Protein
MCA_05051_1
Length
470 amino acids
Gene name: SHM2
Description: Serine hydroxymethyltransferase, cytosolic
Browser: contigD:229428-230912+
RNA-seq: read pairs 16679, FPKM 437.6, percentile rank 93.8% (100% = highest expression)
Protein function
Annotation: | SHM2 | Serine hydroxymethyltransferase, cytosolic | |
---|---|---|---|
KEGG: | K00600 | glyA | glycine hydroxymethyltransferase [EC:2.1.2.1] |
EGGNOG: | 0PFHX | SHM2 | Interconversion of serine and glycine (By similarity) |
SGD closest match: | S000004048 | SHM2 | Serine hydroxymethyltransferase, cytosolic |
CGD closest match: | CAL0000189123 | SHM2 | Serine hydroxymethyltransferase, cytosolic |
Protein alignments
%id | Aln length | E-value | ||
---|---|---|---|---|
MIA_04822_1 | 92.13% | 470 | 0.0 | MIA_04822_1 |
A0A167E605_9ASCO | 86.20% | 471 | 0.0 | Serine hydroxymethyltransferase OS=Sugiyamaella lignohabitans GN=SHM2 PE=3 SV=1 |
A0A060SY32_BLAAD | 86.14% | 469 | 0.0 | Serine hydroxymethyltransferase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A17490g PE=3 SV=1 |
A0A0J9X653_GEOCN | 85.32% | 470 | 0.0 | Serine hydroxymethyltransferase OS=Geotrichum candidum GN=BN980_GECA02s08238g PE=3 SV=1 |
Q6C5P5_YARLI | 84.08% | 471 | 0.0 | Serine hydroxymethyltransferase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E16346g PE=3 SV=1 |
A0A1E3PQZ0_9ASCO | 82.94% | 469 | 0.0 | Serine hydroxymethyltransferase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_44577 PE=3 SV=1 |
UniRef50_K0KSA7 | 82.44% | 467 | 0.0 | Serine hydroxymethyltransferase n=85 Tax=Eukaryota TaxID=2759 RepID=K0KSA7_WICCF |
A0A1E4TFX7_9ASCO | 82.05% | 468 | 0.0 | Serine hydroxymethyltransferase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_109062 PE=3 SV=1 |
GLYC_CANAL | 81.28% | 470 | 0.0 | Serine hydroxymethyltransferase, cytosolic OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=SHM2 PE=1 SV=4 |
GLYC_YEAST | 78.59% | 467 | 0.0 | Serine hydroxymethyltransferase, cytosolic OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SHM2 PE=1 SV=2 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.0534
Protein family membership
- Serine hydroxymethyltransferase (IPR001085)
Domains and repeats
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Domain
-
Domain
1
50
100
150
200
250
300
350
400
470
Detailed signature matches
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MF_00051 (SHMT)
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PIRSF000412 (SHMT)
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cd00378 (SHMT)
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-
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SSF53383 (PLP-depen...)
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-
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PS00096 (SHMT)
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![Unintegrated signatures Unintegrated signatures](resources/images/ico_type_uni_small.png)
Unintegrated signatures
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PF00464 (SHMT)
Residue annotation
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dimer interface cd...
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active site cd00378
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glycine-pyridoxal ...
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folate binding sit...
Protein sequence
>MCA_05051_1 MASYALSETHKALLQDRLESFDPEVASIMADEIQRQRESIVLIASENFTSKAVFDALGSPMCNKYSEGYPGARYYGGNQH IDRIERLCQQRALDAFHLDSDKWGVNVQTLSGSPANLQVYQAIMKPHDRLMGLDLPHGGHLSHGYQTDTRKISAVSTYFE TMPYRVDLETGIIDYDMLEKTAVLYRPKVLVAGTSAYCRLIDYKRMREIADKVGAYLVVDMAHISGLIAAQVIPTPFEYA DIVTTTTHKSLRGPRGAMIFFRKGVRSVNPKTGAEVLYDLENPINFSVFPGHQGGPHNHTITALAVALKQAQTPEFVEYQ KQVLKNAKALENKFKELGYNLVSNGTDSHMVLVSLRDKGIDGARVETVCEAMNIALNKNSIPGDKSALVPGGVRIGAPAM TTRGLGEADFARVVEYIDRSIKFAIETQKNLPKEANKLKDFKAAIAKGSPELDQLKAEISEWVKEFPLPV
GO term prediction
Biological Process
GO:0006545 glycine biosynthetic process
GO:0035999 tetrahydrofolate interconversion
Molecular Function
GO:0003824 catalytic activity
GO:0004372 glycine hydroxymethyltransferase activity
GO:0030170 pyridoxal phosphate binding
Cellular Component
None predicted.