MIA_04891_1

Protein

Length

370 amino acids

Protein function

EGGNOG:	0PJXH	FG07287.1	cysteine synthase
SGD closest match:	S000003244	YGR012W	Putative cysteine synthase
CGD closest match:	CAL0000173937	orf19.7152	Uncharacterized protein

Protein alignments

	%id	Aln length	E-value
MCA_02448_1	77.690%	381	0.0	MCA_02448_1
A0A060SY14_BLAAD	77.222%	360	0.0	ARAD1A17028p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A17028g PE=4 SV=1
UniRef50_A0A060SY14	77.222%	360	0.0	ARAD1A17028p n=47 Tax=Eukaryota TaxID=2759 RepID=A0A060SY14_BLAAD
A0A0J9XHP3_GEOCN	76.519%	362	0.0	Similar to Saccharomyces cerevisiae YGR012W Putative cysteine synthase OS=Geotrichum candidum GN=BN980_GECA18s02320g PE=4 SV=1
A0A167E8S3_9ASCO	73.727%	373	0.0	Putative cysteine synthase OS=Sugiyamaella lignohabitans GN=AWJ20_4728 PE=4 SV=1
A0A1D8PRJ1_CANAL	72.832%	346	7.29e-176	Uncharacterized protein OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.7152 PE=4 SV=1
Q6C1R7_YARLI	70.000%	360	9.05e-173	YALI0F14047p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F14047g PE=4 SV=1
A0A1E4TB08_9ASCO	66.469%	337	8.88e-156	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_131213 PE=4 SV=1
A0A1E3PGD1_9ASCO	67.257%	339	2.09e-152	Cysteine synthase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_52605 PE=4 SV=1
CYSKL_YEAST	39.940%	333	2.77e-65	Putative cysteine synthase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YGR012W PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.9902
Predicted cleavage: 50

Protein family membership

None predicted.

Domains and repeats

Domain
38 - 355
Tryptophan synthase beta subunit-like PLP-dependent enzyme (IPR001926)

1 50 100 150 200 250 300 370

Detailed signature matches

IPR001926

Tryptophan synthase beta subunit-like PLP-dependent enzyme
1. SSF53686 (Tryptopha...)
  
  38 - 355
  
  SUPERFAMILY
  SSF53686 (Tryptophan synthase beta subunit-like PLP-dependent enzymes)
2. PF00291 (PALP)
  
  40 - 335
  
  Pfam
  PF00291 (PALP)
IPR001216

Cysteine synthase/cystathionine beta-synthase, pyridoxal-phosphate attachment site
1. PS00901 (CYS_SYNTHASE)
  
  63 - 81
  
  PROSITE patterns
  PS00901 (CYS_SYNTHASE)

no IPR

Unintegrated signatures

G3DSA:3.40.50...

51 - 167

GENE3D
G3DSA:3.40.50.1100 (G3DSA:3.40.50.1100)

168 - 348

GENE3D
G3DSA:3.40.50.1100 (G3DSA:3.40.50.1100)
cd01561 (CBS_like)

42 - 342

CDD
cd01561 (CBS_like)

Residue annotation

dimer interface cd...

46L

dimer interface
46L, 47L, 48R, 61Y, 67L, 69P, 111H, 114R, 130P, 131A, 134S, 135H, 138L, 139L, 196A, 197Q, 298L, 299D, 300E, 302G, 303L, 304F, 328T, 338D, 341A
CDD
cd01561 (CBS_like)

47L

dimer interface
46L, 47L, 48R, 61Y, 67L, 69P, 111H, 114R, 130P, 131A, 134S, 135H, 138L, 139L, 196A, 197Q, 298L, 299D, 300E, 302G, 303L, 304F, 328T, 338D, 341A
CDD
cd01561 (CBS_like)

48R

dimer interface
46L, 47L, 48R, 61Y, 67L, 69P, 111H, 114R, 130P, 131A, 134S, 135H, 138L, 139L, 196A, 197Q, 298L, 299D, 300E, 302G, 303L, 304F, 328T, 338D, 341A
CDD
cd01561 (CBS_like)

61Y

dimer interface
46L, 47L, 48R, 61Y, 67L, 69P, 111H, 114R, 130P, 131A, 134S, 135H, 138L, 139L, 196A, 197Q, 298L, 299D, 300E, 302G, 303L, 304F, 328T, 338D, 341A
CDD
cd01561 (CBS_like)

67L

dimer interface
46L, 47L, 48R, 61Y, 67L, 69P, 111H, 114R, 130P, 131A, 134S, 135H, 138L, 139L, 196A, 197Q, 298L, 299D, 300E, 302G, 303L, 304F, 328T, 338D, 341A
CDD
cd01561 (CBS_like)

69P

dimer interface
46L, 47L, 48R, 61Y, 67L, 69P, 111H, 114R, 130P, 131A, 134S, 135H, 138L, 139L, 196A, 197Q, 298L, 299D, 300E, 302G, 303L, 304F, 328T, 338D, 341A
CDD
cd01561 (CBS_like)

111H

dimer interface
46L, 47L, 48R, 61Y, 67L, 69P, 111H, 114R, 130P, 131A, 134S, 135H, 138L, 139L, 196A, 197Q, 298L, 299D, 300E, 302G, 303L, 304F, 328T, 338D, 341A
CDD
cd01561 (CBS_like)

114R

dimer interface
46L, 47L, 48R, 61Y, 67L, 69P, 111H, 114R, 130P, 131A, 134S, 135H, 138L, 139L, 196A, 197Q, 298L, 299D, 300E, 302G, 303L, 304F, 328T, 338D, 341A
CDD
cd01561 (CBS_like)

130P

dimer interface
46L, 47L, 48R, 61Y, 67L, 69P, 111H, 114R, 130P, 131A, 134S, 135H, 138L, 139L, 196A, 197Q, 298L, 299D, 300E, 302G, 303L, 304F, 328T, 338D, 341A
CDD
cd01561 (CBS_like)

131A

dimer interface
46L, 47L, 48R, 61Y, 67L, 69P, 111H, 114R, 130P, 131A, 134S, 135H, 138L, 139L, 196A, 197Q, 298L, 299D, 300E, 302G, 303L, 304F, 328T, 338D, 341A
CDD
cd01561 (CBS_like)

134S

dimer interface
46L, 47L, 48R, 61Y, 67L, 69P, 111H, 114R, 130P, 131A, 134S, 135H, 138L, 139L, 196A, 197Q, 298L, 299D, 300E, 302G, 303L, 304F, 328T, 338D, 341A
CDD
cd01561 (CBS_like)

135H

dimer interface
46L, 47L, 48R, 61Y, 67L, 69P, 111H, 114R, 130P, 131A, 134S, 135H, 138L, 139L, 196A, 197Q, 298L, 299D, 300E, 302G, 303L, 304F, 328T, 338D, 341A
CDD
cd01561 (CBS_like)

138L

dimer interface
46L, 47L, 48R, 61Y, 67L, 69P, 111H, 114R, 130P, 131A, 134S, 135H, 138L, 139L, 196A, 197Q, 298L, 299D, 300E, 302G, 303L, 304F, 328T, 338D, 341A
CDD
cd01561 (CBS_like)

139L

dimer interface
46L, 47L, 48R, 61Y, 67L, 69P, 111H, 114R, 130P, 131A, 134S, 135H, 138L, 139L, 196A, 197Q, 298L, 299D, 300E, 302G, 303L, 304F, 328T, 338D, 341A
CDD
cd01561 (CBS_like)

196A

dimer interface
46L, 47L, 48R, 61Y, 67L, 69P, 111H, 114R, 130P, 131A, 134S, 135H, 138L, 139L, 196A, 197Q, 298L, 299D, 300E, 302G, 303L, 304F, 328T, 338D, 341A
CDD
cd01561 (CBS_like)

197Q

dimer interface
46L, 47L, 48R, 61Y, 67L, 69P, 111H, 114R, 130P, 131A, 134S, 135H, 138L, 139L, 196A, 197Q, 298L, 299D, 300E, 302G, 303L, 304F, 328T, 338D, 341A
CDD
cd01561 (CBS_like)

298L

dimer interface
46L, 47L, 48R, 61Y, 67L, 69P, 111H, 114R, 130P, 131A, 134S, 135H, 138L, 139L, 196A, 197Q, 298L, 299D, 300E, 302G, 303L, 304F, 328T, 338D, 341A
CDD
cd01561 (CBS_like)

299D

dimer interface
46L, 47L, 48R, 61Y, 67L, 69P, 111H, 114R, 130P, 131A, 134S, 135H, 138L, 139L, 196A, 197Q, 298L, 299D, 300E, 302G, 303L, 304F, 328T, 338D, 341A
CDD
cd01561 (CBS_like)

300E

dimer interface
46L, 47L, 48R, 61Y, 67L, 69P, 111H, 114R, 130P, 131A, 134S, 135H, 138L, 139L, 196A, 197Q, 298L, 299D, 300E, 302G, 303L, 304F, 328T, 338D, 341A
CDD
cd01561 (CBS_like)

302G

dimer interface
46L, 47L, 48R, 61Y, 67L, 69P, 111H, 114R, 130P, 131A, 134S, 135H, 138L, 139L, 196A, 197Q, 298L, 299D, 300E, 302G, 303L, 304F, 328T, 338D, 341A
CDD
cd01561 (CBS_like)

303L

dimer interface
46L, 47L, 48R, 61Y, 67L, 69P, 111H, 114R, 130P, 131A, 134S, 135H, 138L, 139L, 196A, 197Q, 298L, 299D, 300E, 302G, 303L, 304F, 328T, 338D, 341A
CDD
cd01561 (CBS_like)

304F

dimer interface
46L, 47L, 48R, 61Y, 67L, 69P, 111H, 114R, 130P, 131A, 134S, 135H, 138L, 139L, 196A, 197Q, 298L, 299D, 300E, 302G, 303L, 304F, 328T, 338D, 341A
CDD
cd01561 (CBS_like)

328T

dimer interface
46L, 47L, 48R, 61Y, 67L, 69P, 111H, 114R, 130P, 131A, 134S, 135H, 138L, 139L, 196A, 197Q, 298L, 299D, 300E, 302G, 303L, 304F, 328T, 338D, 341A
CDD
cd01561 (CBS_like)

338D

dimer interface
46L, 47L, 48R, 61Y, 67L, 69P, 111H, 114R, 130P, 131A, 134S, 135H, 138L, 139L, 196A, 197Q, 298L, 299D, 300E, 302G, 303L, 304F, 328T, 338D, 341A
CDD
cd01561 (CBS_like)

341A

dimer interface
46L, 47L, 48R, 61Y, 67L, 69P, 111H, 114R, 130P, 131A, 134S, 135H, 138L, 139L, 196A, 197Q, 298L, 299D, 300E, 302G, 303L, 304F, 328T, 338D, 341A
CDD
cd01561 (CBS_like)
catalytic residue ...

74K

catalytic residue
74K
CDD
cd01561 (CBS_like)
pyridoxal 5'-phosp...

74K

pyridoxal 5'-phosphate binding site
74K, 104N, 209T, 210G, 211T, 212G, 213G, 214S, 262G, 308S, 334C, 335D
CDD
cd01561 (CBS_like)

104N

pyridoxal 5'-phosphate binding site
74K, 104N, 209T, 210G, 211T, 212G, 213G, 214S, 262G, 308S, 334C, 335D
CDD
cd01561 (CBS_like)

209T

pyridoxal 5'-phosphate binding site
74K, 104N, 209T, 210G, 211T, 212G, 213G, 214S, 262G, 308S, 334C, 335D
CDD
cd01561 (CBS_like)

210G

pyridoxal 5'-phosphate binding site
74K, 104N, 209T, 210G, 211T, 212G, 213G, 214S, 262G, 308S, 334C, 335D
CDD
cd01561 (CBS_like)

211T

pyridoxal 5'-phosphate binding site
74K, 104N, 209T, 210G, 211T, 212G, 213G, 214S, 262G, 308S, 334C, 335D
CDD
cd01561 (CBS_like)

212G

pyridoxal 5'-phosphate binding site
74K, 104N, 209T, 210G, 211T, 212G, 213G, 214S, 262G, 308S, 334C, 335D
CDD
cd01561 (CBS_like)

213G

pyridoxal 5'-phosphate binding site
74K, 104N, 209T, 210G, 211T, 212G, 213G, 214S, 262G, 308S, 334C, 335D
CDD
cd01561 (CBS_like)

214S

pyridoxal 5'-phosphate binding site
74K, 104N, 209T, 210G, 211T, 212G, 213G, 214S, 262G, 308S, 334C, 335D
CDD
cd01561 (CBS_like)

262G

pyridoxal 5'-phosphate binding site
74K, 104N, 209T, 210G, 211T, 212G, 213G, 214S, 262G, 308S, 334C, 335D
CDD
cd01561 (CBS_like)

308S

pyridoxal 5'-phosphate binding site
74K, 104N, 209T, 210G, 211T, 212G, 213G, 214S, 262G, 308S, 334C, 335D
CDD
cd01561 (CBS_like)

334C

pyridoxal 5'-phosphate binding site
74K, 104N, 209T, 210G, 211T, 212G, 213G, 214S, 262G, 308S, 334C, 335D
CDD
cd01561 (CBS_like)

335D

pyridoxal 5'-phosphate binding site
74K, 104N, 209T, 210G, 211T, 212G, 213G, 214S, 262G, 308S, 334C, 335D
CDD
cd01561 (CBS_like)

Protein sequence

>MIA_04891_1
MLRNLVKTSLKSSARTFSSRAGSSAIPFIPLVSETGFVGAVGNTPLLRLNSLSKETGANIYGKAEFLNPGGSVKDRAALY
IIQDAERRGLIKPGGTIVEGTAGNTGIGLAHVCRARGYNCVIYMPNTQSPAKISHLKLLGAEVHPVPAVPLADPNNYNHQ
ARRHAEGLENAVWTNQFDNTANRQAHIETTGPEIWAQTDGAVSAFTCATGTGGSFAGTSRYLKDISNGKVQAWLADPPGS
VLYSYINNGKLERTGTGSITEGIGQGRVTDNLKPDLDIIDGALYIPDADTIRMVYRLLDEEGLFLGASSCLNVVAAYELA
KKLGPKSTVVTLLCDGADRYAERLFSASWLKSKDLYKELPSHLLKYVAFD

GO term prediction

Biological Process

GO:0006535 cysteine biosynthetic process from serine

Molecular Function

None predicted.

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features

MIA_04891_1

Protein function

Protein alignments

Mitochondrial localization by mitoprotII

Protein family membership

Domains and repeats

Detailed signature matches

Residue annotation

Protein sequence

GO term prediction

Biological Process

Molecular Function

Cellular Component