Protein
MCA_05132_1
Length
103 amino acids
Gene name: HHF1
Description: Histone H4
Browser: contigD:435022-435334-
RNA-seq: read pairs 17227, FPKM 2046.7, percentile rank 97.8% (100% = highest expression)
Protein function
| Annotation: | HHF1 | Histone H4 | |
|---|---|---|---|
| KEGG: | K11254 | H4 | histone H4 |
| EGGNOG: | 0PPJQ | HHF1 | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling |
| SGD closest match: | S000000213 | HHF1 | Histone H4 |
| CGD closest match: | CAL0000174606 | HHF1 | Histone H4 |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| UniRef50_B4IQE1 | 95.12% | 82 | 3e-48 | Histone H4 (Fragment) n=29 Tax=root TaxID=1 RepID=B4IQE1_DROSE |
| A0A060T8R4_BLAAD | 96.34% | 82 | 3e-51 | Histone H4 OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D05390g PE=3 SV=1 |
| A0A0F7RQR5_GEOCN | 96.34% | 82 | 5e-51 | Histone H4 OS=Geotrichum candidum GN=BN980_GECA12s00461g PE=3 SV=1 |
| MIA_04819_1 | 96.34% | 82 | 1e-50 | MIA_04819_1 |
| A0A167C9J8_9ASCO | 95.12% | 82 | 4e-50 | Histone H4 OS=Sugiyamaella lignohabitans GN=HHF2 PE=3 SV=1 |
| A0A1E3PL74_9ASCO | 95.12% | 82 | 4e-50 | Histone H4 OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_45731 PE=3 SV=1 |
| Q59VN4_CANAL | 95.12% | 82 | 6e-50 | Histone H4 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=HHF1 PE=3 SV=1 |
| H4_YEAST | 93.90% | 82 | 5e-50 | Histone H4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HHF1 PE=1 SV=2 |
| Q6C0C5_YARLI | 93.90% | 82 | 1e-49 | Histone H4 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_C11385g PE=3 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.9932
Predicted cleavage: 48
Protein family membership
- Histone H4 (IPR001951)
Domains and repeats
-
Domain
1
10
20
30
40
50
60
70
80
90
103
Detailed signature matches
no IPR
Unintegrated signatures
Residue annotation
-
H4 interaction sit...
-
H2A interaction si...
-
DNA-binding site c...
-
H2B interaction si...
-
H2A-H2B docking si...
Protein sequence
>MCA_05132_1 MSGRGKGGKGLGKGGAKRHRKILRDNIQGITKPAIRRLARRGGVKRISGLIYEETRSVLKVFLENVIRDAVTYTEHAKRK TVTSLDVVYALKRQGRTLYGFGG
GO term prediction
Biological Process
GO:0006334 nucleosome assembly
Molecular Function
GO:0003677 DNA binding
GO:0046982 protein heterodimerization activity
Cellular Component
GO:0000786 nucleosome
GO:0005634 nucleus