Protein
MCA_05831_1
Length
314 amino acids
Gene name: MTD1
Description: Methylenetetrahydrofolate dehydrogenase [NAD(+)]
Browser: contigD:2449968-2450987-
RNA-seq: read pairs 1467, FPKM 57.5, percentile rank 68.4% (100% = highest expression)
Protein function
Annotation: | MTD1 | Methylenetetrahydrofolate dehydrogenase [NAD(+)] | |
---|---|---|---|
KEGG: | K00295 | MTD1 | methylenetetrahydrofolate dehydrogenase (NAD+) [EC:1.5.1.15] |
EGGNOG: | 0PHTA | FG00417.1 | methylenetetrahydrofolate dehydrogenase |
SGD closest match: | S000001788 | MTD1 | Methylenetetrahydrofolate dehydrogenase [NAD(+)] |
CGD closest match: | CAL0000186217 | orf19.3810 | Methylenetetrahydrofolate dehydrogenase (NAD(+)) |
Protein alignments
%id | Aln length | E-value | ||
---|---|---|---|---|
MIA_05041_1 | 90.26% | 308 | 0.0 | MIA_05041_1 |
A0A0J9X462_GEOCN | 81.09% | 312 | 0.0 | Similar to Saccharomyces cerevisiae YKR080W MTD1 NAD-dependent 5,10-methylenetetrahydrafolate dehydrogenase OS=Geotrichum candidum GN=BN980_GECA02s02771g PE=4 SV=1 |
A0A060T148_BLAAD | 74.92% | 303 | 1e-173 | ARAD1C17600p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C17600g PE=4 SV=1 |
A0A167DWY9_9ASCO | 74.36% | 312 | 1e-173 | Methylenetetrahydrofolate dehydrogenase (NAD(+)) OS=Sugiyamaella lignohabitans GN=MTD1 PE=4 SV=1 |
UniRef50_A0A167DWY9 | 74.36% | 312 | 4e-170 | Methylenetetrahydrofolate dehydrogenase (NAD(+)) n=24 Tax=Fungi TaxID=4751 RepID=A0A167DWY9_9ASCO |
A0A1E3PR53_9ASCO | 74.24% | 295 | 7e-170 | Tetrahydrofolate dehydrogenase/cyclohydrolase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_45527 PE=4 SV=1 |
A0A1E4TGX6_9ASCO | 73.09% | 301 | 2e-168 | Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_31765 PE=4 SV=1 |
Q6CEX7_YARLI | 74.40% | 293 | 5e-166 | YALI0B12078p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_B12078g PE=4 SV=1 |
MTD1_YEAST | 64.52% | 310 | 8e-143 | Methylenetetrahydrofolate dehydrogenase [NAD(+)] OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MTD1 PE=1 SV=1 |
A0A1D8PM44_CANAL | 62.97% | 316 | 2e-132 | Methylenetetrahydrofolate dehydrogenase (NAD(+)) OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.3810 PE=4 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.4284
Protein family membership
- Tetrahydrofolate dehydrogenase/cyclohydrolase (IPR000672)
Domains and repeats
-
Domain
1
50
100
150
200
250
314
Detailed signature matches
no IPR
Unintegrated signatures
Residue annotation
-
NAD binding site c...
-
putative homodimer...
Protein sequence
>MCA_05831_1 MSAPNAFPCKTVLASTIAKPFVQEVKDGVAALGRSPKLVGFLANSDPAAQMYADWTAKTATELGFTYELRKVDKDDLEEE IIAANNDDDVDGIMVYFPVFGGGQDLYIQQVLSSEKDVEGLSHIFIQNMYHNIRFLDKAETQKSILPCTPLAIVKILEFL GVYNTLIPYGNRLYGKTITVVNRSEIVGRPLAALLANDGATVYSVDVTGIQKFTRGQGLKFKKHQVDDISISLQEAISHS DVVITGVPSKEYKFPVEYLKDGAVCINFSSEKNFDPSVKEHASLYVPSIGKVTISMLLRNLLRLIENKKQRQMK
GO term prediction
Biological Process
GO:0055114 oxidation-reduction process
Molecular Function
GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity
Cellular Component
None predicted.