MIA_05010_1

Protein

Length

1,656 amino acids

Protein function

EGGNOG:	0PFHB	PGUG_03305	serine threonine protein kinase
SGD closest match:	S000001584	HSL1	Probable serine/threonine-protein kinase HSL1
CGD closest match:	CAL0000190859	HSL1	Serine/threonine-protein kinase HSL1

Protein alignments

	%id	Aln length	E-value
MCA_03485_1	57.828%	709	0.0	MCA_03485_1
A0A060T7U6_BLAAD	77.031%	357	2.78e-176	ARAD1B22880p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B22880g PE=4 SV=1
UniRef50_A0A060T7U6	77.031%	357	6.86e-173	ARAD1B22880p n=1 Tax=Blastobotrys adeninivorans TaxID=409370 RepID=A0A060T7U6_BLAAD
A0A167E8L5_9ASCO	70.757%	383	8.61e-172	Protein kinase HSL1 OS=Sugiyamaella lignohabitans GN=HSL1 PE=4 SV=1
A0A0J9XI83_GEOCN	74.238%	361	7.14e-170	Similar to Saccharomyces cerevisiae YKL101W HSL1 Nim1p-related protein kinase that regulates the morphogenesis and septin checkpoints OS=Geotrichum candidum GN=BN980_GECA18s01704g PE=4 SV=1
W0TYM1_YARLI	75.706%	354	4.37e-160	YALI0E06519p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E06519g PE=4 SV=1
HSL1_CANAL	68.245%	359	1.39e-147	Serine/threonine-protein kinase HSL1 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=HSL1 PE=1 SV=2
A0A1E3PJ26_9ASCO	81.752%	274	1.51e-144	Pkinase-domain-containing protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_70857 PE=3 SV=1
HSL1_YEAST	58.290%	386	4.16e-129	Probable serine/threonine-protein kinase HSL1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HSL1 PE=1 SV=2
A0A1E4TGC4_9ASCO	76.779%	267	1.27e-126	Uncharacterized protein (Fragment) OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_24884 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0135

Protein family membership

None predicted.

Domains and repeats

Domain
79 - 349
Protein kinase-like domain (IPR011009)
Protein kinase domain (IPR000719)
431 - 489
Protein kinase-like domain (IPR011009)
1,257 - 1,410
Fungal kinase associated-1 domain (IPR031850)

1 200 400 600 800 1000 1200 1400 1656

Detailed signature matches

IPR011009

Protein kinase-like domain
1. SSF56112 (Protein k...)
  
  431 - 489
  
  SUPERFAMILY
  SSF56112 (Protein kinase-like (PK-like))
  
  79 - 349
  
  SUPERFAMILY
  SSF56112 (Protein kinase-like (PK-like))
IPR000719

Protein kinase domain
1. PS50011 (PROTEIN_KI...)
  
  82 - 348
  
  PROSITE profiles
  PS50011 (PROTEIN_KINASE_DOM)
2. PF00069 (Pkinase)
  
  84 - 347
  
  Pfam
  PF00069 (Pkinase)
3. SM00220 (serkin_6)
  
  82 - 348
  
  SMART
  SM00220 (serkin_6)
IPR031850

Fungal kinase associated-1 domain
1. PF16797 (Fungal_KA1)
  
  1,257 - 1,410
  
  Pfam
  PF16797 (Fungal_KA1)
IPR017441

Protein kinase, ATP binding site
1. PS00107 (PROTEIN_KI...)
  
  88 - 111
  
  PROSITE patterns
  PS00107 (PROTEIN_KINASE_ATP)
IPR008271

Serine/threonine-protein kinase, active site
1. PS00108 (PROTEIN_KI...)
  
  215 - 227
  
  PROSITE patterns
  PS00108 (PROTEIN_KINASE_ST)

no IPR

Unintegrated signatures

G3DSA:1.10.51...

191 - 614

GENE3D
G3DSA:1.10.510.10 (G3DSA:1.10.510.10)
G3DSA:3.30.20...

54 - 190

GENE3D
G3DSA:3.30.200.20 (G3DSA:3.30.200.20)
cd14081 (STKc_BRSK1_2)

80 - 348

CDD
cd14081 (STKc_BRSK1_2)
mobidb-lite (disord...)

622 - 644

MobiDB Lite
mobidb-lite (disorder_prediction)

1,422 - 1,441

MobiDB Lite
mobidb-lite (disorder_prediction)

969 - 1,048

MobiDB Lite
mobidb-lite (disorder_prediction)

881 - 911

MobiDB Lite
mobidb-lite (disorder_prediction)

1,533 - 1,600

MobiDB Lite
mobidb-lite (disorder_prediction)

1,269 - 1,313

MobiDB Lite
mobidb-lite (disorder_prediction)

1,633 - 1,656

MobiDB Lite
mobidb-lite (disorder_prediction)

1,452 - 1,481

MobiDB Lite
mobidb-lite (disorder_prediction)

433 - 545

MobiDB Lite
mobidb-lite (disorder_prediction)

1 - 96

MobiDB Lite
mobidb-lite (disorder_prediction)

770 - 834

MobiDB Lite
mobidb-lite (disorder_prediction)

1,093 - 1,219

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

ATP binding site c...

88L

ATP binding site
88L, 89G, 90R, 91G, 96V, 109A, 111K, 157M, 173L, 174E, 175Y, 176I, 180E, 223E, 224N, 226L, 236A, 237D
CDD
cd14081 (STKc_BRSK1_2)

89G

ATP binding site
88L, 89G, 90R, 91G, 96V, 109A, 111K, 157M, 173L, 174E, 175Y, 176I, 180E, 223E, 224N, 226L, 236A, 237D
CDD
cd14081 (STKc_BRSK1_2)

90R

ATP binding site
88L, 89G, 90R, 91G, 96V, 109A, 111K, 157M, 173L, 174E, 175Y, 176I, 180E, 223E, 224N, 226L, 236A, 237D
CDD
cd14081 (STKc_BRSK1_2)

91G

ATP binding site
88L, 89G, 90R, 91G, 96V, 109A, 111K, 157M, 173L, 174E, 175Y, 176I, 180E, 223E, 224N, 226L, 236A, 237D
CDD
cd14081 (STKc_BRSK1_2)

96V

ATP binding site
88L, 89G, 90R, 91G, 96V, 109A, 111K, 157M, 173L, 174E, 175Y, 176I, 180E, 223E, 224N, 226L, 236A, 237D
CDD
cd14081 (STKc_BRSK1_2)

109A

ATP binding site
88L, 89G, 90R, 91G, 96V, 109A, 111K, 157M, 173L, 174E, 175Y, 176I, 180E, 223E, 224N, 226L, 236A, 237D
CDD
cd14081 (STKc_BRSK1_2)

111K

ATP binding site
88L, 89G, 90R, 91G, 96V, 109A, 111K, 157M, 173L, 174E, 175Y, 176I, 180E, 223E, 224N, 226L, 236A, 237D
CDD
cd14081 (STKc_BRSK1_2)

157M

ATP binding site
88L, 89G, 90R, 91G, 96V, 109A, 111K, 157M, 173L, 174E, 175Y, 176I, 180E, 223E, 224N, 226L, 236A, 237D
CDD
cd14081 (STKc_BRSK1_2)

173L

ATP binding site
88L, 89G, 90R, 91G, 96V, 109A, 111K, 157M, 173L, 174E, 175Y, 176I, 180E, 223E, 224N, 226L, 236A, 237D
CDD
cd14081 (STKc_BRSK1_2)

174E

ATP binding site
88L, 89G, 90R, 91G, 96V, 109A, 111K, 157M, 173L, 174E, 175Y, 176I, 180E, 223E, 224N, 226L, 236A, 237D
CDD
cd14081 (STKc_BRSK1_2)

175Y

ATP binding site
88L, 89G, 90R, 91G, 96V, 109A, 111K, 157M, 173L, 174E, 175Y, 176I, 180E, 223E, 224N, 226L, 236A, 237D
CDD
cd14081 (STKc_BRSK1_2)

176I

ATP binding site
88L, 89G, 90R, 91G, 96V, 109A, 111K, 157M, 173L, 174E, 175Y, 176I, 180E, 223E, 224N, 226L, 236A, 237D
CDD
cd14081 (STKc_BRSK1_2)

180E

ATP binding site
88L, 89G, 90R, 91G, 96V, 109A, 111K, 157M, 173L, 174E, 175Y, 176I, 180E, 223E, 224N, 226L, 236A, 237D
CDD
cd14081 (STKc_BRSK1_2)

223E

ATP binding site
88L, 89G, 90R, 91G, 96V, 109A, 111K, 157M, 173L, 174E, 175Y, 176I, 180E, 223E, 224N, 226L, 236A, 237D
CDD
cd14081 (STKc_BRSK1_2)

224N

ATP binding site
88L, 89G, 90R, 91G, 96V, 109A, 111K, 157M, 173L, 174E, 175Y, 176I, 180E, 223E, 224N, 226L, 236A, 237D
CDD
cd14081 (STKc_BRSK1_2)

226L

ATP binding site
88L, 89G, 90R, 91G, 96V, 109A, 111K, 157M, 173L, 174E, 175Y, 176I, 180E, 223E, 224N, 226L, 236A, 237D
CDD
cd14081 (STKc_BRSK1_2)

236A

ATP binding site
88L, 89G, 90R, 91G, 96V, 109A, 111K, 157M, 173L, 174E, 175Y, 176I, 180E, 223E, 224N, 226L, 236A, 237D
CDD
cd14081 (STKc_BRSK1_2)

237D

ATP binding site
88L, 89G, 90R, 91G, 96V, 109A, 111K, 157M, 173L, 174E, 175Y, 176I, 180E, 223E, 224N, 226L, 236A, 237D
CDD
cd14081 (STKc_BRSK1_2)
active site cd14081

88L

active site
88L, 89G, 90R, 91G, 92S, 96V, 109A, 111K, 157M, 173L, 174E, 175Y, 176I, 180E, 182F, 183D, 185L, 218R, 219D, 221K, 223E, 224N, 226L, 236A, 237D, 240M, 254C, 255G, 256S, 257P, 258H, 260A, 290G, 291H, 292L, 293P
CDD
cd14081 (STKc_BRSK1_2)

89G

active site
88L, 89G, 90R, 91G, 92S, 96V, 109A, 111K, 157M, 173L, 174E, 175Y, 176I, 180E, 182F, 183D, 185L, 218R, 219D, 221K, 223E, 224N, 226L, 236A, 237D, 240M, 254C, 255G, 256S, 257P, 258H, 260A, 290G, 291H, 292L, 293P
CDD
cd14081 (STKc_BRSK1_2)

90R

active site
88L, 89G, 90R, 91G, 92S, 96V, 109A, 111K, 157M, 173L, 174E, 175Y, 176I, 180E, 182F, 183D, 185L, 218R, 219D, 221K, 223E, 224N, 226L, 236A, 237D, 240M, 254C, 255G, 256S, 257P, 258H, 260A, 290G, 291H, 292L, 293P
CDD
cd14081 (STKc_BRSK1_2)

91G

active site
88L, 89G, 90R, 91G, 92S, 96V, 109A, 111K, 157M, 173L, 174E, 175Y, 176I, 180E, 182F, 183D, 185L, 218R, 219D, 221K, 223E, 224N, 226L, 236A, 237D, 240M, 254C, 255G, 256S, 257P, 258H, 260A, 290G, 291H, 292L, 293P
CDD
cd14081 (STKc_BRSK1_2)

92S

active site
88L, 89G, 90R, 91G, 92S, 96V, 109A, 111K, 157M, 173L, 174E, 175Y, 176I, 180E, 182F, 183D, 185L, 218R, 219D, 221K, 223E, 224N, 226L, 236A, 237D, 240M, 254C, 255G, 256S, 257P, 258H, 260A, 290G, 291H, 292L, 293P
CDD
cd14081 (STKc_BRSK1_2)

96V

active site
88L, 89G, 90R, 91G, 92S, 96V, 109A, 111K, 157M, 173L, 174E, 175Y, 176I, 180E, 182F, 183D, 185L, 218R, 219D, 221K, 223E, 224N, 226L, 236A, 237D, 240M, 254C, 255G, 256S, 257P, 258H, 260A, 290G, 291H, 292L, 293P
CDD
cd14081 (STKc_BRSK1_2)

109A

active site
88L, 89G, 90R, 91G, 92S, 96V, 109A, 111K, 157M, 173L, 174E, 175Y, 176I, 180E, 182F, 183D, 185L, 218R, 219D, 221K, 223E, 224N, 226L, 236A, 237D, 240M, 254C, 255G, 256S, 257P, 258H, 260A, 290G, 291H, 292L, 293P
CDD
cd14081 (STKc_BRSK1_2)

111K

active site
88L, 89G, 90R, 91G, 92S, 96V, 109A, 111K, 157M, 173L, 174E, 175Y, 176I, 180E, 182F, 183D, 185L, 218R, 219D, 221K, 223E, 224N, 226L, 236A, 237D, 240M, 254C, 255G, 256S, 257P, 258H, 260A, 290G, 291H, 292L, 293P
CDD
cd14081 (STKc_BRSK1_2)

157M

active site
88L, 89G, 90R, 91G, 92S, 96V, 109A, 111K, 157M, 173L, 174E, 175Y, 176I, 180E, 182F, 183D, 185L, 218R, 219D, 221K, 223E, 224N, 226L, 236A, 237D, 240M, 254C, 255G, 256S, 257P, 258H, 260A, 290G, 291H, 292L, 293P
CDD
cd14081 (STKc_BRSK1_2)

173L

active site
88L, 89G, 90R, 91G, 92S, 96V, 109A, 111K, 157M, 173L, 174E, 175Y, 176I, 180E, 182F, 183D, 185L, 218R, 219D, 221K, 223E, 224N, 226L, 236A, 237D, 240M, 254C, 255G, 256S, 257P, 258H, 260A, 290G, 291H, 292L, 293P
CDD
cd14081 (STKc_BRSK1_2)

174E

active site
88L, 89G, 90R, 91G, 92S, 96V, 109A, 111K, 157M, 173L, 174E, 175Y, 176I, 180E, 182F, 183D, 185L, 218R, 219D, 221K, 223E, 224N, 226L, 236A, 237D, 240M, 254C, 255G, 256S, 257P, 258H, 260A, 290G, 291H, 292L, 293P
CDD
cd14081 (STKc_BRSK1_2)

175Y

active site
88L, 89G, 90R, 91G, 92S, 96V, 109A, 111K, 157M, 173L, 174E, 175Y, 176I, 180E, 182F, 183D, 185L, 218R, 219D, 221K, 223E, 224N, 226L, 236A, 237D, 240M, 254C, 255G, 256S, 257P, 258H, 260A, 290G, 291H, 292L, 293P
CDD
cd14081 (STKc_BRSK1_2)

176I

active site
88L, 89G, 90R, 91G, 92S, 96V, 109A, 111K, 157M, 173L, 174E, 175Y, 176I, 180E, 182F, 183D, 185L, 218R, 219D, 221K, 223E, 224N, 226L, 236A, 237D, 240M, 254C, 255G, 256S, 257P, 258H, 260A, 290G, 291H, 292L, 293P
CDD
cd14081 (STKc_BRSK1_2)

180E

active site
88L, 89G, 90R, 91G, 92S, 96V, 109A, 111K, 157M, 173L, 174E, 175Y, 176I, 180E, 182F, 183D, 185L, 218R, 219D, 221K, 223E, 224N, 226L, 236A, 237D, 240M, 254C, 255G, 256S, 257P, 258H, 260A, 290G, 291H, 292L, 293P
CDD
cd14081 (STKc_BRSK1_2)

182F

active site
88L, 89G, 90R, 91G, 92S, 96V, 109A, 111K, 157M, 173L, 174E, 175Y, 176I, 180E, 182F, 183D, 185L, 218R, 219D, 221K, 223E, 224N, 226L, 236A, 237D, 240M, 254C, 255G, 256S, 257P, 258H, 260A, 290G, 291H, 292L, 293P
CDD
cd14081 (STKc_BRSK1_2)

183D

active site
88L, 89G, 90R, 91G, 92S, 96V, 109A, 111K, 157M, 173L, 174E, 175Y, 176I, 180E, 182F, 183D, 185L, 218R, 219D, 221K, 223E, 224N, 226L, 236A, 237D, 240M, 254C, 255G, 256S, 257P, 258H, 260A, 290G, 291H, 292L, 293P
CDD
cd14081 (STKc_BRSK1_2)

185L

active site
88L, 89G, 90R, 91G, 92S, 96V, 109A, 111K, 157M, 173L, 174E, 175Y, 176I, 180E, 182F, 183D, 185L, 218R, 219D, 221K, 223E, 224N, 226L, 236A, 237D, 240M, 254C, 255G, 256S, 257P, 258H, 260A, 290G, 291H, 292L, 293P
CDD
cd14081 (STKc_BRSK1_2)

218R

active site
88L, 89G, 90R, 91G, 92S, 96V, 109A, 111K, 157M, 173L, 174E, 175Y, 176I, 180E, 182F, 183D, 185L, 218R, 219D, 221K, 223E, 224N, 226L, 236A, 237D, 240M, 254C, 255G, 256S, 257P, 258H, 260A, 290G, 291H, 292L, 293P
CDD
cd14081 (STKc_BRSK1_2)

219D

active site
88L, 89G, 90R, 91G, 92S, 96V, 109A, 111K, 157M, 173L, 174E, 175Y, 176I, 180E, 182F, 183D, 185L, 218R, 219D, 221K, 223E, 224N, 226L, 236A, 237D, 240M, 254C, 255G, 256S, 257P, 258H, 260A, 290G, 291H, 292L, 293P
CDD
cd14081 (STKc_BRSK1_2)

221K

active site
88L, 89G, 90R, 91G, 92S, 96V, 109A, 111K, 157M, 173L, 174E, 175Y, 176I, 180E, 182F, 183D, 185L, 218R, 219D, 221K, 223E, 224N, 226L, 236A, 237D, 240M, 254C, 255G, 256S, 257P, 258H, 260A, 290G, 291H, 292L, 293P
CDD
cd14081 (STKc_BRSK1_2)

223E

active site
88L, 89G, 90R, 91G, 92S, 96V, 109A, 111K, 157M, 173L, 174E, 175Y, 176I, 180E, 182F, 183D, 185L, 218R, 219D, 221K, 223E, 224N, 226L, 236A, 237D, 240M, 254C, 255G, 256S, 257P, 258H, 260A, 290G, 291H, 292L, 293P
CDD
cd14081 (STKc_BRSK1_2)

224N

active site
88L, 89G, 90R, 91G, 92S, 96V, 109A, 111K, 157M, 173L, 174E, 175Y, 176I, 180E, 182F, 183D, 185L, 218R, 219D, 221K, 223E, 224N, 226L, 236A, 237D, 240M, 254C, 255G, 256S, 257P, 258H, 260A, 290G, 291H, 292L, 293P
CDD
cd14081 (STKc_BRSK1_2)

226L

active site
88L, 89G, 90R, 91G, 92S, 96V, 109A, 111K, 157M, 173L, 174E, 175Y, 176I, 180E, 182F, 183D, 185L, 218R, 219D, 221K, 223E, 224N, 226L, 236A, 237D, 240M, 254C, 255G, 256S, 257P, 258H, 260A, 290G, 291H, 292L, 293P
CDD
cd14081 (STKc_BRSK1_2)

236A

active site
88L, 89G, 90R, 91G, 92S, 96V, 109A, 111K, 157M, 173L, 174E, 175Y, 176I, 180E, 182F, 183D, 185L, 218R, 219D, 221K, 223E, 224N, 226L, 236A, 237D, 240M, 254C, 255G, 256S, 257P, 258H, 260A, 290G, 291H, 292L, 293P
CDD
cd14081 (STKc_BRSK1_2)

237D

active site
88L, 89G, 90R, 91G, 92S, 96V, 109A, 111K, 157M, 173L, 174E, 175Y, 176I, 180E, 182F, 183D, 185L, 218R, 219D, 221K, 223E, 224N, 226L, 236A, 237D, 240M, 254C, 255G, 256S, 257P, 258H, 260A, 290G, 291H, 292L, 293P
CDD
cd14081 (STKc_BRSK1_2)

240M

active site
88L, 89G, 90R, 91G, 92S, 96V, 109A, 111K, 157M, 173L, 174E, 175Y, 176I, 180E, 182F, 183D, 185L, 218R, 219D, 221K, 223E, 224N, 226L, 236A, 237D, 240M, 254C, 255G, 256S, 257P, 258H, 260A, 290G, 291H, 292L, 293P
CDD
cd14081 (STKc_BRSK1_2)

254C

active site
88L, 89G, 90R, 91G, 92S, 96V, 109A, 111K, 157M, 173L, 174E, 175Y, 176I, 180E, 182F, 183D, 185L, 218R, 219D, 221K, 223E, 224N, 226L, 236A, 237D, 240M, 254C, 255G, 256S, 257P, 258H, 260A, 290G, 291H, 292L, 293P
CDD
cd14081 (STKc_BRSK1_2)

255G

active site
88L, 89G, 90R, 91G, 92S, 96V, 109A, 111K, 157M, 173L, 174E, 175Y, 176I, 180E, 182F, 183D, 185L, 218R, 219D, 221K, 223E, 224N, 226L, 236A, 237D, 240M, 254C, 255G, 256S, 257P, 258H, 260A, 290G, 291H, 292L, 293P
CDD
cd14081 (STKc_BRSK1_2)

256S

active site
88L, 89G, 90R, 91G, 92S, 96V, 109A, 111K, 157M, 173L, 174E, 175Y, 176I, 180E, 182F, 183D, 185L, 218R, 219D, 221K, 223E, 224N, 226L, 236A, 237D, 240M, 254C, 255G, 256S, 257P, 258H, 260A, 290G, 291H, 292L, 293P
CDD
cd14081 (STKc_BRSK1_2)

257P

active site
88L, 89G, 90R, 91G, 92S, 96V, 109A, 111K, 157M, 173L, 174E, 175Y, 176I, 180E, 182F, 183D, 185L, 218R, 219D, 221K, 223E, 224N, 226L, 236A, 237D, 240M, 254C, 255G, 256S, 257P, 258H, 260A, 290G, 291H, 292L, 293P
CDD
cd14081 (STKc_BRSK1_2)

258H

active site
88L, 89G, 90R, 91G, 92S, 96V, 109A, 111K, 157M, 173L, 174E, 175Y, 176I, 180E, 182F, 183D, 185L, 218R, 219D, 221K, 223E, 224N, 226L, 236A, 237D, 240M, 254C, 255G, 256S, 257P, 258H, 260A, 290G, 291H, 292L, 293P
CDD
cd14081 (STKc_BRSK1_2)

260A

active site
88L, 89G, 90R, 91G, 92S, 96V, 109A, 111K, 157M, 173L, 174E, 175Y, 176I, 180E, 182F, 183D, 185L, 218R, 219D, 221K, 223E, 224N, 226L, 236A, 237D, 240M, 254C, 255G, 256S, 257P, 258H, 260A, 290G, 291H, 292L, 293P
CDD
cd14081 (STKc_BRSK1_2)

290G

active site
88L, 89G, 90R, 91G, 92S, 96V, 109A, 111K, 157M, 173L, 174E, 175Y, 176I, 180E, 182F, 183D, 185L, 218R, 219D, 221K, 223E, 224N, 226L, 236A, 237D, 240M, 254C, 255G, 256S, 257P, 258H, 260A, 290G, 291H, 292L, 293P
CDD
cd14081 (STKc_BRSK1_2)

291H

active site
88L, 89G, 90R, 91G, 92S, 96V, 109A, 111K, 157M, 173L, 174E, 175Y, 176I, 180E, 182F, 183D, 185L, 218R, 219D, 221K, 223E, 224N, 226L, 236A, 237D, 240M, 254C, 255G, 256S, 257P, 258H, 260A, 290G, 291H, 292L, 293P
CDD
cd14081 (STKc_BRSK1_2)

292L

active site
88L, 89G, 90R, 91G, 92S, 96V, 109A, 111K, 157M, 173L, 174E, 175Y, 176I, 180E, 182F, 183D, 185L, 218R, 219D, 221K, 223E, 224N, 226L, 236A, 237D, 240M, 254C, 255G, 256S, 257P, 258H, 260A, 290G, 291H, 292L, 293P
CDD
cd14081 (STKc_BRSK1_2)

293P

active site
88L, 89G, 90R, 91G, 92S, 96V, 109A, 111K, 157M, 173L, 174E, 175Y, 176I, 180E, 182F, 183D, 185L, 218R, 219D, 221K, 223E, 224N, 226L, 236A, 237D, 240M, 254C, 255G, 256S, 257P, 258H, 260A, 290G, 291H, 292L, 293P
CDD
cd14081 (STKc_BRSK1_2)
polypeptide substr...

180E

polypeptide substrate binding site
180E, 182F, 183D, 185L, 219D, 221K, 223E, 240M, 254C, 255G, 256S, 257P, 258H, 260A, 290G, 291H, 292L, 293P
CDD
cd14081 (STKc_BRSK1_2)

182F

polypeptide substrate binding site
180E, 182F, 183D, 185L, 219D, 221K, 223E, 240M, 254C, 255G, 256S, 257P, 258H, 260A, 290G, 291H, 292L, 293P
CDD
cd14081 (STKc_BRSK1_2)

183D

polypeptide substrate binding site
180E, 182F, 183D, 185L, 219D, 221K, 223E, 240M, 254C, 255G, 256S, 257P, 258H, 260A, 290G, 291H, 292L, 293P
CDD
cd14081 (STKc_BRSK1_2)

185L

polypeptide substrate binding site
180E, 182F, 183D, 185L, 219D, 221K, 223E, 240M, 254C, 255G, 256S, 257P, 258H, 260A, 290G, 291H, 292L, 293P
CDD
cd14081 (STKc_BRSK1_2)

219D

polypeptide substrate binding site
180E, 182F, 183D, 185L, 219D, 221K, 223E, 240M, 254C, 255G, 256S, 257P, 258H, 260A, 290G, 291H, 292L, 293P
CDD
cd14081 (STKc_BRSK1_2)

221K

polypeptide substrate binding site
180E, 182F, 183D, 185L, 219D, 221K, 223E, 240M, 254C, 255G, 256S, 257P, 258H, 260A, 290G, 291H, 292L, 293P
CDD
cd14081 (STKc_BRSK1_2)

223E

polypeptide substrate binding site
180E, 182F, 183D, 185L, 219D, 221K, 223E, 240M, 254C, 255G, 256S, 257P, 258H, 260A, 290G, 291H, 292L, 293P
CDD
cd14081 (STKc_BRSK1_2)

240M

polypeptide substrate binding site
180E, 182F, 183D, 185L, 219D, 221K, 223E, 240M, 254C, 255G, 256S, 257P, 258H, 260A, 290G, 291H, 292L, 293P
CDD
cd14081 (STKc_BRSK1_2)

254C

polypeptide substrate binding site
180E, 182F, 183D, 185L, 219D, 221K, 223E, 240M, 254C, 255G, 256S, 257P, 258H, 260A, 290G, 291H, 292L, 293P
CDD
cd14081 (STKc_BRSK1_2)

255G

polypeptide substrate binding site
180E, 182F, 183D, 185L, 219D, 221K, 223E, 240M, 254C, 255G, 256S, 257P, 258H, 260A, 290G, 291H, 292L, 293P
CDD
cd14081 (STKc_BRSK1_2)

256S

polypeptide substrate binding site
180E, 182F, 183D, 185L, 219D, 221K, 223E, 240M, 254C, 255G, 256S, 257P, 258H, 260A, 290G, 291H, 292L, 293P
CDD
cd14081 (STKc_BRSK1_2)

257P

polypeptide substrate binding site
180E, 182F, 183D, 185L, 219D, 221K, 223E, 240M, 254C, 255G, 256S, 257P, 258H, 260A, 290G, 291H, 292L, 293P
CDD
cd14081 (STKc_BRSK1_2)

258H

polypeptide substrate binding site
180E, 182F, 183D, 185L, 219D, 221K, 223E, 240M, 254C, 255G, 256S, 257P, 258H, 260A, 290G, 291H, 292L, 293P
CDD
cd14081 (STKc_BRSK1_2)

260A

polypeptide substrate binding site
180E, 182F, 183D, 185L, 219D, 221K, 223E, 240M, 254C, 255G, 256S, 257P, 258H, 260A, 290G, 291H, 292L, 293P
CDD
cd14081 (STKc_BRSK1_2)

290G

polypeptide substrate binding site
180E, 182F, 183D, 185L, 219D, 221K, 223E, 240M, 254C, 255G, 256S, 257P, 258H, 260A, 290G, 291H, 292L, 293P
CDD
cd14081 (STKc_BRSK1_2)

291H

polypeptide substrate binding site
180E, 182F, 183D, 185L, 219D, 221K, 223E, 240M, 254C, 255G, 256S, 257P, 258H, 260A, 290G, 291H, 292L, 293P
CDD
cd14081 (STKc_BRSK1_2)

292L

polypeptide substrate binding site
180E, 182F, 183D, 185L, 219D, 221K, 223E, 240M, 254C, 255G, 256S, 257P, 258H, 260A, 290G, 291H, 292L, 293P
CDD
cd14081 (STKc_BRSK1_2)

293P

polypeptide substrate binding site
180E, 182F, 183D, 185L, 219D, 221K, 223E, 240M, 254C, 255G, 256S, 257P, 258H, 260A, 290G, 291H, 292L, 293P
CDD
cd14081 (STKc_BRSK1_2)
activation loop (A...

236A

activation loop (A-loop)
236A, 237D, 238F, 239G, 240M, 241A, 242A, 243L, 244E, 245T, 246S, 247D, 249M, 250L, 251E, 252T, 253S, 254C, 255G, 256S, 257P, 258H
CDD
cd14081 (STKc_BRSK1_2)

237D

activation loop (A-loop)
236A, 237D, 238F, 239G, 240M, 241A, 242A, 243L, 244E, 245T, 246S, 247D, 249M, 250L, 251E, 252T, 253S, 254C, 255G, 256S, 257P, 258H
CDD
cd14081 (STKc_BRSK1_2)

238F

activation loop (A-loop)
236A, 237D, 238F, 239G, 240M, 241A, 242A, 243L, 244E, 245T, 246S, 247D, 249M, 250L, 251E, 252T, 253S, 254C, 255G, 256S, 257P, 258H
CDD
cd14081 (STKc_BRSK1_2)

239G

activation loop (A-loop)
236A, 237D, 238F, 239G, 240M, 241A, 242A, 243L, 244E, 245T, 246S, 247D, 249M, 250L, 251E, 252T, 253S, 254C, 255G, 256S, 257P, 258H
CDD
cd14081 (STKc_BRSK1_2)

240M

activation loop (A-loop)
236A, 237D, 238F, 239G, 240M, 241A, 242A, 243L, 244E, 245T, 246S, 247D, 249M, 250L, 251E, 252T, 253S, 254C, 255G, 256S, 257P, 258H
CDD
cd14081 (STKc_BRSK1_2)

241A

activation loop (A-loop)
236A, 237D, 238F, 239G, 240M, 241A, 242A, 243L, 244E, 245T, 246S, 247D, 249M, 250L, 251E, 252T, 253S, 254C, 255G, 256S, 257P, 258H
CDD
cd14081 (STKc_BRSK1_2)

242A

activation loop (A-loop)
236A, 237D, 238F, 239G, 240M, 241A, 242A, 243L, 244E, 245T, 246S, 247D, 249M, 250L, 251E, 252T, 253S, 254C, 255G, 256S, 257P, 258H
CDD
cd14081 (STKc_BRSK1_2)

243L

activation loop (A-loop)
236A, 237D, 238F, 239G, 240M, 241A, 242A, 243L, 244E, 245T, 246S, 247D, 249M, 250L, 251E, 252T, 253S, 254C, 255G, 256S, 257P, 258H
CDD
cd14081 (STKc_BRSK1_2)

244E

activation loop (A-loop)
236A, 237D, 238F, 239G, 240M, 241A, 242A, 243L, 244E, 245T, 246S, 247D, 249M, 250L, 251E, 252T, 253S, 254C, 255G, 256S, 257P, 258H
CDD
cd14081 (STKc_BRSK1_2)

245T

activation loop (A-loop)
236A, 237D, 238F, 239G, 240M, 241A, 242A, 243L, 244E, 245T, 246S, 247D, 249M, 250L, 251E, 252T, 253S, 254C, 255G, 256S, 257P, 258H
CDD
cd14081 (STKc_BRSK1_2)

246S

activation loop (A-loop)
236A, 237D, 238F, 239G, 240M, 241A, 242A, 243L, 244E, 245T, 246S, 247D, 249M, 250L, 251E, 252T, 253S, 254C, 255G, 256S, 257P, 258H
CDD
cd14081 (STKc_BRSK1_2)

247D

activation loop (A-loop)
236A, 237D, 238F, 239G, 240M, 241A, 242A, 243L, 244E, 245T, 246S, 247D, 249M, 250L, 251E, 252T, 253S, 254C, 255G, 256S, 257P, 258H
CDD
cd14081 (STKc_BRSK1_2)

249M

activation loop (A-loop)
236A, 237D, 238F, 239G, 240M, 241A, 242A, 243L, 244E, 245T, 246S, 247D, 249M, 250L, 251E, 252T, 253S, 254C, 255G, 256S, 257P, 258H
CDD
cd14081 (STKc_BRSK1_2)

250L

activation loop (A-loop)
236A, 237D, 238F, 239G, 240M, 241A, 242A, 243L, 244E, 245T, 246S, 247D, 249M, 250L, 251E, 252T, 253S, 254C, 255G, 256S, 257P, 258H
CDD
cd14081 (STKc_BRSK1_2)

251E

activation loop (A-loop)
236A, 237D, 238F, 239G, 240M, 241A, 242A, 243L, 244E, 245T, 246S, 247D, 249M, 250L, 251E, 252T, 253S, 254C, 255G, 256S, 257P, 258H
CDD
cd14081 (STKc_BRSK1_2)

252T

activation loop (A-loop)
236A, 237D, 238F, 239G, 240M, 241A, 242A, 243L, 244E, 245T, 246S, 247D, 249M, 250L, 251E, 252T, 253S, 254C, 255G, 256S, 257P, 258H
CDD
cd14081 (STKc_BRSK1_2)

253S

activation loop (A-loop)
236A, 237D, 238F, 239G, 240M, 241A, 242A, 243L, 244E, 245T, 246S, 247D, 249M, 250L, 251E, 252T, 253S, 254C, 255G, 256S, 257P, 258H
CDD
cd14081 (STKc_BRSK1_2)

254C

activation loop (A-loop)
236A, 237D, 238F, 239G, 240M, 241A, 242A, 243L, 244E, 245T, 246S, 247D, 249M, 250L, 251E, 252T, 253S, 254C, 255G, 256S, 257P, 258H
CDD
cd14081 (STKc_BRSK1_2)

255G

activation loop (A-loop)
236A, 237D, 238F, 239G, 240M, 241A, 242A, 243L, 244E, 245T, 246S, 247D, 249M, 250L, 251E, 252T, 253S, 254C, 255G, 256S, 257P, 258H
CDD
cd14081 (STKc_BRSK1_2)

256S

activation loop (A-loop)
236A, 237D, 238F, 239G, 240M, 241A, 242A, 243L, 244E, 245T, 246S, 247D, 249M, 250L, 251E, 252T, 253S, 254C, 255G, 256S, 257P, 258H
CDD
cd14081 (STKc_BRSK1_2)

257P

activation loop (A-loop)
236A, 237D, 238F, 239G, 240M, 241A, 242A, 243L, 244E, 245T, 246S, 247D, 249M, 250L, 251E, 252T, 253S, 254C, 255G, 256S, 257P, 258H
CDD
cd14081 (STKc_BRSK1_2)

258H

activation loop (A-loop)
236A, 237D, 238F, 239G, 240M, 241A, 242A, 243L, 244E, 245T, 246S, 247D, 249M, 250L, 251E, 252T, 253S, 254C, 255G, 256S, 257P, 258H
CDD
cd14081 (STKc_BRSK1_2)

Protein sequence

>MIA_05010_1
MSYSPPPQGAQVVQHHYPHQQPPHHHHAPTAQPSVPPPAPPVNRNSQASAASFGPDDPSQKRLSQASSSSASKRTKTHIG
PWRLGRTLGRGSSGRVRLAKHNVTGQLAAVKIVPKSLVSNDSNKENQADSQKDANGFSYGIEREVIIMKLIEHPNVMALY
DVWENKGELYLVLEYIEGGELFDYLIKKGRLEEREALHYFRQIINGVDYCHHFNICHRDLKPENLLLDKNRNIKIADFGM
AALETSDKMLETSCGSPHYASPEIVSGKNYHGGPSDIWSCGIILFALLTGHLPFDDENIRKLLLKVQAGRFHMPHDLSIE
AKDLISRMLCVDPDQRITMPEILNHPLLKKYPSKRATRTYDQINKPLLPMSVSKPVNSREDIDPEILKNLQTLWHGADRE
TVVTRLLSPDQNAEKTFYCLLMKYRHDHIDDANKPPVIPAAPSMSRSSSRQVIRHSASNQHLNFNSGSQHHHHHHRRSSH
GRQSSRVSRHSRAGSKSSTITASSSHKRGVSFSSIKQRTKSSNSIKSNAGSVSRPESSPPPLPSDAIEMQMQASVDYSQD
HSQLSYAEYDETAQHFQEHMLPQQQPPTQILEEPSQEDDWTKEAKRTSSEFASMLEHAFDYPSTSPAPSVPVPPVPSNKA
QLNRRGTRIVSDPLPTSGNVNPSNLDATILADANVTERRRVVSNFVHPTESSLDPFSAGFSPQPSTAAVYSPSTHSSLDN
IQQVSESSPELAEEEPLAAGLLNVDYLLPMIFEEDDRFADAIEEEMDMHFNEPKPKRQSVQKQPPPSKPINVPTQSQKLV
PKVSAGQARSDWTRARNPHLQTHRSNQRYTAADHSHLHSDVEDDLNMAPFDESVVEIGFNGTGIVGVGVHDTSLTAFDTS
ETGSMNNSFNKSNTIQQNTSPSGSNTQGDFSNVSVISSDSSRLRISGLLKTESFKARGSFSNFKTPSMVDIVEQRVVPEY
QLNVANDILSQGPSQDHQNTHVQMPSSSSPRQSSLQEQTSEHVEQPLSTSAPTRIETPTGSNSSNTFNEQDKADADGMPK
FMESPKMNTHSFIPSLATQQAQAYQPPNIVKLGEEPKANSGRSANILRKFSLNPKRQAPAPPAPSVSPAPETKPAEPSAS
SNLAPTRTPTLTTTLTSGSISAGTPKPKLIATKMPVVLLPTPPPSEPQSRVASGSSQMSSATTAVSSSTAHTHFDAAHQA
SATRSMVSTSPPATTKPASATIVTSTMTSKPVSATVYKSEPLKPVQQQPQAHNEPVKQNWFMKMLNLRTEPESDGHGSHG
AGYGSRSRSRGRMPEKISPTPYEPRTGHNNDSNGNRFMQPGTPTTVNQAGTPGYKSSRGYYSLLTATQVRRHVVEVLKGW
EQYGVSGIKISDGEVSSNGAKAIIVRAKISSRNALSLRSTRFRVEIEAHELRSYIAVPNKTKAPAPAVPTSAPAPPQQQS
KNVFKRIFGGSKSSKNEQQAPAPAPAPAPAPAPASTTTTTTKVTSILIIQERGSLSTFGRFLKEMEQALEARNAISGTSS
TAVLGQTLSAATATDPLSSGTTRATTTTTTRPMSSSSSAWRPISTASDSNRNSTFSGYNLGGGSGSRPTSGYTSGYTTGH
ENDFEDEEVVLIGSGYPKSSTTAQYKYTYHDSAAPASSGTGGETNNRNSQGLGIVV

GO term prediction

Biological Process

GO:0006468 protein phosphorylation

Molecular Function

GO:0004672 protein kinase activity
GO:0005524 ATP binding

Cellular Component