MCA_04986_1

Protein

Length

1,495 amino acids

Gene name: SMC4

Description: Structural maintenance of chromosomes protein 4

Browser: contigD:33546-38158+

RNA-seq: read pairs 986, FPKM 8.1, percentile rank 22.7% (100% = highest expression)

Protein function

Annotation:		SMC4	Structural maintenance of chromosomes protein 4
KEGG:	K06675	SMC4	structural maintenance of chromosome 4
EGGNOG:	0PFHT	PGUG_02184	structural maintenance of chromosomes protein
SGD closest match:	S000004076	SMC4	Structural maintenance of chromosomes protein 4
CGD closest match:	CAL0000183293	SMC4	Structural maintenance of chromosomes protein

Protein alignments

	%id	Aln length
MIA_04716_1	53.24%	1279	MIA_04716_1
A0A0J9X9N6_GEOCN	51.80%	1280	Similar to Saccharomyces cerevisiae YLR086W SMC4 Subunit of the condensin complex OS=Geotrichum candidum GN=BN980_GECA05s03002g PE=4 SV=1
A0A060T4P0_BLAAD	49.17%	1320	Structural maintenance of chromosomes protein OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B04840g PE=3 SV=1
UniRef50_A0A0J9X9E0	46.89%	1288	Structural maintenance of chromosomes protein n=3 Tax=Saccharomycetales TaxID=4892 RepID=A0A0J9X9E0_GEOCN
A0A161HLS3_9ASCO	47.93%	1208	Structural maintenance of chromosomes protein OS=Sugiyamaella lignohabitans GN=SMC4 PE=3 SV=1
A0A1E3PJ65_9ASCO	45.79%	1260	Structural maintenance of chromosomes protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_25651 PE=3 SV=1
Q6CBG2_YARLI	44.79%	1268	YALI0C19129p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_C19129g PE=4 SV=1
Q5A4Y2_CANAL	42.00%	1281	Structural maintenance of chromosomes protein OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=SMC4 PE=3 SV=1
SMC4_YEAST	40.92%	1288	Structural maintenance of chromosomes protein 4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SMC4 PE=1 SV=1
A0A1E4TCH7_9ASCO	41.66%	1265	Structural maintenance of chromosomes protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_28590 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0421

Protein family membership

Structural maintenance of chromosomes protein (IPR024704)

Domains and repeats

Domain
248 - 473
P-loop containing nucleoside triphosphate hydrolase (IPR027417)
916 - 1,051
P-loop containing nucleoside triphosphate hydrolase (IPR027417)
1,278 - 1,489
P-loop containing nucleoside triphosphate hydrolase (IPR027417)
Domain
250 - 1,487
RecF/RecN/SMC, N-terminal (IPR003395)
Domain
739 - 928
SMCs flexible hinge (IPR010935)

1 200 400 600 800 1000 1200 1495

Detailed signature matches

IPR024704

Structural maintenance of chromosomes protein
1. PIRSF005719 (SMC)
  
  247 - 1,495
  
  PIRSF
  PIRSF005719 (SMC)
IPR027417

P-loop containing nucleoside triphosphate hydrolase
1. SSF52540 (P-loop co...)
  
  1,278 - 1,489
  
  SUPERFAMILY
  SSF52540 (P-loop containing nucleoside triphosphate hydrolases)
  
  252 - 300
  
  SUPERFAMILY
  SSF52540 (P-loop containing nucleoside triphosphate hydrolases)
  
  916 - 1,051
  
  SUPERFAMILY
  SSF52540 (P-loop containing nucleoside triphosphate hydrolases)
  
  248 - 473
  
  SUPERFAMILY
  SSF52540 (P-loop containing nucleoside triphosphate hydrolases)
  
  1,394 - 1,480
  
  SUPERFAMILY
  SSF52540 (P-loop containing nucleoside triphosphate hydrolases)
IPR003395

RecF/RecN/SMC, N-terminal
1. PF02463 (SMC_N)
  
  250 - 1,487
  
  Pfam
  PF02463 (SMC_N)
IPR010935

SMCs flexible hinge
1. PF06470 (SMC_hinge)
  
  780 - 894
  
  Pfam
  PF06470 (SMC_hinge)
2. SM00968 (SMC_hinge_2)
  
  780 - 894
  
  SMART
  SM00968 (SMC_hinge_2)
3. SSF75553 (Smc hinge...)
  
  739 - 928
  
  SUPERFAMILY
  SSF75553 (Smc hinge domain)

no IPR

Unintegrated signatures

Coil

564 - 584

COILS
Coil (Coil)

948 - 1,021

COILS
Coil (Coil)

1,028 - 1,062

COILS
Coil (Coil)

1,186 - 1,217

COILS
Coil (Coil)

673 - 700

COILS
Coil (Coil)

1,099 - 1,168

COILS
Coil (Coil)

606 - 640

COILS
Coil (Coil)

427 - 468

COILS
Coil (Coil)

708 - 756

COILS
Coil (Coil)

1,284 - 1,304

COILS
Coil (Coil)

1,308 - 1,345

COILS
Coil (Coil)

494 - 514

COILS
Coil (Coil)

1,071 - 1,091

COILS
Coil (Coil)
G3DSA:1.20.5.170

564 - 657

GENE3D
G3DSA:1.20.5.170 (G3DSA:1.20.5.170)

938 - 1,021

GENE3D
G3DSA:1.20.5.170 (G3DSA:1.20.5.170)
G3DSA:1.20.5.340

1,117 - 1,217

GENE3D
G3DSA:1.20.5.340 (G3DSA:1.20.5.340)

431 - 561

GENE3D
G3DSA:1.20.5.340 (G3DSA:1.20.5.340)

1,023 - 1,116

GENE3D
G3DSA:1.20.5.340 (G3DSA:1.20.5.340)

658 - 772

GENE3D
G3DSA:1.20.5.340 (G3DSA:1.20.5.340)
G3DSA:3.40.50...

247 - 430

GENE3D
G3DSA:3.40.50.300 (G3DSA:3.40.50.300)

1,218 - 1,495

GENE3D
G3DSA:3.40.50.300 (G3DSA:3.40.50.300)
SSF57997 (Tropomyosin)

620 - 763

SUPERFAMILY
SSF57997 (Tropomyosin)
cd03274 (ABC_SMC4_euk)

1,394 - 1,490

CDD
cd03274 (ABC_SMC4_euk)

248 - 409

CDD
cd03274 (ABC_SMC4_euk)
mobidb-lite (disord...)

1 - 36

MobiDB Lite
mobidb-lite (disorder_prediction)

93 - 166

MobiDB Lite
mobidb-lite (disorder_prediction)

922 - 941

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

Walker A/P-loop cd...

279G

Walker A/P-loop
279G, 280P, 281N, 282G, 283S, 284G, 285K, 286S
CDD
cd03274 (ABC_SMC4_euk)

280P

Walker A/P-loop
279G, 280P, 281N, 282G, 283S, 284G, 285K, 286S
CDD
cd03274 (ABC_SMC4_euk)

281N

Walker A/P-loop
279G, 280P, 281N, 282G, 283S, 284G, 285K, 286S
CDD
cd03274 (ABC_SMC4_euk)

282G

Walker A/P-loop
279G, 280P, 281N, 282G, 283S, 284G, 285K, 286S
CDD
cd03274 (ABC_SMC4_euk)

283S

Walker A/P-loop
279G, 280P, 281N, 282G, 283S, 284G, 285K, 286S
CDD
cd03274 (ABC_SMC4_euk)

284G

Walker A/P-loop
279G, 280P, 281N, 282G, 283S, 284G, 285K, 286S
CDD
cd03274 (ABC_SMC4_euk)

285K

Walker A/P-loop
279G, 280P, 281N, 282G, 283S, 284G, 285K, 286S
CDD
cd03274 (ABC_SMC4_euk)

286S

Walker A/P-loop
279G, 280P, 281N, 282G, 283S, 284G, 285K, 286S
CDD
cd03274 (ABC_SMC4_euk)
ATP binding site c...

282G

ATP binding site
282G, 283S, 285K, 286S, 287N, 396Q
CDD
cd03274 (ABC_SMC4_euk)

283S

ATP binding site
282G, 283S, 285K, 286S, 287N, 396Q
CDD
cd03274 (ABC_SMC4_euk)

285K

ATP binding site
282G, 283S, 285K, 286S, 287N, 396Q
CDD
cd03274 (ABC_SMC4_euk)

286S

ATP binding site
282G, 283S, 285K, 286S, 287N, 396Q
CDD
cd03274 (ABC_SMC4_euk)

287N

ATP binding site
282G, 283S, 285K, 286S, 287N, 396Q
CDD
cd03274 (ABC_SMC4_euk)

396Q

ATP binding site
282G, 283S, 285K, 286S, 287N, 396Q
CDD
cd03274 (ABC_SMC4_euk)
Q-loop/lid cd03274

393L

Q-loop/lid
393L, 394I, 395L, 396Q
CDD
cd03274 (ABC_SMC4_euk)

394I

Q-loop/lid
393L, 394I, 395L, 396Q
CDD
cd03274 (ABC_SMC4_euk)

395L

Q-loop/lid
393L, 394I, 395L, 396Q
CDD
cd03274 (ABC_SMC4_euk)

396Q

Q-loop/lid
393L, 394I, 395L, 396Q
CDD
cd03274 (ABC_SMC4_euk)
ABC transporter si...

1,406L

ABC transporter signature motif
1,406L, 1,407S, 1,408G, 1,409G, 1,410E, 1,411K, 1,412T, 1,413L, 1,414S, 1,415S
CDD
cd03274 (ABC_SMC4_euk)

1,407S

ABC transporter signature motif
1,406L, 1,407S, 1,408G, 1,409G, 1,410E, 1,411K, 1,412T, 1,413L, 1,414S, 1,415S
CDD
cd03274 (ABC_SMC4_euk)

1,408G

ABC transporter signature motif
1,406L, 1,407S, 1,408G, 1,409G, 1,410E, 1,411K, 1,412T, 1,413L, 1,414S, 1,415S
CDD
cd03274 (ABC_SMC4_euk)

1,409G

ABC transporter signature motif
1,406L, 1,407S, 1,408G, 1,409G, 1,410E, 1,411K, 1,412T, 1,413L, 1,414S, 1,415S
CDD
cd03274 (ABC_SMC4_euk)

1,410E

ABC transporter signature motif
1,406L, 1,407S, 1,408G, 1,409G, 1,410E, 1,411K, 1,412T, 1,413L, 1,414S, 1,415S
CDD
cd03274 (ABC_SMC4_euk)

1,411K

ABC transporter signature motif
1,406L, 1,407S, 1,408G, 1,409G, 1,410E, 1,411K, 1,412T, 1,413L, 1,414S, 1,415S
CDD
cd03274 (ABC_SMC4_euk)

1,412T

ABC transporter signature motif
1,406L, 1,407S, 1,408G, 1,409G, 1,410E, 1,411K, 1,412T, 1,413L, 1,414S, 1,415S
CDD
cd03274 (ABC_SMC4_euk)

1,413L

ABC transporter signature motif
1,406L, 1,407S, 1,408G, 1,409G, 1,410E, 1,411K, 1,412T, 1,413L, 1,414S, 1,415S
CDD
cd03274 (ABC_SMC4_euk)

1,414S

ABC transporter signature motif
1,406L, 1,407S, 1,408G, 1,409G, 1,410E, 1,411K, 1,412T, 1,413L, 1,414S, 1,415S
CDD
cd03274 (ABC_SMC4_euk)

1,415S

ABC transporter signature motif
1,406L, 1,407S, 1,408G, 1,409G, 1,410E, 1,411K, 1,412T, 1,413L, 1,414S, 1,415S
CDD
cd03274 (ABC_SMC4_euk)
Walker B cd03274

1,430L

Walker B
1,430L, 1,431Y, 1,432V, 1,433M, 1,434D, 1,435E
CDD
cd03274 (ABC_SMC4_euk)

1,431Y

Walker B
1,430L, 1,431Y, 1,432V, 1,433M, 1,434D, 1,435E
CDD
cd03274 (ABC_SMC4_euk)

1,432V

Walker B
1,430L, 1,431Y, 1,432V, 1,433M, 1,434D, 1,435E
CDD
cd03274 (ABC_SMC4_euk)

1,433M

Walker B
1,430L, 1,431Y, 1,432V, 1,433M, 1,434D, 1,435E
CDD
cd03274 (ABC_SMC4_euk)

1,434D

Walker B
1,430L, 1,431Y, 1,432V, 1,433M, 1,434D, 1,435E
CDD
cd03274 (ABC_SMC4_euk)

1,435E

Walker B
1,430L, 1,431Y, 1,432V, 1,433M, 1,434D, 1,435E
CDD
cd03274 (ABC_SMC4_euk)
ATP binding site c...

1,434D

ATP binding site
1,434D, 1,435E, 1,466L
CDD
cd03274 (ABC_SMC4_euk)

1,435E

ATP binding site
1,434D, 1,435E, 1,466L
CDD
cd03274 (ABC_SMC4_euk)

1,466L

ATP binding site
1,434D, 1,435E, 1,466L
CDD
cd03274 (ABC_SMC4_euk)
D-loop cd03274

1,438A

D-loop
1,438A, 1,439A, 1,440L, 1,441D
CDD
cd03274 (ABC_SMC4_euk)

1,439A

D-loop
1,438A, 1,439A, 1,440L, 1,441D
CDD
cd03274 (ABC_SMC4_euk)

1,440L

D-loop
1,438A, 1,439A, 1,440L, 1,441D
CDD
cd03274 (ABC_SMC4_euk)

1,441D

D-loop
1,438A, 1,439A, 1,440L, 1,441D
CDD
cd03274 (ABC_SMC4_euk)
H-loop/switch regi...

1,462I

H-loop/switch region
1,462I, 1,463V, 1,464I, 1,465S, 1,466L, 1,467R, 1,468N
CDD
cd03274 (ABC_SMC4_euk)

1,463V

H-loop/switch region
1,462I, 1,463V, 1,464I, 1,465S, 1,466L, 1,467R, 1,468N
CDD
cd03274 (ABC_SMC4_euk)

1,464I

H-loop/switch region
1,462I, 1,463V, 1,464I, 1,465S, 1,466L, 1,467R, 1,468N
CDD
cd03274 (ABC_SMC4_euk)

1,465S

H-loop/switch region
1,462I, 1,463V, 1,464I, 1,465S, 1,466L, 1,467R, 1,468N
CDD
cd03274 (ABC_SMC4_euk)

1,466L

H-loop/switch region
1,462I, 1,463V, 1,464I, 1,465S, 1,466L, 1,467R, 1,468N
CDD
cd03274 (ABC_SMC4_euk)

1,467R

H-loop/switch region
1,462I, 1,463V, 1,464I, 1,465S, 1,466L, 1,467R, 1,468N
CDD
cd03274 (ABC_SMC4_euk)

1,468N

H-loop/switch region
1,462I, 1,463V, 1,464I, 1,465S, 1,466L, 1,467R, 1,468N
CDD
cd03274 (ABC_SMC4_euk)

Protein sequence

>MCA_04986_1
MPPRRNRQKANAGDNLEFQDTVDSNQHDTPIEDIADISSISTTSTRNQKIKIWNRAKKDDLNTTINSNPSTPSRQSYLSN
TEGIMPLSTPSQIANTPLNFNDLPDKTRSNLGKPDDMNYFDQPQQSILERPDAASTPLHKSSSNSNMENDRHIDSGFESE
EKENLQTNHTSMAKPGIKTMNAPGQATGSPLCSFTEDFGNKLNIADANNINKNGKDNLVLVAPANGRLKALEAEKLASQN
NTSTEPRLVISKLVLINFKSYAGTQIVGPFDTSFSAVVGPNGSGKSNVIDSLLFVFGFRASKMRQGKVSALIHKSAAMPN
CNSCTVEIHFRNVIDVHQTGTTTTVPGSELVVSRQAFKNNTSKYFINNRDSSFTEVTKLMRDKGIDLDHKRFLILQGEVE
SIAQMKPKADNDSEDGMLEYLEDIIGTSRYKSEIEESETQLESLNDDCATKANRLDIVKREIAKLQDEKNVILKHLANEN
KLTMKKSLLFQSHIHHLNKKIHEKATQLQKVKDEYESGKAEFQNAFELSQSIETDIKNKAAQKSAIQKQHQSLSKQLSKR
SISSIQLEEKSKHLSAKTKKLEKQIASAQHAVNELNIWLQHYEEGVASLKNRNVDLGVKLEEKRQEYEQVQQGLKGKTEE
FTSQIEAIENQLAPWNNKILTKKAEIKIADSNIALLQEKIETARTSIQDAKDNLKKMVSEGQFKEQKIVTLTEELEHVTQ
QIQIGEKECARAETKLSAMNEDVEDCRQRFQAAQESISSVNSQSAVLKSLSNLSNSGRITGFHGRLGSLATIDPKYDIAI
STACPELENLVVETVKVGEECVQYLKRNNIGRAKFILLDKLPNWNIEKNFQSPLNAPRLFDLINPVDEKFLPAFYTVLRD
TLVAENVDDARKIAYGTSGTKYKVVTLDGILIDPSGTITGGGNISKGRMSTSNGKATSFQHTNNPAEFERLKEELEKKEA
KYTKAQEVFEKMSDALQNLKKRKPEIELEISKLHMDIEALTENLNEAKKEYNELKKNLKDSIPSQAELDQAEKVKTNLEN
DLKKLLTECSGLETQKSLLQEKIMEVGGVKLRLLKSEIDDITGEIELIQSRLSNQVLDKARKENELKKNANLIKETENEI
DNLRSDSSSSQQALETQMLENRQLEQQIEELRVEIEKLDDAIGELKTRDKEQSENVNKFKLMELELTNQMENLSKSIAER
ERAKQNYIKEIRKLELHSITDVPDIIDSKKKHTKNSKEFGDNADIDDEDENANDEYINVPTDNDLNEVQQLREYSPEELE
DVDVKELETEIAKLSDGLDKVSVNMDILKEYKSRAAEYQSRFSEAEEATARRESLKKHCQLLRKQRHDEFLQGFKAISFK
LKEMYQLITMGGNAELELVDSLDPFTEGILFSVMPPKKSWKNISNLSGGEKTLSSLALVFALHHYKPTPLYVMDEIDAAL
DFKNVSIVANYIKQRTKNGQFIVISLRNNMFELANQLVGIYKVNNMTKCVALKNA

GO term prediction

Biological Process

GO:0051276 chromosome organization

Molecular Function

GO:0005515 protein binding
GO:0005524 ATP binding

Cellular Component

GO:0005694 chromosome

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Entry type

Status

Per-residue features