MIA_04716_1

Protein

Length

1,921 amino acids

Protein function

EGGNOG:	0PFHT	PGUG_02184	structural maintenance of chromosomes protein
SGD closest match:	S000004076	SMC4	Structural maintenance of chromosomes protein 4
CGD closest match:	CAL0000183293	SMC4	Structural maintenance of chromosomes protein

Protein alignments

	%id	Aln length
A0A0J9X9N6_GEOCN	54.277%	1321	Similar to Saccharomyces cerevisiae YLR086W SMC4 Subunit of the condensin complex OS=Geotrichum candidum GN=BN980_GECA05s03002g PE=4 SV=1
MCA_04986_1	53.641%	1277	MCA_04986_1
A0A060T4P0_BLAAD	50.304%	1314	Structural maintenance of chromosomes protein OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B04840g PE=3 SV=1
UniRef50_A0A0J9X9E0	50.435%	1263	Structural maintenance of chromosomes protein n=3 Tax=Saccharomycetales TaxID=4892 RepID=A0A0J9X9E0_GEOCN
A0A1E3PJ65_9ASCO	50.492%	1220	Structural maintenance of chromosomes protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_25651 PE=3 SV=1
A0A161HLS3_9ASCO	49.749%	1194	Structural maintenance of chromosomes protein OS=Sugiyamaella lignohabitans GN=SMC4 PE=3 SV=1
Q6CBG2_YARLI	47.631%	1245	YALI0C19129p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_C19129g PE=4 SV=1
Q5A4Y2_CANAL	46.486%	1252	Structural maintenance of chromosomes protein OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=SMC4 PE=3 SV=1
SMC4_YEAST	39.896%	1341	Structural maintenance of chromosomes protein 4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SMC4 PE=1 SV=1
A0A1E4TCH7_9ASCO	41.525%	1233	Structural maintenance of chromosomes protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_28590 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.2981
Predicted cleavage: 17

Protein family membership

None predicted.

Domains and repeats

Domain
391 - 560
P-loop containing nucleoside triphosphate hydrolase (IPR027417)
880 - 1,081
SMCs flexible hinge (IPR010935)
1,489 - 1,590
P-loop containing nucleoside triphosphate hydrolase (IPR027417)
Domain
392 - 1,596
RecF/RecN/SMC, N-terminal (IPR003395)

1 200 400 600 800 1000 1200 1400 1600 1800 1921

Detailed signature matches

IPR027417

P-loop containing nucleoside triphosphate hydrolase
1. SSF52540 (P-loop co...)
  
  1,489 - 1,590
  
  SUPERFAMILY
  SSF52540 (P-loop containing nucleoside triphosphate hydrolases)
  
  391 - 560
  
  SUPERFAMILY
  SSF52540 (P-loop containing nucleoside triphosphate hydrolases)
IPR003395

RecF/RecN/SMC, N-terminal
1. PF02463 (SMC_N)
  
  392 - 1,596
  
  Pfam
  PF02463 (SMC_N)
IPR010935

SMCs flexible hinge
1. PF06470 (SMC_hinge)
  
  921 - 1,034
  
  Pfam
  PF06470 (SMC_hinge)
2. SM00968 (SMC_hinge_2)
  
  921 - 1,034
  
  SMART
  SM00968 (SMC_hinge_2)
3. SSF75553 (Smc hinge...)
  
  880 - 1,081
  
  SUPERFAMILY
  SSF75553 (Smc hinge domain)

no IPR

Unintegrated signatures

Coil

635 - 676

COILS
Coil (Coil)

1,160 - 1,194

COILS
Coil (Coil)

568 - 623

COILS
Coil (Coil)

800 - 827

COILS
Coil (Coil)

1,231 - 1,310

COILS
Coil (Coil)

870 - 897

COILS
Coil (Coil)

1,433 - 1,453

COILS
Coil (Coil)

89 - 128

COILS
Coil (Coil)

1,129 - 1,149

COILS
Coil (Coil)

740 - 792

COILS
Coil (Coil)

1,080 - 1,114

COILS
Coil (Coil)

1,203 - 1,223

COILS
Coil (Coil)

684 - 725

COILS
Coil (Coil)
G3DSA:1.10.28...

574 - 702

GENE3D
G3DSA:1.10.287.620 (G3DSA:1.10.287.620)
G3DSA:1.20.12...

790 - 913

GENE3D
G3DSA:1.20.120.330 (G3DSA:1.20.120.330)

1,063 - 1,213

GENE3D
G3DSA:1.20.120.330 (G3DSA:1.20.120.330)

1,214 - 1,344

GENE3D
G3DSA:1.20.120.330 (G3DSA:1.20.120.330)
G3DSA:1.20.5.170

703 - 789

GENE3D
G3DSA:1.20.5.170 (G3DSA:1.20.5.170)
G3DSA:3.40.50...

1,345 - 1,607

GENE3D
G3DSA:3.40.50.300 (G3DSA:3.40.50.300)

389 - 573

GENE3D
G3DSA:3.40.50.300 (G3DSA:3.40.50.300)
SSF57997 (Tropomyosin)

699 - 899

SUPERFAMILY
SSF57997 (Tropomyosin)
cd03274 (ABC_SMC4_euk)

390 - 550

CDD
cd03274 (ABC_SMC4_euk)

1,502 - 1,598

CDD
cd03274 (ABC_SMC4_euk)
mobidb-lite (disord...)

1,617 - 1,637

MobiDB Lite
mobidb-lite (disorder_prediction)

1,656 - 1,921

MobiDB Lite
mobidb-lite (disorder_prediction)

275 - 343

MobiDB Lite
mobidb-lite (disorder_prediction)

1,230 - 1,250

MobiDB Lite
mobidb-lite (disorder_prediction)

1 - 232

MobiDB Lite
mobidb-lite (disorder_prediction)

244 - 263

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

Walker A/P-loop cd...

421G

Walker A/P-loop
421G, 422P, 423N, 424G, 425S, 426G, 427K, 428S
CDD
cd03274 (ABC_SMC4_euk)

422P

Walker A/P-loop
421G, 422P, 423N, 424G, 425S, 426G, 427K, 428S
CDD
cd03274 (ABC_SMC4_euk)

423N

Walker A/P-loop
421G, 422P, 423N, 424G, 425S, 426G, 427K, 428S
CDD
cd03274 (ABC_SMC4_euk)

424G

Walker A/P-loop
421G, 422P, 423N, 424G, 425S, 426G, 427K, 428S
CDD
cd03274 (ABC_SMC4_euk)

425S

Walker A/P-loop
421G, 422P, 423N, 424G, 425S, 426G, 427K, 428S
CDD
cd03274 (ABC_SMC4_euk)

426G

Walker A/P-loop
421G, 422P, 423N, 424G, 425S, 426G, 427K, 428S
CDD
cd03274 (ABC_SMC4_euk)

427K

Walker A/P-loop
421G, 422P, 423N, 424G, 425S, 426G, 427K, 428S
CDD
cd03274 (ABC_SMC4_euk)

428S

Walker A/P-loop
421G, 422P, 423N, 424G, 425S, 426G, 427K, 428S
CDD
cd03274 (ABC_SMC4_euk)
ATP binding site c...

424G

ATP binding site
424G, 425S, 427K, 428S, 429N, 537Q
CDD
cd03274 (ABC_SMC4_euk)

425S

ATP binding site
424G, 425S, 427K, 428S, 429N, 537Q
CDD
cd03274 (ABC_SMC4_euk)

427K

ATP binding site
424G, 425S, 427K, 428S, 429N, 537Q
CDD
cd03274 (ABC_SMC4_euk)

428S

ATP binding site
424G, 425S, 427K, 428S, 429N, 537Q
CDD
cd03274 (ABC_SMC4_euk)

429N

ATP binding site
424G, 425S, 427K, 428S, 429N, 537Q
CDD
cd03274 (ABC_SMC4_euk)

537Q

ATP binding site
424G, 425S, 427K, 428S, 429N, 537Q
CDD
cd03274 (ABC_SMC4_euk)
Q-loop/lid cd03274

534L

Q-loop/lid
534L, 535I, 536L, 537Q
CDD
cd03274 (ABC_SMC4_euk)

535I

Q-loop/lid
534L, 535I, 536L, 537Q
CDD
cd03274 (ABC_SMC4_euk)

536L

Q-loop/lid
534L, 535I, 536L, 537Q
CDD
cd03274 (ABC_SMC4_euk)

537Q

Q-loop/lid
534L, 535I, 536L, 537Q
CDD
cd03274 (ABC_SMC4_euk)
ABC transporter si...

1,514L

ABC transporter signature motif
1,514L, 1,515S, 1,516G, 1,517G, 1,518E, 1,519K, 1,520T, 1,521L, 1,522S, 1,523S
CDD
cd03274 (ABC_SMC4_euk)

1,515S

ABC transporter signature motif
1,514L, 1,515S, 1,516G, 1,517G, 1,518E, 1,519K, 1,520T, 1,521L, 1,522S, 1,523S
CDD
cd03274 (ABC_SMC4_euk)

1,516G

ABC transporter signature motif
1,514L, 1,515S, 1,516G, 1,517G, 1,518E, 1,519K, 1,520T, 1,521L, 1,522S, 1,523S
CDD
cd03274 (ABC_SMC4_euk)

1,517G

ABC transporter signature motif
1,514L, 1,515S, 1,516G, 1,517G, 1,518E, 1,519K, 1,520T, 1,521L, 1,522S, 1,523S
CDD
cd03274 (ABC_SMC4_euk)

1,518E

ABC transporter signature motif
1,514L, 1,515S, 1,516G, 1,517G, 1,518E, 1,519K, 1,520T, 1,521L, 1,522S, 1,523S
CDD
cd03274 (ABC_SMC4_euk)

1,519K

ABC transporter signature motif
1,514L, 1,515S, 1,516G, 1,517G, 1,518E, 1,519K, 1,520T, 1,521L, 1,522S, 1,523S
CDD
cd03274 (ABC_SMC4_euk)

1,520T

ABC transporter signature motif
1,514L, 1,515S, 1,516G, 1,517G, 1,518E, 1,519K, 1,520T, 1,521L, 1,522S, 1,523S
CDD
cd03274 (ABC_SMC4_euk)

1,521L

ABC transporter signature motif
1,514L, 1,515S, 1,516G, 1,517G, 1,518E, 1,519K, 1,520T, 1,521L, 1,522S, 1,523S
CDD
cd03274 (ABC_SMC4_euk)

1,522S

ABC transporter signature motif
1,514L, 1,515S, 1,516G, 1,517G, 1,518E, 1,519K, 1,520T, 1,521L, 1,522S, 1,523S
CDD
cd03274 (ABC_SMC4_euk)

1,523S

ABC transporter signature motif
1,514L, 1,515S, 1,516G, 1,517G, 1,518E, 1,519K, 1,520T, 1,521L, 1,522S, 1,523S
CDD
cd03274 (ABC_SMC4_euk)
Walker B cd03274

1,538L

Walker B
1,538L, 1,539Y, 1,540V, 1,541M, 1,542D, 1,543E
CDD
cd03274 (ABC_SMC4_euk)

1,539Y

Walker B
1,538L, 1,539Y, 1,540V, 1,541M, 1,542D, 1,543E
CDD
cd03274 (ABC_SMC4_euk)

1,540V

Walker B
1,538L, 1,539Y, 1,540V, 1,541M, 1,542D, 1,543E
CDD
cd03274 (ABC_SMC4_euk)

1,541M

Walker B
1,538L, 1,539Y, 1,540V, 1,541M, 1,542D, 1,543E
CDD
cd03274 (ABC_SMC4_euk)

1,542D

Walker B
1,538L, 1,539Y, 1,540V, 1,541M, 1,542D, 1,543E
CDD
cd03274 (ABC_SMC4_euk)

1,543E

Walker B
1,538L, 1,539Y, 1,540V, 1,541M, 1,542D, 1,543E
CDD
cd03274 (ABC_SMC4_euk)
ATP binding site c...

1,542D

ATP binding site
1,542D, 1,543E, 1,574L
CDD
cd03274 (ABC_SMC4_euk)

1,543E

ATP binding site
1,542D, 1,543E, 1,574L
CDD
cd03274 (ABC_SMC4_euk)

1,574L

ATP binding site
1,542D, 1,543E, 1,574L
CDD
cd03274 (ABC_SMC4_euk)
D-loop cd03274

1,546A

D-loop
1,546A, 1,547A, 1,548L, 1,549D
CDD
cd03274 (ABC_SMC4_euk)

1,547A

D-loop
1,546A, 1,547A, 1,548L, 1,549D
CDD
cd03274 (ABC_SMC4_euk)

1,548L

D-loop
1,546A, 1,547A, 1,548L, 1,549D
CDD
cd03274 (ABC_SMC4_euk)

1,549D

D-loop
1,546A, 1,547A, 1,548L, 1,549D
CDD
cd03274 (ABC_SMC4_euk)
H-loop/switch regi...

1,570I

H-loop/switch region
1,570I, 1,571V, 1,572I, 1,573S, 1,574L, 1,575R, 1,576N
CDD
cd03274 (ABC_SMC4_euk)

1,571V

H-loop/switch region
1,570I, 1,571V, 1,572I, 1,573S, 1,574L, 1,575R, 1,576N
CDD
cd03274 (ABC_SMC4_euk)

1,572I

H-loop/switch region
1,570I, 1,571V, 1,572I, 1,573S, 1,574L, 1,575R, 1,576N
CDD
cd03274 (ABC_SMC4_euk)

1,573S

H-loop/switch region
1,570I, 1,571V, 1,572I, 1,573S, 1,574L, 1,575R, 1,576N
CDD
cd03274 (ABC_SMC4_euk)

1,574L

H-loop/switch region
1,570I, 1,571V, 1,572I, 1,573S, 1,574L, 1,575R, 1,576N
CDD
cd03274 (ABC_SMC4_euk)

1,575R

H-loop/switch region
1,570I, 1,571V, 1,572I, 1,573S, 1,574L, 1,575R, 1,576N
CDD
cd03274 (ABC_SMC4_euk)

1,576N

H-loop/switch region
1,570I, 1,571V, 1,572I, 1,573S, 1,574L, 1,575R, 1,576N
CDD
cd03274 (ABC_SMC4_euk)

Protein sequence

>MIA_04716_1
MPRKTRRRIQVSDDESDESSFSAADLSVAKDAGDATAMASRRQTRSTRRVQKRQASNSPVNPRQRVKPSTSDDDQDSDDD
HDSDESVEKEDDEDDDDEEEDEEESEEEEEEEKKNKENTEEKDQADEEKNVNNSNNLKDSDDDHSKETIDPDEEPAKSSK
KLENQQPNVPSTPNASHSLENIPAHLRSPTAETPAPQSTASQNPTPTADVSGNDSFLINPVAGSTPNALSTPIGLAASDI
VNSSTPDTPVHPVQKDLMPPPSRSILNLTEATALRPDTPLEPNSSQPPSSQTSPRKPTSSSSSNMGPPPSTPSSRHNSAP
KTPHHPSLSGELPDFASRGSVSHREPMASFRLQNTNVATLVPISPSKTRLRALEAEKKASMLHLAKVPRLVISKLVLNNF
KSYAGVQEIGPFDNSFSAVVGPNGSGKSNVIDSLLFVFGFRASKLRQGKVSGLIHNSKAQPNVSSCKVEIHFKEIVESDD
GGSQDVPNSVLVVARAAYKNNKSEYFINGRASTYTEVTTLMRQRGIDLDHKRFLILQGEVESISQMKPKAENDNDDGLLE
YLEDIIGTSDHKKAIEEAENDLTLLTEDCDAKTSRFEIVKKDIEKLQDKRDEVVRNMRLENELTMKRSLFYQVNIRRLEA
SITSHTEDLEKSTAQLEKDREESREIREEIVHLEEQVKTDGEALSELRKQHQKLSKNLSRHEIQKVQVEEKAKHLTAKQK
KLEKQIVTSQRSFNEADSWIKNYDEQAEEFRARSHQLEKDLETKQEEYNEVQESLKGKTENITKEISKLQQELAPWREKI
AAKEADIAIAQSEIDIINEKHENAKKSLKRSKQHVATIVKEGEQKEQRLVELEQSLVYVTDQISKGTVEVEEAAVKIKKM
KEELDEFRTRYQVAKESVSSAKSLGAVLTSLTNLSSSGRIEGFNGRLGSLGTIDQKYDVAISTACPALDNLVVDTVDVGE
ECVKYLRKNNIGRAKFILLDKLPKRNLKPIRTPEDVPRLFDLITPKESRFAPAFYSVLFDTLVAKDVEQARRIAYGAHRF
RVVTLNGVVIDTSGTMSGGGRPSQGRMKSQLEAIVTPQEMTQLEEEHSEREAKYARAENAFQKINNALRDYNRQKPQIEL
EISKGKLDIESLKGVFEEAEREYAEMKNNIIGTIPSAEDLEKAQEKKSNLEKELAQIQENSADLEKRISDLREKIMEIGG
VKLRFLKSQIDDIKNEMEMISSRTSSQVLERTKKENERKKHTRAMESARSEIEAARNEVLASEQELEQHRAEVSQLEDEV
ETTRVAILEKEDALNELKKTTKEKRELVDKTLSAEIELVNSIEHLQKALRGFRHSLKCTNEEFGKLTLHAVHQIPQVNTR
EDNEEDAENDEKEEDYVEIVRYSSEELGDVNPLDVEREIKTLESKLEDVVIDSSIIHDYIRRAKEYNNRRTELAEVTTQR
EAKKRRCENLHKQRLEEFLEGFNLISLKLKEMYQMITMGGNAELELVDSLDPFSEGILFSVMPPKKSWKNISNLSGGEKT
LSSLALVFALHHYKPTPLYVMDEIDAALDFRNVSIVANYIRERTKNGQFIVISLRNNMFELASQLVGIYKVNNMTKSVAI
KNKDQPPERSSLQIQQQIRSTTFSASQPSQAQLDRRSTVGSMYGSVYSQMSDQNARHMSVGLSTATSSRQSSMAPGEGSS
RHESTAPTGPAPSLATKQGSHVTPMTVLPDDDKQEKDKAAEPEKTNEKENVDDDSTTSGSEDEESEDEDGESDKENVIAP
KKTVKKKVEESSDSSDEEQEEDKSESDEEKVSAPNKVKNKVEESLEKPDDKEDEDVDQKDTETQSKEESESESSDSSDSD
SDDDSIEIVSSFKHETPQKAAKASFNESSDEEKKPKQSRILRKRPQRRGSAPTGGTKKKIKKEESSSDEEDSDRDSDSDD
E

GO term prediction

Biological Process

GO:0051276 chromosome organization

Molecular Function

GO:0005515 protein binding
GO:0005524 ATP binding

Cellular Component

GO:0005694 chromosome

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Entry type

Status

Per-residue features