Protein

MCA_03485_1

Length
1,435 amino acids

Gene name: HSL1

Description: Serine/threonine protein kinase Hsl1; in S. cerevisiae it is a septin-binding kinase that localizes to the bud neck septin ring and regulates the morphogenesis checkpoint.

Browser: contigC:91081-95561-

RNA-seq: read pairs 1160, FPKM 10.0, percentile rank 25.9% (100% = highest expression)

Protein function

Annotation:HSL1Serine/threonine protein kinase Hsl1; in S. cerevisiae it is a septin-binding kinase that localizes to the bud neck septin ring and regulates the morphogenesis checkpoint.
KEGG:K02515HSL1 serine/threonine-protein kinase HSL1, negative regulator of Swe1 kinase [EC:2.7.11.-]
EGGNOG:0PFHBPGUG_03305serine threonine protein kinase
SGD closest match:S000001584HSL1Probable serine/threonine-protein kinase HSL1
CGD closest match:CAL0000190859HSL1Serine/threonine-protein kinase HSL1

Protein alignments

%idAln lengthE-value
MIA_05010_158.03%7220.0MIA_05010_1
A0A167E8L5_9ASCO70.26%3900.0Protein kinase HSL1 OS=Sugiyamaella lignohabitans GN=HSL1 PE=4 SV=1
UniRef50_A0A167E8L570.26%3900.0Protein kinase HSL1 n=1 Tax=Sugiyamaella lignohabitans TaxID=796027 RepID=A0A167E8L5_9ASCO
A0A060T7U6_BLAAD71.93%3740.0ARAD1B22880p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B22880g PE=4 SV=1
A0A0J9XI83_GEOCN71.91%3880.0Similar to Saccharomyces cerevisiae YKL101W HSL1 Nim1p-related protein kinase that regulates the morphogenesis and septin checkpoints OS=Geotrichum candidum GN=BN980_GECA18s01704g PE=4 SV=1
W0TYM1_YARLI74.53%3738e-176YALI0E06519p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E06519g PE=4 SV=1
HSL1_CANAL65.19%3624e-156Serine/threonine-protein kinase HSL1 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=HSL1 PE=1 SV=2
HSL1_YEAST58.97%3906e-144Probable serine/threonine-protein kinase HSL1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HSL1 PE=1 SV=2
A0A1E3PJ26_9ASCO72.59%3211e-156Pkinase-domain-containing protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_70857 PE=3 SV=1
A0A1E4TGC4_9ASCO75.09%2737e-140Uncharacterized protein (Fragment) OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_24884 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0894

Protein family membership

None predicted.

Domains and repeats

  1. Domain
1 200 400 600 800 1000 1200 1435

Detailed signature matches

  1. Domain IPR011009
    Protein kinase-like domain
    1. SSF56112 (Protein k...)
  2. Domain IPR000719
    Protein kinase domain
    1. PS50011 (PROTEIN_KI...)
    2. PF00069 (Pkinase)
    3. SM00220 (serkin_6)
  3. SITE IPR017441
    Protein kinase, ATP binding site
    1. PS00107 (PROTEIN_KI...)
  4. SITE IPR008271
    Serine/threonine-protein kinase, active site
    1. PS00108 (PROTEIN_KI...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:1.10.51...
  2. G3DSA:3.30.20...
  3. cd14081 (STKc_BRSK1_2)
  4. mobidb-lite (disord...)

Residue annotation

  1. ATP binding site c...
  2. active site cd14081
  3. polypeptide substr...
  4. activation loop (A...

Protein sequence

>MCA_03485_1
MSSSYQILNNDSHSFSSSEAKRLSQTSTSSYTKKTKSHVGPWRLGRTLGIGSSGRVRLAKHNVTGQLAAVKIVPKASTSS
PNTTTDSAMPSSSNTNTNESKQTNFPYGIEREVIIMKLIEHPNVMALYDVWENKGELYLVLEYIEGGELFDYLIKKGSLE
EREALHYFRQIINGVDYCHRFNICHRDLKPENLLLDKNRNIKIADFGMAALETSDRMLETSCGSPHYASPEVVSGKNYHG
GPSDIWSCGIILFALLTGHLPFDDDNIRRLLLKVQAGKFSMPPDLSPEAQDLISRMLCVDPEKRITMPEILAHPFLHKYP
PSKRSMSYYKAPPPIPVSHPVNSVEEIDSEILKNLQTLWHGADKETIINQLLSPEQNSEKTFYCLLMKYRHDHIDDYKND
NYSTNEKTKPTLSSSMSKQKLRHSHSNSHIKRHSHHNHHHYSNHTRHSSRNSSRHSRSGSKSSIITASSSHKRGVSFSSV
KQKTRSNNSIKMLHSRQSSPPPPLPLDALKLLAEQEMKLNNQKPKNVNWTTDVKRNSAEFASMLEQAFNFDISSTINSNR
AVSDPFPIPYQHTSNMHTPVPENHETDPSLDPYYQNNPVSKLPQESHEYIKNYPYQIELHDNNHQNLPEYLLPMIFEEED
RFADAIEEEMDIHFLNDNSHDNKKHNIIDNNRRKTVASSYNNKLNYPTNRSNNPVASDQSSVKSKALILPEIPDTPIYED
VDLRRAHTDAKVRAMRAHRHEDVDTSFNTTSDNTQDNLNTLNTSIISGDTSRLRISGLLKTESFKSRSNAYSAFGNQHDS
AAYDSFDFTRPANQFQNSNEFRRRSSVLEYNSSFKVNKSIENDDHYMDRGNTRSTNTLRQESPKHNHLQRISHPPSIAQT
SIISSDLHSNRSNITQSSHSKFMESPKLNNNNFNARLTSGRRVTDYSKQTTSETLANFVEGTTNKNSDNVEKPTAKPTAN
AKQVEEKKSKSSGLFRKFTLNPKRQAPPPPSQVTNTSLLQPALPISIASKQLPTPPTSEPQSRVASGSSMTHVTTTITPP
GSLGNNYQQQAANVKATVYKSTTPKENFSKKSSTADFASPSLYNLETSGVKQNWFMKMLNKNVVSQPSSNGFNELSSPTK
TLVSYQYNGQMMHRFIIEILKSWKKYGISNITDFIGAPFTSNIKSTDDYHDSNTGSNDIIENEDGFDFEIVSHKKANTQQ
ATKYIFIKQTSQKFVINAKISPRNVLSLRSSRFRIEIESKITEKTVQTIIGNGKSDAGVRENANTTENATNTHTGAFRRL
FQRSKSKTPATMSDTRNKKNETSTEGVKTGSTTTTSYETRIHIIKERGSESAFNRLVVEMESILKEKGLATEVVSATPNN
NNNNNTKPSPKSPDTLGSTLQKKQQGNNQNNDNQHGINTYLARPRSNFYEQSHQQYGQNNNNNNNNLSNGLGIIV

GO term prediction

Biological Process

GO:0006468 protein phosphorylation

Molecular Function

GO:0004672 protein kinase activity
GO:0005524 ATP binding

Cellular Component

None predicted.