Protein
MCA_04976_1
Length
820 amino acids
Gene name: MLH1
Description: DNA mismatch repair protein MLH1
Browser: contigD:12814-15331+
RNA-seq: read pairs 695, FPKM 10.5, percentile rank 26.7% (100% = highest expression)
Protein function
| Annotation: | MLH1 | DNA mismatch repair protein MLH1 | |
|---|---|---|---|
| KEGG: | K08734 | MLH1 | DNA mismatch repair protein MLH1 |
| EGGNOG: | 0PH9T | MLH1 | DNA mismatch repair protein |
| SGD closest match: | S000004777 | MLH1 | DNA mismatch repair protein MLH1 |
| CGD closest match: | CAL0000200670 | MLH1 | Mismatch repair ATPase |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| MIA_04776_1 | 51.97% | 889 | 0.0 | MIA_04776_1 |
| A0A0J9X465_GEOCN | 50.63% | 630 | 0.0 | Similar to Saccharomyces cerevisiae YMR167W MLH1 Protein required for mismatch repair in mitosis and meiosis as well as crossing over during meiosis OS=Geotrichum candidum GN=BN980_GECA02s07105g PE=4 SV=1 |
| UniRef50_A0A0J9X465 | 50.63% | 630 | 0.0 | Similar to Saccharomyces cerevisiae YMR167W MLH1 Protein required for mismatch repair in mitosis and meiosis as well as crossing over during meiosis n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9X465_GEOCN |
| A0A1E3PP95_9ASCO | 46.36% | 686 | 0.0 | DNA mismatch repair protein MutL OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_49690 PE=4 SV=1 |
| A0A167E383_9ASCO | 44.19% | 645 | 5e-170 | Mismatch repair ATPase MLH1 OS=Sugiyamaella lignohabitans GN=MLH1 PE=4 SV=1 |
| A0A060TCK7_BLAAD | 44.82% | 627 | 4e-164 | ARAD1B17160p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B17160g PE=4 SV=1 |
| Q59SL0_CANAL | 45.44% | 647 | 1e-162 | Mismatch repair ATPase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=MLH1 PE=4 SV=1 |
| MLH1_YEAST | 43.29% | 656 | 5e-161 | DNA mismatch repair protein MLH1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MLH1 PE=1 SV=2 |
| A0A1E4TDN3_9ASCO | 39.20% | 625 | 2e-139 | Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_147756 PE=4 SV=1 |
| Q6CCE6_YARLI | 36.23% | 632 | 2e-108 | YALI0C10032p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_C10032g PE=4 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.3773
Protein family membership
- DNA mismatch repair protein family (IPR002099)
Domains and repeats
-
Domain
1
100
200
300
400
500
600
700
820
Detailed signature matches
no IPR
Unintegrated signatures
-
PF13589 (HATPase_c_3)
-
cd00075 (HATPase_c)
-
mobidb-lite (disord...)
Residue annotation
-
ATP binding site c...
-
Mg2+ binding site ...
-
G-X-G motif cd00075
Protein sequence
>MCA_04976_1 MTSPARIKPLSETVINKIAAGEIIIAPANALKEMLENSIDAGSTSIEILVKDGGLKLLQITDNGSGILKEDLPILCERFT TSKITKFEDLSNINTYGFRGEALASISHIAHLTVTTKSKTSPCAWRQTYQNGKPLNKDPAPTAGKNGTIILVEDLFYNVP SRRKAFKSTSEEFGKILDVVGKYAIHCTNVAFSCKKHGDSHASLVISANATNNSKKKPEVDRIRQVYGSSIANELISVDI PPKPEYGFLGGQGQITSANYNDKKSIAPVFFINHRSVASNPLRRAIMQGVYSRHLSKGGHAFVYLSLEFDPRNLDVNVHP TKREVRFLYEEEIIDHVCASLQEVLVSQGSSRTFQTQSVFAPSGFASNSSVKGLETAKSGTNSEFTLSQKTEVKKPYEYK MVRTDATQEKLTSMFLEGDRRSALATRSSKEDSTEGDTYIVDYKDVQSHETENLNPPSSIADINYDTEAALYTKTPLETM DLRERTDVRLKSIRILKQRLEEHSNEQLTRVFSEHTFIGVVDHRRRLCTFQYGVKIYMVDYGQLCKHFFYQCVLAEFSNM GKITLQTQSRNNQSASTQIDGNTGISVKDILNENEVKNYPKSQLQKFLVMKEMLEEYFGLKVSVYPEKVIPNNSKTTKED VPHDNKDNGGISNPTENLKNAPHQSTSPATKIRDTKELGDTSHGISEPNKDEEISEYRTFMNSRIETLPMIIKNFIPPIS KLGLFLESMILNVNYDDELECFEGVAKELAKFYIPEPILEDDNDTEANEIRKLRRQEISNDLEHLIFPAIKHRFLAPEVM TKDVVEIANLPGLYKVFERC
GO term prediction
Biological Process
GO:0006298 mismatch repair
Molecular Function
GO:0005524 ATP binding
GO:0030983 mismatched DNA binding
Cellular Component
None predicted.