Protein

MIA_04776_1

Length
845 amino acids

Browser: contig06:962851-965449-

Protein function

EGGNOG:0PH9TMLH1DNA mismatch repair protein
SGD closest match:S000004777MLH1DNA mismatch repair protein MLH1
CGD closest match:CAL0000200670MLH1Mismatch repair ATPase

Protein alignments

%idAln lengthE-value
MCA_04976_152.381%8820.0MCA_04976_1
A0A0J9X465_GEOCN46.382%8430.0Similar to Saccharomyces cerevisiae YMR167W MLH1 Protein required for mismatch repair in mitosis and meiosis as well as crossing over during meiosis OS=Geotrichum candidum GN=BN980_GECA02s07105g PE=4 SV=1
UniRef50_A0A0J9X46546.382%8430.0Similar to Saccharomyces cerevisiae YMR167W MLH1 Protein required for mismatch repair in mitosis and meiosis as well as crossing over during meiosis n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9X465_GEOCN
A0A167E383_9ASCO42.541%8580.0Mismatch repair ATPase MLH1 OS=Sugiyamaella lignohabitans GN=MLH1 PE=4 SV=1
MLH1_YEAST41.274%8480.0DNA mismatch repair protein MLH1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MLH1 PE=1 SV=2
A0A060TCK7_BLAAD40.238%8400.0ARAD1B17160p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B17160g PE=4 SV=1
Q59SL0_CANAL41.005%8560.0Mismatch repair ATPase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=MLH1 PE=4 SV=1
A0A1E3PP95_9ASCO57.778%4501.38e-153DNA mismatch repair protein MutL OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_49690 PE=4 SV=1
A0A1E4TDN3_9ASCO45.958%4331.08e-115Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_147756 PE=4 SV=1
Q6CCE6_YARLI30.742%8495.05e-107YALI0C10032p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_C10032g PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.1498

Protein family membership

Domains and repeats

  1. Domain
1 100 200 300 400 500 600 700 845

Detailed signature matches

  1. Family IPR002099
    DNA mismatch repair protein family
    1. TIGR00585
  2. Domain IPR003594
    Histidine kinase-like ATPase, C-terminal domain
    1. G3DSA:3.30.56...
    2. SSF55874 (ATPase do...)
  3. Domain IPR020568
    Ribosomal protein S5 domain 2-type fold
    1. SSF54211 (Ribosomal...)
  4. Domain IPR014721
    Ribosomal protein S5 domain 2-type fold, subgroup
    1. G3DSA:3.30.23...
  5. Domain IPR013507
    DNA mismatch repair protein, C-terminal
    1. SM01340 (DNA_mis_re...)
    2. PF01119 (DNA_mis_re...)
  6. Domain IPR032189
    DNA mismatch repair protein Mlh1, C-terminal
    1. PF16413 (Mlh1_C)
  7. SITE IPR014762
    DNA mismatch repair, conserved site
    1. PS00058 (DNA_MISMAT...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. PF13589 (HATPase_c_3)
  2. cd00075 (HATPase_c)
  3. mobidb-lite (disord...)

Residue annotation

  1. ATP binding site c...
  2. Mg2+ binding site ...
  3. G-X-G motif cd00075

Protein sequence

>MIA_04776_1
MASSSGEKSVLEPARIKPLEELVVNRIAAGEIIIAPANALKEMLENSIDAGSTSIDILVKDGGLKLLQIVDNGSGINKDD
LPILCQRFTTSKLREFEDLSRLTTYGFRGEALSSISHIAHLTVTTKTRDSPCAWKQSYNNGKPSTENPTPTAGKNGTMMI
VEDLFYNVPSRRRVFKSSSEEYGKVLDVIGRYAIHCTQASFSCKKYGDSHPSLIVSASTAAMSSKKKAPQVDRIRQVYGS
SIANELIEINIPPKPEYGFLGGKGQITSANYSAKKSISPVFFINNRSVASDPLRRALLQGVYGQYLPKGGHAFVYLALDF
DTRNLDVNIHPTKREVRFLYEDEIIDHICTSFQEVLAAQSSSRTFQTQTVFASSGVARDKLDGTSGVDFALGKRTRSVLG
ESQLEIVENNNSTENLSVFSQPQAKKRQENKLVRTDSQQQRLPTLFREAMHQSDSIKSRTTKNADINEDDVILEEESSFG
IPKSQDSSEDNEKNETEGTRPSTAESDQIKEILSKLQSKSGGYNGSKMRYVDRSRVDVRLRSVKELKKEIEENVHSSLTQ
VLSEHTYIGVVDYRRRLAAFQHKVQMFIVDYGILSQAIFYQSALTEFSNLGTITLYEGGDENNDPNETRVEQEDTNNGEC
GIKISDLLDRETTTYDVNHIKSLWNMREMLSEYFSIKFTKGENSHGSENKNDDAEESEEEDEDSVEEFWNGRIETLPMII
KGYSPPIIKLPVFLDQLLTRVTFDDEKECFRGILQELARFYAPEPVLDDHEKVPSKNNEEEDDDGDEDEESVIEYRAERR
LQIADSLEHYIFPAVKQRLLAPRGLLKDVVEIANLPGLYKVFERC

GO term prediction

Biological Process

GO:0006298 mismatch repair

Molecular Function

GO:0005524 ATP binding
GO:0030983 mismatched DNA binding

Cellular Component

None predicted.