Protein

MCA_05134_1

Length
370 amino acids

Gene name: CFD1

Description: Cytosolic Fe-S cluster assembly factor CFD1

Browser: contigD:437151-438264+

RNA-seq: read pairs 539, FPKM 18.0, percentile rank 38.4% (100% = highest expression)

Protein function

Annotation:CFD1Cytosolic Fe-S cluster assembly factor CFD1
EGGNOG:0PH4DCFD1Component of the cytosolic iron-sulfur (Fe S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins
SGD closest match:S000001265CFD1Cytosolic Fe-S cluster assembly factor CFD1
CGD closest match:CAL0000176016CFD1Cytosolic Fe-S cluster assembly factor CFD1

Protein alignments

%idAln lengthE-value
MIA_04817_165.68%3381e-125MIA_04817_1
A0A0J9XFS0_GEOCN61.76%3406e-114Cytosolic Fe-S cluster assembly factor CFD1 OS=Geotrichum candidum GN=CFD1 PE=3 SV=1
A0A060TBI4_BLAAD56.39%3212e-101Cytosolic Fe-S cluster assembly factor CFD1 OS=Blastobotrys adeninivorans GN=CFD1 PE=3 SV=1
A0A1E3PGJ7_9ASCO55.70%2981e-100Cytosolic Fe-S cluster assembly factor CFD1 OS=Nadsonia fulvescens var. elongata DSM 6958 GN=CFD1 PE=3 SV=1
A0A170QZV9_9ASCO55.22%2973e-99Cytosolic Fe-S cluster assembly factor CFD1 OS=Sugiyamaella lignohabitans GN=CFD1 PE=3 SV=1
CFD1_YARLI59.02%2447e-93Cytosolic Fe-S cluster assembly factor CFD1 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=CFD1 PE=3 SV=1
UniRef50_Q6FPP752.72%2944e-88Cytosolic Fe-S cluster assembly factor CFD1 n=135 Tax=Eukaryota TaxID=2759 RepID=CFD1_CANGA
CFD1_CANAL49.67%3004e-90Cytosolic Fe-S cluster assembly factor CFD1 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=CFD1 PE=3 SV=1
CFD1_YEAST49.34%3024e-88Cytosolic Fe-S cluster assembly factor CFD1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CFD1 PE=1 SV=1
A0A1E4TIV1_9ASCO51.00%3002e-88Cytosolic Fe-S cluster assembly factor CFD1 OS=Tortispora caseinolytica NRRL Y-17796 GN=CFD1 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0466

Protein family membership

Domains and repeats

  1. Domain
1 50 100 150 200 250 300 370

Detailed signature matches

  1. Family IPR033756
    Flagellum site-determining protein YlxH/ Fe-S cluster assembling factor NBP35
    1. PF10609 (ParA)
  2. Family IPR019591
    Mrp/NBP35 ATP-binding protein
    1. MF_02040 (Mrp_NBP35)
    2. cd02037 (MRP-like)
  3. Family IPR028600
    Cytosolic Fe-S cluster assembly factor NUBP2/Cfd1, eukaryotes
    1. MF_03039 (NUBP2)
  4. Domain IPR027417
    P-loop containing nucleoside triphosphate hydrolase
    1. SSF52540 (P-loop co...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.40.50...
  2. mobidb-lite (disord...)

Residue annotation

  1. Walker A motif cd0...

Protein sequence

>MCA_05134_1
MNSIPDSLPSLDSVKHVVLVLSGKGGVGKSSVTTQLALTLVAKYNYNVGVLDIDLTGPSAPRMFGLEGRQVHQSTAGWIP
VYVKLPSGSSLKDESIESPSNTPKKKTGSLAVMSLGFLLENRGDAVVWRGPKKTAMIRQLLTEMVWAKDLDYLLIDTPPG
TSDEHISIAECLLQRTVSNNHASADGAPFRDGAVLVTTPQGVATADVRKELSFCRKVGFNVLGVIENMSGFMCPHCTDVH
YIFGKDGGLNLAKQFDLKMLGSVPIDPRFVLMIEQQQQDNNNDDNGNEERNNEISTKEKKSDDTLVEKYSKESSLYPIFQ
DIVQKLISQFDDSPESPSVNQFQNGQNNQETETSLTSTSLEKDLSSVNIS

GO term prediction

Biological Process

GO:0016226 iron-sulfur cluster assembly

Molecular Function

GO:0051539 4 iron, 4 sulfur cluster binding

Cellular Component

None predicted.