Protein

MIA_04817_1

Length
308 amino acids

Browser: contig06:1063595-1064522-

Protein function

EGGNOG:0PH4DCFD1Component of the cytosolic iron-sulfur (Fe S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins
SGD closest match:S000001265CFD1Cytosolic Fe-S cluster assembly factor CFD1
CGD closest match:CAL0000176016CFD1Cytosolic Fe-S cluster assembly factor CFD1

Protein alignments

%idAln lengthE-value
A0A0J9XFS0_GEOCN76.491%2854.11e-149Cytosolic Fe-S cluster assembly factor CFD1 OS=Geotrichum candidum GN=CFD1 PE=3 SV=1
MCA_05134_165.569%3341.03e-135MCA_05134_1
A0A060TBI4_BLAAD71.174%2812.58e-131Cytosolic Fe-S cluster assembly factor CFD1 OS=Blastobotrys adeninivorans GN=CFD1 PE=3 SV=1
A0A170QZV9_9ASCO71.378%2839.63e-130Cytosolic Fe-S cluster assembly factor CFD1 OS=Sugiyamaella lignohabitans GN=CFD1 PE=3 SV=1
A0A1E3PGJ7_9ASCO69.611%2835.86e-129Cytosolic Fe-S cluster assembly factor CFD1 OS=Nadsonia fulvescens var. elongata DSM 6958 GN=CFD1 PE=3 SV=1
CFD1_YARLI71.849%2386.60e-115Cytosolic Fe-S cluster assembly factor CFD1 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=CFD1 PE=3 SV=1
CFD1_YEAST61.071%2806.70e-114Cytosolic Fe-S cluster assembly factor CFD1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CFD1 PE=1 SV=1
UniRef50_P4055861.071%2801.60e-110Cytosolic Fe-S cluster assembly factor CFD1 n=261 Tax=cellular organisms TaxID=131567 RepID=CFD1_YEAST
CFD1_CANAL61.379%2901.45e-113Cytosolic Fe-S cluster assembly factor CFD1 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=CFD1 PE=3 SV=1
A0A1E4TIV1_9ASCO63.509%2851.52e-111Cytosolic Fe-S cluster assembly factor CFD1 OS=Tortispora caseinolytica NRRL Y-17796 GN=CFD1 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0549

Protein family membership

Domains and repeats

  1. Domain
1 50 100 150 200 250 308

Detailed signature matches

  1. Family IPR033756
    Flagellum site-determining protein YlxH/ Fe-S cluster assembling factor NBP35
    1. PF10609 (ParA)
  2. Family IPR019591
    Mrp/NBP35 ATP-binding protein
    1. MF_02040 (Mrp_NBP35)
    2. cd02037 (MRP-like)
  3. Family IPR028600
    Cytosolic Fe-S cluster assembly factor NUBP2/Cfd1, eukaryotes
    1. MF_03039 (NUBP2)
  4. Domain IPR027417
    P-loop containing nucleoside triphosphate hydrolase
    1. SSF52540 (P-loop co...)
  5. SITE IPR000808
    Mrp, conserved site
    1. PS01215 (MRP)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.40.50...
  2. cd01983 (Fer4_NifH)

Residue annotation

  1. Walker A motif cd0...

Protein sequence

>MIA_04817_1
MNAIPDDLPSLKSVKHIILVLSGKGGVGKSSVTTQLALTLVAKNYKVGVLDIDLTGPSAPRMFGLEGRQVHQSVAGWVPV
YAQPPSAGSGSLAVMSLGFLLQQRGDAVVWRGPKKTAMIRQLLTDMVWGDLDYLLIDTPPGTSDEHISVAEALKNAANPD
GAVLVTTPQGIATADVRKELSFCRKVGFNVLGVVENMSGYVCPHCSECSNIFSSGGGLKLAQQFNLPFLGSVPIDPQFVL
MIESQKSNKIGKDDEPHSHADEPSLVQKYKDTSALYPIFSTIVDKLVQQIKNDDTDALDISQVDINKP

GO term prediction

Biological Process

GO:0016226 iron-sulfur cluster assembly

Molecular Function

GO:0005524 ATP binding
GO:0051539 4 iron, 4 sulfur cluster binding

Cellular Component

None predicted.