Protein

MIA_05041_1

Length
318 amino acids

Browser: contig07:532679-533927+

Protein function

EGGNOG:0PHTAFG00417.1methylenetetrahydrofolate dehydrogenase
SGD closest match:S000001788MTD1Methylenetetrahydrofolate dehydrogenase [NAD(+)]
CGD closest match:CAL0000186217orf19.3810Methylenetetrahydrofolate dehydrogenase (NAD(+))

Protein alignments

%idAln lengthE-value
MCA_05831_190.260%3080.0MCA_05831_1
A0A0J9X462_GEOCN84.539%3040.0Similar to Saccharomyces cerevisiae YKR080W MTD1 NAD-dependent 5,10-methylenetetrahydrafolate dehydrogenase OS=Geotrichum candidum GN=BN980_GECA02s02771g PE=4 SV=1
A0A167DWY9_9ASCO76.159%3021.33e-177Methylenetetrahydrofolate dehydrogenase (NAD(+)) OS=Sugiyamaella lignohabitans GN=MTD1 PE=4 SV=1
UniRef50_A0A167DWY976.159%3023.65e-174Methylenetetrahydrofolate dehydrogenase (NAD(+)) n=24 Tax=Fungi TaxID=4751 RepID=A0A167DWY9_9ASCO
A0A060T148_BLAAD75.000%3043.59e-176ARAD1C17600p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C17600g PE=4 SV=1
A0A1E4TGX6_9ASCO74.751%3012.44e-173Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_31765 PE=4 SV=1
A0A1E3PH63_9ASCO71.947%3034.94e-172NAD(P)-binding protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_52612 PE=4 SV=1
Q6CEX7_YARLI73.973%2926.30e-165YALI0B12078p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_B12078g PE=4 SV=1
MTD1_YEAST64.194%3101.57e-143Methylenetetrahydrofolate dehydrogenase [NAD(+)] OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MTD1 PE=1 SV=1
A0A1D8PM44_CANAL66.450%3072.52e-138Methylenetetrahydrofolate dehydrogenase (NAD(+)) OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.3810 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.3837

Protein family membership

Domains and repeats

  1. Domain
1 50 100 150 200 250 318

Detailed signature matches

  1. Family IPR000672
    Tetrahydrofolate dehydrogenase/cyclohydrolase
    1. PR00085 (THFDHDRGNASE)
  2. Domain IPR020630
    Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
    1. PF00763 (THF_DHG_CYH)
  3. Domain IPR016040
    NAD(P)-binding domain
    1. SSF51735 (NAD(P)-bi...)
  4. Domain IPR020631
    Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
    1. PF02882 (THF_DHG_CYH_C)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.40.50...
  2. G3DSA:3.40.50...
  3. SSF53223 (Aminoacid...)
  4. cd01079 (NAD_bind_m...)

Residue annotation

  1. NAD binding site c...
  2. putative homodimer...

Protein sequence

>MIA_05041_1
MSAAPAPPAAFPCKTVLASTIAKPFVQEVKDGVAALGRSPKLVGFLANADPAAQMYADWTAKTATDLGFTYELRKVDKDD
LEESIIAANEDDNVDGIMVYFPVFGGGQDQYLQQVVSPEKDVEGLSHIYIQNMYHNTRFLDKAETQKSILPCTPLAMVKI
LEYLGVYNTLIPYGNRLYGKTVTIVNRSEIVGRPLAALLANDGATVYSVDITGTQKFTRGQGLKFKRHQVADVEIPLSDA
VSHSDVVITGVPSPSYKFPVEYLKDGAVCINFSSEKNFDPNVKEHASLYVPSIGKVTISMLLRNLLRLIENKKQRENK

GO term prediction

Biological Process

GO:0055114 oxidation-reduction process

Molecular Function

GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity

Cellular Component

None predicted.