 164T, 165H, 166L, 167Q, 168R, 169A, 170Q, 176H, 180L, 181H, 187N, 190K, 191R, 194Q, 198R, 209L, 210A, 211G, 212H, 213P, 215G, 218R, 232G, 233N, 234S, 235L, 236A, 239S, 240D, 242D, 246E, 249F, 253L, 256N, 257H, 259A, 260K, 263E, 264D, 269S, 270T, 273F, 281A, 287S, 288L, 289M, 290P, 292K, 293K, 294N, 296D, 299E, 300L, 302R, 303G, 304K, 305S, 306G, 307R, 309F, 310G, 311Q, 314G, 316M, 317M, 318S, 326Y, 327N, 328K, 329D, 332E, 335E, 346H, 349Q, 375A, 380D, 384R, 389F, 390R, 393H, 396S, 443R, 445A, 446I, 447G, 448G, 449T, 457Q
CDD
cd01359 (Argininosuccinate_lyase)

294N

tetramer interface
106K, 110G, 113H, 114T, 163Y, 164T, 165H, 166L, 167Q, 168R, 169A, 170Q, 176H, 180L, 181H, 187N, 190K, 191R, 194Q, 198R, 209L, 210A, 211G, 212H, 213P, 215G, 218R, 232G, 233N, 234S, 235L, 236A, 239S, 240D, 242D, 246E, 249F, 253L, 256N, 257H, 259A, 260K, 263E, 264D, 269S, 270T, 273F, 281A, 287S, 288L, 289M, 290P, 292K, 293K, 294N, 296D, 299E, 300L, 302R, 303G, 304K, 305S, 306G, 307R, 309F, 310G, 311Q, 314G, 316M, 317M, 318S, 326Y, 327N, 328K, 329D, 332E, 335E, 346H, 349Q, 375A, 380D, 384R, 389F, 390R, 393H, 396S, 443R, 445A, 446I, 447G, 448G, 449T, 457Q
CDD
cd01359 (Argininosuccinate_lyase)

296D

tetramer interface
106K, 110G, 113H, 114T, 163Y, 164T, 165H, 166L, 167Q, 168R, 169A, 170Q, 176H, 180L, 181H, 187N, 190K, 191R, 194Q, 198R, 209L, 210A, 211G, 212H, 213P, 215G, 218R, 232G, 233N, 234S, 235L, 236A, 239S, 240D, 242D, 246E, 249F, 253L, 256N, 257H, 259A, 260K, 263E, 264D, 269S, 270T, 273F, 281A, 287S, 288L, 289M, 290P, 292K, 293K, 294N, 296D, 299E, 300L, 302R, 303G, 304K, 305S, 306G, 307R, 309F, 310G, 311Q, 314G, 316M, 317M, 318S, 326Y, 327N, 328K, 329D, 332E, 335E, 346H, 349Q, 375A, 380D, 384R, 389F, 390R, 393H, 396S, 443R, 445A, 446I, 447G, 448G, 449T, 457Q
CDD
cd01359 (Argininosuccinate_lyase)

299E

tetramer interface
106K, 110G, 113H, 114T, 163Y, 164T, 165H, 166L, 167Q, 168R, 169A, 170Q, 176H, 180L, 181H, 187N, 190K, 191R, 194Q, 198R, 209L, 210A, 211G, 212H, 213P, 215G, 218R, 232G, 233N, 234S, 235L, 236A, 239S, 240D, 242D, 246E, 249F, 253L, 256N, 257H, 259A, 260K, 263E, 264D, 269S, 270T, 273F, 281A, 287S, 288L, 289M, 290P, 292K, 293K, 294N, 296D, 299E, 300L, 302R, 303G, 304K, 305S, 306G, 307R, 309F, 310G, 311Q, 314G, 316M, 317M, 318S, 326Y, 327N, 328K, 329D, 332E, 335E, 346H, 349Q, 375A, 380D, 384R, 389F, 390R, 393H, 396S, 443R, 445A, 446I, 447G, 448G, 449T, 457Q
CDD
cd01359 (Argininosuccinate_lyase)

300L

tetramer interface
106K, 110G, 113H, 114T, 163Y, 164T, 165H, 166L, 167Q, 168R, 169A, 170Q, 176H, 180L, 181H, 187N, 190K, 191R, 194Q, 198R, 209L, 210A, 211G, 212H, 213P, 215G, 218R, 232G, 233N, 234S, 235L, 236A, 239S, 240D, 242D, 246E, 249F, 253L, 256N, 257H, 259A, 260K, 263E, 264D, 269S, 270T, 273F, 281A, 287S, 288L, 289M, 290P, 292K, 293K, 294N, 296D, 299E, 300L, 302R, 303G, 304K, 305S, 306G, 307R, 309F, 310G, 311Q, 314G, 316M, 317M, 318S, 326Y, 327N, 328K, 329D, 332E, 335E, 346H, 349Q, 375A, 380D, 384R, 389F, 390R, 393H, 396S, 443R, 445A, 446I, 447G, 448G, 449T, 457Q
CDD
cd01359 (Argininosuccinate_lyase)

302R

tetramer interface
106K, 110G, 113H, 114T, 163Y, 164T, 165H, 166L, 167Q, 168R, 169A, 170Q, 176H, 180L, 181H, 187N, 190K, 191R, 194Q, 198R, 209L, 210A, 211G, 212H, 213P, 215G, 218R, 232G, 233N, 234S, 235L, 236A, 239S, 240D, 242D, 246E, 249F, 253L, 256N, 257H, 259A, 260K, 263E, 264D, 269S, 270T, 273F, 281A, 287S, 288L, 289M, 290P, 292K, 293K, 294N, 296D, 299E, 300L, 302R, 303G, 304K, 305S, 306G, 307R, 309F, 310G, 311Q, 314G, 316M, 317M, 318S, 326Y, 327N, 328K, 329D, 332E, 335E, 346H, 349Q, 375A, 380D, 384R, 389F, 390R, 393H, 396S, 443R, 445A, 446I, 447G, 448G, 449T, 457Q
CDD
cd01359 (Argininosuccinate_lyase)

303G

tetramer interface
106K, 110G, 113H, 114T, 163Y, 164T, 165H, 166L, 167Q, 168R, 169A, 170Q, 176H, 180L, 181H, 187N, 190K, 191R, 194Q, 198R, 209L, 210A, 211G, 212H, 213P, 215G, 218R, 232G, 233N, 234S, 235L, 236A, 239S, 240D, 242D, 246E, 249F, 253L, 256N, 257H, 259A, 260K, 263E, 264D, 269S, 270T, 273F, 281A, 287S, 288L, 289M, 290P, 292K, 293K, 294N, 296D, 299E, 300L, 302R, 303G, 304K, 305S, 306G, 307R, 309F, 310G, 311Q, 314G, 316M, 317M, 318S, 326Y, 327N, 328K, 329D, 332E, 335E, 346H, 349Q, 375A, 380D, 384R, 389F, 390R, 393H, 396S, 443R, 445A, 446I, 447G, 448G, 449T, 457Q
CDD
cd01359 (Argininosuccinate_lyase)

304K

tetramer interface
106K, 110G, 113H, 114T, 163Y, 164T, 165H, 166L, 167Q, 168R, 169A, 170Q, 176H, 180L, 181H, 187N, 190K, 191R, 194Q, 198R, 209L, 210A, 211G, 212H, 213P, 215G, 218R, 232G, 233N, 234S, 235L, 236A, 239S, 240D, 242D, 246E, 249F, 253L, 256N, 257H, 259A, 260K, 263E, 264D, 269S, 270T, 273F, 281A, 287S, 288L, 289M, 290P, 292K, 293K, 294N, 296D, 299E, 300L, 302R, 303G, 304K, 305S, 306G, 307R, 309F, 310G, 311Q, 314G, 316M, 317M, 318S, 326Y, 327N, 328K, 329D, 332E, 335E, 346H, 349Q, 375A, 380D, 384R, 389F, 390R, 393H, 396S, 443R, 445A, 446I, 447G, 448G, 449T, 457Q
CDD
cd01359 (Argininosuccinate_lyase)

305S

tetramer interface
106K, 110G, 113H, 114T, 163Y, 164T, 165H, 166L, 167Q, 168R, 169A, 170Q, 176H, 180L, 181H, 187N, 190K, 191R, 194Q, 198R, 209L, 210A, 211G, 212H, 213P, 215G, 218R, 232G, 233N, 234S, 235L, 236A, 239S, 240D, 242D, 246E, 249F, 253L, 256N, 257H, 259A, 260K, 263E, 264D, 269S, 270T, 273F, 281A, 287S, 288L, 289M, 290P, 292K, 293K, 294N, 296D, 299E, 300L, 302R, 303G, 304K, 305S, 306G, 307R, 309F, 310G, 311Q, 314G, 316M, 317M, 318S, 326Y, 327N, 328K, 329D, 332E, 335E, 346H, 349Q, 375A, 380D, 384R, 389F, 390R, 393H, 396S, 443R, 445A, 446I, 447G, 448G, 449T, 457Q
CDD
cd01359 (Argininosuccinate_lyase)

306G

tetramer interface
106K, 110G, 113H, 114T, 163Y, 164T, 165H, 166L, 167Q, 168R, 169A, 170Q, 176H, 180L, 181H, 187N, 190K, 191R, 194Q, 198R, 209L, 210A, 211G, 212H, 213P, 215G, 218R, 232G, 233N, 234S, 235L, 236A, 239S, 240D, 242D, 246E, 249F, 253L, 256N, 257H, 259A, 260K, 263E, 264D, 269S, 270T, 273F, 281A, 287S, 288L, 289M, 290P, 292K, 293K, 294N, 296D, 299E, 300L, 302R, 303G, 304K, 305S, 306G, 307R, 309F, 310G, 311Q, 314G, 316M, 317M, 318S, 326Y, 327N, 328K, 329D, 332E, 335E, 346H, 349Q, 375A, 380D, 384R, 389F, 390R, 393H, 396S, 443R, 445A, 446I, 447G, 448G, 449T, 457Q
CDD
cd01359 (Argininosuccinate_lyase)

307R

tetramer interface
106K, 110G, 113H, 114T, 163Y, 164T, 165H, 166L, 167Q, 168R, 169A, 170Q, 176H, 180L, 181H, 187N, 190K, 191R, 194Q, 198R, 209L, 210A, 211G, 212H, 213P, 215G, 218R, 232G, 233N, 234S, 235L, 236A, 239S, 240D, 242D, 246E, 249F, 253L, 256N, 257H, 259A, 260K, 263E, 264D, 269S, 270T, 273F, 281A, 287S, 288L, 289M, 290P, 292K, 293K, 294N, 296D, 299E, 300L, 302R, 303G, 304K, 305S, 306G, 307R, 309F, 310G, 311Q, 314G, 316M, 317M, 318S, 326Y, 327N, 328K, 329D, 332E, 335E, 346H, 349Q, 375A, 380D, 384R, 389F, 390R, 393H, 396S, 443R, 445A, 446I, 447G, 448G, 449T, 457Q
CDD
cd01359 (Argininosuccinate_lyase)

309F

tetramer interface
106K, 110G, 113H, 114T, 163Y, 164T, 165H, 166L, 167Q, 168R, 169A, 170Q, 176H, 180L, 181H, 187N, 190K, 191R, 194Q, 198R, 209L, 210A, 211G, 212H, 213P, 215G, 218R, 232G, 233N, 234S, 235L, 236A, 239S, 240D, 242D, 246E, 249F, 253L, 256N, 257H, 259A, 260K, 263E, 264D, 269S, 270T, 273F, 281A, 287S, 288L, 289M, 290P, 292K, 293K, 294N, 296D, 299E, 300L, 302R, 303G, 304K, 305S, 306G, 307R, 309F, 310G, 311Q, 314G, 316M, 317M, 318S, 326Y, 327N, 328K, 329D, 332E, 335E, 346H, 349Q, 375A, 380D, 384R, 389F, 390R, 393H, 396S, 443R, 445A, 446I, 447G, 448G, 449T, 457Q
CDD
cd01359 (Argininosuccinate_lyase)

310G

tetramer interface
106K, 110G, 113H, 114T, 163Y, 164T, 165H, 166L, 167Q, 168R, 169A, 170Q, 176H, 180L, 181H, 187N, 190K, 191R, 194Q, 198R, 209L, 210A, 211G, 212H, 213P, 215G, 218R, 232G, 233N, 234S, 235L, 236A, 239S, 240D, 242D, 246E, 249F, 253L, 256N, 257H, 259A, 260K, 263E, 264D, 269S, 270T, 273F, 281A, 287S, 288L, 289M, 290P, 292K, 293K, 294N, 296D, 299E, 300L, 302R, 303G, 304K, 305S, 306G, 307R, 309F, 310G, 311Q, 314G, 316M, 317M, 318S, 326Y, 327N, 328K, 329D, 332E, 335E, 346H, 349Q, 375A, 380D, 384R, 389F, 390R, 393H, 396S, 443R, 445A, 446I, 447G, 448G, 449T, 457Q
CDD
cd01359 (Argininosuccinate_lyase)

311Q

tetramer interface
106K, 110G, 113H, 114T, 163Y, 164T, 165H, 166L, 167Q, 168R, 169A, 170Q, 176H, 180L, 181H, 187N, 190K, 191R, 194Q, 198R, 209L, 210A, 211G, 212H, 213P, 215G, 218R, 232G, 233N, 234S, 235L, 236A, 239S, 240D, 242D, 246E, 249F, 253L, 256N, 257H, 259A, 260K, 263E, 264D, 269S, 270T, 273F, 281A, 287S, 288L, 289M, 290P, 292K, 293K, 294N, 296D, 299E, 300L, 302R, 303G, 304K, 305S, 306G, 307R, 309F, 310G, 311Q, 314G, 316M, 317M, 318S, 326Y, 327N, 328K, 329D, 332E, 335E, 346H, 349Q, 375A, 380D, 384R, 389F, 390R, 393H, 396S, 443R, 445A, 446I, 447G, 448G, 449T, 457Q
CDD
cd01359 (Argininosuccinate_lyase)

314G

tetramer interface
106K, 110G, 113H, 114T, 163Y, 164T, 165H, 166L, 167Q, 168R, 169A, 170Q, 176H, 180L, 181H, 187N, 190K, 191R, 194Q, 198R, 209L, 210A, 211G, 212H, 213P, 215G, 218R, 232G, 233N, 234S, 235L, 236A, 239S, 240D, 242D, 246E, 249F, 253L, 256N, 257H, 259A, 260K, 263E, 264D, 269S, 270T, 273F, 281A, 287S, 288L, 289M, 290P, 292K, 293K, 294N, 296D, 299E, 300L, 302R, 303G, 304K, 305S, 306G, 307R, 309F, 310G, 311Q, 314G, 316M, 317M, 318S, 326Y, 327N, 328K, 329D, 332E, 335E, 346H, 349Q, 375A, 380D, 384R, 389F, 390R, 393H, 396S, 443R, 445A, 446I, 447G, 448G, 449T, 457Q
CDD
cd01359 (Argininosuccinate_lyase)

316M

tetramer interface
106K, 110G, 113H, 114T, 163Y, 164T, 165H, 166L, 167Q, 168R, 169A, 170Q, 176H, 180L, 181H, 187N, 190K, 191R, 194Q, 198R, 209L, 210A, 211G, 212H, 213P, 215G, 218R, 232G, 233N, 234S, 235L, 236A, 239S, 240D, 242D, 246E, 249F, 253L, 256N, 257H, 259A, 260K, 263E, 264D, 269S, 270T, 273F, 281A, 287S, 288L, 289M, 290P, 292K, 293K, 294N, 296D, 299E, 300L, 302R, 303G, 304K, 305S, 306G, 307R, 309F, 310G, 311Q, 314G, 316M, 317M, 318S, 326Y, 327N, 328K, 329D, 332E, 335E, 346H, 349Q, 375A, 380D, 384R, 389F, 390R, 393H, 396S, 443R, 445A, 446I, 447G, 448G, 449T, 457Q
CDD
cd01359 (Argininosuccinate_lyase)

317M

tetramer interface
106K, 110G, 113H, 114T, 163Y, 164T, 165H, 166L, 167Q, 168R, 169A, 170Q, 176H, 180L, 181H, 187N, 190K, 191R, 194Q, 198R, 209L, 210A, 211G, 212H, 213P, 215G, 218R, 232G, 233N, 234S, 235L, 236A, 239S, 240D, 242D, 246E, 249F, 253L, 256N, 257H, 259A, 260K, 263E, 264D, 269S, 270T, 273F, 281A, 287S, 288L, 289M, 290P, 292K, 293K, 294N, 296D, 299E, 300L, 302R, 303G, 304K, 305S, 306G, 307R, 309F, 310G, 311Q, 314G, 316M, 317M, 318S, 326Y, 327N, 328K, 329D, 332E, 335E, 346H, 349Q, 375A, 380D, 384R, 389F, 390R, 393H, 396S, 443R, 445A, 446I, 447G, 448G, 449T, 457Q
CDD
cd01359 (Argininosuccinate_lyase)

318S

tetramer interface
106K, 110G, 113H, 114T, 163Y, 164T, 165H, 166L, 167Q, 168R, 169A, 170Q, 176H, 180L, 181H, 187N, 190K, 191R, 194Q, 198R, 209L, 210A, 211G, 212H, 213P, 215G, 218R, 232G, 233N, 234S, 235L, 236A, 239S, 240D, 242D, 246E, 249F, 253L, 256N, 257H, 259A, 260K, 263E, 264D, 269S, 270T, 273F, 281A, 287S, 288L, 289M, 290P, 292K, 293K, 294N, 296D, 299E, 300L, 302R, 303G, 304K, 305S, 306G, 307R, 309F, 310G, 311Q, 314G, 316M, 317M, 318S, 326Y, 327N, 328K, 329D, 332E, 335E, 346H, 349Q, 375A, 380D, 384R, 389F, 390R, 393H, 396S, 443R, 445A, 446I, 447G, 448G, 449T, 457Q
CDD
cd01359 (Argininosuccinate_lyase)

326Y

tetramer interface
106K, 110G, 113H, 114T, 163Y, 164T, 165H, 166L, 167Q, 168R, 169A, 170Q, 176H, 180L, 181H, 187N, 190K, 191R, 194Q, 198R, 209L, 210A, 211G, 212H, 213P, 215G, 218R, 232G, 233N, 234S, 235L, 236A, 239S, 240D, 242D, 246E, 249F, 253L, 256N, 257H, 259A, 260K, 263E, 264D, 269S, 270T, 273F, 281A, 287S, 288L, 289M, 290P, 292K, 293K, 294N, 296D, 299E, 300L, 302R, 303G, 304K, 305S, 306G, 307R, 309F, 310G, 311Q, 314G, 316M, 317M, 318S, 326Y, 327N, 328K, 329D, 332E, 335E, 346H, 349Q, 375A, 380D, 384R, 389F, 390R, 393H, 396S, 443R, 445A, 446I, 447G, 448G, 449T, 457Q
CDD
cd01359 (Argininosuccinate_lyase)

327N

tetramer interface
106K, 110G, 113H, 114T, 163Y, 164T, 165H, 166L, 167Q, 168R, 169A, 170Q, 176H, 180L, 181H, 187N, 190K, 191R, 194Q, 198R, 209L, 210A, 211G, 212H, 213P, 215G, 218R, 232G, 233N, 234S, 235L, 236A, 239S, 240D, 242D, 246E, 249F, 253L, 256N, 257H, 259A, 260K, 263E, 264D, 269S, 270T, 273F, 281A, 287S, 288L, 289M, 290P, 292K, 293K, 294N, 296D, 299E, 300L, 302R, 303G, 304K, 305S, 306G, 307R, 309F, 310G, 311Q, 314G, 316M, 317M, 318S, 326Y, 327N, 328K, 329D, 332E, 335E, 346H, 349Q, 375A, 380D, 384R, 389F, 390R, 393H, 396S, 443R, 445A, 446I, 447G, 448G, 449T, 457Q
CDD
cd01359 (Argininosuccinate_lyase)

328K

tetramer interface
106K, 110G, 113H, 114T, 163Y, 164T, 165H, 166L, 167Q, 168R, 169A, 170Q, 176H, 180L, 181H, 187N, 190K, 191R, 194Q, 198R, 209L, 210A, 211G, 212H, 213P, 215G, 218R, 232G, 233N, 234S, 235L, 236A, 239S, 240D, 242D, 246E, 249F, 253L, 256N, 257H, 259A, 260K, 263E, 264D, 269S, 270T, 273F, 281A, 287S, 288L, 289M, 290P, 292K, 293K, 294N, 296D, 299E, 300L, 302R, 303G, 304K, 305S, 306G, 307R, 309F, 310G, 311Q, 314G, 316M, 317M, 318S, 326Y, 327N, 328K, 329D, 332E, 335E, 346H, 349Q, 375A, 380D, 384R, 389F, 390R, 393H, 396S, 443R, 445A, 446I, 447G, 448G, 449T, 457Q
CDD
cd01359 (Argininosuccinate_lyase)

329D

tetramer interface
106K, 110G, 113H, 114T, 163Y, 164T, 165H, 166L, 167Q, 168R, 169A, 170Q, 176H, 180L, 181H, 187N, 190K, 191R, 194Q, 198R, 209L, 210A, 211G, 212H, 213P, 215G, 218R, 232G, 233N, 234S, 235L, 236A, 239S, 240D, 242D, 246E, 249F, 253L, 256N, 257H, 259A, 260K, 263E, 264D, 269S, 270T, 273F, 281A, 287S, 288L, 289M, 290P, 292K, 293K, 294N, 296D, 299E, 300L, 302R, 303G, 304K, 305S, 306G, 307R, 309F, 310G, 311Q, 314G, 316M, 317M, 318S, 326Y, 327N, 328K, 329D, 332E, 335E, 346H, 349Q, 375A, 380D, 384R, 389F, 390R, 393H, 396S, 443R, 445A, 446I, 447G, 448G, 449T, 457Q
CDD
cd01359 (Argininosuccinate_lyase)

332E

tetramer interface
106K, 110G, 113H, 114T, 163Y, 164T, 165H, 166L, 167Q, 168R, 169A, 170Q, 176H, 180L, 181H, 187N, 190K, 191R, 194Q, 198R, 209L, 210A, 211G, 212H, 213P, 215G, 218R, 232G, 233N, 234S, 235L, 236A, 239S, 240D, 242D, 246E, 249F, 253L, 256N, 257H, 259A, 260K, 263E, 264D, 269S, 270T, 273F, 281A, 287S, 288L, 289M, 290P, 292K, 293K, 294N, 296D, 299E, 300L, 302R, 303G, 304K, 305S, 306G, 307R, 309F, 310G, 311Q, 314G, 316M, 317M, 318S, 326Y, 327N, 328K, 329D, 332E, 335E, 346H, 349Q, 375A, 380D, 384R, 389F, 390R, 393H, 396S, 443R, 445A, 446I, 447G, 448G, 449T, 457Q
CDD
cd01359 (Argininosuccinate_lyase)

335E

tetramer interface
106K, 110G, 113H, 114T, 163Y, 164T, 165H, 166L, 167Q, 168R, 169A, 170Q, 176H, 180L, 181H, 187N, 190K, 191R, 194Q, 198R, 209L, 210A, 211G, 212H, 213P, 215G, 218R, 232G, 233N, 234S, 235L, 236A, 239S, 240D, 242D, 246E, 249F, 253L, 256N, 257H, 259A, 260K, 263E, 264D, 269S, 270T, 273F, 281A, 287S, 288L, 289M, 290P, 292K, 293K, 294N, 296D, 299E, 300L, 302R, 303G, 304K, 305S, 306G, 307R, 309F, 310G, 311Q, 314G, 316M, 317M, 318S, 326Y, 327N, 328K, 329D, 332E, 335E, 346H, 349Q, 375A, 380D, 384R, 389F, 390R, 393H, 396S, 443R, 445A, 446I, 447G, 448G, 449T, 457Q
CDD
cd01359 (Argininosuccinate_lyase)

346H

tetramer interface
106K, 110G, 113H, 114T, 163Y, 164T, 165H, 166L, 167Q, 168R, 169A, 170Q, 176H, 180L, 181H, 187N, 190K, 191R, 194Q, 198R, 209L, 210A, 211G, 212H, 213P, 215G, 218R, 232G, 233N, 234S, 235L, 236A, 239S, 240D, 242D, 246E, 249F, 253L, 256N, 257H, 259A, 260K, 263E, 264D, 269S, 270T, 273F, 281A, 287S, 288L, 289M, 290P, 292K, 293K, 294N, 296D, 299E, 300L, 302R, 303G, 304K, 305S, 306G, 307R, 309F, 310G, 311Q, 314G, 316M, 317M, 318S, 326Y, 327N, 328K, 329D, 332E, 335E, 346H, 349Q, 375A, 380D, 384R, 389F, 390R, 393H, 396S, 443R, 445A, 446I, 447G, 448G, 449T, 457Q
CDD
cd01359 (Argininosuccinate_lyase)

349Q

tetramer interface
106K, 110G, 113H, 114T, 163Y, 164T, 165H, 166L, 167Q, 168R, 169A, 170Q, 176H, 180L, 181H, 187N, 190K, 191R, 194Q, 198R, 209L, 210A, 211G, 212H, 213P, 215G, 218R, 232G, 233N, 234S, 235L, 236A, 239S, 240D, 242D, 246E, 249F, 253L, 256N, 257H, 259A, 260K, 263E, 264D, 269S, 270T, 273F, 281A, 287S, 288L, 289M, 290P, 292K, 293K, 294N, 296D, 299E, 300L, 302R, 303G, 304K, 305S, 306G, 307R, 309F, 310G, 311Q, 314G, 316M, 317M, 318S, 326Y, 327N, 328K, 329D, 332E, 335E, 346H, 349Q, 375A, 380D, 384R, 389F, 390R, 393H, 396S, 443R, 445A, 446I, 447G, 448G, 449T, 457Q
CDD
cd01359 (Argininosuccinate_lyase)

375A

tetramer interface
106K, 110G, 113H, 114T, 163Y, 164T, 165H, 166L, 167Q, 168R, 169A, 170Q, 176H, 180L, 181H, 187N, 190K, 191R, 194Q, 198R, 209L, 210A, 211G, 212H, 213P, 215G, 218R, 232G, 233N, 234S, 235L, 236A, 239S, 240D, 242D, 246E, 249F, 253L, 256N, 257H, 259A, 260K, 263E, 264D, 269S, 270T, 273F, 281A, 287S, 288L, 289M, 290P, 292K, 293K, 294N, 296D, 299E, 300L, 302R, 303G, 304K, 305S, 306G, 307R, 309F, 310G, 311Q, 314G, 316M, 317M, 318S, 326Y, 327N, 328K, 329D, 332E, 335E, 346H, 349Q, 375A, 380D, 384R, 389F, 390R, 393H, 396S, 443R, 445A, 446I, 447G, 448G, 449T, 457Q
CDD
cd01359 (Argininosuccinate_lyase)

380D

tetramer interface
106K, 110G, 113H, 114T, 163Y, 164T, 165H, 166L, 167Q, 168R, 169A, 170Q, 176H, 180L, 181H, 187N, 190K, 191R, 194Q, 198R, 209L, 210A, 211G, 212H, 213P, 215G, 218R, 232G, 233N, 234S, 235L, 236A, 239S, 240D, 242D, 246E, 249F, 253L, 256N, 257H, 259A, 260K, 263E, 264D, 269S, 270T, 273F, 281A, 287S, 288L, 289M, 290P, 292K, 293K, 294N, 296D, 299E, 300L, 302R, 303G, 304K, 305S, 306G, 307R, 309F, 310G, 311Q, 314G, 316M, 317M, 318S, 326Y, 327N, 328K, 329D, 332E, 335E, 346H, 349Q, 375A, 380D, 384R, 389F, 390R, 393H, 396S, 443R, 445A, 446I, 447G, 448G, 449T, 457Q
CDD
cd01359 (Argininosuccinate_lyase)

384R

tetramer interface
106K, 110G, 113H, 114T, 163Y, 164T, 165H, 166L, 167Q, 168R, 169A, 170Q, 176H, 180L, 181H, 187N, 190K, 191R, 194Q, 198R, 209L, 210A, 211G, 212H, 213P, 215G, 218R, 232G, 233N, 234S, 235L, 236A, 239S, 240D, 242D, 246E, 249F, 253L, 256N, 257H, 259A, 260K, 263E, 264D, 269S, 270T, 273F, 281A, 287S, 288L, 289M, 290P, 292K, 293K, 294N, 296D, 299E, 300L, 302R, 303G, 304K, 305S, 306G, 307R, 309F, 310G, 311Q, 314G, 316M, 317M, 318S, 326Y, 327N, 328K, 329D, 332E, 335E, 346H, 349Q, 375A, 380D, 384R, 389F, 390R, 393H, 396S, 443R, 445A, 446I, 447G, 448G, 449T, 457Q
CDD
cd01359 (Argininosuccinate_lyase)

389F

tetramer interface
106K, 110G, 113H, 114T, 163Y, 164T, 165H, 166L, 167Q, 168R, 169A, 170Q, 176H, 180L, 181H, 187N, 190K, 191R, 194Q, 198R, 209L, 210A, 211G, 212H, 213P, 215G, 218R, 232G, 233N, 234S, 235L, 236A, 239S, 240D, 242D, 246E, 249F, 253L, 256N, 257H, 259A, 260K, 263E, 264D, 269S, 270T, 273F, 281A, 287S, 288L, 289M, 290P, 292K, 293K, 294N, 296D, 299E, 300L, 302R, 303G, 304K, 305S, 306G, 307R, 309F, 310G, 311Q, 314G, 316M, 317M, 318S, 326Y, 327N, 328K, 329D, 332E, 335E, 346H, 349Q, 375A, 380D, 384R, 389F, 390R, 393H, 396S, 443R, 445A, 446I, 447G, 448G, 449T, 457Q
CDD
cd01359 (Argininosuccinate_lyase)

390R

tetramer interface
106K, 110G, 113H, 114T, 163Y, 164T, 165H, 166L, 167Q, 168R, 169A, 170Q, 176H, 180L, 181H, 187N, 190K, 191R, 194Q, 198R, 209L, 210A, 211G, 212H, 213P, 215G, 218R, 232G, 233N, 234S, 235L, 236A, 239S, 240D, 242D, 246E, 249F, 253L, 256N, 257H, 259A, 260K, 263E, 264D, 269S, 270T, 273F, 281A, 287S, 288L, 289M, 290P, 292K, 293K, 294N, 296D, 299E, 300L, 302R, 303G, 304K, 305S, 306G, 307R, 309F, 310G, 311Q, 314G, 316M, 317M, 318S, 326Y, 327N, 328K, 329D, 332E, 335E, 346H, 349Q, 375A, 380D, 384R, 389F, 390R, 393H, 396S, 443R, 445A, 446I, 447G, 448G, 449T, 457Q
CDD
cd01359 (Argininosuccinate_lyase)

393H

tetramer interface
106K, 110G, 113H, 114T, 163Y, 164T, 165H, 166L, 167Q, 168R, 169A, 170Q, 176H, 180L, 181H, 187N, 190K, 191R, 194Q, 198R, 209L, 210A, 211G, 212H, 213P, 215G, 218R, 232G, 233N, 234S, 235L, 236A, 239S, 240D, 242D, 246E, 249F, 253L, 256N, 257H, 259A, 260K, 263E, 264D, 269S, 270T, 273F, 281A, 287S, 288L, 289M, 290P, 292K, 293K, 294N, 296D, 299E, 300L, 302R, 303G, 304K, 305S, 306G, 307R, 309F, 310G, 311Q, 314G, 316M, 317M, 318S, 326Y, 327N, 328K, 329D, 332E, 335E, 346H, 349Q, 375A, 380D, 384R, 389F, 390R, 393H, 396S, 443R, 445A, 446I, 447G, 448G, 449T, 457Q
CDD
cd01359 (Argininosuccinate_lyase)

396S

tetramer interface
106K, 110G, 113H, 114T, 163Y, 164T, 165H, 166L, 167Q, 168R, 169A, 170Q, 176H, 180L, 181H, 187N, 190K, 191R, 194Q, 198R, 209L, 210A, 211G, 212H, 213P, 215G, 218R, 232G, 233N, 234S, 235L, 236A, 239S, 240D, 242D, 246E, 249F, 253L, 256N, 257H, 259A, 260K, 263E, 264D, 269S, 270T, 273F, 281A, 287S, 288L, 289M, 290P, 292K, 293K, 294N, 296D, 299E, 300L, 302R, 303G, 304K, 305S, 306G, 307R, 309F, 310G, 311Q, 314G, 316M, 317M, 318S, 326Y, 327N, 328K, 329D, 332E, 335E, 346H, 349Q, 375A, 380D, 384R, 389F, 390R, 393H, 396S, 443R, 445A, 446I, 447G, 448G, 449T, 457Q
CDD
cd01359 (Argininosuccinate_lyase)

443R

tetramer interface
106K, 110G, 113H, 114T, 163Y, 164T, 165H, 166L, 167Q, 168R, 169A, 170Q, 176H, 180L, 181H, 187N, 190K, 191R, 194Q, 198R, 209L, 210A, 211G, 212H, 213P, 215G, 218R, 232G, 233N, 234S, 235L, 236A, 239S, 240D, 242D, 246E, 249F, 253L, 256N, 257H, 259A, 260K, 263E, 264D, 269S, 270T, 273F, 281A, 287S, 288L, 289M, 290P, 292K, 293K, 294N, 296D, 299E, 300L, 302R, 303G, 304K, 305S, 306G, 307R, 309F, 310G, 311Q, 314G, 316M, 317M, 318S, 326Y, 327N, 328K, 329D, 332E, 335E, 346H, 349Q, 375A, 380D, 384R, 389F, 390R, 393H, 396S, 443R, 445A, 446I, 447G, 448G, 449T, 457Q
CDD
cd01359 (Argininosuccinate_lyase)

445A

tetramer interface
106K, 110G, 113H, 114T, 163Y, 164T, 165H, 166L, 167Q, 168R, 169A, 170Q, 176H, 180L, 181H, 187N, 190K, 191R, 194Q, 198R, 209L, 210A, 211G, 212H, 213P, 215G, 218R, 232G, 233N, 234S, 235L, 236A, 239S, 240D, 242D, 246E, 249F, 253L, 256N, 257H, 259A, 260K, 263E, 264D, 269S, 270T, 273F, 281A, 287S, 288L, 289M, 290P, 292K, 293K, 294N, 296D, 299E, 300L, 302R, 303G, 304K, 305S, 306G, 307R, 309F, 310G, 311Q, 314G, 316M, 317M, 318S, 326Y, 327N, 328K, 329D, 332E, 335E, 346H, 349Q, 375A, 380D, 384R, 389F, 390R, 393H, 396S, 443R, 445A, 446I, 447G, 448G, 449T, 457Q
CDD
cd01359 (Argininosuccinate_lyase)

446I

tetramer interface
106K, 110G, 113H, 114T, 163Y, 164T, 165H, 166L, 167Q, 168R, 169A, 170Q, 176H, 180L, 181H, 187N, 190K, 191R, 194Q, 198R, 209L, 210A, 211G, 212H, 213P, 215G, 218R, 232G, 233N, 234S, 235L, 236A, 239S, 240D, 242D, 246E, 249F, 253L, 256N, 257H, 259A, 260K, 263E, 264D, 269S, 270T, 273F, 281A, 287S, 288L, 289M, 290P, 292K, 293K, 294N, 296D, 299E, 300L, 302R, 303G, 304K, 305S, 306G, 307R, 309F, 310G, 311Q, 314G, 316M, 317M, 318S, 326Y, 327N, 328K, 329D, 332E, 335E, 346H, 349Q, 375A, 380D, 384R, 389F, 390R, 393H, 396S, 443R, 445A, 446I, 447G, 448G, 449T, 457Q
CDD
cd01359 (Argininosuccinate_lyase)

447G

tetramer interface
106K, 110G, 113H, 114T, 163Y, 164T, 165H, 166L, 167Q, 168R, 169A, 170Q, 176H, 180L, 181H, 187N, 190K, 191R, 194Q, 198R, 209L, 210A, 211G, 212H, 213P, 215G, 218R, 232G, 233N, 234S, 235L, 236A, 239S, 240D, 242D, 246E, 249F, 253L, 256N, 257H, 259A, 260K, 263E, 264D, 269S, 270T, 273F, 281A, 287S, 288L, 289M, 290P, 292K, 293K, 294N, 296D, 299E, 300L, 302R, 303G, 304K, 305S, 306G, 307R, 309F, 310G, 311Q, 314G, 316M, 317M, 318S, 326Y, 327N, 328K, 329D, 332E, 335E, 346H, 349Q, 375A, 380D, 384R, 389F, 390R, 393H, 396S, 443R, 445A, 446I, 447G, 448G, 449T, 457Q
CDD
cd01359 (Argininosuccinate_lyase)

448G

tetramer interface
106K, 110G, 113H, 114T, 163Y, 164T, 165H, 166L, 167Q, 168R, 169A, 170Q, 176H, 180L, 181H, 187N, 190K, 191R, 194Q, 198R, 209L, 210A, 211G, 212H, 213P, 215G, 218R, 232G, 233N, 234S, 235L, 236A, 239S, 240D, 242D, 246E, 249F, 253L, 256N, 257H, 259A, 260K, 263E, 264D, 269S, 270T, 273F, 281A, 287S, 288L, 289M, 290P, 292K, 293K, 294N, 296D, 299E, 300L, 302R, 303G, 304K, 305S, 306G, 307R, 309F, 310G, 311Q, 314G, 316M, 317M, 318S, 326Y, 327N, 328K, 329D, 332E, 335E, 346H, 349Q, 375A, 380D, 384R, 389F, 390R, 393H, 396S, 443R, 445A, 446I, 447G, 448G, 449T, 457Q
CDD
cd01359 (Argininosuccinate_lyase)

449T

tetramer interface
106K, 110G, 113H, 114T, 163Y, 164T, 165H, 166L, 167Q, 168R, 169A, 170Q, 176H, 180L, 181H, 187N, 190K, 191R, 194Q, 198R, 209L, 210A, 211G, 212H, 213P, 215G, 218R, 232G, 233N, 234S, 235L, 236A, 239S, 240D, 242D, 246E, 249F, 253L, 256N, 257H, 259A, 260K, 263E, 264D, 269S, 270T, 273F, 281A, 287S, 288L, 289M, 290P, 292K, 293K, 294N, 296D, 299E, 300L, 302R, 303G, 304K, 305S, 306G, 307R, 309F, 310G, 311Q, 314G, 316M, 317M, 318S, 326Y, 327N, 328K, 329D, 332E, 335E, 346H, 349Q, 375A, 380D, 384R, 389F, 390R, 393H, 396S, 443R, 445A, 446I, 447G, 448G, 449T, 457Q
CDD
cd01359 (Argininosuccinate_lyase)

457Q

tetramer interface
106K, 110G, 113H, 114T, 163Y, 164T, 165H, 166L, 167Q, 168R, 169A, 170Q, 176H, 180L, 181H, 187N, 190K, 191R, 194Q, 198R, 209L, 210A, 211G, 212H, 213P, 215G, 218R, 232G, 233N, 234S, 235L, 236A, 239S, 240D, 242D, 246E, 249F, 253L, 256N, 257H, 259A, 260K, 263E, 264D, 269S, 270T, 273F, 281A, 287S, 288L, 289M, 290P, 292K, 293K, 294N, 296D, 299E, 300L, 302R, 303G, 304K, 305S, 306G, 307R, 309F, 310G, 311Q, 314G, 316M, 317M, 318S, 326Y, 327N, 328K, 329D, 332E, 335E, 346H, 349Q, 375A, 380D, 384R, 389F, 390R, 393H, 396S, 443R, 445A, 446I, 447G, 448G, 449T, 457Q
CDD
cd01359 (Argininosuccinate_lyase)

Protein sequence

>MIA_05161_1
MASTDAPTETKLWGGRFTGATDPLMELYNASLPYDKKMYAADLEGTRVYTSALEKLGLLTKEELAEIHRGLELIHAEWAN
GTFVEKSGDEDIHTANERRLGELIGKGIAGKVHTGRSRNDQVATDMRLYVRDELNKTQTQLKALIQVIVNRARSEIEILM
PGYTHLQRAQPIRWAHWLSLHATFLANDLKRLEQVIERVNVSPLGSGALAGHPYGIDREYIANELKFDGIIGNSLAAVSD
RDFVVETMFWGSLVLNHLAKLSEDLIIYSTAEFGFIKLADAYSTGSSLMPQKKNPDSLELLRGKSGRTFGQLAGFMMSLK
ATPSTYNKDLQEDKEPLFDNLVTVSHSIQIATGVLSTLKVIPEKMQAALTMDMLATDLADYLVRKGVPFRETHHISGEAV
HLAESTGVSGIDQLTLEQYKSIDGRFEEDVFKVFDFEASVERRTAIGGTAKSAVLAQLENLEKILA

GO term prediction

Biological Process

GO:0042450 arginine biosynthetic process via ornithine

Molecular Function

GO:0003824 catalytic activity
GO:0004056 argininosuccinate lyase activity

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features