Protein
MIA_04905_1
Length
536 amino acids
Browser: contig07:127070-128733+
Protein function
| EGGNOG: | 0PHBK | FG04128.1 | thiamin biosynthesis protein |
|---|---|---|---|
| SGD closest match: | S000006179 | THI21 | Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI21 |
| CGD closest match: | CAL0000198499 | THI20 | Trifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase/thiaminase |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| MCA_01263_1 | 57.299% | 548 | 0.0 | MCA_01263_1 |
| A0A0J9XIZ5_GEOCN | 55.722% | 533 | 0.0 | Similar to Saccharomyces cerevisiae YPL258C THI21 Hydroxymethylpyrimidine phosphate kinase OS=Geotrichum candidum GN=BN980_GECA23s00494g PE=4 SV=1 |
| A0A060T133_BLAAD | 53.195% | 532 | 0.0 | ARAD1C20988p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C20988g PE=4 SV=1 |
| UniRef50_A0A060T133 | 53.195% | 532 | 0.0 | ARAD1C20988p n=5 Tax=Saccharomycetales TaxID=4892 RepID=A0A060T133_BLAAD |
| A0A1E3PJG6_9ASCO | 50.185% | 542 | 2.47e-161 | Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_52032 PE=4 SV=1 |
| A0A167DC95_9ASCO | 49.692% | 487 | 4.96e-160 | Putative phosphomethylpyrimidine kinase OS=Sugiyamaella lignohabitans GN=THI22 PE=4 SV=1 |
| A0A1E4TLI3_9ASCO | 46.717% | 533 | 3.06e-151 | Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_1212 PE=4 SV=1 |
| Q6C731_YARLI | 46.442% | 534 | 8.07e-146 | YALI0E04224p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E04224g PE=4 SV=1 |
| THI21_YEAST | 36.204% | 569 | 4.28e-87 | Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI21 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=THI21 PE=1 SV=1 |
| A0A1D8PH02_CANAL | 33.880% | 549 | 6.49e-85 | Trifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase/thiaminase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=THI20 PE=4 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.1065
Protein family membership
- Thiaminase II (IPR027574)
Domains and repeats
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Domain
-
Domain
1
50
100
150
200
250
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350
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450
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536
Detailed signature matches
Residue annotation
-
dimer interface cd...
-
substrate binding ...
-
ATP binding site c...
Protein sequence
>MIA_04905_1 MSAIPKVLTIAGSDSSGGAGIEADLKTMTAYNCYGMTCITGLTAQNTLGVKDIYPVTDQSFLEKTLDAVFSDVGVDALKT GMLSTVATVDTIAAKLREYQTGDCRLNLVVDPVMISTSGANLIPVEAVDKYIDVLIPLAKVFTPNLIEAKYILEHLKKRE DGSDKPLGASGFEITSLDDMKTMAKALQERLKCETVLLKGGHIAFNKKLEVEREPTKEGRVIVDVFYDGQDFETLQSDFI ETKATHGTGCTLSSAIACNLALANKKEKKTLVKAVTDSVHYVQEAIRTAHTIGHGFGPVNHMHNLQHRPFIAGKFVDYLL GHPKVRDNWERYVGHEFTRQIAYNTLDMKSFKFFLEQDYVYLKHYARCYGLGIYKSDDMETITKGAGVIEHIAHEMQLHV GYCQKFGLTVDDLEQVQEGQATYAYSRWLLEVGAKDDWFALQVALSPCLFGYLEAAARLKRDPQAVVGGDKNPYWRWVET YTAPDFAEAADEGREILESGVLKHSVDKIEMLVDIFATATRMECEFWDAALAYGRK
GO term prediction
Biological Process
GO:0006772 thiamine metabolic process
GO:0009228 thiamine biosynthetic process
Molecular Function
GO:0008972 phosphomethylpyrimidine kinase activity
GO:0050334 thiaminase activity
Cellular Component
None predicted.