MIA_04977_1

Protein

Length

201 amino acids

Protein function

EGGNOG:	0PF82	PGUG_02200	Vesicle transport V-snare protein
SGD closest match:	S000004810	VTI1	t-SNARE VTI1
CGD closest match:	CAL0000188283	VTI1	V-SNARE protein

Protein alignments

	%id	Aln length	E-value
MCA_01465_1	69.849%	199	1.31e-85	MCA_01465_1
A0A0J9X541_GEOCN	66.495%	194	5.14e-72	Similar to Saccharomyces cerevisiae YMR197C VTI1 Protein involved in cis-Golgi membrane traffic OS=Geotrichum candidum GN=BN980_GECA02s07809g PE=4 SV=1
A0A060TAX9_BLAAD	63.590%	195	1.09e-67	ARAD1D29942p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D29942g PE=4 SV=1
Q6CFZ4_YARLI	61.538%	195	5.89e-65	YALI0B02244p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_B02244g PE=4 SV=1
UniRef50_Q6CFZ4	61.538%	195	1.36e-61	YALI0B02244p n=33 Tax=Saccharomycetales TaxID=4892 RepID=Q6CFZ4_YARLI
A0A1E3PIH9_9ASCO	58.462%	195	2.36e-61	V-snare-domain-containing protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_51809 PE=4 SV=1
A0A1E4TLN1_9ASCO	50.769%	195	2.08e-49	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_90531 PE=4 SV=1
A0A161HM49_9ASCO	65.248%	141	8.00e-49	Vti1p OS=Sugiyamaella lignohabitans GN=VTI1 PE=4 SV=1
A0A1D8PJW1_CANAL	50.521%	192	2.11e-44	V-SNARE protein OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=VTI1 PE=4 SV=1
VTI1_YEAST	41.327%	196	4.08e-29	t-SNARE VTI1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=VTI1 PE=1 SV=3

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.2097

Protein family membership

None predicted.

Domains and repeats

Domain
12 - 96
SNARE (IPR010989)
Vesicle transport v-SNARE, N-terminal (IPR007705)
131 - 198
Target SNARE coiled-coil homology domain (IPR000727)

1 20 40 60 80 100 120 140 160 180 201

Detailed signature matches

IPR010989

SNARE
1. SSF47661 (t-snare p...)
  
  12 - 96
  
  SUPERFAMILY
  SSF47661 (t-snare proteins)
IPR007705

Vesicle transport v-SNARE, N-terminal
1. PF05008 (V-SNARE)
  
  18 - 96
  
  Pfam
  PF05008 (V-SNARE)
IPR000727

Target SNARE coiled-coil homology domain
1. SM00397 (tSNARE_6)
  
  131 - 198
  
  SMART
  SM00397 (tSNARE_6)

no IPR

Unintegrated signatures

Coil

44 - 64

COILS
Coil (Coil)

80 - 100

COILS
Coil (Coil)
G3DSA:1.20.5.110

126 - 199

GENE3D
G3DSA:1.20.5.110 (G3DSA:1.20.5.110)
G3DSA:1.20.58...

9 - 99

GENE3D
G3DSA:1.20.58.400 (G3DSA:1.20.58.400)
PF12352 (V-SNARE_C)

138 - 201

Pfam
PF12352 (V-SNARE_C)
SSF58038 (SNARE fus...)

139 - 198

SUPERFAMILY
SSF58038 (SNARE fusion complex)
cd15862 (SNARE_Vti1)

136 - 197

CDD
cd15862 (SNARE_Vti1)

Residue annotation

heterotetramer int...

141R

heterotetramer interface
141R, 142S, 145R, 146L, 148D, 149S, 150Q, 152L, 153A, 154S, 155E, 156T, 157E, 159I, 160G, 161A, 163I, 164L, 166D, 167L, 170Q, 171R, 173Q, 174I, 175T, 176N, 177A, 178R, 180T, 181L, 182M, 184A, 185D, 187Y, 188V, 189D, 190K, 191S, 192I, 194T, 195L
CDD
cd15862 (SNARE_Vti1)

142S

heterotetramer interface
141R, 142S, 145R, 146L, 148D, 149S, 150Q, 152L, 153A, 154S, 155E, 156T, 157E, 159I, 160G, 161A, 163I, 164L, 166D, 167L, 170Q, 171R, 173Q, 174I, 175T, 176N, 177A, 178R, 180T, 181L, 182M, 184A, 185D, 187Y, 188V, 189D, 190K, 191S, 192I, 194T, 195L
CDD
cd15862 (SNARE_Vti1)

145R

heterotetramer interface
141R, 142S, 145R, 146L, 148D, 149S, 150Q, 152L, 153A, 154S, 155E, 156T, 157E, 159I, 160G, 161A, 163I, 164L, 166D, 167L, 170Q, 171R, 173Q, 174I, 175T, 176N, 177A, 178R, 180T, 181L, 182M, 184A, 185D, 187Y, 188V, 189D, 190K, 191S, 192I, 194T, 195L
CDD
cd15862 (SNARE_Vti1)

146L

heterotetramer interface
141R, 142S, 145R, 146L, 148D, 149S, 150Q, 152L, 153A, 154S, 155E, 156T, 157E, 159I, 160G, 161A, 163I, 164L, 166D, 167L, 170Q, 171R, 173Q, 174I, 175T, 176N, 177A, 178R, 180T, 181L, 182M, 184A, 185D, 187Y, 188V, 189D, 190K, 191S, 192I, 194T, 195L
CDD
cd15862 (SNARE_Vti1)

148D

heterotetramer interface
141R, 142S, 145R, 146L, 148D, 149S, 150Q, 152L, 153A, 154S, 155E, 156T, 157E, 159I, 160G, 161A, 163I, 164L, 166D, 167L, 170Q, 171R, 173Q, 174I, 175T, 176N, 177A, 178R, 180T, 181L, 182M, 184A, 185D, 187Y, 188V, 189D, 190K, 191S, 192I, 194T, 195L
CDD
cd15862 (SNARE_Vti1)

149S

heterotetramer interface
141R, 142S, 145R, 146L, 148D, 149S, 150Q, 152L, 153A, 154S, 155E, 156T, 157E, 159I, 160G, 161A, 163I, 164L, 166D, 167L, 170Q, 171R, 173Q, 174I, 175T, 176N, 177A, 178R, 180T, 181L, 182M, 184A, 185D, 187Y, 188V, 189D, 190K, 191S, 192I, 194T, 195L
CDD
cd15862 (SNARE_Vti1)

150Q

heterotetramer interface
141R, 142S, 145R, 146L, 148D, 149S, 150Q, 152L, 153A, 154S, 155E, 156T, 157E, 159I, 160G, 161A, 163I, 164L, 166D, 167L, 170Q, 171R, 173Q, 174I, 175T, 176N, 177A, 178R, 180T, 181L, 182M, 184A, 185D, 187Y, 188V, 189D, 190K, 191S, 192I, 194T, 195L
CDD
cd15862 (SNARE_Vti1)

152L

heterotetramer interface
141R, 142S, 145R, 146L, 148D, 149S, 150Q, 152L, 153A, 154S, 155E, 156T, 157E, 159I, 160G, 161A, 163I, 164L, 166D, 167L, 170Q, 171R, 173Q, 174I, 175T, 176N, 177A, 178R, 180T, 181L, 182M, 184A, 185D, 187Y, 188V, 189D, 190K, 191S, 192I, 194T, 195L
CDD
cd15862 (SNARE_Vti1)

153A

heterotetramer interface
141R, 142S, 145R, 146L, 148D, 149S, 150Q, 152L, 153A, 154S, 155E, 156T, 157E, 159I, 160G, 161A, 163I, 164L, 166D, 167L, 170Q, 171R, 173Q, 174I, 175T, 176N, 177A, 178R, 180T, 181L, 182M, 184A, 185D, 187Y, 188V, 189D, 190K, 191S, 192I, 194T, 195L
CDD
cd15862 (SNARE_Vti1)

154S

heterotetramer interface
141R, 142S, 145R, 146L, 148D, 149S, 150Q, 152L, 153A, 154S, 155E, 156T, 157E, 159I, 160G, 161A, 163I, 164L, 166D, 167L, 170Q, 171R, 173Q, 174I, 175T, 176N, 177A, 178R, 180T, 181L, 182M, 184A, 185D, 187Y, 188V, 189D, 190K, 191S, 192I, 194T, 195L
CDD
cd15862 (SNARE_Vti1)

155E

heterotetramer interface
141R, 142S, 145R, 146L, 148D, 149S, 150Q, 152L, 153A, 154S, 155E, 156T, 157E, 159I, 160G, 161A, 163I, 164L, 166D, 167L, 170Q, 171R, 173Q, 174I, 175T, 176N, 177A, 178R, 180T, 181L, 182M, 184A, 185D, 187Y, 188V, 189D, 190K, 191S, 192I, 194T, 195L
CDD
cd15862 (SNARE_Vti1)

156T

heterotetramer interface
141R, 142S, 145R, 146L, 148D, 149S, 150Q, 152L, 153A, 154S, 155E, 156T, 157E, 159I, 160G, 161A, 163I, 164L, 166D, 167L, 170Q, 171R, 173Q, 174I, 175T, 176N, 177A, 178R, 180T, 181L, 182M, 184A, 185D, 187Y, 188V, 189D, 190K, 191S, 192I, 194T, 195L
CDD
cd15862 (SNARE_Vti1)

157E

heterotetramer interface
141R, 142S, 145R, 146L, 148D, 149S, 150Q, 152L, 153A, 154S, 155E, 156T, 157E, 159I, 160G, 161A, 163I, 164L, 166D, 167L, 170Q, 171R, 173Q, 174I, 175T, 176N, 177A, 178R, 180T, 181L, 182M, 184A, 185D, 187Y, 188V, 189D, 190K, 191S, 192I, 194T, 195L
CDD
cd15862 (SNARE_Vti1)

159I

heterotetramer interface
141R, 142S, 145R, 146L, 148D, 149S, 150Q, 152L, 153A, 154S, 155E, 156T, 157E, 159I, 160G, 161A, 163I, 164L, 166D, 167L, 170Q, 171R, 173Q, 174I, 175T, 176N, 177A, 178R, 180T, 181L, 182M, 184A, 185D, 187Y, 188V, 189D, 190K, 191S, 192I, 194T, 195L
CDD
cd15862 (SNARE_Vti1)

160G

heterotetramer interface
141R, 142S, 145R, 146L, 148D, 149S, 150Q, 152L, 153A, 154S, 155E, 156T, 157E, 159I, 160G, 161A, 163I, 164L, 166D, 167L, 170Q, 171R, 173Q, 174I, 175T, 176N, 177A, 178R, 180T, 181L, 182M, 184A, 185D, 187Y, 188V, 189D, 190K, 191S, 192I, 194T, 195L
CDD
cd15862 (SNARE_Vti1)

161A

heterotetramer interface
141R, 142S, 145R, 146L, 148D, 149S, 150Q, 152L, 153A, 154S, 155E, 156T, 157E, 159I, 160G, 161A, 163I, 164L, 166D, 167L, 170Q, 171R, 173Q, 174I, 175T, 176N, 177A, 178R, 180T, 181L, 182M, 184A, 185D, 187Y, 188V, 189D, 190K, 191S, 192I, 194T, 195L
CDD
cd15862 (SNARE_Vti1)

163I

heterotetramer interface
141R, 142S, 145R, 146L, 148D, 149S, 150Q, 152L, 153A, 154S, 155E, 156T, 157E, 159I, 160G, 161A, 163I, 164L, 166D, 167L, 170Q, 171R, 173Q, 174I, 175T, 176N, 177A, 178R, 180T, 181L, 182M, 184A, 185D, 187Y, 188V, 189D, 190K, 191S, 192I, 194T, 195L
CDD
cd15862 (SNARE_Vti1)

164L

heterotetramer interface
141R, 142S, 145R, 146L, 148D, 149S, 150Q, 152L, 153A, 154S, 155E, 156T, 157E, 159I, 160G, 161A, 163I, 164L, 166D, 167L, 170Q, 171R, 173Q, 174I, 175T, 176N, 177A, 178R, 180T, 181L, 182M, 184A, 185D, 187Y, 188V, 189D, 190K, 191S, 192I, 194T, 195L
CDD
cd15862 (SNARE_Vti1)

166D

heterotetramer interface
141R, 142S, 145R, 146L, 148D, 149S, 150Q, 152L, 153A, 154S, 155E, 156T, 157E, 159I, 160G, 161A, 163I, 164L, 166D, 167L, 170Q, 171R, 173Q, 174I, 175T, 176N, 177A, 178R, 180T, 181L, 182M, 184A, 185D, 187Y, 188V, 189D, 190K, 191S, 192I, 194T, 195L
CDD
cd15862 (SNARE_Vti1)

167L

heterotetramer interface
141R, 142S, 145R, 146L, 148D, 149S, 150Q, 152L, 153A, 154S, 155E, 156T, 157E, 159I, 160G, 161A, 163I, 164L, 166D, 167L, 170Q, 171R, 173Q, 174I, 175T, 176N, 177A, 178R, 180T, 181L, 182M, 184A, 185D, 187Y, 188V, 189D, 190K, 191S, 192I, 194T, 195L
CDD
cd15862 (SNARE_Vti1)

170Q

heterotetramer interface
141R, 142S, 145R, 146L, 148D, 149S, 150Q, 152L, 153A, 154S, 155E, 156T, 157E, 159I, 160G, 161A, 163I, 164L, 166D, 167L, 170Q, 171R, 173Q, 174I, 175T, 176N, 177A, 178R, 180T, 181L, 182M, 184A, 185D, 187Y, 188V, 189D, 190K, 191S, 192I, 194T, 195L
CDD
cd15862 (SNARE_Vti1)

171R

heterotetramer interface
141R, 142S, 145R, 146L, 148D, 149S, 150Q, 152L, 153A, 154S, 155E, 156T, 157E, 159I, 160G, 161A, 163I, 164L, 166D, 167L, 170Q, 171R, 173Q, 174I, 175T, 176N, 177A, 178R, 180T, 181L, 182M, 184A, 185D, 187Y, 188V, 189D, 190K, 191S, 192I, 194T, 195L
CDD
cd15862 (SNARE_Vti1)

173Q

heterotetramer interface
141R, 142S, 145R, 146L, 148D, 149S, 150Q, 152L, 153A, 154S, 155E, 156T, 157E, 159I, 160G, 161A, 163I, 164L, 166D, 167L, 170Q, 171R, 173Q, 174I, 175T, 176N, 177A, 178R, 180T, 181L, 182M, 184A, 185D, 187Y, 188V, 189D, 190K, 191S, 192I, 194T, 195L
CDD
cd15862 (SNARE_Vti1)

174I

heterotetramer interface
141R, 142S, 145R, 146L, 148D, 149S, 150Q, 152L, 153A, 154S, 155E, 156T, 157E, 159I, 160G, 161A, 163I, 164L, 166D, 167L, 170Q, 171R, 173Q, 174I, 175T, 176N, 177A, 178R, 180T, 181L, 182M, 184A, 185D, 187Y, 188V, 189D, 190K, 191S, 192I, 194T, 195L
CDD
cd15862 (SNARE_Vti1)

175T

heterotetramer interface
141R, 142S, 145R, 146L, 148D, 149S, 150Q, 152L, 153A, 154S, 155E, 156T, 157E, 159I, 160G, 161A, 163I, 164L, 166D, 167L, 170Q, 171R, 173Q, 174I, 175T, 176N, 177A, 178R, 180T, 181L, 182M, 184A, 185D, 187Y, 188V, 189D, 190K, 191S, 192I, 194T, 195L
CDD
cd15862 (SNARE_Vti1)

176N

heterotetramer interface
141R, 142S, 145R, 146L, 148D, 149S, 150Q, 152L, 153A, 154S, 155E, 156T, 157E, 159I, 160G, 161A, 163I, 164L, 166D, 167L, 170Q, 171R, 173Q, 174I, 175T, 176N, 177A, 178R, 180T, 181L, 182M, 184A, 185D, 187Y, 188V, 189D, 190K, 191S, 192I, 194T, 195L
CDD
cd15862 (SNARE_Vti1)

177A

heterotetramer interface
141R, 142S, 145R, 146L, 148D, 149S, 150Q, 152L, 153A, 154S, 155E, 156T, 157E, 159I, 160G, 161A, 163I, 164L, 166D, 167L, 170Q, 171R, 173Q, 174I, 175T, 176N, 177A, 178R, 180T, 181L, 182M, 184A, 185D, 187Y, 188V, 189D, 190K, 191S, 192I, 194T, 195L
CDD
cd15862 (SNARE_Vti1)

178R

heterotetramer interface
141R, 142S, 145R, 146L, 148D, 149S, 150Q, 152L, 153A, 154S, 155E, 156T, 157E, 159I, 160G, 161A, 163I, 164L, 166D, 167L, 170Q, 171R, 173Q, 174I, 175T, 176N, 177A, 178R, 180T, 181L, 182M, 184A, 185D, 187Y, 188V, 189D, 190K, 191S, 192I, 194T, 195L
CDD
cd15862 (SNARE_Vti1)

180T

heterotetramer interface
141R, 142S, 145R, 146L, 148D, 149S, 150Q, 152L, 153A, 154S, 155E, 156T, 157E, 159I, 160G, 161A, 163I, 164L, 166D, 167L, 170Q, 171R, 173Q, 174I, 175T, 176N, 177A, 178R, 180T, 181L, 182M, 184A, 185D, 187Y, 188V, 189D, 190K, 191S, 192I, 194T, 195L
CDD
cd15862 (SNARE_Vti1)

181L

heterotetramer interface
141R, 142S, 145R, 146L, 148D, 149S, 150Q, 152L, 153A, 154S, 155E, 156T, 157E, 159I, 160G, 161A, 163I, 164L, 166D, 167L, 170Q, 171R, 173Q, 174I, 175T, 176N, 177A, 178R, 180T, 181L, 182M, 184A, 185D, 187Y, 188V, 189D, 190K, 191S, 192I, 194T, 195L
CDD
cd15862 (SNARE_Vti1)

182M

heterotetramer interface
141R, 142S, 145R, 146L, 148D, 149S, 150Q, 152L, 153A, 154S, 155E, 156T, 157E, 159I, 160G, 161A, 163I, 164L, 166D, 167L, 170Q, 171R, 173Q, 174I, 175T, 176N, 177A, 178R, 180T, 181L, 182M, 184A, 185D, 187Y, 188V, 189D, 190K, 191S, 192I, 194T, 195L
CDD
cd15862 (SNARE_Vti1)

184A

heterotetramer interface
141R, 142S, 145R, 146L, 148D, 149S, 150Q, 152L, 153A, 154S, 155E, 156T, 157E, 159I, 160G, 161A, 163I, 164L, 166D, 167L, 170Q, 171R, 173Q, 174I, 175T, 176N, 177A, 178R, 180T, 181L, 182M, 184A, 185D, 187Y, 188V, 189D, 190K, 191S, 192I, 194T, 195L
CDD
cd15862 (SNARE_Vti1)

185D

heterotetramer interface
141R, 142S, 145R, 146L, 148D, 149S, 150Q, 152L, 153A, 154S, 155E, 156T, 157E, 159I, 160G, 161A, 163I, 164L, 166D, 167L, 170Q, 171R, 173Q, 174I, 175T, 176N, 177A, 178R, 180T, 181L, 182M, 184A, 185D, 187Y, 188V, 189D, 190K, 191S, 192I, 194T, 195L
CDD
cd15862 (SNARE_Vti1)

187Y

heterotetramer interface
141R, 142S, 145R, 146L, 148D, 149S, 150Q, 152L, 153A, 154S, 155E, 156T, 157E, 159I, 160G, 161A, 163I, 164L, 166D, 167L, 170Q, 171R, 173Q, 174I, 175T, 176N, 177A, 178R, 180T, 181L, 182M, 184A, 185D, 187Y, 188V, 189D, 190K, 191S, 192I, 194T, 195L
CDD
cd15862 (SNARE_Vti1)

188V

heterotetramer interface
141R, 142S, 145R, 146L, 148D, 149S, 150Q, 152L, 153A, 154S, 155E, 156T, 157E, 159I, 160G, 161A, 163I, 164L, 166D, 167L, 170Q, 171R, 173Q, 174I, 175T, 176N, 177A, 178R, 180T, 181L, 182M, 184A, 185D, 187Y, 188V, 189D, 190K, 191S, 192I, 194T, 195L
CDD
cd15862 (SNARE_Vti1)

189D

heterotetramer interface
141R, 142S, 145R, 146L, 148D, 149S, 150Q, 152L, 153A, 154S, 155E, 156T, 157E, 159I, 160G, 161A, 163I, 164L, 166D, 167L, 170Q, 171R, 173Q, 174I, 175T, 176N, 177A, 178R, 180T, 181L, 182M, 184A, 185D, 187Y, 188V, 189D, 190K, 191S, 192I, 194T, 195L
CDD
cd15862 (SNARE_Vti1)

190K

heterotetramer interface
141R, 142S, 145R, 146L, 148D, 149S, 150Q, 152L, 153A, 154S, 155E, 156T, 157E, 159I, 160G, 161A, 163I, 164L, 166D, 167L, 170Q, 171R, 173Q, 174I, 175T, 176N, 177A, 178R, 180T, 181L, 182M, 184A, 185D, 187Y, 188V, 189D, 190K, 191S, 192I, 194T, 195L
CDD
cd15862 (SNARE_Vti1)

191S

heterotetramer interface
141R, 142S, 145R, 146L, 148D, 149S, 150Q, 152L, 153A, 154S, 155E, 156T, 157E, 159I, 160G, 161A, 163I, 164L, 166D, 167L, 170Q, 171R, 173Q, 174I, 175T, 176N, 177A, 178R, 180T, 181L, 182M, 184A, 185D, 187Y, 188V, 189D, 190K, 191S, 192I, 194T, 195L
CDD
cd15862 (SNARE_Vti1)

192I

heterotetramer interface
141R, 142S, 145R, 146L, 148D, 149S, 150Q, 152L, 153A, 154S, 155E, 156T, 157E, 159I, 160G, 161A, 163I, 164L, 166D, 167L, 170Q, 171R, 173Q, 174I, 175T, 176N, 177A, 178R, 180T, 181L, 182M, 184A, 185D, 187Y, 188V, 189D, 190K, 191S, 192I, 194T, 195L
CDD
cd15862 (SNARE_Vti1)

194T

heterotetramer interface
141R, 142S, 145R, 146L, 148D, 149S, 150Q, 152L, 153A, 154S, 155E, 156T, 157E, 159I, 160G, 161A, 163I, 164L, 166D, 167L, 170Q, 171R, 173Q, 174I, 175T, 176N, 177A, 178R, 180T, 181L, 182M, 184A, 185D, 187Y, 188V, 189D, 190K, 191S, 192I, 194T, 195L
CDD
cd15862 (SNARE_Vti1)

195L

heterotetramer interface
141R, 142S, 145R, 146L, 148D, 149S, 150Q, 152L, 153A, 154S, 155E, 156T, 157E, 159I, 160G, 161A, 163I, 164L, 166D, 167L, 170Q, 171R, 173Q, 174I, 175T, 176N, 177A, 178R, 180T, 181L, 182M, 184A, 185D, 187Y, 188V, 189D, 190K, 191S, 192I, 194T, 195L
CDD
cd15862 (SNARE_Vti1)
zero layer cd15862

170Q

zero layer
170Q
CDD
cd15862 (SNARE_Vti1)

Protein sequence

>MIA_04977_1
MANLMDNDLISKYESEFGLTSTEITQKLDALTTEVDRDQRKKLLSSVERAIEEAYEILDQLAVEIQNIPSAGRGPYNARL
RDYRASLDKAKRDVKRAGEESARVELFGSRALNGSVPGASSDDIALDQRQQLLSGTASLERSSQRLRDSQRLASETEQIG
ANILSDLRGQREQITNARNTLMEADGYVDKSIRTLRSMARR

GO term prediction

Biological Process

GO:0006886 intracellular protein transport
GO:0016192 vesicle-mediated transport

Molecular Function