Protein

MCA_04583_1

Length
569 amino acids

Gene name: NPL4

Description: Nuclear protein localization protein 4

Browser: contigC:3434308-3436379+

RNA-seq: read pairs 2629, FPKM 57.0, percentile rank 68.2% (100% = highest expression)

Protein function

Annotation:NPL4Nuclear protein localization protein 4
KEGG:K14015NPLOC4 nuclear protein localization protein 4 homolog
EGGNOG:0PFEINPL4Involved in the import of nuclear-targeted proteins into the nucleus and the export of poly(A) RNA out of the nucleus. Has a role in the endoplasmic reticulum-associated degradation (ERAD) pathway (By similarity)
SGD closest match:S000000374NPL4Nuclear protein localization protein 4
CGD closest match:CAL0000200595NPL4Nuclear protein localization protein 4

Protein alignments

%idAln lengthE-value
MIA_05020_169.98%5330.0MIA_05020_1
A0A0J9X863_GEOCN65.67%5710.0Similar to Saccharomyces cerevisiae YBR170C NPL4 Ubiquitin-binding protein involved in protein degradation OS=Geotrichum candidum GN=BN980_GECA05s01583g PE=4 SV=1
A0A060T581_BLAAD62.57%5690.0ARAD1B08514p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B08514g PE=4 SV=1
A0A1E3PHA8_9ASCO57.75%5680.0Nuclear protein localization protein 4 OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_43087 PE=4 SV=1
A0A167ECU0_9ASCO58.91%4940.0Npl4p OS=Sugiyamaella lignohabitans GN=NPL4 PE=4 SV=1
UniRef50_A0A167ECU058.91%4940.0Npl4p n=1 Tax=Sugiyamaella lignohabitans TaxID=796027 RepID=A0A167ECU0_9ASCO
A0A1E4TD35_9ASCO49.73%5650.0Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_142508 PE=4 SV=1
NPL4_YARLI50.09%5710.0Nuclear protein localization protein 4 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=NPL4 PE=3 SV=2
NPL4_YEAST49.91%5750.0Nuclear protein localization protein 4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NPL4 PE=1 SV=1
NPL4_CANAL43.95%6039e-155Nuclear protein localization protein 4 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=NPL4 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0448

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 100 200 300 400 500 569

Detailed signature matches

  1. Family IPR016563
    Nuclear protein localization protein 4
    1. PIRSF010052 (Polyub...)
  2. Domain IPR007716
    NPL4, zinc-binding putative
    1. PF05020 (zf-NPL4)
  3. Domain IPR007717
    Nuclear pore localisation protein NPL4, C-terminal
    1. PF05021 (NPL4)
    2. cd08061 (MPN_NPL4)
Unintegrated signatures no IPR
Unintegrated signatures
  1. Coil

Protein sequence

>MCA_04583_1
MSYNLTPEGTFRVTVQPTDDFSVALDQLSKNLPGYSSNSFLFSDNPTFEGHPVSKFVGHSISELELKHGDLLFVKLGDKF
NTESENSEKPLASASAKEVFEKVKQLELDDILDKKDGKIHRPRDPKMCRHGEKAMCEFCMPLEPFDTTYQEEHKIKHLSF
HAYLAKLNTQSNSSNKSTGASYVAPLTEPDYSVMKNCPSGHPSWPAGICSKCQPSAITLQRQEFRMVDHVEFSSSGIVNT
FIDAWRQSGNQRIGYLYGHYEEYDSVPLGIKAVVEAIYEPPQQDERDGVILTLPWEEEVRIDKVASFCGLQKVGVIFTDL
LDAGTGDSSVVCKRHIDSYFLSSLEICFAAEMQRRNPNPSRWSMSGQYSSKFVTCVISGNVNNEIDIASYQVSLSAEAMI
KADLIEPSVNPSYMRVKEPSETRYVPDVFYTKINEYKRKVQENAKPAFPVEYLLVTLTHGFPESSYPMFLSDNENFTIEN
RSYLGQSQDLEALSRQLGISRNNSNDMDIPAEKISNFHMLCYIASMEILSENEIKLLCKYAVSPSPEVASELKASPGWAT
LKTIIRESI

GO term prediction

Biological Process

GO:0006511 ubiquitin-dependent protein catabolic process

Molecular Function

None predicted.

Cellular Component

None predicted.