MCA_05797_1

Protein

Length

468 amino acids

Gene name: ARG4

Description: Argininosuccinate lyase

Browser: contigD:2361818-2363310-

RNA-seq: read pairs 3887, FPKM 102.4, percentile rank 79.1% (100% = highest expression)

Protein function

Annotation:		ARG4	Argininosuccinate lyase
KEGG:	K01755	argH	argininosuccinate lyase [EC:4.3.2.1]
EGGNOG:	0PHD8	ARG4	argininosuccinate lyase
SGD closest match:	S000001060	ARG4	Argininosuccinate lyase
CGD closest match:	CAL0000190527	ARG4	Argininosuccinate lyase

Protein alignments

	%id	Aln length
MIA_05161_1	89.22%	464	MIA_05161_1
A0A0J9XHU7_GEOCN	86.77%	461	Similar to Saccharomyces cerevisiae YHR018C ARG4 Argininosuccinate lyase, catalyzes the final step in the arginine biosynthesis pathway OS=Geotrichum candidum GN=BN980_GECA17s01814g PE=3 SV=1
A0A167C5K1_9ASCO	81.18%	457	Argininosuccinate lyase ARG4 OS=Sugiyamaella lignohabitans GN=ARG4 PE=3 SV=1
Q6C7P9_YARLI	78.40%	463	YALI0D26367p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D26367g PE=3 SV=1
A0A060T606_BLAAD	79.08%	459	ARAD1B07062p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B07062g PE=3 SV=1
A0A1E3PJG0_9ASCO	75.22%	460	Argininosuccinate lyase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_42754 PE=3 SV=1
A0A1E4TID6_9ASCO	73.91%	460	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_71770 PE=3 SV=1
Q59R31_CANAL	72.01%	468	Argininosuccinate lyase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=ARG4 PE=3 SV=1
ARLY_YEAST	72.63%	453	Argininosuccinate lyase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ARG4 PE=1 SV=2
UniRef50_S8ALK6	67.54%	456	Uncharacterized protein n=1 Tax=Dactylellina haptotyla (strain CBS 200.50) TaxID=1284197 RepID=S8ALK6_DACHA

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.1947

Protein family membership

Fumarate lyase family (IPR000362)
- Argininosuccinate lyase (IPR009049)

Domains and repeats

Domain
13 - 312
Fumarase/histidase, N-terminal (IPR024083)
Fumarate lyase, N-terminal (IPR022761)
375 - 443
Argininosuccinate lyase, C-terminal (IPR029419)
Domain
17 - 467
L-Aspartase-like (IPR008948)

1 50 100 150 200 250 300 350 400 468

Detailed signature matches

IPR000362

Fumarate lyase family
1. PR00149 (FUMRATELYASE)
  
  114 - 132
  
  PRINTS
  PR00149 (FUMRATELYASE)
  
  243 - 270
  
  PRINTS
  PR00149 (FUMRATELYASE)
  
  287 - 303
  
  PRINTS
  PR00149 (FUMRATELYASE)
  
  159 - 177
  
  PRINTS
  PR00149 (FUMRATELYASE)
IPR009049

Argininosuccinate lyase
1. cd01359 (Argininosu...)
  
  33 - 467
  
  CDD
  cd01359 (Argininosuccinate_lyase)
2. MF_00006 (Arg_succ_...)
  
  13 - 465
  
  HAMAP
  MF_00006 (Arg_succ_lyase)
3. TIGR00838
  
  14 - 464
  
  TIGRFAMs
  TIGR00838 (TIGR00838)
IPR024083

Fumarase/histidase, N-terminal
1. G3DSA:1.10.27...
  
  13 - 118
  
  GENE3D
  G3DSA:1.10.275.10 (G3DSA:1.10.275.10)
IPR022761

Fumarate lyase, N-terminal
1. PF00206 (Lyase_1)
  
  17 - 312
  
  Pfam
  PF00206 (Lyase_1)
IPR008948

L-Aspartase-like
1. SSF48557 (L-asparta...)
  
  17 - 467
  
  SUPERFAMILY
  SSF48557 (L-aspartase-like)
IPR029419

Argininosuccinate lyase, C-terminal
1. PF14698 (ASL_C2)
  
  375 - 443
  
  Pfam
  PF14698 (ASL_C2)
IPR020557

Fumarate lyase, conserved site
1. PS00163 (FUMARATE_L...)
  
  287 - 296
  
  PROSITE patterns
  PS00163 (FUMARATE_LYASES)

no IPR

Unintegrated signatures

G3DSA:1.10.40.30

385 - 444

GENE3D
G3DSA:1.10.40.30 (G3DSA:1.10.40.30)
G3DSA:1.20.20...

119 - 384

GENE3D
G3DSA:1.20.200.10 (G3DSA:1.20.200.10)
PR00145 (ARGSUCLYASE)

205 - 221

PRINTS
PR00145 (ARGSUCLYASE)

322 - 341

PRINTS
PR00145 (ARGSUCLYASE)

287 - 303

PRINTS
PR00145 (ARGSUCLYASE)

113 - 135

PRINTS
PR00145 (ARGSUCLYASE)

154 - 174

PRINTS
PR00145 (ARGSUCLYASE)

243 - 267

PRINTS
PR00145 (ARGSUCLYASE)

Residue annotation

active sites cd01359

33S

active sites
33S, 37D, 93D, 95H, 119S, 120R, 121N, 124V, 166T, 167H, 243R, 286T, 288S, 296N, 298D, 301E, 328Y, 330K, 333Q, 335D, 336K
CDD
cd01359 (Argininosuccinate_lyase)

37D

active sites
33S, 37D, 93D, 95H, 119S, 120R, 121N, 124V, 166T, 167H, 243R, 286T, 288S, 296N, 298D, 301E, 328Y, 330K, 333Q, 335D, 336K
CDD
cd01359 (Argininosuccinate_lyase)

93D

active sites
33S, 37D, 93D, 95H, 119S, 120R, 121N, 124V, 166T, 167H, 243R, 286T, 288S, 296N, 298D, 301E, 328Y, 330K, 333Q, 335D, 336K
CDD
cd01359 (Argininosuccinate_lyase)

95H

active sites
33S, 37D, 93D, 95H, 119S, 120R, 121N, 124V, 166T, 167H, 243R, 286T, 288S, 296N, 298D, 301E, 328Y, 330K, 333Q, 335D, 336K
CDD
cd01359 (Argininosuccinate_lyase)

119S

active sites
33S, 37D, 93D, 95H, 119S, 120R, 121N, 124V, 166T, 167H, 243R, 286T, 288S, 296N, 298D, 301E, 328Y, 330K, 333Q, 335D, 336K
CDD
cd01359 (Argininosuccinate_lyase)

120R

active sites
33S, 37D, 93D, 95H, 119S, 120R, 121N, 124V, 166T, 167H, 243R, 286T, 288S, 296N, 298D, 301E, 328Y, 330K, 333Q, 335D, 336K
CDD
cd01359 (Argininosuccinate_lyase)

121N

active sites
33S, 37D, 93D, 95H, 119S, 120R, 121N, 124V, 166T, 167H, 243R, 286T, 288S, 296N, 298D, 301E, 328Y, 330K, 333Q, 335D, 336K
CDD
cd01359 (Argininosuccinate_lyase)

124V

active sites
33S, 37D, 93D, 95H, 119S, 120R, 121N, 124V, 166T, 167H, 243R, 286T, 288S, 296N, 298D, 301E, 328Y, 330K, 333Q, 335D, 336K
CDD
cd01359 (Argininosuccinate_lyase)

166T

active sites
33S, 37D, 93D, 95H, 119S, 120R, 121N, 124V, 166T, 167H, 243R, 286T, 288S, 296N, 298D, 301E, 328Y, 330K, 333Q, 335D, 336K
CDD
cd01359 (Argininosuccinate_lyase)

167H

active sites
33S, 37D, 93D, 95H, 119S, 120R, 121N, 124V, 166T, 167H, 243R, 286T, 288S, 296N, 298D, 301E, 328Y, 330K, 333Q, 335D, 336K
CDD
cd01359 (Argininosuccinate_lyase)

243R

active sites
33S, 37D, 93D, 95H, 119S, 120R, 121N, 124V, 166T, 167H, 243R, 286T, 288S, 296N, 298D, 301E, 328Y, 330K, 333Q, 335D, 336K
CDD
cd01359 (Argininosuccinate_lyase)

286T

active sites
33S, 37D, 93D, 95H, 119S, 120R, 121N, 124V, 166T, 167H, 243R, 286T, 288S, 296N, 298D, 301E, 328Y, 330K, 333Q, 335D, 336K
CDD
cd01359 (Argininosuccinate_lyase)

288S

active sites
33S, 37D, 93D, 95H, 119S, 120R, 121N, 124V, 166T, 167H, 243R, 286T, 288S, 296N, 298D, 301E, 328Y, 330K, 333Q, 335D, 336K
CDD
cd01359 (Argininosuccinate_lyase)

296N

active sites
33S, 37D, 93D, 95H, 119S, 120R, 121N, 124V, 166T, 167H, 243R, 286T, 288S, 296N, 298D, 301E, 328Y, 330K, 333Q, 335D, 336K
CDD
cd01359 (Argininosuccinate_lyase)

298D

active sites
33S, 37D, 93D, 95H, 119S, 120R, 121N, 124V, 166T, 167H, 243R, 286T, 288S, 296N, 298D, 301E, 328Y, 330K, 333Q, 335D, 336K
CDD
cd01359 (Argininosuccinate_lyase)

301E

active sites
33S, 37D, 93D, 95H, 119S, 120R, 121N, 124V, 166T, 167H, 243R, 286T, 288S, 296N, 298D, 301E, 328Y, 330K, 333Q, 335D, 336K
CDD
cd01359 (Argininosuccinate_lyase)

328Y

active sites
33S, 37D, 93D, 95H, 119S, 120R, 121N, 124V, 166T, 167H, 243R, 286T, 288S, 296N, 298D, 301E, 328Y, 330K, 333Q, 335D, 336K
CDD
cd01359 (Argininosuccinate_lyase)

330K

active sites
33S, 37D, 93D, 95H, 119S, 120R, 121N, 124V, 166T, 167H, 243R, 286T, 288S, 296N, 298D, 301E, 328Y, 330K, 333Q, 335D, 336K
CDD
cd01359 (Argininosuccinate_lyase)

333Q

active sites
33S, 37D, 93D, 95H, 119S, 120R, 121N, 124V, 166T, 167H, 243R, 286T, 288S, 296N, 298D, 301E, 328Y, 330K, 333Q, 335D, 336K
CDD
cd01359 (Argininosuccinate_lyase)

335D

active sites
33S, 37D, 93D, 95H, 119S, 120R, 121N, 124V, 166T, 167H, 243R, 286T, 288S, 296N, 298D, 301E, 328Y, 330K, 333Q, 335D, 336K
CDD
cd01359 (Argininosuccinate_lyase)

336K

active sites
33S, 37D, 93D, 95H, 119S, 120R, 121N, 124V, 166T, 167H, 243R, 286T, 288S, 296N, 298D, 301E, 328Y, 330K, 333Q, 335D, 336K
CDD
cd01359 (Argininosuccinate_lyase)
tetramer interface...

109N

tetramer interface
109N, 112G, 115H, 116T, 165Y, 166T, 167H, 168L, 169Q, 170R, 171A, 172Q, 178H, 182L, 183H, 189N, 192Q, 193R, 196Q, 200R, 211L, 212A, 213G, 214H, 215P, 217G, 220R, 234G, 235N, 236S, 237L, 238A, 241S, 242D, 244D, 248E, 251F, 255L, 258N, 259H, 261A, 262K, 265E, 266D, 271S, 272T, 275F, 283A, 289S, 290L, 291M, 292P, 294K, 295K, 296N, 298D, 301E, 302L, 304R, 305G, 306K, 307S, 308G, 309R, 311F, 312G, 313Q, 316G, 318M, 319M, 320S, 328Y, 329N, 330K, 331D, 334E, 337E, 348H, 351Q, 377A, 382D, 386R, 391F, 392R, 395H, 398S, 445R, 447A, 448I, 449G, 450G, 451T, 459Q
CDD
cd01359 (Argininosuccinate_lyase)

112G

tetramer interface
109N, 112G, 115H, 116T, 165Y, 166T, 167H, 168L, 169Q, 170R, 171A, 172Q, 178H, 182L, 183H, 189N, 192Q, 193R, 196Q, 200R, 211L, 212A, 213G, 214H, 215P, 217G, 220R, 234G, 235N, 236S, 237L, 238A, 241S, 242D, 244D, 248E, 251F, 255L, 258N, 259H, 261A, 262K, 265E, 266D, 271S, 272T, 275F, 283A, 289S, 290L, 291M, 292P, 294K, 295K, 296N, 298D, 301E, 302L, 304R, 305G, 306K, 307S, 308G, 309R, 311F, 312G, 313Q, 316G, 318M, 319M, 320S, 328Y, 329N, 330K, 331D, 334E, 337E, 348H, 351Q, 377A, 382D, 386R, 391F, 392R, 395H, 398S, 445R, 447A, 448I, 449G, 450G, 451T, 459Q
CDD
cd01359 (Argininosuccinate_lyase)

115H

tetramer interface
109N, 112G, 115H, 116T, 165Y, 166T, 167H, 168L, 169Q, 170R, 171A, 172Q, 178H, 182L, 183H, 189N, 192Q, 193R, 196Q, 200R, 211L, 212A, 213G, 214H, 215P, 217G, 220R, 234G, 235N, 236S, 237L, 238A, 241S, 242D, 244D, 248E, 251F, 255L, 258N, 259H, 261A, 262K, 265E, 266D, 271S, 272T, 275F, 283A, 289S, 290L, 291M, 292P, 294K, 295K, 296N, 298D, 301E, 302L, 304R, 305G, 306K, 307S, 308G, 309R, 311F, 312G, 313Q, 316G, 318M, 319M, 320S, 328Y, 329N, 330K, 331D, 334E, 337E, 348H, 351Q, 377A, 382D, 386R, 391F, 392R, 395H, 398S, 445R, 447A, 448I, 449G, 450G, 451T, 459Q
CDD
cd01359 (Argininosuccinate_lyase)

116T

tetramer interface
109N, 112G, 115H, 116T, 165Y, 166T, 167H, 168L, 169Q, 170R, 171A, 172Q, 178H, 182L, 183H, 189N, 192Q, 193R, 196Q, 200R, 211L, 212A, 213G, 214H, 215P, 217G, 220R, 234G, 235N, 236S, 237L, 238A, 241S, 242D, 244D, 248E, 251F, 255L, 258N, 259H, 261A, 262K, 265E, 266D, 271S, 272T, 275F, 283A, 289S, 290L, 291M, 292P, 294K, 295K, 296N, 298D, 301E, 302L, 304R, 305G, 306K, 307S, 308G, 309R, 311F, 312G, 313Q, 316G, 318M, 319M, 320S, 328Y, 329N, 330K, 331D, 334E, 337E, 348H, 351Q, 377A, 382D, 386R, 391F, 392R, 395H, 398S, 445R, 447A, 448I, 449G, 450G, 451T, 459Q
CDD
cd01359 (Argininosuccinate_lyase)

165Y

tetramer interface
109N, 112G, 115H, 116T, 165Y, 166T, 167H, 168L, 169Q, 170R, 171A, 172Q, 178H, 182L, 183H, 189N, 192Q, 193R, 196Q, 200R, 211L, 212A, 213G, 214H, 215P, 217G, 220R, 234G, 235N, 236S, 237L, 238A, 241S, 242D, 244D, 248E, 251F, 255L, 258N, 259H, 261A, 262K, 265E, 266D, 271S, 272T, 275F, 283A, 289S, 290L, 291M, 292P, 294K, 295K, 296N, 298D, 301E, 302L, 304R, 305G, 306K, 307S, 308G, 309R, 311F, 312G, 313Q, 316G, 318M, 319M, 320S, 328Y, 329N, 330K, 331D, 334E, 337E, 348H, 351Q, 377A, 382D, 386R, 391F, 392R, 395H, 398S, 445R, 447A, 448I, 449G, 450G, 451T, 459Q
CDD
cd01359 (Argininosuccinate_lyase)

166T

tetramer interface
109N, 112G, 115H, 116T, 165Y, 166T, 167H, 168L, 169Q, 170R, 171A, 172Q, 178H, 182L, 183H, 189N, 192Q, 193R, 196Q, 200R, 211L, 212A, 213G, 214H, 215P, 217G, 220R, 234G, 235N, 236S, 237L, 238A, 241S, 242D, 244D, 248E, 251F, 255L, 258N, 259H, 261A, 262K, 265E, 266D, 271S, 272T, 275F, 283A, 289S, 290L, 291M, 292P, 294K, 295K, 296N, 298D, 301E, 302L, 304R, 305G, 306K, 307S, 308G, 309R, 311F, 312G, 313Q, 316G, 318M, 319M, 320S, 328Y, 329N, 330K, 331D, 334E, 337E, 348H, 351Q, 377A, 382D, 386R, 391F, 392R, 395H, 398S, 445R, 447A, 448I, 449G, 450G, 451T, 459Q
CDD
cd01359 (Argininosuccinate_lyase)

167H

tetramer interface
109N, 112G, 115H, 116T, 165Y, 166T, 167H, 168L, 169Q, 170R, 171A, 172Q, 178H, 182L, 183H, 189N, 192Q, 193R, 196Q, 200R, 211L, 212A, 213G, 214H, 215P, 217G, 220R, 234G, 235N, 236S, 237L, 238A, 241S, 242D, 244D, 248E, 251F, 255L, 258N, 259H, 261A, 262K, 265E, 266D, 271S, 272T, 275F, 283A, 289S, 290L, 291M, 292P, 294K, 295K, 296N, 298D, 301E, 302L, 304R, 305G, 306K, 307S, 308G, 309R, 311F, 312G, 313Q, 316G, 318M, 319M, 320S, 328Y, 329N, 330K, 331D, 334E, 337E, 348H, 351Q, 377A, 382D, 386R, 391F, 392R, 395H, 398S, 445R, 447A, 448I, 449G, 450G, 451T, 459Q
CDD
cd01359 (Argininosuccinate_lyase)

168L

tetramer interface
109N, 112G, 115H, 116T, 165Y, 166T, 167H, 168L, 169Q, 170R, 171A, 172Q, 178H, 182L, 183H, 189N, 192Q, 193R, 196Q, 200R, 211L, 212A, 213G, 214H, 215P, 217G, 220R, 234G, 235N, 236S, 237L, 238A, 241S, 242D, 244D, 248E, 251F, 255L, 258N, 259H, 261A, 262K, 265E, 266D, 271S, 272T, 275F, 283A, 289S, 290L, 291M, 292P, 294K, 295K, 296N, 298D, 301E, 302L, 304R, 305G, 306K, 307S, 308G, 309R, 311F, 312G, 313Q, 316G, 318M, 319M, 320S, 328Y, 329N, 330K, 331D, 334E, 337E, 348H, 351Q, 377A, 382D, 386R, 391F, 392R, 395H, 398S, 445R, 447A, 448I, 449G, 450G, 451T, 459Q
CDD
cd01359 (Argininosuccinate_lyase)

169Q

tetramer interface
109N, 112G, 115H, 116T, 165Y, 166T, 167H, 168L, 169Q, 170R, 171A, 172Q, 178H, 182L, 183H, 189N, 192Q, 193R, 196Q, 200R, 211L, 212A, 213G, 214H, 215P, 217G, 220R, 234G, 235N, 236S, 237L, 238A, 241S, 242D, 244D, 248E, 251F, 255L, 258N, 259H, 261A, 262K, 265E, 266D, 271S, 272T, 275F, 283A, 289S, 290L, 291M, 292P, 294K, 295K, 296N, 298D, 301E, 302L, 304R, 305G, 306K, 307S, 308G, 309R, 311F, 312G, 313Q, 316G, 318M, 319M, 320S, 328Y, 329N, 330K, 331D, 334E, 337E, 348H, 351Q, 377A, 382D, 386R, 391F, 392R, 395H, 398S, 445R, 447A, 448I, 449G, 450G, 451T, 459Q
CDD
cd01359 (Argininosuccinate_lyase)

170R

tetramer interface
109N, 112G, 115H, 116T, 165Y, 166T, 167H, 168L, 169Q, 170R, 171A, 172Q, 178H, 182L, 183H, 189N, 192Q, 193R, 196Q, 200R, 211L, 212A, 213G, 214H, 215P, 217G, 220R, 234G, 235N, 236S, 237L, 238A, 241S, 242D, 244D, 248E, 251F, 255L, 258N, 259H, 261A, 262K, 265E, 266D, 271S, 272T, 275F, 283A, 289S, 290L, 291M, 292P, 294K, 295K, 296N, 298D, 301E, 302L, 304R, 305G, 306K, 307S, 308G, 309R, 311F, 312G, 313Q, 316G, 318M, 319M, 320S, 328Y, 329N, 330K, 331D, 334E, 337E, 348H, 351Q, 377A, 382D, 386R, 391F, 392R, 395H, 398S, 445R, 447A, 448I, 449G, 450G, 451T, 459Q
CDD
cd01359 (Argininosuccinate_lyase)

171A

tetramer interface
109N, 112G, 115H, 116T, 165Y, 166T, 167H, 168L, 169Q, 170R, 171A, 172Q, 178H, 182L, 183H, 189N, 192Q, 193R, 196Q, 200R, 211L, 212A, 213G, 214H, 215P, 217G, 220R, 234G, 235N, 236S, 237L, 238A, 241S, 242D, 244D, 248E, 251F, 255L, 258N, 259H, 261A, 262K, 265E, 266D, 271S, 272T, 275F, 283A, 289S, 290L, 291M, 292P, 294K, 295K, 296N, 298D, 301E, 302L, 304R, 305G, 306K, 307S, 308G, 309R, 311F, 312G, 313Q, 316G, 318M, 319M, 320S, 328Y, 329N, 330K, 331D, 334E, 337E, 348H, 351Q, 377A, 382D, 386R, 391F, 392R, 395H, 398S, 445R, 447A, 448I, 449G, 450G, 451T, 459Q
CDD
cd01359 (Argininosuccinate_lyase)

172Q

tetramer interface
109N, 112G, 115H, 116T, 165Y, 166T, 167H, 168L, 169Q, 170R, 171A, 172Q, 178H, 182L, 183H, 189N, 192Q, 193R, 196Q, 200R, 211L, 212A, 213G, 214H, 215P, 217G, 220R, 234G, 235N, 236S, 237L, 238A, 241S, 242D, 244D, 248E, 251F, 255L, 258N, 259H, 261A, 262K, 265E, 266D, 271S, 272T, 275F, 283A, 289S, 290L, 291M, 292P, 294K, 295K, 296N, 298D, 301E, 302L, 304R, 305G, 306K, 307S, 308G, 309R, 311F, 312G, 313Q, 316G, 318M, 319M, 320S, 328Y, 329N, 330K, 331D, 334E, 337E, 348H, 351Q, 377A, 382D, 386R, 391F, 392R, 395H, 398S, 445R, 447A, 448I, 449G, 450G, 451T, 459Q
CDD
cd01359 (Argininosuccinate_lyase)

178H

tetramer interface
109N, 112G, 115H, 116T, 165Y, 166T, 167H, 168L, 169Q, 170R, 171A, 172Q, 178H, 182L, 183H, 189N, 192Q, 193R, 196Q, 200R, 211L, 212A, 213G, 214H, 215P, 217G, 220R, 234G, 235N, 236S, 237L, 238A, 241S, 242D, 244D, 248E, 251F, 255L, 258N, 259H, 261A, 262K, 265E, 266D, 271S, 272T, 275F, 283A, 289S, 290L, 291M, 292P, 294K, 295K, 296N, 298D, 301E, 302L, 304R, 305G, 306K, 307S, 308G, 309R, 311F, 312G, 313Q, 316G, 318M, 319M, 320S, 328Y, 329N, 330K, 331D, 334E, 337E, 348H, 351Q, 377A, 382D, 386R, 391F, 392R, 395H, 398S, 445R, 447A, 448I, 449G, 450G, 451T, 459Q
CDD
cd01359 (Argininosuccinate_lyase)

182L

tetramer interface
109N, 112G, 115H, 116T, 165Y, 166T, 167H, 168L, 169Q, 170R, 171A, 172Q, 178H, 182L, 183H, 189N, 192Q, 193R, 196Q, 200R, 211L, 212A, 213G, 214H, 215P, 217G, 220R, 234G, 235N, 236S, 237L, 238A, 241S, 242D, 244D, 248E, 251F, 255L, 258N, 259H, 261A, 262K, 265E, 266D, 271S, 272T, 275F, 283A, 289S, 290L, 291M, 292P, 294K, 295K, 296N, 298D, 301E, 302L, 304R, 305G, 306K, 307S, 308G, 309R, 311F, 312G, 313Q, 316G, 318M, 319M, 320S, 328Y, 329N, 330K, 331D, 334E, 337E, 348H, 351Q, 377A, 382D, 386R, 391F, 392R, 395H, 398S, 445R, 447A, 448I, 449G, 450G, 451T, 459Q
CDD
cd01359 (Argininosuccinate_lyase)

183H

tetramer interface
109N, 112G, 115H, 116T, 165Y, 166T, 167H, 168L, 169Q, 170R, 171A, 172Q, 178H, 182L, 183H, 189N, 192Q, 193R, 196Q, 200R, 211L, 212A, 213G, 214H, 215P, 217G, 220R, 234G, 235N, 236S, 237L, 238A, 241S, 242D, 244D, 248E, 251F, 255L, 258N, 259H, 261A, 262K, 265E, 266D, 271S, 272T, 275F, 283A, 289S, 290L, 291M, 292P, 294K, 295K, 296N, 298D, 301E, 302L, 304R, 305G, 306K, 307S, 308G, 309R, 311F, 312G, 313Q, 316G, 318M, 319M, 320S, 328Y, 329N, 330K, 331D, 334E, 337E, 348H, 351Q, 377A, 382D, 386R, 391F, 392R, 395H, 398S, 445R, 447A, 448I, 449G, 450G, 451T, 459Q
CDD
cd01359 (Argininosuccinate_lyase)

189N

tetramer interface
109N, 112G, 115H, 116T, 165Y, 166T, 167H, 168L, 169Q, 170R, 171A, 172Q, 178H, 182L, 183H, 189N, 192Q, 193R, 196Q, 200R, 211L, 212A, 213G, 214H, 215P, 217G, 220R, 234G, 235N, 236S, 237L, 238A, 241S, 242D, 244D, 248E, 251F, 255L, 258N, 259H, 261A, 262K, 265E, 266D, 271S, 272T, 275F, 283A, 289S, 290L, 291M, 292P, 294K, 295K, 296N, 298D, 301E, 302L, 304R, 305G, 306K, 307S, 308G, 309R, 311F, 312G, 313Q, 316G, 318M, 319M, 320S, 328Y, 329N, 330K, 331D, 334E, 337E, 348H, 351Q, 377A, 382D, 386R, 391F, 392R, 395H, 398S, 445R, 447A, 448I, 449G, 450G, 451T, 459Q
CDD
cd01359 (Argininosuccinate_lyase)

192Q

tetramer interface
109N, 112G, 115H, 116T, 165Y, 166T, 167H, 168L, 169Q, 170R, 171A, 172Q, 178H, 182L, 183H, 189N, 192Q, 193R, 196Q, 200R, 211L, 212A, 213G, 214H, 215P, 217G, 220R, 234G, 235N, 236S, 237L, 238A, 241S, 242D, 244D, 248E, 251F, 255L, 258N, 259H, 261A, 262K, 265E, 266D, 271S, 272T, 275F, 283A, 289S, 290L, 291M, 292P, 294K, 295K, 296N, 298D, 301E, 302L, 304R, 305G, 306K, 307S, 308G, 309R, 311F, 312G, 313Q, 316G, 318M, 319M, 320S, 328Y, 329N, 330K, 331D, 334E, 337E, 348H, 351Q, 377A, 382D, 386R, 391F, 392R, 395H, 398S, 445R, 447A, 448I, 449G, 450G, 451T, 459Q
CDD
cd01359 (Argininosuccinate_lyase)

193R

tetramer interface
109N, 112G, 115H, 116T, 165Y, 166T, 167H, 168L, 169Q, 170R, 171A, 172Q, 178H, 182L, 183H, 189N, 192Q, 193R, 196Q, 200R, 211L, 212A, 213G, 214H, 215P, 217G, 220R, 234G, 235N, 236S, 237L, 238A, 241S, 242D, 244D, 248E, 251F, 255L, 258N, 259H, 261A, 262K, 265E, 266D, 271S, 272T, 275F, 283A, 289S, 290L, 291M, 292P, 294K, 295K, 296N, 298D, 301E, 302L, 304R, 305G, 306K, 307S, 308G, 309R, 311F, 312G, 313Q, 316G, 318M, 319M, 320S, 328Y, 329N, 330K, 331D, 334E, 337E, 348H, 351Q, 377A, 382D, 386R, 391F, 392R, 395H, 398S, 445R, 447A, 448I, 449G, 450G, 451T, 459Q
CDD
cd01359 (Argininosuccinate_lyase)

196Q

tetramer interface
109N, 112G, 115H, 116T, 165Y, 166T, 167H, 168L, 169Q, 170R, 171A, 172Q, 178H, 182L, 183H, 189N, 192Q, 193R, 196Q, 200R, 211L, 212A, 213G, 214H, 215P, 217G, 220R, 234G, 235N, 236S, 237L, 238A, 241S, 242D, 244D, 248E, 251F, 255L, 258N, 259H, 261A, 262K, 265E, 266D, 271S, 272T, 275F, 283A, 289S, 290L, 291M, 292P, 294K, 295K, 296N, 298D, 301E, 302L, 304R, 305G, 306K, 307S, 308G, 309R, 311F, 312G, 313Q, 316G, 318M, 319M, 320S, 328Y, 329N, 330K, 331D, 334E, 337E, 348H, 351Q, 377A, 382D, 386R, 391F, 392R, 395H, 398S, 445R, 447A, 448I, 449G, 450G, 451T, 459Q
CDD
cd01359 (Argininosuccinate_lyase)

200R

tetramer interface
109N, 112G, 115H, 116T, 165Y, 166T, 167H, 168L, 169Q, 170R, 171A, 172Q, 178H, 182L, 183H, 189N, 192Q, 193R, 196Q, 200R, 211L, 212A, 213G, 214H, 215P, 217G, 220R, 234G, 235N, 236S, 237L, 238A, 241S, 242D, 244D, 248E, 251F, 255L, 258N, 259H, 261A, 262K, 265E, 266D, 271S, 272T, 275F, 283A, 289S, 290L, 291M, 292P, 294K, 295K, 296N, 298D, 301E, 302L, 304R, 305G, 306K, 307S, 308G, 309R, 311F, 312G, 313Q, 316G, 318M, 319M, 320S, 328Y, 329N, 330K, 331D, 334E, 337E, 348H, 351Q, 377A, 382D, 386R, 391F, 392R, 395H, 398S, 445R, 447A, 448I, 449G, 450G, 451T, 459Q
CDD
cd01359 (Argininosuccinate_lyase)

211L

tetramer interface
109N, 112G, 115H, 116T, 165Y, 166T, 167H, 168L, 169Q, 170R, 171A, 172Q, 178H, 182L, 183H, 189N, 192Q, 193R, 196Q, 200R, 211L, 212A, 213G, 214H, 215P, 217G, 220R, 234G, 235N, 236S, 237L, 238A, 241S, 242D, 244D, 248E, 251F, 255L, 258N, 259H, 261A, 262K, 265E, 266D, 271S, 272T, 275F, 283A, 289S, 290L, 291M, 292P, 294K, 295K, 296N, 298D, 301E, 302L, 304R, 305G, 306K, 307S, 308G, 309R, 311F, 312G, 313Q, 316G, 318M, 319M, 320S, 328Y, 329N, 330K, 331D, 334E, 337E, 348H, 351Q, 377A, 382D, 386R, 391F, 392R, 395H, 398S, 445R, 447A, 448I, 449G, 450G, 451T, 459Q
CDD
cd01359 (Argininosuccinate_lyase)

212A

tetramer interface
109N, 112G, 115H, 116T, 165Y, 166T, 167H, 168L, 169Q, 170R, 171A, 172Q, 178H, 182L, 183H, 189N, 192Q, 193R, 196Q, 200R, 211L, 212A, 213G, 214H, 215P, 217G, 220R, 234G, 235N, 236S, 237L, 238A, 241S, 242D, 244D, 248E, 251F, 255L, 258N, 259H, 261A, 262K, 265E, 266D, 271S, 272T, 275F, 283A, 289S, 290L, 291M, 292P, 294K, 295K, 296N, 298D, 301E, 302L, 304R, 305G, 306K, 307S, 308G, 309R, 311F, 312G, 313Q, 316G, 318M, 319M, 320S, 328Y, 329N, 330K, 331D, 334E, 337E, 348H, 351Q, 377A, 382D, 386R, 391F, 392R, 395H, 398S, 445R, 447A, 448I, 449G, 450G, 451T, 459Q
CDD
cd01359 (Argininosuccinate_lyase)

213G

tetramer interface
109N, 112G, 115H, 116T, 165Y, 166T, 167H, 168L, 169Q, 170R, 171A, 172Q, 178H, 182L, 183H, 189N, 192Q, 193R, 196Q, 200R, 211L, 212A, 213G, 214H, 215P, 217G, 220R, 234G, 235N, 236S, 237L, 238A, 241S, 242D, 244D, 248E, 251F, 255L, 258N, 259H, 261A, 262K, 265E, 266D, 271S, 272T, 275F, 283A, 289S, 290L, 291M, 292P, 294K, 295K, 296N, 298D, 301E, 302L, 304R, 305G, 306K, 307S, 308G, 309R, 311F, 312G, 313Q, 316G, 318M, 319M, 320S, 328Y, 329N, 330K, 331D, 334E, 337E, 348H, 351Q, 377A, 382D, 386R, 391F, 392R, 395H, 398S, 445R, 447A, 448I, 449G, 450G, 451T, 459Q
CDD
cd01359 (Argininosuccinate_lyase)

214H

tetramer interface
109N, 112G, 115H, 116T, 165Y, 166T, 167H, 168L, 169Q, 170R, 171A, 172Q, 178H, 182L, 183H, 189N, 192Q, 193R, 196Q, 200R, 211L, 212A, 213G, 214H, 215P, 217G, 220R, 234G, 235N, 236S, 237L, 238A, 241S, 242D, 244D, 248E, 251F, 255L, 258N, 259H, 261A, 262K, 265E, 266D, 271S, 272T, 275F, 283A, 289S, 290L, 291M, 292P, 294K, 295K, 296N, 298D, 301E, 302L, 304R, 305G, 306K, 307S, 308G, 309R, 311F, 312G, 313Q, 316G, 318M, 319M, 320S, 328Y, 329N, 330K, 331D, 334E, 337E, 348H, 351Q, 377A, 382D, 386R, 391F, 392R, 395H, 398S, 445R, 447A, 448I, 449G, 450G, 451T, 459Q
CDD
cd01359 (Argininosuccinate_lyase)

215P

tetramer interface
109N, 112G, 115H, 116T, 165Y, 166T, 167H, 168L, 169Q, 170R, 171A, 172Q, 178H, 182L, 183H, 189N, 192Q, 193R, 196Q, 200R, 211L, 212A, 213G, 214H, 215P, 217G, 220R, 234G, 235N, 236S, 237L, 238A, 241S, 242D, 244D, 248E, 251F, 255L, 258N, 259H, 261A, 262K, 265E, 266D, 271S, 272T, 275F, 283A, 289S, 290L, 291M, 292P, 294K, 295K, 296N, 298D, 301E, 302L, 304R, 305G, 306K, 307S, 308G, 309R, 311F, 312G, 313Q, 316G, 318M, 319M, 320S, 328Y, 329N, 330K, 331D, 334E, 337E, 348H, 351Q, 377A, 382D, 386R, 391F, 392R, 395H, 398S, 445R, 447A, 448I, 449G, 450G, 451T, 459Q
CDD
cd01359 (Argininosuccinate_lyase)

217G

tetramer interface
109N, 112G, 115H, 116T, 165Y, 166T, 167H, 168L, 169Q, 170R, 171A, 172Q, 178H, 182L, 183H, 189N, 192Q, 193R, 196Q, 200R, 211L, 212A, 213G, 214H, 215P, 217G, 220R, 234G, 235N, 236S, 237L, 238A, 241S, 242D, 244D, 248E, 251F, 255L, 258N, 259H, 261A, 262K, 265E, 266D, 271S, 272T, 275F, 283A, 289S, 290L, 291M, 292P, 294K, 295K, 296N, 298D, 301E, 302L, 304R, 305G, 306K, 307S, 308G, 309R, 311F, 312G, 313Q, 316G, 318M, 319M, 320S, 328Y, 329N, 330K, 331D, 334E, 337E, 348H, 351Q, 377A, 382D, 386R, 391F, 392R, 395H, 398S, 445R, 447A, 448I, 449G, 450G, 451T, 459Q
CDD
cd01359 (Argininosuccinate_lyase)

220R

tetramer interface
109N, 112G, 115H, 116T, 165Y, 166T, 167H, 168L, 169Q, 170R, 171A, 172Q, 178H, 182L, 183H, 189N, 192Q, 193R, 196Q, 200R, 211L, 212A, 213G, 214H, 215P, 217G, 220R, 234G, 235N, 236S, 237L, 238A, 241S, 242D, 244D, 248E, 251F, 255L, 258N, 259H, 261A, 262K, 265E, 266D, 271S, 272T, 275F, 283A, 289S, 290L, 291M, 292P, 294K, 295K, 296N, 298D, 301E, 302L, 304R, 305G, 306K, 307S, 308G, 309R, 311F, 312G, 313Q, 316G, 318M, 319M, 320S, 328Y, 329N, 330K, 331D, 334E, 337E, 348H, 351Q, 377A, 382D, 386R, 391F, 392R, 395H, 398S, 445R, 447A, 448I, 449G, 450G, 451T, 459Q
CDD
cd01359 (Argininosuccinate_lyase)

234G

tetramer interface
109N, 112G, 115H, 116T, 165Y, 166T, 167H, 168L, 169Q, 170R, 171A, 172Q, 178H, 182L, 183H, 189N, 192Q, 193R, 196Q, 200R, 211L, 212A, 213G, 214H, 215P, 217G, 220R, 234G, 235N, 236S, 237L, 238A, 241S, 242D, 244D, 248E, 251F, 255L, 258N, 259H, 261A, 262K, 265E, 266D, 271S, 272T, 275F, 283A, 289S, 290L, 291M, 292P, 294K, 295K, 296N, 298D, 301E, 302L, 304R, 305G, 306K, 307S, 308G, 309R, 311F, 312G, 313Q, 316G, 318M, 319M, 320S, 328Y, 329N, 330K, 331D, 334E, 337E, 348H, 351Q, 377A, 382D, 386R, 391F, 392R, 395H, 398S, 445R, 447A, 448I, 449G, 450G, 451T, 459Q
CDD
cd01359 (Argininosuccinate_lyase)

235N

tetramer interface
109N, 112G, 115H, 116T, 165Y, 166T, 167H, 168L, 169Q, 170R, 171A, 172Q, 178H, 182L, 183H, 189N, 192Q, 193R, 196Q, 200R, 211L, 212A, 213G, 214H, 215P, 217G, 220R, 234G, 235N, 236S, 237L, 238A, 241S, 242D, 244D, 248E, 251F, 255L, 258N, 259H, 261A, 262K, 265E, 266D, 271S, 272T, 275F, 283A, 289S, 290L, 291M, 292P, 294K, 295K, 296N, 298D, 301E, 302L, 304R, 305G, 306K, 307S, 308G, 309R, 311F, 312G, 313Q, 316G, 318M, 319M, 320S, 328Y, 329N, 330K, 331D, 334E, 337E, 348H, 351Q, 377A, 382D, 386R, 391F, 392R, 395H, 398S, 445R, 447A, 448I, 449G, 450G, 451T, 459Q
CDD
cd01359 (Argininosuccinate_lyase)

236S

tetramer interface
109N, 112G, 115H, 116T, 165Y, 166T, 167H, 168L, 169Q, 170R, 171A, 172Q, 178H, 182L, 183H, 189N, 192Q, 193R, 196Q, 200R, 211L, 212A, 213G, 214H, 215P, 217G, 220R, 234G, 235N, 236S, 237L, 238A, 241S, 242D, 244D, 248E, 251F, 255L, 258N, 259H, 261A, 262K, 265E, 266D, 271S, 272T, 275F, 283A, 289S, 290L, 291M, 292P, 294K, 295K, 296N, 298D, 301E, 302L, 304R, 305G, 306K, 307S, 308G, 309R, 311F, 312G, 313Q, 316G, 318M, 319M, 320S, 328Y, 329N, 330K, 331D, 334E, 337E, 348H, 351Q, 377A, 382D, 386R, 391F, 392R, 395H, 398S, 445R, 447A, 448I, 449G, 450G, 451T, 459Q
CDD
cd01359 (Argininosuccinate_lyase)

237L

tetramer interface
109N, 112G, 115H, 116T, 165Y, 166T, 167H, 168L, 169Q, 170R, 171A, 172Q, 178H, 182L, 183H, 189N, 192Q, 193R, 196Q, 200R, 211L, 212A, 213G, 214H, 215P, 217G, 220R, 234G, 235N, 236S, 237L, 238A, 241S, 242D, 244D, 248E, 251F, 255L, 258N, 259H, 261A, 262K, 265E, 266D, 271S, 272T, 275F, 283A, 289S, 290L, 291M, 292P, 294K, 295K, 296N, 298D, 301E, 302L, 304R, 305G, 306K, 307S, 308G, 309R, 311F, 312G, 313Q, 316G, 318M, 319M, 320S, 328Y, 329N, 330K, 331D, 334E, 337E, 348H, 351Q, 377A, 382D, 386R, 391F, 392R, 395H, 398S, 445R, 447A, 448I, 449G, 450G, 451T, 459Q
CDD
cd01359 (Argininosuccinate_lyase)

238A

tetramer interface
109N, 112G, 115H, 116T, 165Y, 166T, 167H, 168L, 169Q, 170R, 171A, 172Q, 178H, 182L, 183H, 189N, 192Q, 193R, 196Q, 200R, 211L, 212A, 213G, 214H, 215P, 217G, 220R, 234G, 235N, 236S, 237L, 238A, 241S, 242D, 244D, 248E, 251F, 255L, 258N, 259H, 261A, 262K, 265E, 266D, 271S, 272T, 275F, 283A, 289S, 290L, 291M, 292P, 294K, 295K, 296N, 298D, 301E, 302L, 304R, 305G, 306K, 307S, 308G, 309R, 311F, 312G, 313Q, 316G, 318M, 319M, 320S, 328Y, 329N, 330K, 331D, 334E, 337E, 348H, 351Q, 377A, 382D, 386R, 391F, 392R, 395H, 398S, 445R, 447A, 448I, 449G, 450G, 451T, 459Q
CDD
cd01359 (Argininosuccinate_lyase)

241S

tetramer interface
109N, 112G, 115H, 116T, 165Y, 166T, 167H, 168L, 169Q, 170R, 171A, 172Q, 178H, 182L, 183H, 189N, 192Q, 193R, 196Q, 200R, 211L, 212A, 213G, 214H, 215P, 217G, 220R, 234G, 235N, 236S, 237L, 238A, 241S, 242D, 244D, 248E, 251F, 255L, 258N, 259H, 261A, 262K, 265E, 266D, 271S, 272T, 275F, 283A, 289S, 290L, 291M, 292P, 294K, 295K, 296N, 298D, 301E, 302L, 304R, 305G, 306K, 307S, 308G, 309R, 311F, 312G, 313Q, 316G, 318M, 319M, 320S, 328Y, 329N, 330K, 331D, 334E, 337E, 348H, 351Q, 377A, 382D, 386R, 391F, 392R, 395H, 398S, 445R, 447A, 448I, 449G, 450G, 451T, 459Q
CDD
cd01359 (Argininosuccinate_lyase)

242D

tetramer interface
109N, 112G, 115H, 116T, 165Y, 166T, 167H, 168L, 169Q, 170R, 171A, 172Q, 178H, 182L, 183H, 189N, 192Q, 193R, 196Q, 200R, 211L, 212A, 213G, 214H, 215P, 217G, 220R, 234G, 235N, 236S, 237L, 238A, 241S, 242D, 244D, 248E, 251F, 255L, 258N, 259H, 261A, 262K, 265E, 266D, 271S, 272T, 275F, 283A, 289S, 290L, 291M, 292P, 294K, 295K, 296N, 298D, 301E, 302L, 304R, 305G, 306K, 307S, 308G, 309R, 311F, 312G, 313Q, 316G, 318M, 319M, 320S, 328Y, 329N, 330K, 331D, 334E, 337E, 348H, 351Q, 377A, 382D, 386R, 391F, 392R, 395H, 398S, 445R, 447A, 448I, 449G, 450G, 451T, 459Q
CDD
cd01359 (Argininosuccinate_lyase)

244D

tetramer interface
109N, 112G, 115H, 116T, 165Y, 166T, 167H, 168L, 169Q, 170R, 171A, 172Q, 178H, 182L, 183H, 189N, 192Q, 193R, 196Q, 200R, 211L, 212A, 213G, 214H, 215P, 217G, 220R, 234G, 235N, 236S, 237L, 238A, 241S, 242D, 244D, 248E, 251F, 255L, 258N, 259H, 261A, 262K, 265E, 266D, 271S, 272T, 275F, 283A, 289S, 290L, 291M, 292P, 294K, 295K, 296N, 298D, 301E, 302L, 304R, 305G, 306K, 307S, 308G, 309R, 311F, 312G, 313Q, 316G, 318M, 319M, 320S, 328Y, 329N, 330K, 331D, 334E, 337E, 348H, 351Q, 377A, 382D, 386R, 391F, 392R, 395H, 398S, 445R, 447A, 448I, 449G, 450G, 451T, 459Q
CDD
cd01359 (Argininosuccinate_lyase)

248E

tetramer interface
109N, 112G, 115H, 116T, 165Y, 166T, 167H, 168L, 169Q, 170R, 171A, 172Q, 178H, 182L, 183H, 189N, 192Q, 193R, 196Q, 200R, 211L, 212A, 213G, 214H, 215P, 217G, 220R, 234G, 235N, 236S, 237L, 238A, 241S, 242D, 244D, 248E, 251F, 255L, 258N, 259H, 261A, 262K, 265E, 266D, 271S, 272T, 275F, 283A, 289S, 290L, 291M, 292P, 294K, 295K, 296N, 298D, 301E, 302L, 304R, 305G, 306K, 307S, 308G, 309R, 311F, 312G, 313Q, 316G, 318M, 319M, 320S, 328Y, 329N, 330K, 331D, 334E, 337E, 348H, 351Q, 377A, 382D, 386R, 391F, 392R, 395H, 398S, 445R, 447A, 448I, 449G, 450G, 451T, 459Q
CDD
cd01359 (Argininosuccinate_lyase)

251F

tetramer interface
109N, 112G, 115H, 116T, 165Y, 166T, 167H, 168L, 169Q, 170R, 171A, 172Q, 178H, 182L, 183H, 189N, 192Q, 193R, 196Q, 200R, 211L, 212A, 213G, 214H, 215P, 217G, 220R, 234G, 235N, 236S, 237L, 238A, 241S, 242D, 244D, 248E, 251F, 255L, 258N, 259H, 261A, 262K, 265E, 266D, 271S, 272T, 275F, 283A, 289S, 290L, 291M, 292P, 294K, 295K, 296N, 298D, 301E, 302L, 304R, 305G, 306K, 307S, 308G, 309R, 311F, 312G, 313Q, 316G, 318M, 319M, 320S, 328Y, 329N, 330K, 331D, 334E, 337E, 348H, 351Q, 377A, 382D, 386R, 391F, 392R, 395H, 398S, 445R, 447A, 448I, 449G, 450G, 451T, 459Q
CDD
cd01359 (Argininosuccinate_lyase)

255L

tetramer interface
109N, 112G, 115H, 116T, 165Y, 166T, 167H, 168L, 169Q, 170R, 171A, 172Q, 178H, 182L, 183H, 189N, 192Q, 193R, 196Q, 200R, 211L, 212A, 213G, 214H, 215P, 217G, 220R, 234G, 235N, 236S, 237L, 238A, 241S, 242D, 244D, 248E, 251F, 255L, 258N, 259H, 261A, 262K, 265E, 266D, 271S, 272T, 275F, 283A, 289S, 290L, 291M, 292P, 294K, 295K, 296N, 298D, 301E, 302L, 304R, 305G, 306K, 307S, 308G, 309R, 311F, 312G, 313Q, 316G, 318M, 319M, 320S, 328Y, 329N, 330K, 331D, 334E, 337E, 348H, 351Q, 377A, 382D, 386R, 391F, 392R, 395H, 398S, 445R, 447A, 448I, 449G, 450G, 451T, 459Q
CDD
cd01359 (Argininosuccinate_lyase)

258N

tetramer interface
109N, 112G, 115H, 116T, 165Y, 166T, 167H, 168L, 169Q, 170R, 171A, 172Q, 178H, 182L, 183H, 189N, 192Q, 193R, 196Q, 200R, 211L, 212A, 213G, 214H, 215P, 217G, 220R, 234G, 235N, 236S, 237L, 238A, 241S, 242D, 244D, 248E, 251F, 255L, 258N, 259H, 261A, 262K, 265E, 266D, 271S, 272T, 275F, 283A, 289S, 290L, 291M, 292P, 294K, 295K, 296N, 298D, 301E, 302L, 304R, 305G, 306K, 307S, 308G, 309R, 311F, 312G, 313Q, 316G, 318M, 319M, 320S, 328Y, 329N, 330K, 331D, 334E, 337E, 348H, 351Q, 377A, 382D, 386R, 391F, 392R, 395H, 398S, 445R, 447A, 448I, 449G, 450G, 451T, 459Q
CDD
cd01359 (Argininosuccinate_lyase)

259H

tetramer interface
109N, 112G, 115H, 116T, 165Y, 166T, 167H, 168L, 169Q, 170R, 171A, 172Q, 178H, 182L, 183H, 189N, 192Q, 193R, 196Q, 200R, 211L, 212A, 213G, 214H, 215P, 217G, 220R, 234G, 235N, 236S, 237L, 238A, 241S, 242D, 244D, 248E, 251F, 255L, 258N, 259H, 261A, 262K, 265E, 266D, 271S, 272T, 275F, 283A, 289S, 290L, 291M, 292P, 294K, 295K, 296N, 298D, 301E, 302L, 304R, 305G, 306K, 307S, 308G, 309R, 311F, 312G, 313Q, 316G, 318M, 319M, 320S, 328Y, 329N, 330K, 331D, 334E, 337E, 348H, 351Q, 377A, 382D, 386R, 391F, 392R, 395H, 398S, 445R, 447A, 448I, 449G, 450G, 451T, 459Q
CDD
cd01359 (Argininosuccinate_lyase)

261A

tetramer interface
109N, 112G, 115H, 116T, 165Y, 166T, 167H, 168L, 169Q, 170R, 171A, 172Q, 178H, 182L, 183H, 189N, 192Q, 193R, 196Q, 200R, 211L, 212A, 213G, 214H, 215P, 217G, 220R, 234G, 235N, 236S, 237L, 238A, 241S, 242D, 244D, 248E, 251F, 255L, 258N, 259H, 261A, 262K, 265E, 266D, 271S, 272T, 275F, 283A, 289S, 290L, 291M, 292P, 294K, 295K, 296N, 298D, 301E, 302L, 304R, 305G, 306K, 307S, 308G, 309R, 311F, 312G, 313Q, 316G, 318M, 319M, 320S, 328Y, 329N, 330K, 331D, 334E, 337E, 348H, 351Q, 377A, 382D, 386R, 391F, 392R, 395H, 398S, 445R, 447A, 448I, 449G, 450G, 451T, 459Q
CDD
cd01359 (Argininosuccinate_lyase)

262K

tetramer interface
109N, 112G, 115H, 116T, 165Y, 166T, 167H, 168L, 169Q, 170R, 171A, 172Q, 178H, 182L, 183H, 189N, 192Q, 193R, 196Q, 200R, 211L, 212A, 213G, 214H, 215P, 217G, 220R, 234G, 235N, 236S, 237L, 238A, 241S, 242D, 244D, 248E, 251F, 255L, 258N, 259H, 261A, 262K, 265E, 266D, 271S, 272T, 275F, 283A, 289S, 290L, 291M, 292P, 294K, 295K, 296N, 298D, 301E, 302L, 304R, 305G, 306K, 307S, 308G, 309R, 311F, 312G, 313Q, 316G, 318M, 319M, 320S, 328Y, 329N, 330K, 331D, 334E, 337E, 348H, 351Q, 377A, 382D, 386R, 391F, 392R, 395H, 398S, 445R, 447A, 448I, 449G, 450G, 451T, 459Q
CDD
cd01359 (Argininosuccinate_lyase)

265E

tetramer interface
109N, 112G, 115H, 116T, 165Y, 166T, 167H, 168L, 169Q, 170R, 171A, 172Q, 178H, 182L, 183H, 189N, 192Q, 193R, 196Q, 200R, 211L, 212A, 213G, 214H, 215P, 217G, 220R, 234G, 235N, 236S, 237L, 238A, 241S, 242D, 244D, 248E, 251F, 255L, 258N, 259H, 261A, 262K, 265E, 266D, 271S, 272T, 275F, 283A, 289S, 290L, 291M, 292P, 294K, 295K, 296N, 298D, 301E, 302L, 304R, 305G, 306K, 307S, 308G, 309R, 311F, 312G, 313Q, 316G, 318M, 319M, 320S, 328Y, 329N, 330K, 331D, 334E, 337E, 348H, 351Q, 377A, 382D, 386R, 391F, 392R, 395H, 398S, 445R, 447A, 448I, 449G, 450G, 451T, 459Q
CDD
cd01359 (Argininosuccinate_lyase)

266D

tetramer interface
109N, 112G, 115H, 116T, 165Y, 166T, 167H, 168L, 169Q, 170R, 171A, 172Q, 178H, 182L, 183H, 189N, 192Q, 193R, 196Q, 200R, 211L, 212A, 213G, 214H, 215P, 217G, 220R, 234G, 235N, 236S, 237L, 238A, 241S, 242D, 244D, 248E, 251F, 255L, 258N, 259H, 261A, 262K, 265E, 266D, 271S, 272T, 275F, 283A, 289S, 290L, 291M, 292P, 294K, 295K, 296N, 298D, 301E, 302L, 304R, 305G, 306K, 307S, 308G, 309R, 311F, 312G, 313Q, 316G, 318M, 319M, 320S, 328Y, 329N, 330K, 331D, 334E, 337E, 348H, 351Q, 377A, 382D, 386R, 391F, 392R, 395H, 398S, 445R, 447A, 448I, 449G, 450G, 451T, 459Q
CDD
cd01359 (Argininosuccinate_lyase)

271S

tetramer interface
109N, 112G, 115H, 116T, 165Y, 166T, 167H, 168L, 169Q, 170R, 171A, 172Q, 178H, 182L, 183H, 189N, 192Q, 193R, 196Q, 200R, 211L, 212A, 213G, 214H, 215P, 217G, 220R, 234G, 235N, 236S, 237L, 238A, 241S, 242D, 244D, 248E, 251F, 255L, 258N, 259H, 261A, 262K, 265E, 266D, 271S, 272T, 275F, 283A, 289S, 290L, 291M, 292P, 294K, 295K, 296N, 298D, 301E, 302L, 304R, 305G, 306K, 307S, 308G, 309R, 311F, 312G, 313Q, 316G, 318M, 319M, 320S, 328Y, 329N, 330K, 331D, 334E, 337E, 348H, 351Q, 377A, 382D, 386R, 391F, 392R, 395H, 398S, 445R, 447A, 448I, 449G, 450G, 451T, 459Q
CDD
cd01359 (Argininosuccinate_lyase)

272T

tetramer interface
109N, 112G, 115H, 116T, 165Y, 166T, 167H, 168L, 169Q, 170R, 171A, 172Q, 178H, 182L, 183H, 189N, 192Q, 193R, 196Q, 200R, 211L, 212A, 213G, 214H, 215P, 217G, 220R, 234G, 235N, 236S, 237L, 238A, 241S, 242D, 244D, 248E, 251F, 255L, 258N, 259H, 261A, 262K, 265E, 266D, 271S, 272T, 275F, 283A, 289S, 290L, 291M, 292P, 294K, 295K, 296N, 298D, 301E, 302L, 304R, 305G, 306K, 307S, 308G, 309R, 311F, 312G, 313Q, 316G, 318M, 319M, 320S, 328Y, 329N, 330K, 331D, 334E, 337E, 348H, 351Q, 377A, 382D, 386R, 391F, 392R, 395H, 398S, 445R, 447A, 448I, 449G, 450G, 451T, 459Q
CDD
cd01359 (Argininosuccinate_lyase)

275F

tetramer interface
109N, 112G, 115H, 116T, 165Y, 166T, 167H, 168L, 169Q, 170R, 171A, 172Q, 178H, 182L, 183H, 189N, 192Q, 193R, 196Q, 200R, 211L, 212A, 213G, 214H, 215P, 217G, 220R, 234G, 235N, 236S, 237L, 238A, 241S, 242D, 244D, 248E, 251F, 255L, 258N, 259H, 261A, 262K, 265E, 266D, 271S, 272T, 275F, 283A, 289S, 290L, 291M, 292P, 294K, 295K, 296N, 298D, 301E, 302L, 304R, 305G, 306K, 307S, 308G, 309R, 311F, 312G, 313Q, 316G, 318M, 319M, 320S, 328Y, 329N, 330K, 331D, 334E, 337E, 348H, 351Q, 377A, 382D, 386R, 391F, 392R, 395H, 398S, 445R, 447A, 448I, 449G, 450G, 451T, 459Q
CDD
cd01359 (Argininosuccinate_lyase)

283A

tetramer interface
109N, 112G, 115H, 116T, 165Y, 166T, 167H, 168L, 169Q, 170R, 171A, 172Q, 178H, 182L, 183H, 189N, 192Q, 193R, 196Q, 200R, 211L, 212A, 213G, 214H, 215P, 217G, 220R, 234G, 235N, 236S, 237L, 238A, 241S, 242D, 244D, 248E, 251F, 255L, 258N, 259H, 261A, 262K, 265E, 266D, 271S, 272T, 275F, 283A, 289S, 290L, 291M, 292P, 294K, 295K, 296N, 298D, 301E, 302L, 304R, 305G, 306K, 307S, 308G, 309R, 311F, 312G, 313Q, 316G, 318M, 319M, 320S, 328Y, 329N, 330K, 331D, 334E, 337E, 348H, 351Q, 377A, 382D, 386R, 391F, 392R, 395H, 398S, 445R, 447A, 448I, 449G, 450G, 451T, 459Q
CDD
cd01359 (Argininosuccinate_lyase)

289S

tetramer interface
109N, 112G, 115H, 116T, 165Y, 166T, 167H, 168L, 169Q, 170R, 171A, 172Q, 178H, 182L, 183H, 189N, 192Q, 193R, 196Q, 200R, 211L, 212A, 213G, 214H, 215P, 217G, 220R, 234G, 235N, 236S, 237L, 238A, 241S, 242D, 244D, 248E, 251F, 255L, 258N, 259H, 261A, 262K, 265E, 266D, 271S, 272T, 275F, 283A, 289S, 290L, 291M, 292P, 294K, 295K, 296N, 298D, 301E, 302L, 304R, 305G, 306K, 307S, 308G, 309R, 311F, 312G, 313Q, 316G, 318M, 319M, 320S, 328Y, 329N, 330K, 331D, 334E, 337E, 348H, 351Q, 377A, 382D, 386R, 391F, 392R, 395H, 398S, 445R, 447A, 448I, 449G, 450G, 451T, 459Q
CDD
cd01359 (Argininosuccinate_lyase)

290L

tetramer interface
109N, 112G, 115H, 116T, 165Y, 166T, 167H, 168L, 169Q, 170R, 171A, 172Q, 178H, 182L, 183H, 189N, 192Q, 193R, 196Q, 200R, 211L, 212A, 213G, 214H, 215P, 217G, 220R, 234G, 235N, 236S, 237L, 238A, 241S, 242D, 244D, 248E, 251F, 255L, 258N, 259H, 261A, 262K, 265E, 266D, 271S, 272T, 275F, 283A, 289S, 290L, 291M, 292P, 294K, 295K, 296N, 298D, 301E, 302L, 304R, 305G, 306K, 307S, 308G, 309R, 311F, 312G, 313Q, 316G, 318M, 319M, 320S, 328Y, 329N, 330K, 331D, 334E, 337E, 348H, 351Q, 377A, 382D, 386R, 391F, 392R, 395H, 398S, 445R, 447A, 448I, 449G, 450G, 451T, 459Q
CDD
cd01359 (Argininosuccinate_lyase)

291M

tetramer interface
109N, 112G, 115H, 116T, 165Y, 166T, 167H, 168L, 169Q, 170R, 171A, 172Q, 178H, 182L, 183H, 189N, 192Q, 193R, 196Q, 200R, 211L, 212A, 213G, 214H, 215P, 217G, 220R, 234G, 235N, 236S, 237L, 238A, 241S, 242D, 244D, 248E, 251F, 255L, 258N, 259H, 261A, 262K, 265E, 266D, 271S, 272T, 275F, 283A, 289S, 290L, 291M, 292P, 294K, 295K, 296N, 298D, 301E, 302L, 304R, 305G, 306K, 307S, 308G, 309R, 311F, 312G, 313Q, 316G, 318M, 319M, 320S, 328Y, 329N, 330K, 331D, 334E, 337E, 348H, 351Q, 377A, 382D, 386R, 391F, 392R, 395H, 398S, 445R, 447A, 448I, 449G, 450G, 451T, 459Q
CDD
cd01359 (Argininosuccinate_lyase)

292P

tetramer interface
109N, 112G, 115H, 116T, 165Y, 166T, 167H, 168L, 169Q, 170R, 171A, 172Q, 178H, 182L, 183H, 189N, 192Q, 193R, 196Q, 200R, 211L, 212A, 213G, 214H, 215P, 217G, 220R, 234G, 235N, 236S, 237L, 238A, 241S, 242D, 244D, 248E, 251F, 255L, 258N, 259H, 261A, 262K, 265E, 266D, 271S, 272T, 275F, 283A, 289S, 290L, 291M, 292P, 294K, 295K, 296N, 298D, 301E, 302L, 304R, 305G, 306K, 307S, 308G, 309R, 311F, 312G, 313Q, 316G, 318M, 319M, 320S, 328Y, 329N, 330K, 331D, 334E, 337E, 348H, 351Q, 377A, 382D, 386R, 391F, 392R, 395H, 398S, 445R, 447A, 448I, 449G, 450G, 451T, 459Q
CDD
cd01359 (Argininosuccinate_lyase)

294K

tetramer interface
109N, 112G, 115H, 116T, 165Y, 166T, 167H, 168L, 169Q, 170R, 171A, 172Q, 178H, 182L, 183H, 189N, 192Q, 193R, 196Q, 200R, 211L, 212A, 213G, 214H, 215P, 217G, 220R, 234G, 235N, 236S, 237L, 238A, 241S, 242D, 244D, 248E, 251F, 255L, 258N, 259H, 261A, 262K, 265E, 266D, 271S, 272T, 275F, 283A, 289S, 290L, 291M, 292P, 294K, 295K, 296N, 298D, 301E, 302L, 304R, 305G, 306K, 307S, 308G, 309R, 311F, 312G, 313Q, 316G, 318M, 319M, 320S, 328Y, 329N, 330K, 331D, 334E, 337E, 348H, 351Q, 377A, 382D, 386R, 391F, 392R, 395H, 398S, 445R, 447A, 448I, 449G, 450G, 451T, 459Q
CDD
cd01359 (Argininosuccinate_lyase)

295K

tetramer interface
109N, 112G, 115H, 116T, 165Y, 166T, 167H, 168L, 169Q, 170R, 171A, 172Q, 178H, 182L, 183H, 189N, 192Q, 193R, 196Q, 200R, 211L, 212A, 213G, 214H, 215P, 217G, 220R, 234G, 235N, 236S, 237L, 238A, 241S, 242D, 244D, 248E, 251F, 255L, 258N, 259H, 261A, 262K, 265E, 266D, 271S, 272T, 275F, 283A, 289S, 290L, 291M, 292P, 294K, 295K, 296N, 298D, 301E, 302L, 304R, 305G, 306K, 307S, 308G, 309R, 311F, 312G, 313Q, 316G, 318M, 319M, 320S, 328Y, 329N, 330K, 331D, 334E, 337E, 348H, 351Q, 377A, 382D, 386R, 391F, 392R, 395H, 398S, 445R, 447A, 448I, 449G, 450G, 451T, 459Q
CDD
cd01359 (Argininosuccinate_lyase)

296N

tetramer interface
109N, 112G, 115H, 116T, 165Y, 166T, 167H, 168L, 169Q, 170R, 171A, 172Q, 178H, 182L, 183H, 189N, 192Q, 193R, 196Q, 200R, 211L, 212A, 213G, 214H, 215P, 217G, 220R, 234G, 235N, 236S, 237L, 238A, 241S, 242D, 244D, 248E, 251F, 255L, 258N, 259H, 261A, 262K, 265E, 266D, 271S, 272T, 275F, 283A, 289S, 290L, 291M, 292P, 294K, 295K, 296N, 298D, 301E, 302L, 304R, 305G, 306K, 307S, 308G, 309R, 311F, 312G, 313Q, 316G, 318M, 319M, 320S, 328Y, 329N, 330K, 331D, 334E, 337E, 348H, 351Q, 377A, 382D, 386R, 391F, 392R, 395H, 398S, 445R, 447A, 448I, 449G, 450G, 451T, 459Q
CDD
cd01359 (Argininosuccinate_lyase)

298D

tetramer interface
109N, 112G, 115H, 116T, 165Y, 166T, 167H, 168L, 169Q, 170R, 171A, 172Q, 178H, 182L, 183H, 189N, 192Q, 193R, 196Q, 200R, 211L, 212A, 213G, 214H, 215P, 217G, 220R, 234G, 235N, 236S, 237L, 238A, 241S, 242D, 244D, 248E, 251F, 255L, 258N, 259H, 261A, 262K, 265E, 266D, 271S, 272T, 275F, 283A, 289S, 290L, 291M, 292P, 294K, 295K, 296N, 298D, 301E, 302L, 304R, 305G, 306K, 307S, 308G, 309R, 311F, 312G, 313Q, 316G, 318M, 319M, 320S, 328Y, 329N, 330K, 331D, 334E, 337E, 348H, 351Q, 377A, 382D, 386R, 391F, 392R, 395H, 398S, 445R, 447A, 448I, 449G, 450G, 451T, 459Q
CDD
cd01359 (Argininosuccinate_lyase)

301E

tetramer interface
109N, 112G, 115H, 116T, 165Y, 166T, 167H, 168L, 169Q, 170R, 171A, 172Q, 178H, 182L, 183H, 189N, 192Q, 193R, 196Q, 200R, 211L, 212A, 213G, 214H, 215P, 217G, 220R, 234G, 235N, 236S, 237L, 238A, 241S, 242D, 244D, 248E, 251F, 255L, 258N, 259H, 261A, 262K, 265E, 266D, 271S, 272T, 275F, 283A, 289S, 290L, 291M, 292P, 294K, 295K, 296N, 298D, 301E, 302L, 304R, 305G, 306K, 307S, 308G, 309R, 311F, 312G, 313Q, 316G, 318M, 319M, 320S, 328Y, 329N, 330K, 331D, 334E, 337E, 348H, 351Q, 377A, 382D, 386R, 391F, 392R, 395H, 398S, 445R, 447A, 448I, 449G, 450G, 451T, 459Q
CDD
cd01359 (Argininosuccinate_lyase)

302L

tetramer interface
109N, 112G, 115H, 116T, 165Y, 166T, 167H, 168L, 169Q, 170R, 171A, 172Q, 178H, 182L, 183H, 189N, 192Q, 193R, 196Q, 200R, 211L, 212A, 213G, 214H, 215P, 217G, 220R, 234G, 235N, 236S, 237L, 238A, 241S, 242D, 244D, 248E, 251F, 255L, 258N, 259H, 261A, 262K, 265E, 266D, 271S, 272T, 275F, 283A, 289S, 290L, 291M, 292P, 294K, 295K, 296N, 298D, 301E, 302L, 304R, 305G, 306K, 307S, 308G, 309R, 311F, 312G, 313Q, 316G, 318M, 319M, 320S, 328Y, 329N, 330K, 331D, 334E, 337E, 348H, 351Q, 377A, 382D, 386R, 391F, 392R, 395H, 398S, 445R, 447A, 448I, 449G, 450G, 451T, 459Q
CDD
cd01359 (Argininosuccinate_lyase)

304R

tetramer interface
109N, 112G, 115H, 116T, 165Y, 166T, 167H, 168L, 169Q, 170R, 171A, 172Q, 178H, 182L, 183H, 189N, 192Q, 193R, 196Q, 200R, 211L, 212A, 213G, 214H, 215P, 217G, 220R, 234G, 235N, 236S, 237L, 238A, 241S, 242D, 244D, 248E, 251F, 255L, 258N, 259H, 261A, 262K, 265E, 266D, 271S, 272T, 275F, 283A, 289S, 290L, 291M, 292P, 294K, 295K, 296N, 298D, 301E, 302L, 304R, 305G, 306K, 307S, 308G, 309R, 311F, 312G, 313Q, 316G, 318M, 319M, 320S, 328Y, 329N, 330K, 331D, 334E, 337E, 348H, 351Q, 377A, 382D, 386R, 391F, 392R, 395H, 398S, 445R, 447A, 448I, 449G, 450G, 451T, 459Q
CDD
cd01359 (Argininosuccinate_lyase)

305G

tetramer interface
109N, 112G, 115H, 116T, 165Y, 166T, 167H, 168L, 169Q, 170R, 171A, 172Q, 178H, 182L, 183H, 189N, 192Q, 193R, 196Q, 200R, 211L, 212A, 213G, 214H, 215P, 217G, 220R, 234G, 235N, 236S, 237L, 238A, 241S, 242D, 244D, 248E, 251F, 255L, 258N, 259H, 261A, 262K, 265E, 266D, 271S, 272T, 275F, 283A, 289S, 290L, 291M, 292P, 294K, 295K, 296N, 298D, 301E, 302L, 304R, 305G, 306K, 307S, 308G, 309R, 311F, 312G, 313Q, 316G, 318M, 319M, 320S, 328Y, 329N, 330K, 331D, 334E, 337E, 348H, 351Q, 377A, 382D, 386R, 391F, 392R, 395H, 398S, 445R, 447A, 448I, 449G, 450G, 451T, 459Q
CDD
cd01359 (Argininosuccinate_lyase)

306K

tetramer interface
109N, 112G, 115H, 116T, 165Y, 166T, 167H, 168L, 169Q, 170R, 171A, 172Q, 178H, 182L, 183H, 189N, 192Q, 193R, 196Q, 200R, 211L, 212A, 213G, 214H, 215P, 217G, 220R, 234G, 235N, 236S, 237L, 238A, 241S, 242D, 244D, 248E, 251F, 255L, 258N, 259H, 261A, 262K, 265E, 266D, 271S, 272T, 275F, 283A, 289S, 290L, 291M, 292P, 294K, 295K, 296N, 298D, 301E, 302L, 304R, 305G, 306K, 307S, 308G, 309R, 311F, 312G, 313Q, 316G, 318M, 319M, 320S, 328Y, 329N, 330K, 331D, 334E, 337E, 348H, 351Q, 377A, 382D, 386R, 391F, 392R, 395H, 398S, 445R, 447A, 448I, 449G, 450G, 451T, 459Q
CDD
cd01359 (Argininosuccinate_lyase)

307S

tetramer interface
109N, 112G, 115H, 116T, 165Y, 166T, 167H, 168L, 169Q, 170R, 171A, 172Q, 178H, 182L, 183H, 189N, 192Q, 193R, 196Q, 200R, 211L, 212A, 213G, 214H, 215P, 217G, 220R, 234G, 235N, 236S, 237L, 238A, 241S, 242D, 244D, 248E, 251F, 255L, 258N, 259H, 261A, 262K, 265E, 266D, 271S, 272T, 275F, 283A, 289S, 290L, 291M, 292P, 294K, 295K, 296N, 298D, 301E, 302L, 304R, 305G, 306K, 307S, 308G, 309R, 311F, 312G, 313Q, 316G, 318M, 319M, 320S, 328Y, 329N, 330K, 331D, 334E, 337E, 348H, 351Q, 377A, 382D, 386R, 391F, 392R, 395H, 398S, 445R, 447A, 448I, 449G, 450G, 451T, 459Q
CDD
cd01359 (Argininosuccinate_lyase)

308G

tetramer interface
109N, 112G, 115H, 116T, 165Y, 166T, 167H, 168L, 169Q, 170R, 171A, 172Q, 178H, 182L, 183H, 189N, 192Q, 193R, 196Q, 200R, 211L, 212A, 213G, 214H, 215P, 217G, 220R, 234G, 235N, 236S, 237L, 238A, 241S, 242D, 244D, 248E, 251F, 255L, 258N, 259H, 261A, 262K, 265E, 266D, 271S, 272T, 275F, 283A, 289S, 290L, 291M, 292P, 294K, 295K, 296N, 298D, 301E, 302L, 304R, 305G, 306K, 307S, 308G, 309R, 311F, 312G, 313Q, 316G, 318M, 319M, 320S, 328Y, 329N, 330K, 331D, 334E, 337E, 348H, 351Q, 377A, 382D, 386R, 391F, 392R, 395H, 398S, 445R, 447A, 448I, 449G, 450G, 451T, 459Q
CDD
cd01359 (Argininosuccinate_lyase)

309R

tetramer interface
109N, 112G, 115H, 116T, 165Y, 166T, 167H, 168L, 169Q, 170R, 171A, 172Q, 178H, 182L, 183H, 189N, 192Q, 193R, 196Q, 200R, 211L, 212A, 213G, 214H, 215P, 217G, 220R, 234G, 235N, 236S, 237L, 238A, 241S, 242D, 244D, 248E, 251F, 255L, 258N, 259H, 261A, 262K, 265E, 266D, 271S, 272T, 275F, 283A, 289S, 290L, 291M, 292P, 294K, 295K, 296N, 298D, 301E, 302L, 304R, 305G, 306K, 307S, 308G, 309R, 311F, 312G, 313Q, 316G, 318M, 319M, 320S, 328Y, 329N, 330K, 331D, 334E, 337E, 348H, 351Q, 377A, 382D, 386R, 391F, 392R, 395H, 398S, 445R, 447A, 448I, 449G, 450G, 451T, 459Q
CDD
cd01359 (Argininosuccinate_lyase)

311F

tetramer interface
109N, 112G, 115H, 116T, 165Y, 166T, 167H, 168L, 169Q, 170R, 171A, 172Q, 178H, 182L, 183H, 189N, 192Q, 193R, 196Q, 200R, 211L, 212A, 213G, 214H, 215P, 217G, 220R, 234G, 235N, 236S, 237L, 238A, 241S, 242D, 244D, 248E, 251F, 255L, 258N, 259H, 261A, 262K, 265E, 266D, 271S, 272T, 275F, 283A, 289S, 290L, 291M, 292P, 294K, 295K, 296N, 298D, 301E, 302L, 304R, 305G, 306K, 307S, 308G, 309R, 311F, 312G, 313Q, 316G, 318M, 319M, 320S, 328Y, 329N, 330K, 331D, 334E, 337E, 348H, 351Q, 377A, 382D, 386R, 391F, 392R, 395H, 398S, 445R, 447A, 448I, 449G, 450G, 451T, 459Q
CDD
cd01359 (Argininosuccinate_lyase)

312G

tetramer interface
109N, 112G, 115H, 116T, 165Y, 166T, 167H, 168L, 169Q, 170R, 171A, 172Q, 178H, 182L, 183H, 189N, 192Q, 193R, 196Q, 200R, 211L, 212A, 213G, 214H, 215P, 217G, 220R, 234G, 235N, 236S, 237L, 238A, 241S, 242D, 244D, 248E, 251F, 255L, 258N, 259H, 261A, 262K, 265E, 266D, 271S, 272T, 275F, 283A, 289S, 290L, 291M, 292P, 294K, 295K, 296N, 298D, 301E, 302L, 304R, 305G, 306K, 307S, 308G, 309R, 311F, 312G, 313Q, 316G, 318M, 319M, 320S, 328Y, 329N, 330K, 331D, 334E, 337E, 348H, 351Q, 377A, 382D, 386R, 391F, 392R, 395H, 398S, 445R, 447A, 448I, 449G, 450G, 451T, 459Q
CDD
cd01359 (Argininosuccinate_lyase)

313Q

tetramer interface
109N, 112G, 115H, 116T, 165Y, 166T, 167H, 168L, 169Q, 170R, 171A, 172Q, 178H, 182L, 183H, 189N, 192Q, 193R, 196Q, 200R, 211L, 212A, 213G, 214H, 215P, 217G, 220R, 234G, 235N, 236S, 237L, 238A, 241S, 242D, 244D, 248E, 251F, 255L, 258N, 259H, 261A, 262K, 265E, 266D, 271S, 272T, 275F, 283A, 289S, 290L, 291M, 292P, 294K, 295K, 296N, 298D, 301E, 302L, 304R, 305G, 306K, 307S, 308G, 309R, 311F, 312G, 313Q, 316G, 318M, 319M, 320S, 328Y, 329N, 330K, 331D, 334E, 337E, 348H, 351Q, 377A, 382D, 386R, 391F, 392R, 395H, 398S, 445R, 447A, 448I, 449G, 450G, 451T, 459Q
CDD
cd01359 (Argininosuccinate_lyase)

316G

tetramer interface
109N, 112G, 115H, 116T, 165Y, 166T, 167H, 168L, 169Q, 170R, 171A, 172Q, 178H, 182L, 183H, 189N, 192Q, 193R, 196Q, 200R, 211L, 212A, 213G, 214H, 215P, 217G, 220R, 234G, 235N, 236S, 237L, 238A, 241S, 242D, 244D, 248E, 251F, 255L, 258N, 259H, 261A, 262K, 265E, 266D, 271S, 272T, 275F, 283A, 289S, 290L, 291M, 292P, 294K, 295K, 296N, 298D, 301E, 302L, 304R, 305G, 306K, 307S, 308G, 309R, 311F, 312G, 313Q, 316G, 318M, 319M, 320S, 328Y, 329N, 330K, 331D, 334E, 337E, 348H, 351Q, 377A, 382D, 386R, 391F, 392R, 395H, 398S, 445R, 447A, 448I, 449G, 450G, 451T, 459Q
CDD
cd01359 (Argininosuccinate_lyase)

318M

tetramer interface
109N, 112G, 115H, 116T, 165Y, 166T, 167H, 168L, 169Q, 170R, 171A, 172Q, 178H, 182L, 183H, 189N, 192Q, 193R, 196Q, 200R, 211L, 212A, 213G, 214H, 215P, 217G, 220R, 234G, 235N, 236S, 237L, 238A, 241S, 242D, 244D, 248E, 251F, 255L, 258N, 259H, 261A, 262K, 265E, 266D, 271S, 272T, 275F, 283A, 289S, 290L, 291M, 292P, 294K, 295K, 296N, 298D, 301E, 302L, 304R, 305G, 306K, 307S, 308G, 309R, 311F, 312G, 313Q, 316G, 318M, 319M, 320S, 328Y, 329N, 330K, 331D, 334E, 337E, 348H, 351Q, 377A, 382D, 386R, 391F, 392R, 395H, 398S, 445R, 447A, 448I, 449G, 450G, 451T, 459Q
CDD
cd01359 (Argininosuccinate_lyase)

319M

tetramer interface
109N, 112G, 115H, 116T, 165Y, 166T, 167H, 168L, 169Q, 170R, 171A, 172Q, 178H, 182L, 183H, 189N, 192Q, 193R, 196Q, 200R, 211L, 212A, 213G, 214H, 215P, 217G, 220R, 234G, 235N, 236S, 237L, 238A, 241S, 242D, 244D, 248E, 251F, 255L, 258N, 259H, 261A, 262K, 265E, 266D, 271S, 272T, 275F, 283A, 289S, 290L, 291M, 292P, 294K, 295K, 296N, 298D, 301E, 302L, 304R, 305G, 306K, 307S, 308G, 309R, 311F, 312G, 313Q, 316G, 318M, 319M, 320S, 328Y, 329N, 330K, 331D, 334E, 337E, 348H, 351Q, 377A, 382D, 386R, 391F, 392R, 395H, 398S, 445R, 447A, 448I, 449G, 450G, 451T, 459Q
CDD
cd01359 (Argininosuccinate_lyase)

320S

tetramer interface
109N, 112G, 115H, 116T, 165Y, 166T, 167H, 168L, 169Q, 170R, 171A, 172Q, 178H, 182L, 183H, 189N, 192Q, 193R, 196Q, 200R, 211L, 212A, 213G, 214H, 215P, 217G, 220R, 234G, 235N, 236S, 237L, 238A, 241S, 242D, 244D, 248E, 251F, 255L, 258N, 259H, 261A, 262K, 265E, 266D, 271S, 272T, 275F, 283A, 289S, 290L, 291M, 292P, 294K, 295K, 296N, 298D, 301E, 302L, 304R, 305G, 306K, 307S, 308G, 309R, 311F, 312G, 313Q, 316G, 318M, 319M, 320S, 328Y, 329N, 330K, 331D, 334E, 337E, 348H, 351Q, 377A, 382D, 386R, 391F, 392R, 395H, 398S, 445R, 447A, 448I, 449G, 450G, 451T, 459Q
CDD
cd01359 (Argininosuccinate_lyase)

328Y

tetramer interface
109N, 112G, 115H, 116T, 165Y, 166T, 167H, 168L, 169Q, 170R, 171A, 172Q, 178H, 182L, 183H, 189N, 192Q, 193R, 196Q, 200R, 211L, 212A, 213G, 214H, 215P, 217G, 220R, 234G, 235N, 236S, 237L, 238A, 241S, 242D, 244D, 248E, 251F, 255L, 258N, 259H, 261A, 262K, 265E, 266D, 271S, 272T, 275F, 283A, 289S, 290L, 291M, 292P, 294K, 295K, 296N, 298D, 301E, 302L, 304R, 305G, 306K, 307S, 308G, 309R, 311F, 312G, 313Q, 316G, 318M, 319M, 320S, 328Y, 329N, 330K, 331D, 334E, 337E, 348H, 351Q, 377A, 382D, 386R, 391F, 392R, 395H, 398S, 445R, 447A, 448I, 449G, 450G, 451T, 459Q
CDD
cd01359 (Argininosuccinate_lyase)

329N

tetramer interface
109N, 112G, 115H, 116T, 165Y, 166T, 167H, 168L, 169Q, 170R, 171A, 172Q, 178H, 182L, 183H, 189N, 192Q, 193R, 196Q, 200R, 211L, 212A, 213G, 214H, 215P, 217G, 220R, 234G, 235N, 236S, 237L, 238A, 241S, 242D, 244D, 248E, 251F, 255L, 258N, 259H, 261A, 262K, 265E, 266D, 271S, 272T, 275F, 283A, 289S, 290L, 291M, 292P, 294K, 295K, 296N, 298D, 301E, 302L, 304R, 305G, 306K, 307S, 308G, 309R, 311F, 312G, 313Q, 316G, 318M, 319M, 320S, 328Y, 329N, 330K, 331D, 334E, 337E, 348H, 351Q, 377A, 382D, 386R, 391F, 392R, 395H, 398S, 445R, 447A, 448I, 449G, 450G, 451T, 459Q
CDD
cd01359 (Argininosuccinate_lyase)

330K

tetramer interface
109N, 112G, 115H, 116T, 165Y, 166T, 167H, 168L, 169Q, 170R, 171A, 172Q, 178H, 182L, 183H, 189N, 192Q, 193R, 196Q, 200R, 211L, 212A, 213G, 214H, 215P, 217G, 220R, 234G, 235N, 236S, 237L, 238A, 241S, 242D, 244D, 248E, 251F, 255L, 258N, 259H, 261A, 262K, 265E, 266D, 271S, 272T, 275F, 283A, 289S, 290L, 291M, 292P, 294K, 295K, 296N, 298D, 301E, 302L, 304R, 305G, 306K, 307S, 308G, 309R, 311F, 312G, 313Q, 316G, 318M, 319M, 320S, 328Y, 329N, 330K, 331D, 334E, 337E, 348H, 351Q, 377A, 382D, 386R, 391F, 392R, 395H, 398S, 445R, 447A, 448I, 449G, 450G, 451T, 459Q
CDD
cd01359 (Argininosuccinate_lyase)

331D

tetramer interface
109N, 112G, 115H, 116T, 165Y, 166T, 167H, 168L, 169Q, 170R, 171A, 172Q, 178H, 182L, 183H, 189N, 192Q, 193R, 196Q, 200R, 211L, 212A, 213G, 214H, 215P, 217G, 220R, 234G, 235N, 236S, 237L, 238A, 241S, 242D, 244D, 248E, 251F, 255L, 258N, 259H, 261A, 262K, 265E, 266D, 271S, 272T, 275F, 283A, 289S, 290L, 291M, 292P, 294K, 295K, 296N, 298D, 301E, 302L, 304R, 305G, 306K, 307S, 308G, 309R, 311F, 312G, 313Q, 316G, 318M, 319M, 320S, 328Y, 329N, 330K, 331D, 334E, 337E, 348H, 351Q, 377A, 382D, 386R, 391F, 392R, 395H, 398S, 445R, 447A, 448I, 449G, 450G, 451T, 459Q
CDD
cd01359 (Argininosuccinate_lyase)

334E

tetramer interface
109N, 112G, 115H, 116T, 165Y, 166T, 167H, 168L, 169Q, 170R, 171A, 172Q, 178H, 182L, 183H, 189N, 192Q, 193R, 196Q, 200R, 211L, 212A, 213G, 214H, 215P, 217G, 220R, 234G, 235N, 236S, 237L, 238A, 241S, 242D, 244D, 248E, 251F, 255L, 258N, 259H, 261A, 262K, 265E, 266D, 271S, 272T, 275F, 283A, 289S, 290L, 291M, 292P, 294K, 295K, 296N, 298D, 301E, 302L, 304R, 305G, 306K, 307S, 308G, 309R, 311F, 312G, 313Q, 316G, 318M, 319M, 320S, 328Y, 329N, 330K, 331D, 334E, 337E, 348H, 351Q, 377A, 382D, 386R, 391F, 392R, 395H, 398S, 445R, 447A, 448I, 449G, 450G, 451T, 459Q
CDD
cd01359 (Argininosuccinate_lyase)

337E

tetramer interface
109N, 112G, 115H, 116T, 165Y, 166T, 167H, 168L, 169Q, 170R, 171A, 172Q, 178H, 182L, 183H, 189N, 192Q, 193R, 196Q, 200R, 211L, 212A, 213G, 214H, 215P, 217G, 220R, 234G, 235N, 236S, 237L, 238A, 241S, 242D, 244D, 248E, 251F, 255L, 258N, 259H, 261A, 262K, 265E, 266D, 271S, 272T, 275F, 283A, 289S, 290L, 291M, 292P, 294K, 295K, 296N, 298D, 301E, 302L, 304R, 305G, 306K, 307S, 308G, 309R, 311F, 312G, 313Q, 316G, 318M, 319M, 320S, 328Y, 329N, 330K, 331D, 334E, 337E, 348H, 351Q, 377A, 382D, 386R, 391F, 392R, 395H, 398S, 445R, 447A, 448I, 449G, 450G, 451T, 459Q
CDD
cd01359 (Argininosuccinate_lyase)

348H

tetramer interface
109N, 112G, 115H, 116T, 165Y, 166T, 167H, 168L, 169Q, 170R, 171A, 172Q, 178H, 182L, 183H, 189N, 192Q, 193R, 196Q, 200R, 211L, 212A, 213G, 214H, 215P, 217G, 220R, 234G, 235N, 236S, 237L, 238A, 241S, 242D, 244D, 248E, 251F, 255L, 258N, 259H, 261A, 262K, 265E, 266D, 271S, 272T, 275F, 283A, 289S, 290L, 291M, 292P, 294K, 295K, 296N, 298D, 301E, 302L, 304R, 305G, 306K, 307S, 308G, 309R, 311F, 312G, 313Q, 316G, 318M, 319M, 320S, 328Y, 329N, 330K, 331D, 334E, 337E, 348H, 351Q, 377A, 382D, 386R, 391F, 392R, 395H, 398S, 445R, 447A, 448I, 449G, 450G, 451T, 459Q
CDD
cd01359 (Argininosuccinate_lyase)

351Q

tetramer interface
109N, 112G, 115H, 116T, 165Y, 166T, 167H, 168L, 169Q, 170R, 171A, 172Q, 178H, 182L, 183H, 189N, 192Q, 193R, 196Q, 200R, 211L, 212A, 213G, 214H, 215P, 217G, 220R, 234G, 235N, 236S, 237L, 238A, 241S, 242D, 244D, 248E, 251F, 255L, 258N, 259H, 261A, 262K, 265E, 266D, 271S, 272T, 275F, 283A, 289S, 290L, 291M, 292P, 294K, 295K, 296N, 298D, 301E, 302L, 304R, 305G, 306K, 307S, 308G, 309R, 311F, 312G, 313Q, 316G, 318M, 319M, 320S, 328Y, 329N, 330K, 331D, 334E, 337E, 348H, 351Q, 377A, 382D, 386R, 391F, 392R, 395H, 398S, 445R, 447A, 448I, 449G, 450G, 451T, 459Q
CDD
cd01359 (Argininosuccinate_lyase)

377A

tetramer interface
109N, 112G, 115H, 116T, 165Y, 166T, 167H, 168L, 169Q, 170R, 171A, 172Q, 178H, 182L, 183H, 189N, 192Q, 193R, 196Q, 200R, 211L, 212A, 213G, 214H, 215P, 217G, 220R, 234G, 235N, 236S, 237L, 238A, 241S, 242D, 244D, 248E, 251F, 255L, 258N, 259H, 261A, 262K, 265E, 266D, 271S, 272T, 275F, 283A, 289S, 290L, 291M, 292P, 294K, 295K, 296N, 298D, 301E, 302L, 304R, 305G, 306K, 307S, 308G, 309R, 311F, 312G, 313Q, 316G, 318M, 319M, 320S, 328Y, 329N, 330K, 331D, 334E, 337E, 348H, 351Q, 377A, 382D, 386R, 391F, 392R, 395H, 398S, 445R, 447A, 448I, 449G, 450G, 451T, 459Q
CDD
cd01359 (Argininosuccinate_lyase)

382D

tetramer interface
109N, 112G, 115H, 116T, 165Y, 166T, 167H, 168L, 169Q, 170R, 171A, 172Q, 178H, 182L, 183H, 189N, 192Q, 193R, 196Q, 200R, 211L, 212A, 213G, 214H, 215P, 217G, 220R, 234G, 235N, 236S, 237L, 238A, 241S, 242D, 244D, 248E, 251F, 255L, 258N, 259H, 261A, 262K, 265E, 266D, 271S, 272T, 275F, 283A, 289S, 290L, 291M, 292P, 294K, 295K, 296N, 298D, 301E, 302L, 304R, 305G, 306K, 307S, 308G, 309R, 311F, 312G, 313Q, 316G, 318M, 319M, 320S, 328Y, 329N, 330K, 331D, 334E, 337E, 348H, 351Q, 377A, 382D, 386R, 391F, 392R, 395H, 398S, 445R, 447A, 448I, 449G, 450G, 451T, 459Q
CDD
cd01359 (Argininosuccinate_lyase)

386R

tetramer interface
109N, 112G, 115H, 116T, 165Y, 166T, 167H, 168L, 169Q, 170R, 171A, 172Q, 178H, 182L, 183H, 189N, 192Q, 193R, 196Q, 200R, 211L, 212A, 213G, 214H, 215P, 217G, 220R, 234G, 235N, 236S, 237L, 238A, 241S, 242D, 244D, 248E, 251F, 255L, 258N, 259H, 261A, 262K, 265E, 266D, 271S, 272T, 275F, 283A, 289S, 290L, 291M, 292P, 294K, 295K, 296N, 298D, 301E, 302L, 304R, 305G, 306K, 307S, 308G, 309R, 311F, 312G, 313Q, 316G, 318M, 319M, 320S, 328Y, 329N, 330K, 331D, 334E, 337E, 348H, 351Q, 377A, 382D, 386R, 391F, 392R, 395H, 398S, 445R, 447A, 448I, 449G, 450G, 451T, 459Q
CDD
cd01359 (Argininosuccinate_lyase)

391F

tetramer interface
109N, 112G, 115H, 116T, 165Y, 166T, 167H, 168L, 169Q, 170R, 171A, 172Q, 178H, 182L, 183H, 189N, 192Q, 193R, 196Q, 200R, 211L, 212A, 213G, 214H, 215P, 217G, 220R, 234G, 235N, 236S, 237L, 238A, 241S, 242D, 244D, 248E, 251F, 255L, 258N, 259H, 261A, 262K, 265E, 266D, 271S, 272T, 275F, 283A, 289S, 290L, 291M, 292P, 294K, 295K, 296N, 298D, 301E, 302L, 304R, 305G, 306K, 307S, 308G, 309R, 311F, 312G, 313Q, 316G, 318M, 319M, 320S, 328Y, 329N, 330K, 331D, 334E, 337E, 348H, 351Q, 377A, 382D, 386R, 391F, 392R, 395H, 398S, 445R, 447A, 448I, 449G, 450G, 451T, 459Q
CDD
cd01359 (Argininosuccinate_lyase)

392R

tetramer interface
109N, 112G, 115H, 116T, 165Y, 166T, 167H, 168L, 169Q, 170R, 171A, 172Q, 178H, 182L, 183H, 189N, 192Q, 193R, 196Q, 200R, 211L, 212A, 213G, 214H, 215P, 217G, 220R, 234G, 235N, 236S, 237L, 238A, 241S, 242D, 244D, 248E, 251F, 255L, 258N, 259H, 261A, 262K, 265E, 266D, 271S, 272T, 275F, 283A, 289S, 290L, 291M, 292P, 294K, 295K, 296N, 298D, 301E, 302L, 304R, 305G, 306K, 307S, 308G, 309R, 311F, 312G, 313Q, 316G, 318M, 319M, 320S, 328Y, 329N, 330K, 331D, 334E, 337E, 348H, 351Q, 377A, 382D, 386R, 391F, 392R, 395H, 398S, 445R, 447A, 448I, 449G, 450G, 451T, 459Q
CDD
cd01359 (Argininosuccinate_lyase)

395H

tetramer interface
109N, 112G, 115H, 116T, 165Y, 166T, 167H, 168L, 169Q, 170R, 171A, 172Q, 178H, 182L, 183H, 189N, 192Q, 193R, 196Q, 200R, 211L, 212A, 213G, 214H, 215P, 217G, 220R, 234G, 235N, 236S, 237L, 238A, 241S, 242D, 244D, 248E, 251F, 255L, 258N, 259H, 261A, 262K, 265E, 266D, 271S, 272T, 275F, 283A, 289S, 290L, 291M, 292P, 294K, 295K, 296N, 298D, 301E, 302L, 304R, 305G, 306K, 307S, 308G, 309R, 311F, 312G, 313Q, 316G, 318M, 319M, 320S, 328Y, 329N, 330K, 331D, 334E, 337E, 348H, 351Q, 377A, 382D, 386R, 391F, 392R, 395H, 398S, 445R, 447A, 448I, 449G, 450G, 451T, 459Q
CDD
cd01359 (Argininosuccinate_lyase)

398S

tetramer interface
109N, 112G, 115H, 116T, 165Y, 166T, 167H, 168L, 169Q, 170R, 171A, 172Q, 178H, 182L, 183H, 189N, 192Q, 193R, 196Q, 200R, 211L, 212A, 213G, 214H, 215P, 217G, 220R, 234G, 235N, 236S, 237L, 238A, 241S, 242D, 244D, 248E, 251F, 255L, 258N, 259H, 261A, 262K, 265E, 266D, 271S, 272T, 275F, 283A, 289S, 290L, 291M, 292P, 294K, 295K, 296N, 298D, 301E, 302L, 304R, 305G, 306K, 307S, 308G, 309R, 311F, 312G, 313Q, 316G, 318M, 319M, 320S, 328Y, 329N, 330K, 331D, 334E, 337E, 348H, 351Q, 377A, 382D, 386R, 391F, 392R, 395H, 398S, 445R, 447A, 448I, 449G, 450G, 451T, 459Q
CDD
cd01359 (Argininosuccinate_lyase)

445R

tetramer interface
109N, 112G, 115H, 116T, 165Y, 166T, 167H, 168L, 169Q, 170R, 171A, 172Q, 178H, 182L, 183H, 189N, 192Q, 193R, 196Q, 200R, 211L, 212A, 213G, 214H, 215P, 217G, 220R, 234G, 235N, 236S, 237L, 238A, 241S, 242D, 244D, 248E, 251F, 255L, 258N, 259H, 261A, 262K, 265E, 266D, 271S, 272T, 275F, 283A, 289S, 290L, 291M, 292P, 294K, 295K, 296N, 298D, 301E, 302L, 304R, 305G, 306K, 307S, 308G, 309R, 311F, 312G, 313Q, 316G, 318M, 319M, 320S, 328Y, 329N, 330K, 331D, 334E, 337E, 348H, 351Q, 377A, 382D, 386R, 391F, 392R, 395H, 398S, 445R, 447A, 448I, 449G, 450G, 451T, 459Q
CDD
cd01359 (Argininosuccinate_lyase)

447A

tetramer interface
109N, 112G, 115H, 116T, 165Y, 166T, 167H, 168L, 169Q, 170R, 171A, 172Q, 178H, 182L, 183H, 189N, 192Q, 193R, 196Q, 200R, 211L, 212A, 213G, 214H, 215P, 217G, 220R, 234G, 235N, 236S, 237L, 238A, 241S, 242D, 244D, 248E, 251F, 255L, 258N, 259H, 261A, 262K, 265E, 266D, 271S, 272T, 275F, 283A, 289S, 290L, 291M, 292P, 294K, 295K, 296N, 298D, 301E, 302L, 304R, 305G, 306K, 307S, 308G, 309R, 311F, 312G, 313Q, 316G, 318M, 319M, 320S, 328Y, 329N, 330K, 331D, 334E, 337E, 348H, 351Q, 377A, 382D, 386R, 391F, 392R, 395H, 398S, 445R, 447A, 448I, 449G, 450G, 451T, 459Q
CDD
cd01359 (Argininosuccinate_lyase)

448I

tetramer interface
109N, 112G, 115H, 116T, 165Y, 166T, 167H, 168L, 169Q, 170R, 171A, 172Q, 178H, 182L, 183H, 189N, 192Q, 193R, 196Q, 200R, 211L, 212A, 213G, 214H, 215P, 217G, 220R, 234G, 235N, 236S, 237L, 238A, 241S, 242D, 244D, 248E, 251F, 255L, 258N, 259H, 261A, 262K, 265E, 266D, 271S, 272T, 275F, 283A, 289S, 290L, 291M, 292P, 294K, 295K, 296N, 298D, 301E, 302L, 304R, 305G, 306K, 307S, 308G, 309R, 311F, 312G, 313Q, 316G, 318M, 319M, 320S, 328Y, 329N, 330K, 331D, 334E, 337E, 348H, 351Q, 377A, 382D, 386R, 391F, 392R, 395H, 398S, 445R, 447A, 448I, 449G, 450G, 451T, 459Q
CDD
cd01359 (Argininosuccinate_lyase)

449G

tetramer interface
109N, 112G, 115H, 116T, 165Y, 166T, 167H, 168L, 169Q, 170R, 171A, 172Q, 178H, 182L, 183H, 189N, 192Q, 193R, 196Q, 200R, 211L, 212A, 213G, 214H, 215P, 217G, 220R, 234G, 235N, 236S, 237L, 238A, 241S, 242D, 244D, 248E, 251F, 255L, 258N, 259H, 261A, 262K, 265E, 266D, 271S, 272T, 275F, 283A, 289S, 290L, 291M, 292P, 294K, 295K, 296N, 298D, 301E, 302L, 304R, 305G, 306K, 307S, 308G, 309R, 311F, 312G, 313Q, 316G, 318M, 319M, 320S, 328Y, 329N, 330K, 331D, 334E, 337E, 348H, 351Q, 377A, 382D, 386R, 391F, 392R, 395H, 398S, 445R, 447A, 448I, 449G, 450G, 451T, 459Q
CDD
cd01359 (Argininosuccinate_lyase)

450G

tetramer interface
109N, 112G, 115H, 116T, 165Y, 166T, 167H, 168L, 169Q, 170R, 171A, 172Q, 178H, 182L, 183H, 189N, 192Q, 193R, 196Q, 200R, 211L, 212A, 213G, 214H, 215P, 217G, 220R, 234G, 235N, 236S, 237L, 238A, 241S, 242D, 244D, 248E, 251F, 255L, 258N, 259H, 261A, 262K, 265E, 266D, 271S, 272T, 275F, 283A, 289S, 290L, 291M, 292P, 294K, 295K, 296N, 298D, 301E, 302L, 304R, 305G, 306K, 307S, 308G, 309R, 311F, 312G, 313Q, 316G, 318M, 319M, 320S, 328Y, 329N, 330K, 331D, 334E, 337E, 348H, 351Q, 377A, 382D, 386R, 391F, 392R, 395H, 398S, 445R, 447A, 448I, 449G, 450G, 451T, 459Q
CDD
cd01359 (Argininosuccinate_lyase)

451T

tetramer interface
109N, 112G, 115H, 116T, 165Y, 166T, 167H, 168L, 169Q, 170R, 171A, 172Q, 178H, 182L, 183H, 189N, 192Q, 193R, 196Q, 200R, 211L, 212A, 213G, 214H, 215P, 217G, 220R, 234G, 235N, 236S, 237L, 238A, 241S, 242D, 244D, 248E, 251F, 255L, 258N, 259H, 261A, 262K, 265E, 266D, 271S, 272T, 275F, 283A, 289S, 290L, 291M, 292P, 294K, 295K, 296N, 298D, 301E, 302L, 304R, 305G, 306K, 307S, 308G, 309R, 311F, 312G, 313Q, 316G, 318M, 319M, 320S, 328Y, 329N, 330K, 331D, 334E, 337E, 348H, 351Q, 377A, 382D, 386R, 391F, 392R, 395H, 398S, 445R, 447A, 448I, 449G, 450G, 451T, 459Q
CDD
cd01359 (Argininosuccinate_lyase)

459Q

tetramer interface
109N, 112G, 115H, 116T, 165Y, 166T, 167H, 168L, 169Q, 170R, 171A, 172Q, 178H, 182L, 183H, 189N, 192Q, 193R, 196Q, 200R, 211L, 212A, 213G, 214H, 215P, 217G, 220R, 234G, 235N, 236S, 237L, 238A, 241S, 242D, 244D, 248E, 251F, 255L, 258N, 259H, 261A, 262K, 265E, 266D, 271S, 272T, 275F, 283A, 289S, 290L, 291M, 292P, 294K, 295K, 296N, 298D, 301E, 302L, 304R, 305G, 306K, 307S, 308G, 309R, 311F, 312G, 313Q, 316G, 318M, 319M, 320S, 328Y, 329N, 330K, 331D, 334E, 337E, 348H, 351Q, 377A, 382D, 386R, 391F, 392R, 395H, 398S, 445R, 447A, 448I, 449G, 450G, 451T, 459Q
CDD
cd01359 (Argininosuccinate_lyase)

Protein sequence

>MCA_05797_1
MSSNSTDAPSELKLWGGRFTGATDPLMELYNASLPYDKKMYAADLEGTRVYTAALAKLGLLTEDELSEIHRGLKVIAEEW
KENKFVEKPGDEDIHTANERRLGEIIGRNIAGKVHTGRSRNDQVATDMRLYVRDELNKIKIQLKALIEVMVKRARSEIDV
LMPGYTHLQRAQPIRWAHWLSLHATFLANDLQRLEQVIERVNVSPLGAGALAGHPFGIDREYIAKELGFEGIIGNSLAAV
SDRDFVVETMFWGSLVLNHLAKLSEDLIIYSTAEFGFVKLSDAYSTGSSLMPQKKNPDSLELLRGKSGRTFGQLAGFMMS
MKATPSTYNKDLQEDKEPLFDNLVTTSHSIQIATGVLSTMKIIPEKMKAALTMDMLATDLADYLVRKGVPFRETHHISGE
AVHMAESNNLSGIDQLTLEQYKSIDSRFEADVTKIFDFEASVERRTAIGGTAKSAVLAQLEALEKIIA

GO term prediction

Biological Process

GO:0042450 arginine biosynthetic process via ornithine

Molecular Function

GO:0003824 catalytic activity
GO:0004056 argininosuccinate lyase activity

Cellular Component

None predicted.

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Entry type

Status

Per-residue features