Protein

MCA_05831_1

Length
314 amino acids

Gene name: MTD1

Description: Methylenetetrahydrofolate dehydrogenase [NAD(+)]

Browser: contigD:2449968-2450987-

RNA-seq: read pairs 1467, FPKM 57.5, percentile rank 68.4% (100% = highest expression)

Protein function

Annotation:MTD1Methylenetetrahydrofolate dehydrogenase [NAD(+)]
KEGG:K00295MTD1 methylenetetrahydrofolate dehydrogenase (NAD+) [EC:1.5.1.15]
EGGNOG:0PHTAFG00417.1methylenetetrahydrofolate dehydrogenase
SGD closest match:S000001788MTD1Methylenetetrahydrofolate dehydrogenase [NAD(+)]
CGD closest match:CAL0000186217orf19.3810Methylenetetrahydrofolate dehydrogenase (NAD(+))

Protein alignments

%idAln lengthE-value
MIA_05041_190.26%3080.0MIA_05041_1
A0A0J9X462_GEOCN81.09%3120.0Similar to Saccharomyces cerevisiae YKR080W MTD1 NAD-dependent 5,10-methylenetetrahydrafolate dehydrogenase OS=Geotrichum candidum GN=BN980_GECA02s02771g PE=4 SV=1
A0A060T148_BLAAD74.92%3031e-173ARAD1C17600p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C17600g PE=4 SV=1
A0A167DWY9_9ASCO74.36%3121e-173Methylenetetrahydrofolate dehydrogenase (NAD(+)) OS=Sugiyamaella lignohabitans GN=MTD1 PE=4 SV=1
UniRef50_A0A167DWY974.36%3124e-170Methylenetetrahydrofolate dehydrogenase (NAD(+)) n=24 Tax=Fungi TaxID=4751 RepID=A0A167DWY9_9ASCO
A0A1E3PR53_9ASCO74.24%2957e-170Tetrahydrofolate dehydrogenase/cyclohydrolase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_45527 PE=4 SV=1
A0A1E4TGX6_9ASCO73.09%3012e-168Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_31765 PE=4 SV=1
Q6CEX7_YARLI74.40%2935e-166YALI0B12078p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_B12078g PE=4 SV=1
MTD1_YEAST64.52%3108e-143Methylenetetrahydrofolate dehydrogenase [NAD(+)] OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MTD1 PE=1 SV=1
A0A1D8PM44_CANAL62.97%3162e-132Methylenetetrahydrofolate dehydrogenase (NAD(+)) OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.3810 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.4284

Protein family membership

Domains and repeats

  1. Domain
1 50 100 150 200 250 314

Detailed signature matches

  1. Family IPR000672
    Tetrahydrofolate dehydrogenase/cyclohydrolase
    1. PR00085 (THFDHDRGNASE)
  2. Domain IPR020630
    Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
    1. PF00763 (THF_DHG_CYH)
  3. Domain IPR016040
    NAD(P)-binding domain
    1. SSF51735 (NAD(P)-bi...)
  4. Domain IPR020631
    Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
    1. PF02882 (THF_DHG_CYH_C)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.40.50...
  2. G3DSA:3.40.50...
  3. SSF53223 (Aminoacid...)
  4. cd01079 (NAD_bind_m...)

Residue annotation

  1. NAD binding site c...
  2. putative homodimer...

Protein sequence

>MCA_05831_1
MSAPNAFPCKTVLASTIAKPFVQEVKDGVAALGRSPKLVGFLANSDPAAQMYADWTAKTATELGFTYELRKVDKDDLEEE
IIAANNDDDVDGIMVYFPVFGGGQDLYIQQVLSSEKDVEGLSHIFIQNMYHNIRFLDKAETQKSILPCTPLAIVKILEFL
GVYNTLIPYGNRLYGKTITVVNRSEIVGRPLAALLANDGATVYSVDVTGIQKFTRGQGLKFKKHQVDDISISLQEAISHS
DVVITGVPSKEYKFPVEYLKDGAVCINFSSEKNFDPSVKEHASLYVPSIGKVTISMLLRNLLRLIENKKQRQMK

GO term prediction

Biological Process

GO:0055114 oxidation-reduction process

Molecular Function

GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity

Cellular Component

None predicted.