Protein

MIA_04822_1

Length
470 amino acids

Browser: contig06:1074806-1076275-

Protein function

EGGNOG:0PFHXSHM2Interconversion of serine and glycine (By similarity)
SGD closest match:S000004048SHM2Serine hydroxymethyltransferase, cytosolic
CGD closest match:CAL0000189123SHM2Serine hydroxymethyltransferase, cytosolic

Protein alignments

%idAln lengthE-value
MCA_05051_192.128%4700.0MCA_05051_1
A0A167E605_9ASCO85.987%4710.0Serine hydroxymethyltransferase OS=Sugiyamaella lignohabitans GN=SHM2 PE=3 SV=1
A0A0J9X653_GEOCN85.106%4700.0Serine hydroxymethyltransferase OS=Geotrichum candidum GN=BN980_GECA02s08238g PE=3 SV=1
A0A060SY32_BLAAD86.141%4690.0Serine hydroxymethyltransferase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A17490g PE=3 SV=1
Q6C5P5_YARLI84.713%4710.0Serine hydroxymethyltransferase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E16346g PE=3 SV=1
A0A1E3PQZ0_9ASCO83.369%4690.0Serine hydroxymethyltransferase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_44577 PE=3 SV=1
GLYC_CANAL82.553%4700.0Serine hydroxymethyltransferase, cytosolic OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=SHM2 PE=1 SV=4
A0A1E4TFX7_9ASCO83.547%4680.0Serine hydroxymethyltransferase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_109062 PE=3 SV=1
UniRef50_K0KSA782.655%4670.0Serine hydroxymethyltransferase n=85 Tax=Eukaryota TaxID=2759 RepID=K0KSA7_WICCF
GLYC_YEAST80.514%4670.0Serine hydroxymethyltransferase, cytosolic OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SHM2 PE=1 SV=2

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0450

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 50 100 150 200 250 300 350 400 470

Detailed signature matches

  1. Family IPR001085
    Serine hydroxymethyltransferase
    1. MF_00051 (SHMT)
    2. PIRSF000412 (SHMT)
    3. cd00378 (SHMT)
  2. Domain IPR015424
    Pyridoxal phosphate-dependent transferase
    1. SSF53383 (PLP-depen...)
  3. Domain IPR015421
    Pyridoxal phosphate-dependent transferase, major region, subdomain 1
    1. G3DSA:3.40.64...
  4. Domain IPR015422
    Pyridoxal phosphate-dependent transferase, subdomain 2
    1. G3DSA:3.90.11...
  5. SITE IPR019798
    Serine hydroxymethyltransferase, pyridoxal phosphate binding site
    1. PS00096 (SHMT)
Unintegrated signatures no IPR
Unintegrated signatures
  1. PF00464 (SHMT)

Residue annotation

  1. dimer interface cd...
  2. active site cd00378
  3. glycine-pyridoxal ...
  4. folate binding sit...

Protein sequence

>MIA_04822_1
MATYALSESHKALLQDRLESFDPEVASIMKDEIQRQKESIVLIASENFTSKAVFDALGSPMCNKYSEGYPGARYYGGNQH
IDRIERLCQQRALDAFHLDHEKWGVNVQTLSGSPANLQVYQAIMKPHERLMGLDLPHGGHLSHGYQTDTRKISAVSTYFE
TMPYRVNLETGIIDYDMLEKTAILYRPKVLVAGTSAYCRLIDYKRMREIADKVGAYLVVDMAHISGLIAAGVIPSPFEYA
DIVTTTTHKSLRGPRGAMIFFRKGVRSINPKTGEPILYDLENPINFSVFPGHQGGPHNHTITALAVALKQAQTPEFVEYQ
KQVLKNAKALEEKFKELGYSLVSNGTDSHMVLVSLRDKGIDGARVEAVCEAINIALNKNSIPGDKSALVPGGVRIGAPAM
TTRGLGEEDFKRVVEYIDRAINIAIDVQKSLPKEANKLKDFKAVIAKGNDTLEGLKDEISQWAKQFPLPV

GO term prediction

Biological Process

GO:0006545 glycine biosynthetic process
GO:0035999 tetrahydrofolate interconversion

Molecular Function

GO:0003824 catalytic activity
GO:0004372 glycine hydroxymethyltransferase activity
GO:0030170 pyridoxal phosphate binding

Cellular Component

None predicted.