Protein
MIA_05020_1
Length
541 amino acids
Browser: contig07:477615-479391+
Protein function
| EGGNOG: | 0PFEI | NPL4 | Involved in the import of nuclear-targeted proteins into the nucleus and the export of poly(A) RNA out of the nucleus. Has a role in the endoplasmic reticulum-associated degradation (ERAD) pathway (By similarity) |
|---|---|---|---|
| SGD closest match: | S000000374 | NPL4 | Nuclear protein localization protein 4 |
| CGD closest match: | CAL0000200595 | NPL4 | Nuclear protein localization protein 4 |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| MCA_04583_1 | 69.981% | 533 | 0.0 | MCA_04583_1 |
| A0A0J9X863_GEOCN | 62.894% | 539 | 0.0 | Similar to Saccharomyces cerevisiae YBR170C NPL4 Ubiquitin-binding protein involved in protein degradation OS=Geotrichum candidum GN=BN980_GECA05s01583g PE=4 SV=1 |
| A0A060T581_BLAAD | 62.692% | 520 | 0.0 | ARAD1B08514p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B08514g PE=4 SV=1 |
| A0A1E3PHA8_9ASCO | 59.057% | 530 | 0.0 | Nuclear protein localization protein 4 OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_43087 PE=4 SV=1 |
| UniRef50_A0A0E9NPT4 | 54.562% | 537 | 0.0 | Uncharacterized protein n=1 Tax=Saitoella complicata NRRL Y-17804 TaxID=698492 RepID=A0A0E9NPT4_9ASCO |
| A0A167ECU0_9ASCO | 58.182% | 495 | 0.0 | Npl4p OS=Sugiyamaella lignohabitans GN=NPL4 PE=4 SV=1 |
| NPL4_YEAST | 51.504% | 532 | 0.0 | Nuclear protein localization protein 4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NPL4 PE=1 SV=1 |
| NPL4_YARLI | 50.752% | 532 | 0.0 | Nuclear protein localization protein 4 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=NPL4 PE=3 SV=2 |
| A0A1E4TD35_9ASCO | 48.423% | 539 | 0.0 | Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_142508 PE=4 SV=1 |
| NPL4_CANAL | 43.478% | 552 | 3.57e-147 | Nuclear protein localization protein 4 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=NPL4 PE=3 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.1911
Protein family membership
- Nuclear protein localization protein 4 (IPR016563)
Domains and repeats
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Domain
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Domain
1
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541
Detailed signature matches
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PIRSF010052 (Polyub...)
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-
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PF05020 (zf-NPL4)
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Protein sequence
>MIA_05020_1 MTFQLSCLRFLFSDSHSFKGHPVDNYIGQTIASLGLKHGDLLFVTIGDPVEAKSQEATSNSKSASAHQIFDNTKQPAIDD ALDKLPGKIPRKRDPRMCRHGEKAMCDYCMPLEPFDTNYQEEHNIKHLSFHSYLRKLNIQPTTNDSTTNTGSFVPPLTEP DYSVKKQCPTGHPPWPAGICSKCQPSAITLQRQEFRMVDHVEFSTSSIVNSFIDSWRQTGKQRIGYLYGHYEQYDAVPLG IKAVVEAIYEPPQQDERDGVKLSFPWEDEETRVEKIAGYCGLERVGVIFTDLLDGGEGNESVVCKRHIDSYFLSSLEICF AAQLQINHPNPSKWSTDGKYSSKFVTCVISGNSNKEIDIASYQVSASAEAMIKADLIEPSINPSVMRVREPTNERYVPDV FYTKLNEYKRTIQENAKPAFPVEYLLVTLTHGFPKNEKPCFTGGVEGFPIENREYLSVSQDLKALAKRLGIRRGSSGPLN ITLDTLSDFHLLCYINSLGVISEDEQKLLCKYAVEHKDESAVALRGSPGWETLKMIIVESI
GO term prediction
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
Molecular Function
None predicted.
Cellular Component
None predicted.