Protein

MCA_05051_1

Length
470 amino acids

Gene name: SHM2

Description: Serine hydroxymethyltransferase, cytosolic

Browser: contigD:229428-230912+

RNA-seq: read pairs 16679, FPKM 437.6, percentile rank 93.8% (100% = highest expression)

Protein function

Annotation:SHM2Serine hydroxymethyltransferase, cytosolic
KEGG:K00600glyA glycine hydroxymethyltransferase [EC:2.1.2.1]
EGGNOG:0PFHXSHM2Interconversion of serine and glycine (By similarity)
SGD closest match:S000004048SHM2Serine hydroxymethyltransferase, cytosolic
CGD closest match:CAL0000189123SHM2Serine hydroxymethyltransferase, cytosolic

Protein alignments

%idAln lengthE-value
MIA_04822_192.13%4700.0MIA_04822_1
A0A167E605_9ASCO86.20%4710.0Serine hydroxymethyltransferase OS=Sugiyamaella lignohabitans GN=SHM2 PE=3 SV=1
A0A060SY32_BLAAD86.14%4690.0Serine hydroxymethyltransferase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A17490g PE=3 SV=1
A0A0J9X653_GEOCN85.32%4700.0Serine hydroxymethyltransferase OS=Geotrichum candidum GN=BN980_GECA02s08238g PE=3 SV=1
Q6C5P5_YARLI84.08%4710.0Serine hydroxymethyltransferase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E16346g PE=3 SV=1
A0A1E3PQZ0_9ASCO82.94%4690.0Serine hydroxymethyltransferase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_44577 PE=3 SV=1
UniRef50_K0KSA782.44%4670.0Serine hydroxymethyltransferase n=85 Tax=Eukaryota TaxID=2759 RepID=K0KSA7_WICCF
A0A1E4TFX7_9ASCO82.05%4680.0Serine hydroxymethyltransferase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_109062 PE=3 SV=1
GLYC_CANAL81.28%4700.0Serine hydroxymethyltransferase, cytosolic OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=SHM2 PE=1 SV=4
GLYC_YEAST78.59%4670.0Serine hydroxymethyltransferase, cytosolic OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SHM2 PE=1 SV=2

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0534

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 50 100 150 200 250 300 350 400 470

Detailed signature matches

  1. Family IPR001085
    Serine hydroxymethyltransferase
    1. MF_00051 (SHMT)
    2. PIRSF000412 (SHMT)
    3. cd00378 (SHMT)
  2. Domain IPR015424
    Pyridoxal phosphate-dependent transferase
    1. SSF53383 (PLP-depen...)
  3. Domain IPR015421
    Pyridoxal phosphate-dependent transferase, major region, subdomain 1
    1. G3DSA:3.40.64...
  4. Domain IPR015422
    Pyridoxal phosphate-dependent transferase, subdomain 2
    1. G3DSA:3.90.11...
  5. SITE IPR019798
    Serine hydroxymethyltransferase, pyridoxal phosphate binding site
    1. PS00096 (SHMT)
Unintegrated signatures no IPR
Unintegrated signatures
  1. PF00464 (SHMT)

Residue annotation

  1. dimer interface cd...
  2. active site cd00378
  3. glycine-pyridoxal ...
  4. folate binding sit...

Protein sequence

>MCA_05051_1
MASYALSETHKALLQDRLESFDPEVASIMADEIQRQRESIVLIASENFTSKAVFDALGSPMCNKYSEGYPGARYYGGNQH
IDRIERLCQQRALDAFHLDSDKWGVNVQTLSGSPANLQVYQAIMKPHDRLMGLDLPHGGHLSHGYQTDTRKISAVSTYFE
TMPYRVDLETGIIDYDMLEKTAVLYRPKVLVAGTSAYCRLIDYKRMREIADKVGAYLVVDMAHISGLIAAQVIPTPFEYA
DIVTTTTHKSLRGPRGAMIFFRKGVRSVNPKTGAEVLYDLENPINFSVFPGHQGGPHNHTITALAVALKQAQTPEFVEYQ
KQVLKNAKALENKFKELGYNLVSNGTDSHMVLVSLRDKGIDGARVETVCEAMNIALNKNSIPGDKSALVPGGVRIGAPAM
TTRGLGEADFARVVEYIDRSIKFAIETQKNLPKEANKLKDFKAAIAKGSPELDQLKAEISEWVKEFPLPV

GO term prediction

Biological Process

GO:0006545 glycine biosynthetic process
GO:0035999 tetrahydrofolate interconversion

Molecular Function

GO:0003824 catalytic activity
GO:0004372 glycine hydroxymethyltransferase activity
GO:0030170 pyridoxal phosphate binding

Cellular Component

None predicted.