Protein

MIA_04745_1

Length
345 amino acids

Browser: contig06:878732-879770-

Protein function

EGGNOG:0PJT2GRE2NADPH-dependent methylglyoxal reductase GRE2
SGD closest match:S000002949YDR541CPutative uncharacterized oxidoreductase YDR541C
CGD closest match:CAL0000179051orf19.5611Methylglyoxal reductase (NADPH-dependent)

Protein alignments

%idAln lengthE-value
MCA_05106_160.057%3481.75e-153MCA_05106_1
A0A0J9XCC0_GEOCN58.187%3425.56e-141Similar to Saccharomyces cerevisiae YGL157W ARI1 NADPH-dependent aldehyde reductase OS=Geotrichum candidum GN=BN980_GECA07s05433g PE=4 SV=1
UniRef50_A0A0J9XB2257.143%3431.40e-132Similar to Saccharomyces cerevisiae YGL157W ARI1 NADPH-dependent aldehyde reductase n=2 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XB22_GEOCN
A0A167C177_9ASCO46.199%3426.94e-98Carbonyl reductase (NADPH-dependent) OS=Sugiyamaella lignohabitans GN=AWJ20_3889 PE=4 SV=1
A0A060T4V0_BLAAD45.266%3382.94e-92ARAD1B02860p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B02860g PE=4 SV=1
Q6C9S0_YARLI45.672%3351.88e-89YALI0D08844p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D08844g PE=4 SV=1
Q5ABT9_CANAL44.311%3341.08e-88Methylglyoxal reductase (NADPH-dependent) OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.5611 PE=4 SV=1
A0A1E3PSR4_9ASCO42.899%3456.77e-88Putative NADPH-dependent methylglyoxal reductase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_45022 PE=4 SV=1
YD541_YEAST45.773%3431.27e-87Putative uncharacterized oxidoreductase YDR541C OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YDR541C PE=3 SV=2
A0A1E4T9D1_9ASCO44.348%3457.97e-81Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_4495 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.3970
Predicted cleavage: 39

Protein family membership

None predicted.

Domains and repeats

  1. Domain
1 50 100 150 200 250 300 345

Detailed signature matches

  1. Domain IPR016040
    NAD(P)-binding domain
    1. SSF51735 (NAD(P)-bi...)
  2. Domain IPR001509
    NAD-dependent epimerase/dehydratase
    1. PF01370 (Epimerase)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.40.50...
  2. G3DSA:3.90.25.10
  3. cd05227 (AR_SDR_e)

Residue annotation

  1. NADP binding site ...
  2. putative substrate...
  3. active site cd05227

Protein sequence

>MIA_04745_1
MTTKHNKVLLTGATGFIAIHTLKLLLERGYTVKATVRSQAKGQYLLDKFPGQPIELAIVEDIRVPGAFDKTLEEDKEITA
VLHTASPFFAAKEDPVNELLIPALEGTKNILKAIKKHAPQVTSVVITSSFAAILDPSKLADHNTVFSESSWSPITWEQAS
TDLSTSYRGSKTFAEKEFWRFIKEEGVNFTGTTVNPPAVFGPVLQEVRSVEALNTSNELLYHGVFNAKEDTDFSAHPHIW
VDVRDVALAHILPLEKPELESKRLFVTPGFFSLQLVLDIVNKNFPELVGKIPVGKPGTGLSKVPEVYQIDNHVTNELLGI
KYHTLEESVKDTFETLIDLKNRLDK

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0003824 catalytic activity
GO:0050662 coenzyme binding

Cellular Component

None predicted.