Protein
MIA_04819_1
Length
103 amino acids
Browser: contig06:1066375-1066687+
Protein function
| EGGNOG: | 0PPJQ | HHF1 | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling |
|---|---|---|---|
| SGD closest match: | S000000213 | HHF1 | Histone H4 |
| CGD closest match: | CAL0000174606 | HHF1 | Histone H4 |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| A0A0F7RQR5_GEOCN | 98.780% | 82 | 9.28e-54 | Histone H4 OS=Geotrichum candidum GN=BN980_GECA12s00461g PE=3 SV=1 |
| A0A167C9J8_9ASCO | 98.780% | 82 | 1.79e-53 | Histone H4 OS=Sugiyamaella lignohabitans GN=HHF2 PE=3 SV=1 |
| A0A1E3PL74_9ASCO | 98.780% | 82 | 1.82e-53 | Histone H4 OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_45731 PE=3 SV=1 |
| UniRef50_A0A0G2J4W8 | 97.561% | 82 | 1.43e-49 | Histone H4 n=5 Tax=leotiomyceta TaxID=716546 RepID=A0A0G2J4W8_9EURO |
| A0A060TAN3_BLAAD | 97.561% | 82 | 1.55e-52 | Histone H4 OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D28160g PE=3 SV=1 |
| H4_YEAST | 96.341% | 82 | 1.67e-52 | Histone H4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HHF1 PE=1 SV=2 |
| MCA_05132_1 | 96.341% | 82 | 1.09e-51 | MCA_05132_1 |
| Q6C0C5_YARLI | 96.341% | 82 | 1.10e-51 | Histone H4 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_C11385g PE=3 SV=1 |
| Q59VN4_CANAL | 93.902% | 82 | 1.05e-50 | Histone H4 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=HHF1 PE=3 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.9937
Predicted cleavage: 48
Protein family membership
- Histone H4 (IPR001951)
Domains and repeats
-
Domain
1
10
20
30
40
50
60
70
80
90
103
Detailed signature matches
no IPR
Unintegrated signatures
-
-
mobidb-lite (disord...)
Residue annotation
-
H4 interaction sit...
-
H2A interaction si...
-
DNA-binding site c...
-
H2B interaction si...
-
H2A-H2B docking si...
Protein sequence
>MIA_04819_1 MSGRGKGGKGLGKGGAKRHRKILRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKSFLESVIRDAVTYTEHAKRK TVTSLDVVYALKRQGRTLYGFGG
GO term prediction
Biological Process
GO:0006334 nucleosome assembly
Molecular Function
GO:0003677 DNA binding
GO:0046982 protein heterodimerization activity
Cellular Component
GO:0000786 nucleosome
GO:0005634 nucleus